Células tronco no tratamento da ceratoconjuntivite seca e break up time test nos períodos pré, trans e pós-operatório em cães (Canis lupus familiaris)
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações do UNICENTRO |
Texto Completo: | http://tede.unicentro.br:8080/jspui/handle/jspui/1783 |
Resumo: | The main function of the lacrimal system is the eye protection. There are some factors that can lead to decrease in lacrimal production and thus to secondary lesions. Keratoconjunctivitis sicca leads to decrease of lacrimal film and therefore to corneal lesions. There are treatments for such condition, however definitive cure don’t exist yet. Recently, the treatment of several diseases with stem cells became more relevant and although their action is not completely understood, this therapy is considered harmless. This study reports the effects of the application of mesenchymal stem cells in dogs with keratoconjunctivitis sicca, applied by two different routes. Another study was conducted objectifying to report the effects of two anesthetic protocols on lacrimal production in healthy dogs, since anesthesia is another factor that may lead to lacrimal reduction. Regarding the cell therapy, there were distinct beneficial effects between the two types of application. The animals that received stem cells as eye drops had significant improvement in clinical signs and those receiving periglandular injections had a significant increase in the Break Up Time (BUT) test, compatible with favorable patient outcomes. In the patients undergoing to anesthesia with two different protocols, it was observed that there was a decrease in the tear production in the trans and post-anesthetic periods in both cases, without significant differences between them. These results suggested that both protocols demand ocular lubrication. The results obtained in BUT in dogs under general anesthesia must be reevaluated after recovering to avoid misdiagnosis of keratoconjunctivitis sicca. |
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Kasecker, Giuliana Gelbckehttp://lattes.cnpq.br/7148385248455514361-564-468-93http://lattes.cnpq.br/0873763065198133Oliveira, Denise Guimarães2021-11-26T13:34:22Z2019-02-28Oliveira, Denise Guimarães. Células tronco no tratamento da ceratoconjuntivite seca e break up time test nos períodos pré, trans e pós-operatório em cães (Canis lupus familiaris). 2019. 61 f. Dissertação (Programa de Pós-Graduação em Medicina Veterinária - Mestrado) - Universidade Estadual do Centro-Oeste, Guarapuava-PR.http://tede.unicentro.br:8080/jspui/handle/jspui/1783The main function of the lacrimal system is the eye protection. There are some factors that can lead to decrease in lacrimal production and thus to secondary lesions. Keratoconjunctivitis sicca leads to decrease of lacrimal film and therefore to corneal lesions. There are treatments for such condition, however definitive cure don’t exist yet. Recently, the treatment of several diseases with stem cells became more relevant and although their action is not completely understood, this therapy is considered harmless. This study reports the effects of the application of mesenchymal stem cells in dogs with keratoconjunctivitis sicca, applied by two different routes. Another study was conducted objectifying to report the effects of two anesthetic protocols on lacrimal production in healthy dogs, since anesthesia is another factor that may lead to lacrimal reduction. Regarding the cell therapy, there were distinct beneficial effects between the two types of application. The animals that received stem cells as eye drops had significant improvement in clinical signs and those receiving periglandular injections had a significant increase in the Break Up Time (BUT) test, compatible with favorable patient outcomes. In the patients undergoing to anesthesia with two different protocols, it was observed that there was a decrease in the tear production in the trans and post-anesthetic periods in both cases, without significant differences between them. These results suggested that both protocols demand ocular lubrication. The results obtained in BUT in dogs under general anesthesia must be reevaluated after recovering to avoid misdiagnosis of keratoconjunctivitis sicca.O sistema lacrimal tem como principal função a proteção ocular. Alguns fatores podem levar a diminuição na produção lacrimal e assim a lesões secundárias. A ceratoconjuntivite seca é uma doença que leva a esta diminuição e assim a lesões corneanas, e apesar de haver tratamentos para a mesma, ainda não há cura definitiva. As células tronco têm se tornado foco de diversas doenças e apesar de sua ação não ser totalmente compreendida, esta terapia é relatada como segura. Diante disto, objetivou-se com este trabalho relatar os efeitos da aplicação de células tronco mesenquimais em cães com ceratoconjuntivite seca, por duas vias de aplicação. Outro objetivo do presente trabalho foi o relatar os efeitos de dois protocolos anestésicos na produção lacrimal em cães hígidos, já que a anestesia é outro fator que pode levar a diminuição lacrimal. Quanto a aplicação das células tronco houve efeitos benéficos distintos entre as duas vias, sendo que os animais que as receberam em forma de colírio tiveram melhora significativa nos sinais clínicos e aqueles que receberam injeções periglandulares tiveram aumento significativo no teste de Break Up Time (BUTT), compatíveis com uma evolução favorável para os pacientes. Na avaliação dos protocolos anestésicos, foi observado decréscimo na produção lacrimal nos períodos trans e pós-anestésico em ambos, sem diferenças significativas entre eles. Diante disto, sugere-se que cães que sejam anestesiados com estes fármacos recebam lubrificantes oculares, e que resultados obtidos no BUTT nestes períodos sejam reavaliados após a alta anestésica para evitar um diagnóstico errôneo de ceratoconjuntivite seca.Submitted by Fabiano Jucá (fjuca@unicentro.br) on 2021-11-26T13:34:22Z No. of bitstreams: 1 Dissertação Denise Guimarães Oliveira.pdf: 1376057 bytes, checksum: af93d16081c3d1594efd4ddd6b0abc4c (MD5)Made available in DSpace on 2021-11-26T13:34:22Z (GMT). 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dc.title.por.fl_str_mv |
