Estudo dos polimorfismos DUFFY em pacientes infectados com Plasmodium vivax
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2015 |
| Tipo de documento: | Dissertação |
| Idioma: | por |
| Título da fonte: | Repositório Institucional da Universidade do Estado do Amazonas (UEA) |
| Texto Completo: | https://ri.uea.edu.br/handle/riuea/2276 |
Resumo: | Introduction: Malaria is a major public health problem, including Brazil, where the Plasmodium vivax is more prevalent. The Duffy glycoprotein acts as facilitator in the tissue invasion of erythroid by P. vivax; however, little is known about the association between DUFFY polymorphisms and malaria susceptibility caused by this type of plasmodium. New perspectives about this subject have emerged in different endemic regions also involving the parasite density infections. Objective: To investigate the impact of DUFFY polymorphisms in patients infected by Plasmodium vivax Materials and Methods: It was studied DNA samples of Patients infected by P. vivax, diagnosed in the Formation of Tropical Medicine Doctor Heitor Vieira Dourado through laboratorial tests which defined the type of malaria parasitaemia as the thick smear methods, genotyping and WBC. The verification of Duffy polymorphisms were carried out in the Amazon Blood Center, through PCR / RFLP and microarray method (Beadchip). The statistical significance of the frequencies found were analyzed using the statistical package R Core Team 2013. Results: We studied 287 patients and 273 individuals with no history of malaria. The FYBES allele was found in 53.2% of subjects with no history of malaria and 11.2% of infected patients. The FYB allele seems to be associated with middle and high parasite density. Discussion: Duffy polymorphism has been considered to be important in areas where P. vivax predominates. In the present study we confirm the FYBES allele is directly associated with a reduced expression of the glycoprotein Duffy, which may have an impact on malarial infection. Conclusion: Duffy polymorphisms may be associated as the frequency of parasite infection well as the density and the severity of the clinical manifestations. |
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Estudo dos polimorfismos DUFFY em pacientes infectados com Plasmodium vivaxStudy of DUFFY polymorphisms in patients infected with Plasmodium vivaxMaláriaPlasmodium vivaxSistema DuffyMedicinaIntroduction: Malaria is a major public health problem, including Brazil, where the Plasmodium vivax is more prevalent. The Duffy glycoprotein acts as facilitator in the tissue invasion of erythroid by P. vivax; however, little is known about the association between DUFFY polymorphisms and malaria susceptibility caused by this type of plasmodium. New perspectives about this subject have emerged in different endemic regions also involving the parasite density infections. Objective: To investigate the impact of DUFFY polymorphisms in patients infected by Plasmodium vivax Materials and Methods: It was studied DNA samples of Patients infected by P. vivax, diagnosed in the Formation of Tropical Medicine Doctor Heitor Vieira Dourado through laboratorial tests which defined the type of malaria parasitaemia as the thick smear methods, genotyping and WBC. The verification of Duffy polymorphisms were carried out in the Amazon Blood Center, through PCR / RFLP and microarray method (Beadchip). The statistical significance of the frequencies found were analyzed using the statistical package R Core Team 2013. Results: We studied 287 patients and 273 individuals with no history of malaria. The FYBES allele was found in 53.2% of subjects with no history of malaria and 11.2% of infected patients. The FYB allele seems to be associated with middle and high parasite density. Discussion: Duffy polymorphism has been considered to be