ESTUDO QUÍMICO E FARMACOLÓGICO DA Verbena minutiflora (VERBENACEAE)
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Tipo de documento: | Tese |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações do UNICENTRO |
Texto Completo: | http://tede.unicentro.br:8080/jspui/handle/jspui/753 |
Resumo: | Verbena minutiflora (Verbenaceae) is popularly known as gervão. It is consumed as an infusion for the treatment of various diseases. However, so far there is no pharmacological or chemical validation to support its therapeutic applications. Therefore, the analysis of the chemical composition and pharmacological activities of V. minutiflora is of paramount importance. In this study, extracts and infusions of the aerial parts of V. minutiflora (leaves, flowers and stems) were analysed during four consecutive years. Extracts of leaves and flowers had significantly higher phenolic content and antiradical capacity than stems regardless of the year of collection. The infusions of leaves presented constant composition throughout the studied period with high levels of bioactive compounds and high antioxidant potential. The chemical composition was elucidated by HPLC-DAD and LC-ESI-MS/MS. The phenylpropanoids, verbascoside and isoverbascoside and the iridoid hastatoside were identified by interpretation and comparison of its UV and ESI-MS/MS spectra with data from literature. An in house validation study showed good accuracy and precision to determine the bioactive compounds in V. minutiflora by HPLC-DAD. Phenylpropanoids varied in extracts (leaves 139.70 to 221.20 mg/g, flowers 106.43 to 227.22 mg/g, stems 42.18 to 56.48 mg/g). Verbascoside was in higher concentration in extracts of leaves (87.66 – 136.16) mg/g and flowers (58.12 – 148.96) mg/g than in stems (19.24 – 24.62) mg/g. Iridoids in extracts were: leaves (46.60 − 54.79) mg/g, flowers (55.88 − 93.87) mg/g and stems (40.05 to 61.74) mg/g. High levels of iridoids (314.70 − 415.10) μg/mL, phenylpropanoids (1996.39 − 2674.13) μg/mL and verbascoside (1029.38 − 1456.42 μg/mL) in infusions support the popular consume of V. minutiflora. The content of metal ions pointed out that Verbena minutiflora is rich in K, Ca, Na and Mg. The analysis in acute diuresis model in rats has shown that ethyl acetate fraction and infusion Verbena minutiflora has diuretic activity. |
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Quináia, Sueli Pérciohttp://lattes.cnpq.br/3256907601004018Torres, Yohandra Reyeshttp://lattes.cnpq.br/9724560887352587031.219.599-05http://lattes.cnpq.br/7995507265516119SOARES, KELLY CRISTINA NOGUEIRA2017-07-06T12:54:30Z2016-02-19SOARES, KELLY CRISTINA NOGUEIRA. ESTUDO QUÍMICO E FARMACOLÓGICO DA Verbena minutiflora (VERBENACEAE). 2016. 160 f. Tese (Programa de Pós-Graduação em Química - Doutorado) - Universidade Estadual do Centro-Oeste, Guarapuava - PR.http://tede.unicentro.br:8080/jspui/handle/jspui/753Verbena minutiflora (Verbenaceae) is popularly known as gervão. It is consumed as an infusion for the treatment of various diseases. However, so far there is no pharmacological or chemical validation to support its therapeutic applications. Therefore, the analysis of the chemical composition and pharmacological activities of V. minutiflora is of paramount importance. In this study, extracts and infusions of the aerial parts of V. minutiflora (leaves, flowers and stems) were analysed during four consecutive years. Extracts of leaves and flowers had significantly higher phenolic content and antiradical capacity than stems regardless of the year of collection. The infusions of leaves presented constant composition throughout the studied period with high levels of bioactive compounds and high antioxidant potential. The chemical composition was elucidated by HPLC-DAD and LC-ESI-MS/MS. The phenylpropanoids, verbascoside and isoverbascoside and the iridoid hastatoside were identified by interpretation and comparison of its UV and ESI-MS/MS spectra with data from literature. An in house validation study showed good accuracy and precision to determine the bioactive compounds in V. minutiflora by HPLC-DAD. Phenylpropanoids varied in extracts (leaves 139.70 to 221.20 mg/g, flowers 