Células tronco no tratamento da ceratoconjuntivite seca e break up time test nos períodos pré, trans e pós-operatório em cães (Canis lupus familiaris) |
dc.title.alternative.eng.fl_str_mv |
Stem cells in the treatment of keratoconjunctivitis sicca and assessment of break up time test values in the pre, trans and postoperative periods in dogs (Canis lupus familiaris) |
title |
Células tronco no tratamento da ceratoconjuntivite seca e break up time test nos períodos pré, trans e pós-operatório em cães (Canis lupus familiaris) |
spellingShingle |
Células tronco no tratamento da ceratoconjuntivite seca e break up time test nos períodos pré, trans e pós-operatório em cães (Canis lupus familiaris) Oliveira, Denise Guimarães CCS deficiência lacrimal Teste de Schirmer terapia celular KCS lacrimal deficiency Schirmer Test cell therapy CIENCIAS AGRARIAS::MEDICINA VETERINARIA |
title_short |
Células tronco no tratamento da ceratoconjuntivite seca e break up time test nos períodos pré, trans e pós-operatório em cães (Canis lupus familiaris) |
title_full |
Células tronco no tratamento da ceratoconjuntivite seca e break up time test nos períodos pré, trans e pós-operatório em cães (Canis lupus familiaris) |
title_fullStr |
Células tronco no tratamento da ceratoconjuntivite seca e break up time test nos períodos pré, trans e pós-operatório em cães (Canis lupus familiaris) |
title_full_unstemmed |
Células tronco no tratamento da ceratoconjuntivite seca e break up time test nos períodos pré, trans e pós-operatório em cães (Canis lupus familiaris) |
title_sort |
Células tronco no tratamento da ceratoconjuntivite seca e break up time test nos períodos pré, trans e pós-operatório em cães (Canis lupus familiaris) |
author |
Oliveira, Denise Guimarães |
author_facet |
Oliveira, Denise Guimarães |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Kasecker, Giuliana Gelbcke |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/7148385248455514 |
dc.contributor.authorID.fl_str_mv |
361-564-468-93 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/0873763065198133 |
dc.contributor.author.fl_str_mv |
Oliveira, Denise Guimarães |
contributor_str_mv |
Kasecker, Giuliana Gelbcke |
dc.subject.por.fl_str_mv |
CCS deficiência lacrimal Teste de Schirmer terapia celular |
topic |
CCS deficiência lacrimal Teste de Schirmer terapia celular KCS lacrimal deficiency Schirmer Test cell therapy CIENCIAS AGRARIAS::MEDICINA VETERINARIA |
dc.subject.eng.fl_str_mv |
KCS lacrimal deficiency Schirmer Test cell therapy |
dc.subject.cnpq.fl_str_mv |
CIENCIAS AGRARIAS::MEDICINA VETERINARIA |
description |
The main function of the lacrimal system is the eye protection. There are some factors that can lead to decrease in lacrimal production and thus to secondary lesions. Keratoconjunctivitis sicca leads to decrease of lacrimal film and therefore to corneal lesions. There are treatments for such condition, however definitive cure don’t exist yet. Recently, the treatment of several diseases with stem cells became more relevant and although their action is not completely understood, this therapy is considered harmless. This study reports the effects of the application of mesenchymal stem cells in dogs with keratoconjunctivitis sicca, applied by two different routes. Another study was conducted objectifying to report the effects of two anesthetic protocols on lacrimal production in healthy dogs, since anesthesia is another factor that may lead to lacrimal reduction. Regarding the cell therapy, there were distinct beneficial effects between the two types of application. The animals that received stem cells as eye drops had significant improvement in clinical signs and those receiving periglandular injections had a significant increase in the Break Up Time (BUT) test, compatible with favorable patient outcomes. In the patients undergoing to anesthesia with two different protocols, it was observed that there was a decrease in the tear production in the trans and post-anesthetic periods in both cases, without significant differences between them. These results suggested that both protocols demand ocular lubrication. The results obtained in BUT in dogs under general anesthesia must be reevaluated after recovering to avoid misdiagnosis of keratoconjunctivitis sicca. |
publishDate |
2019 |
dc.date.issued.fl_str_mv |
2019-02-28 |
dc.date.accessioned.fl_str_mv |
2021-11-26T13:34:22Z |
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Oliveira, Denise Guimarães. Células tronco no tratamento da ceratoconjuntivite seca e break up time test nos períodos pré, trans e pós-operatório em cães (Canis lupus familiaris). 2019. 61 f. Dissertação (Programa de Pós-Graduação em Medicina Veterinária - Mestrado) - Universidade Estadual do Centro-Oeste, Guarapuava-PR. |
dc.identifier.uri.fl_str_mv |
http://tede.unicentro.br:8080/jspui/handle/jspui/1783 |
identifier_str_mv |
Oliveira, Denise Guimarães. Células tronco no tratamento da ceratoconjuntivite seca e break up time test nos períodos pré, trans e pós-operatório em cães (Canis lupus familiaris). 2019. 61 f. Dissertação (Programa de Pós-Graduação em Medicina Veterinária - Mestrado) - Universidade Estadual do Centro-Oeste, Guarapuava-PR. |
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http://tede.unicentro.br:8080/jspui/handle/jspui/1783 |
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Universidade Estadual do Centro-Oeste |
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