important in areas where P. vivax predominates. In the present study we confirm the FYBES allele is directly associated with a reduced expression of the glycoprotein Duffy, which may have an impact on malarial infection. Conclusion: Duffy polymorphisms may be associated as the frequency of parasite infection well as the density and the severity of the clinical manifestations.Introdução: A malária é um importante problema de saúde pública, inclusive no Brasil, onde o Plasmodium vivax é mais prevalente. A glicoproteína Duffy atua como facilitadora da invasão no tecido eritróide pelo P. vivax; porém, ainda pouco se conhece sobre a associação de polimorfismos DUFFY com a susceptibilidade à este tipo de malária. Novas perspectivas, sobre a associação entre esses polimorfismos e o P. vivax, têm surgido em diferentes regiões endêmicas, envolvendo também a densidade parasitária das infecções. Objetivo Investigar o impacto dos polimorfismos DUFFY na malaria causada por Plasmodium vivax Materiais e métodos: Pacientes infectados pelo P. vivax, diagnosticados na Fundação de Medicina Tropical doutor Heitor Vieira Dourado com definição do tipo de malária e parasitemia através dos métodos da gota espessa, genotipagem e leucograma. Para a verificação dos polimorfismos Duffy foram realizadas no Hemocentro do Amazonas, genotipagem através da PCR/RFLP e microarray (Beadchip). Investigamos a significância estatística das frequências encontradas foi analisada utilizando o pacote estatístico R Core Team 2013. Resultados: Foram estudados 287 pacientes e 273 indivíduos sem antecedente de malária. O alelo FYBES foi encontrado em 53,2% de indivíduos sem antecedente de malária e 11,2% de pacientes e o alelo FYB esteve mais associado à média e alta densidade parasitária. Discussão: Os polimorfismos Duffy tem se mostrado importantes nas áreas onde predomina o P. vivax. No presente estudo confirmamos que o alelo FYBES está diretamente associado com uma redução da expressão da glicoproteína Duffy, o que pode exercer um impacto na infecção malárica. Conclusão: Os polimorfismos Duffy podem estar associados tanto com a frequência da infecção quanto com a densidade parasitária e a gravidade das manifestações clínicas.Universidade do Estado do AmazonasBrasilUEAPROGRAMA DE PÓS-GRADUAÇÃO EM CIÊNCIAS APLICADAS Á HEMATOLOGIAAlbuquerque, Sérgio Roberto LopesAlbuquerque, Sérgio Roberto LopesWeber, Simone SchneiderLalwani, Pritesh JaychandAli, Rechfy Kasem Abou2020-03-11T14:04:42Z2024-09-05T18:56:45Z2020-03-112020-03-11T14:04:42Z2015-10-26info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttps://ri.uea.edu.br/handle/riuea/2276por1. World Health Organization. World Malaria Report 2014. WHO Global Malaria Programme. 2015. 2. da Silva Santos S, Clark TG, Campino S, Suarez-Mutis MC, Rockett KA, Kwiatkowski DP, et al. Investigation of Host Candidate Malaria-Associated Risk/Protective SNPs in a Brazilian Amazonian Population. PloS one. 2012;7(5):e36692. 3. Costa DC. A reação em Cadeia da Polimerase como técnica auxiliar no diagnósitco de malária em serviços de saúde de referencia em Minas Gerais; The polymerase chain reaction technique to assist in diagnostic malaria in health services reference in Minas Gerais: Centro de Pesquisas René Rachou; 2010. 4. Katsuragawa TH, Cunha RPdA, Souza DCAd, Gil LHS, Cruz RB, Silva AdA, et al. Malaria and hematological aspects among residents to be impacted by reservoirs for the Santo Antônio and Jirau Hydroelectric Power Stations, Rondônia State, Brazil. Cadernos de Saúde Pública. 2009;25(7):1486-92. 5. Ministério da Saúde. Boletim epidemiológico, Malária: Monitoramento dos casos no Brasil em 2014. Secretaria de Vigilância em Saúde. 2015;Volume 46. 6. Ministério da Saúde SdVeS. Mapa de risco por município de infecção, Brasil, 2014. Portal da Saúde. 2015. 7. Neves DP. Parasitologia humana. 