106.43 to 227.22 mg/g, stems 42.18 to 56.48 mg/g). Verbascoside was in higher concentration in extracts of leaves (87.66 – 136.16) mg/g and flowers (58.12 – 148.96) mg/g than in stems (19.24 – 24.62) mg/g. Iridoids in extracts were: leaves (46.60 − 54.79) mg/g, flowers (55.88 − 93.87) mg/g and stems (40.05 to 61.74) mg/g. High levels of iridoids (314.70 − 415.10) μg/mL, phenylpropanoids (1996.39 − 2674.13) μg/mL and verbascoside (1029.38 − 1456.42 μg/mL) in infusions support the popular consume of V. minutiflora. The content of metal ions pointed out that Verbena minutiflora is rich in K, Ca, Na and Mg. The analysis in acute diuresis model in rats has shown that ethyl acetate fraction and infusion Verbena minutiflora has diuretic activity.Verbena minutiflora (Verbenaceae) é uma planta conhecida popularmente como gervão, muito consumida como infusão (chá) e é frequentemente utilizada para o tratamento de diversas doenças, no entanto, até o momento não existe validação química e farmacológica que subsidie as suas aplicações terapêuticas. A análise da composição química, teor de fenólicos totais, flavonoides e da atividade antioxidante nesta espécie é de grande importância. As partes aéreas da V. minutiflora (folhas, flores e caules) e infusões foram monitoradas por quatro anos consecutivos. Os extratos etanólicos da folha e flor apresentaram em média teores de fenólicos e flavonoides significativamente maiores que o extrato etanólico do caule e da infusão independentemente do ano de coleta, mas a infusão apresentou um potencial antioxidante. A composição química foi elucidada por meio de HPLC-DAD e LC-ESI-MS/MS, os fenilpropanoides, verbascosídeo e isoverbascosídeo e o iridoide hastatosídeo foram identificados através da interpretação e comparação de seus dados de UV e de ESI-MS/MS com a literatura. Um estudo de validação in house demonstrou boa exatidão e precisão para determinar os compostos bioativos em V. minutiflora por HPLC-DAD. O teor de fenilpropanoides variou nos extratos (para folhas 139,70 - 221,20 mg/g, flores 106,43-227,22 mg/g, para caules 42,18 - 56.48 mg/g). O verbascosideo estava em maior concentração nos extratos de folhas (87,66 - 136,16) mg/g e flores (58.12 - 148,96) mg/g do que nos caules (19,24-24,62) mg/g. Iridoides em extratos foram: folhas (46,60-54,79) mg/g, flores (55,88 - 93,87) mg/g e caules (40.05 a 61.74) mg/g. Altos níveis de iridoides (314.70 - 415,10) μg/mL, fenilpropanoides (1996.39 - 2.674,13) μg/mL e verbascosideo (1029.38 - 1.456,42 μg/mL) em infusões corroboram para o uso popular de consumir V. minutiflora. O conteúdo de íons metálicos apontou que a Verbena minutiflora é rica em K, Ca, Na e Mg. A análise no modelo de diurese aguda em ratos demonstrou que a fração acetato de etila e a infusão da Verbena minutiflora possuem atividade diurética.Submitted by Fabiano Jucá (fjuca@unicentro.br) on 2017-07-06T12:54:30Z No. of bitstreams: 1 KELLY CRISTINA NOGUEIRA SOARES.pdf: 8539794 bytes, checksum: 89b9bf6bf198d81db880c9876ba8690a (MD5)Made available in DSpace on 2017-07-06T12:54:30Z (GMT). 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dc.title.por.fl_str_mv |
ESTUDO QUÍMICO E FARMACOLÓGICO DA Verbena minutiflora (VERBENACEAE) |
title |
ESTUDO QUÍMICO E FARMACOLÓGICO DA Verbena minutiflora (VERBENACEAE) |
spellingShingle |
ESTUDO QUÍMICO E FARMACOLÓGICO DA Verbena minutiflora (VERBENACEAE) SOARES, KELLY CRISTINA NOGUEIRA Verbena minutiflora (Verbenaceae) CIENCIAS EXATAS E DA TERRA::QUIMICA |
title_short |
ESTUDO QUÍMICO E FARMACOLÓGICO DA Verbena minutiflora (VERBENACEAE) |
title_full |
ESTUDO QUÍMICO E FARMACOLÓGICO DA Verbena minutiflora (VERBENACEAE) |
title_fullStr |
ESTUDO QUÍMICO E FARMACOLÓGICO DA Verbena minutiflora (VERBENACEAE) |
title_full_unstemmed |
ESTUDO QUÍMICO E FARMACOLÓGICO DA Verbena minutiflora (VERBENACEAE) |
title_sort |
ESTUDO QUÍMICO E FARMACOLÓGICO DA Verbena minutiflora (VERBENACEAE) |
author |
SOARES, KELLY CRISTINA NOGUEIRA |
author_facet |
SOARES, KELLY CRISTINA NOGUEIRA |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Quináia, Sueli Pércio |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/3256907601004018 |
dc.contributor.advisor-co1.fl_str_mv |
Torres, Yohandra Reyes |
dc.contributor.advisor-co1Lattes.fl_str_mv |
http://lattes.cnpq.br/9724560887352587 |
dc.contributor.authorID.fl_str_mv |
031.219.599-05 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/7995507265516119 |
dc.contributor.author.fl_str_mv |
SOARES, KELLY CRISTINA NOGUEIRA |
contributor_str_mv |
Quináia, Sueli Pércio Torres, Yohandra Reyes |
dc.subject.por.fl_str_mv |
Verbena minutiflora (Verbenaceae) |
topic |
Verbena minutiflora (Verbenaceae) CIENCIAS EXATAS E DA TERRA::QUIMICA |
dc.subject.cnpq.fl_str_mv |
CIENCIAS EXATAS E DA TERRA::QUIMICA |
description |
Verbena minutiflora (Verbenaceae) is popularly known as gervão. It is consumed as an infusion for the treatment of various diseases. However, so far there is no pharmacological or chemical validation to support its therapeutic applications. Therefore, the analysis of the chemical composition and pharmacological activities of V. minutiflora is of paramount importance. In this study, extracts and infusions of the aerial parts of V. minutiflora (leaves, flowers and stems) were analysed during four consecutive years. Extracts of leaves and flowers had significantly higher phenolic content and antiradical capacity than stems regardless of the year of collection. The infusions of leaves presented constant composition throughout the studied period with high levels of bioactive compounds and high antioxidant potential. The chemical composition was elucidated by HPLC-DAD and LC-ESI-MS/MS. The phenylpropanoids, verbascoside and isoverbascoside and the iridoid hastatoside were identified by interpretation and comparison of its UV and ESI-MS/MS spectra with data from literature. An in house validation study showed good accuracy and precision to determine the bioactive compounds in V. minutiflora by HPLC-DAD. Phenylpropanoids varied in extracts (leaves 139.70 to 221.20 mg/g, flowers 106.43 to 227.22 mg/g, stems 42.18 to 56.48 mg/g). Verbascoside was in higher concentration in extracts of leaves (87.66 – 136.16) mg/g and flowers (58.12 – 148.96) mg/g than in stems (19.24 – 24.62) mg/g. Iridoids in extracts were: leaves (46.60 − 54.79) mg/g, flowers (55.88 − 93.87) mg/g and stems (40.05 to 61.74) mg/g. High levels of iridoids (314.70 − 415.10) μg/mL, phenylpropanoids (1996.39 − 2674.13) μg/mL and verbascoside (1029.38 − 1456.42 μg/mL) in infusions support the popular consume of V. minutiflora. The content of metal ions pointed out that Verbena minutiflora is rich in K, Ca, Na and Mg. The analysis in acute diuresis model in rats has shown that ethyl acetate fraction and infusion Verbena minutiflora has diuretic activity. |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016-02-19 |
dc.date.accessioned.fl_str_mv |
2017-07-06T12:54:30Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/doctoralThesis |
format |
doctoralThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SOARES, KELLY CRISTINA NOGUEIRA. ESTUDO QUÍMICO E FARMACOLÓGICO DA Verbena minutiflora (VERBENACEAE). 2016. 160 f. Tese (Programa de Pós-Graduação em Química - Doutorado) - Universidade Estadual do Centro-Oeste, Guarapuava - PR. |
dc.identifier.uri.fl_str_mv |
http://tede.unicentro.br:8080/jspui/handle/jspui/753 |
identifier_str_mv |
SOARES, KELLY CRISTINA NOGUEIRA. ESTUDO QUÍMICO E FARMACOLÓGICO DA Verbena minutiflora (VERBENACEAE). 2016. 160 f. Tese (Programa de Pós-Graduação em Química - Doutorado) - Universidade Estadual do Centro-Oeste, Guarapuava - PR. |
url |
http://tede.unicentro.br:8080/jspui/handle/jspui/753 |
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por |
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por |
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3800526532796635565 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Universidade Estadual do Centro-Oeste |
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Programa de Pós-Graduação em Química (Doutorado) |
dc.publisher.initials.fl_str_mv |
UNICENTRO |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Unicentro::Departamento de Ciências Exatas e de Tecnologia |
publisher.none.fl_str_mv |
Universidade Estadual do Centro-Oeste |
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