12 ed ed. São Paulo: Atheneu; 2011. 8. Driss A, Hibbert JM, Wilson NO, Iqbal SA, Adamkiewicz TV, Stiles JK. Genetic polymorphisms linked to susceptibility to malaria. Malar J. 2011;10:271. 9. Rowe JA, Opi DH, Williams TN. Blood groups and malaria: fresh insights into pathogenesis and identification of targets for intervention. Current opinion in hematology. 2009;16(6):480. 10. Da Silva R, Pinto A, Calvosa V, de Souza JM. Esquemas terapêuticos encurtados para o tratamento de malária por Plasmodium vivax. Rev Soc Bras Med Trop. 2003;36:235-9. 11. Sanchez BAM. Caracterização do receptor DARC (Duffy Antigen/Receptor for Chemokines) e da resposta imune anti Duffy Binding Protein em indivíduos expostos ao Plasmodium vivax; Characterization of the receptor DARC (Duffy Antigen/Receptor for Chemokines) and the immune response anti Duffy Binding Protein in individuals exposed to Plasmodium vivax: Centro de Pesquisas René Rachou; 2011. 12. Jotta LdACV, da Silva Carneiro MH. Malária: as imagens utilizadas em livros didáticos de biologia. Anais do VII Encontro Nacional de Pesquisa em Ensino em Ciências. 2009:01-11. 13. Albuquerque SRL, de Oliveira Cavalcante F, Sanguino EC, Tezza L, Chacon F, Castilho L, et al. FY polymorphisms and vivax malaria in inhabitants of Amazonas State, Brazil. Parasitology research. 2010;106(5):1049- 53. 14. Zimmerman PA, Ferreira MU, Howes RE, Mercereau-Puijalon O. Red blood cell polymorphism and susceptibility to Plasmodium vivax. Adv Parasitol. 2013;81:27-76. 15. Grimberg BT, Udomsangpetch R, Xainli J, McHenry A, Panichakul T, Sattabongkot J, et al. Plasmodium vivax invasion of human erythrocytes inhibited by antibodies directed against the Duffy binding protein. PLoS medicine. 2007;4(12):e337. 16. Russell B, Suwanarusk R, Borlon C, Costa FT, Chu CS, Rijken MJ, et al. A reliable ex vivo invasion assay of human reticulocytes by Plasmodium vivax. Blood. 2011;118(13):e74-e81. 17. World Health Organization. Universal access to malaria diagnostic testing: an operational manual. Geneva: WHO. 2011. 18. Teixeira JRM. Resposta terapêutica da malária por Plasmodium vivax a cloroquina e primaquina. [Doutorado]: Universidade Federal do Pará; 2011. 19. Alecrim MdGC. Estudo clínico, resistência e polimorfismo parasitário na malaria pelo Plasmodium vivax, em Manaus-AM: Universidade de Brasília. Departamento de Medicina Tropical; 2000. 20. Cutbush M, Mollison P. The Duffy blood group system. Heredity. 1950;4(3):383. 21. COMPTON A, HABER JM. The Duffy Blood Group System in Transfusion Reactions: A Review of the Literature and Report of Four Cases. Blood. 1960;15(1):186-91. 22. IKIN E, PETTENKOFER H. Discovery of the expected haemagglutinin, anti-Fyb. Nature. 1951;168(4288):1077-8. 23. Jens E, Pagliarini T, Novaretti MC. Sistema de grupo sanguíneo Duffy: Biologia e prática Transfusional. Rev Bras Hematol Hemoter. 2005;27(2):110-9. 24. Donahue RP, Bias WB, Renwick JH, McKusick VA. Probable assignment of the Duffy blood group locus to chromosome 1 in man. Proceedings of the National Academy of Sciences of the United States of America. 1968;61(3):949. 25. Chaudhuri A, Polyakova J, Zbrzezna V, Pogo A. The coding sequence of Duffy blood group gene in humans and simians: restriction fragment length polymorphism, antibody and malarial parasite specificities, and expression in nonerythroid tissues in Duffy-negative individuals. Blood. 1995;85(3):615-21. 44 26. Tournamille C, Le Van Kim C, Gane P, Cartron J-P, Colin Y. Molecular basis and PCR-DNA typing of the Fya/fyb blood group polymorphism. Human genetics. 1995;95(4):407-10. 27. Tournamille C, Colin Y, Cartron JP, Le Van Kim C. Disruption of a GATA motif in the Duffy gene promoter abolishes erythroid gene expression in Duffy–negative individuals. Nature genetics. 1995;10(2):224-8. 28. Zimmerman PA, Woolley I, Masinde GL, Miller SM, McNamara DT, Hazlett F, et al. Emergence of FY* Anull in a Plasmodium vivax-endemic region of Papua New Guinea. Proceedings of the National Academy of Sciences. 1999;96(24):13973-7. 29. Langhi D, Orlando Bordin J. Duffy blood group and malaria. Hematology. 2006;11(5-6):5-6. 30. Castilho L, Rios M, Pellegrino J, Saad S, Costa F, Reid M. A novel FY allele in Brazilians. Vox sanguinis. 2004;87(3):190-5. 31. Oscar Pogo A, Chaudhuri A, editors. The Duffy protein: a malarial and chemokine receptor. Seminars in hematology; 2000: Elsevier. 32. Chown B, Lewis M, Kaita H. The Duffy blood group system in Caucasians: evidence for a new allele. American journal of human genetics. 1965;17(5):384. 33. Olsson ML, Smythe JS, Hansson C, Poole J, Mallinson G, Jones J, et al. The Fyx phenotype is associated with a missense mutation in the Fyb allele predicting Arg89Cys in the Duffy glycoprotein. British journal of haematology. 1998;103(4):1184-91. 34. Tournamille C, Le Van Kim C, Gane P, Le Pennec PY, Roubinet F, Babinet J, et al. Arg89Cys substitution results in very low membrane expression of the Duffy antigen/receptor for chemokines in Fyx individuals. Blood. 1998;92(6):2147-56. 35. Mathew S, Chaudhuri A, Murty V, Pogo A. Confirmation of Duffy blood group antigen locus (FY) at 1q22→ q23 by fluorescence in situ hybridization. Cytogenetics and cell genetics. 1994;67(1):1-22. 36. Forabosco P, Collins A, Morton N. Integration of gene maps: updating chromosome 1. Annals of human genetics. 1995;59(3):291-305. 37. Murphy PM. Chemokine receptors: structure, function and role in microbial pathogenesis. Cytokine & growth factor reviews. 1996;7(1):47-64. 38. Darbonne W, Rice G, Mohler M, Apple T, Hebert C, Valente A, et al. Red blood cells are a sink for interleukin 8, a leukocyte chemotaxin. Journal of Clinical Investigation. 1991;88(4):1362. 39. Nichols M, Rubinstein P, Barnwell J, de Cordoba SR, Rosenfield R. A new human Duffy blood group specificity defined by a murine monoclonal antibody. Immunogenetics and association with susceptibility to Plasmodium vivax. The Journal of experimental medicine. 1987;166(3):776-85. 40. Sellami M, Kaabi H, Midouni B, Dridi A, Mojaat N, Boukef M, et al. Duffy blood group system genotyping in an urban Tunisian population. Annals of human biology. 2008;35(4):406-15. 41. Yazdanbakhsh K, Rios M, Storry J, Kosower N, Parasol N, Chaudhuri A, et al. Molecular mechanisms that lead to reduced expression of Duffy antigens. Transfusion. 2000;40(3):310-20. 42. Woolley I, Hotmire K, Sramkoski R, Zimmerman P, Kazura J. Differential expression of the Duffy antigen receptor for chemokines according to RBC age and FY genotype. Transfusion. 2000;40(8):949-53. 43. Estalote AC, Proto-Siqueira R, Silva Jr W, Zago MA, Palatnik M. The mutation G298A→ Ala100Thr on the coding sequence of the Duffy antigen/chemokine receptor gene in non-caucasian Brazilians. Genet Mol Res. 2005;4(2):166-73. 44. Cavasini CE, de Mattos LC, Couto ÁADA, Bonini-Domingos CR, Valencia SH, de Souza Neiras WC, et al. Plasmodium vivax infection among Duffy antigen-negative individuals from the Brazilian Amazon region: an exception? Transactions of the Royal Society of Tropical Medicine and Hygiene. 2007b;101(10):1042-4. 45. Carvalho TA, Queiroz MG, Cardoso GL, Diniz IG, Silva AN, Pinto AY, et al. Plasmodium vivax infection in Anajás, State of Pará: no differential resistance profile among Duffy-negative and Duffy-positive individuals. Malaria journal. 2012;11(1):1-6. 46. Bruce MC, Day KP. Cross-species regulation of Plasmodium parasitemia in semi-immune children from Papua New Guinea. Trends in parasitology. 2003;19(6):271-7. 47. Mcqueen PG, Mckenzie FE. Competition for red blood cells can enhance Plasmodium vivax parasitemia in mixed-species malaria infections. The American journal of tropical medicine and hygiene. 2006;75(1):112. 48. Chomczynski P. A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples. Biotechniques. 1993;15(3):532-4, 6-7. 49. Ribeiro KAR. Genotipagem eritrocitaria em larga escala: impacto na medicina transfusional: Universidade Estadual de Campinas. Faculdade de Ciências Médicas; 2009. 50. Novaretti MC, Dorlhiac-Llacer PE, Chamone DA. Blood groups in caucasian and black blood donors from São Paulo, Brazil. Revista Brasileira de Hematologia e Hemoterapia. 2000;22(1):23-32. 45 51. Cavasini CE, de Mattos LC, Couto ÁA, Couto VS, Gollino Y, Moretti LJ, et al. Duffy blood group gene polymorphisms among malaria vivax patients in four areas of the Brazilian Amazon region. Malaria journal. 2007a;6(1):167. 52. King CL, Adams JH, Xianli J, Grimberg BT, McHenry AM, Greenberg LJ, et al. Fy(a)/Fy(b) antigen polymorphism in human erythrocyte Duffy antigen affects susceptibility to Plasmodium vivax malaria. Proc Natl Acad Sci U S A. 2011 Dec 13;108(50):20113-8. PubMed PMID: 22123959. Pubmed Central PMCID: 3250126. 53. Menard D, Barnadas C, Bouchier C, Henry-Halldin C, Gray LR, Ratsimbasoa A, et al. Plasmodium vivax clinical malaria is commonly observed in Duffy-negative Malagasy people. Proceedings of the National Academy of Sciences. 2010;107(13):5967-71. 54. Woolley I, Wood E, Sramkoski R, Zimmerman P, Miller J, Kazura J. Expression of Duffy antigen receptor for chemokines during reticulocyte maturation: using a CD71 flow cytometric technique to identify reticulocytes. Immunohematology. 2005;21(1):15-20. 55. Culleton R, Coban C, Zeyrek FY, Cravo P, Kaneko A, Randrianarivelojosia M, et al. The origins of African Plasmodium vivax; insights from mitochondrial genome sequencing. PLoS One. 2011;6(12):e29137. PubMed PMID: 22195007. Pubmed Central PMCID: 3237592. 56. Woldearegai TG, Kremsner PG, Kun JF, Mordmüller B. Plasmodium vivax malaria in Duffy-negative individuals from Ethiopia. Transactions of The Royal Society of Tropical Medicine and Hygiene. 2013;107(5):328- 31.Atribuição-NãoComercial-SemDerivados 3.0 Brasilinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da Universidade do Estado do Amazonas (UEA)instname:Universidade do Estado do Amazonas (UEA)instacron:UEA2024-09-25T21:16:44Zoai:ri.uea.edu.br:riuea/2276Repositório InstitucionalPUBhttps://ri.uea.edu.br/server/oai/requestbibliotecacentral@uea.edu.bropendoar:2024-09-25T21:16:44Repositório Institucional da Universidade do Estado do Amazonas (UEA) - Universidade do Estado do Amazonas (UEA)false |
| dc.title.none.fl_str_mv |
Estudo dos polimorfismos DUFFY em pacientes infectados com Plasmodium vivax Study of DUFFY polymorphisms in patients infected with Plasmodium vivax |
| title |
Estudo dos polimorfismos DUFFY em pacientes infectados com Plasmodium vivax |
| spellingShingle |
Estudo dos polimorfismos DUFFY em pacientes infectados com Plasmodium vivax Ali, Rechfy Kasem Abou Malária Plasmodium vivax Sistema Duffy Medicina |
| title_short |
Estudo dos polimorfismos DUFFY em pacientes infectados com Plasmodium vivax |
| title_full |
Estudo dos polimorfismos DUFFY em pacientes infectados com Plasmodium vivax |
| title_fullStr |
Estudo dos polimorfismos DUFFY em pacientes infectados com Plasmodium vivax |
| title_full_unstemmed |
Estudo dos polimorfismos DUFFY em pacientes infectados com Plasmodium vivax |
| title_sort |
Estudo dos polimorfismos DUFFY em pacientes infectados com Plasmodium vivax |
| author |
Ali, Rechfy Kasem Abou |
| author_facet |
Ali, Rechfy Kasem Abou |
| author_role |
author |
| dc.contributor.none.fl_str_mv |
Albuquerque, Sérgio Roberto Lopes Albuquerque, Sérgio Roberto Lopes Weber, Simone Schneider Lalwani, Pritesh Jaychand |
| dc.contributor.author.fl_str_mv |
Ali, Rechfy Kasem Abou |
| dc.subject.por.fl_str_mv |
Malária Plasmodium vivax Sistema Duffy Medicina |
| topic |
Malária Plasmodium vivax Sistema Duffy Medicina |
| description |
Introduction: Malaria is a major public health problem, including Brazil, where the Plasmodium vivax is more prevalent. The Duffy glycoprotein acts as facilitator in the tissue invasion of erythroid by P. vivax; however, little is known about the association between DUFFY polymorphisms and malaria susceptibility caused by this type of plasmodium. New perspectives about this subject have emerged in different endemic regions also involving the parasite density infections. Objective: To investigate the impact of DUFFY polymorphisms in patients infected by Plasmodium vivax Materials and Methods: It was studied DNA samples of Patients infected by P. vivax, diagnosed in the Formation of Tropical Medicine Doctor Heitor Vieira Dourado through laboratorial tests which defined the type of malaria parasitaemia as the thick smear methods, genotyping and WBC. The verification of Duffy polymorphisms were carried out in the Amazon Blood Center, through PCR / RFLP and microarray method (Beadchip). The statistical significance of the frequencies found were analyzed using the statistical package R Core Team 2013. Results: We studied 287 patients and 273 individuals with no history of malaria. The FYBES allele was found in 53.2% of subjects with no history of malaria and 11.2% of infected patients. The FYB allele seems to be associated with middle and high parasite density. Discussion: Duffy polymorphism has been considered to be important in areas where P. vivax predominates. In the present study we confirm the FYBES allele is directly associated with a reduced expression of the glycoprotein Duffy, which may have an impact on malarial infection. Conclusion: Duffy polymorphisms may be associated as the frequency of parasite infection well as the density and the severity of the clinical manifestations. |
| publishDate |
2015 |
| dc.date.none.fl_str_mv |
2015-10-26 2020-03-11T14:04:42Z 2020-03-11 2020-03-11T14:04:42Z 2024-09-05T18:56:45Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/masterThesis |
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masterThesis |
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publishedVersion |
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https://ri.uea.edu.br/handle/riuea/2276 |
| url |
https://ri.uea.edu.br/handle/riuea/2276 |
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por |
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1. World Health Organization. World Malaria Report 2014. WHO Global Malaria Programme. 2015. 2. da Silva Santos S, Clark TG, Campino S, Suarez-Mutis MC, Rockett KA, Kwiatkowski DP, et al. Investigation of Host Candidate Malaria-Associated Risk/Protective SNPs in a Brazilian Amazonian Population. PloS one. 2012;7(5):e36692. 3. Costa DC. A reação em Cadeia da Polimerase como técnica auxiliar no diagnósitco de malária em serviços de saúde de referencia em Minas Gerais; The polymerase chain reaction technique to assist in diagnostic malaria in health services reference in Minas Gerais: Centro de Pesquisas René Rachou; 2010. 4. Katsuragawa TH, Cunha RPdA, Souza DCAd, Gil LHS, Cruz RB, Silva AdA, et al. Malaria and hematological aspects among residents to be impacted by reservoirs for the Santo Antônio and Jirau Hydroelectric Power Stations, Rondônia State, Brazil. Cadernos de Saúde Pública. 2009;25(7):1486-92. 5. Ministério da Saúde. Boletim epidemiológico, Malária: Monitoramento dos casos no Brasil em 2014. Secretaria de Vigilância em Saúde. 2015;Volume 46. 6. Ministério da Saúde SdVeS. Mapa de risco por município de infecção, Brasil, 2014. Portal da Saúde. 2015. 7. Neves DP. Parasitologia humana. 12 ed ed. São Paulo: Atheneu; 2011. 8. Driss A, Hibbert JM, Wilson NO, Iqbal SA, Adamkiewicz TV, Stiles JK. Genetic polymorphisms linked to susceptibility to malaria. Malar J. 2011;10:271. 9. Rowe JA, Opi DH, Williams TN. Blood groups and malaria: fresh insights into pathogenesis and identification of targets for intervention. Current opinion in hematology. 2009;16(6):480. 10. Da Silva R, Pinto A, Calvosa V, de Souza JM. Esquemas terapêuticos encurtados para o tratamento de malária por Plasmodium vivax. Rev Soc Bras Med Trop. 2003;36:235-9. 11. Sanchez BAM. Caracterização do receptor DARC (Duffy Antigen/Receptor for Chemokines) e da resposta imune anti Duffy Binding Protein em indivíduos expostos ao Plasmodium vivax; Characterization of the receptor DARC (Duffy Antigen/Receptor for Chemokines) and the immune response anti Duffy Binding Protein in individuals exposed to Plasmodium vivax: Centro de Pesquisas René Rachou; 2011. 12. Jotta LdACV, da Silva Carneiro MH. Malária: as imagens utilizadas em livros didáticos de biologia. Anais do VII Encontro Nacional de Pesquisa em Ensino em Ciências. 2009:01-11. 13. Albuquerque SRL, de Oliveira Cavalcante F, Sanguino EC, Tezza L, Chacon F, Castilho L, et al. FY polymorphisms and vivax malaria in inhabitants of Amazonas State, Brazil. Parasitology research. 2010;106(5):1049- 53. 14. Zimmerman PA, Ferreira MU, Howes RE, Mercereau-Puijalon O. Red blood cell polymorphism and susceptibility to Plasmodium vivax. Adv Parasitol. 2013;81:27-76. 15. Grimberg BT, Udomsangpetch R, Xainli J, McHenry A, Panichakul T, Sattabongkot J, et al. Plasmodium vivax invasion of human erythrocytes inhibited by antibodies directed against the Duffy binding protein. PLoS medicine. 2007;4(12):e337. 16. Russell B, Suwanarusk R, Borlon C, Costa FT, Chu CS, Rijken MJ, et al. A reliable ex vivo invasion assay of human reticulocytes by Plasmodium vivax. Blood. 2011;118(13):e74-e81. 17. World Health Organization. Universal access to malaria diagnostic testing: an operational manual. Geneva: WHO. 2011. 18. Teixeira JRM. Resposta terapêutica da malária por Plasmodium vivax a cloroquina e primaquina. [Doutorado]: Universidade Federal do Pará; 2011. 19. Alecrim MdGC. Estudo clínico, resistência e polimorfismo parasitário na malaria pelo Plasmodium vivax, em Manaus-AM: Universidade de Brasília. Departamento de Medicina Tropical; 2000. 20. Cutbush M, Mollison P. The Duffy blood group system. Heredity. 1950;4(3):383. 21. COMPTON A, HABER JM. The Duffy Blood Group System in Transfusion Reactions: A Review of the Literature and Report of Four Cases. Blood. 1960;15(1):186-91. 22. IKIN E, PETTENKOFER H. Discovery of the expected haemagglutinin, anti-Fyb. Nature. 1951;168(4288):1077-8. 23. Jens E, Pagliarini T, Novaretti MC. Sistema de grupo sanguíneo Duffy: Biologia e prática Transfusional. Rev Bras Hematol Hemoter. 2005;27(2):110-9. 24. Donahue RP, Bias WB, Renwick JH, McKusick VA. Probable assignment of the Duffy blood group locus to chromosome 1 in man. Proceedings of the National Academy of Sciences of the United States of America. 1968;61(3):949. 25. Chaudhuri A, Polyakova J, Zbrzezna V, Pogo A. The coding sequence of Duffy blood group gene in humans and simians: restriction fragment length polymorphism, antibody and malarial parasite specificities, and expression in nonerythroid tissues in Duffy-negative individuals. Blood. 1995;85(3):615-21. 44 26. Tournamille C, Le Van Kim C, Gane P, Cartron J-P, Colin Y. 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Duffy blood group gene polymorphisms among malaria vivax patients in four areas of the Brazilian Amazon region. Malaria journal. 2007a;6(1):167. 52. King CL, Adams JH, Xianli J, Grimberg BT, McHenry AM, Greenberg LJ, et al. Fy(a)/Fy(b) antigen polymorphism in human erythrocyte Duffy antigen affects susceptibility to Plasmodium vivax malaria. Proc Natl Acad Sci U S A. 2011 Dec 13;108(50):20113-8. PubMed PMID: 22123959. Pubmed Central PMCID: 3250126. 53. Menard D, Barnadas C, Bouchier C, Henry-Halldin C, Gray LR, Ratsimbasoa A, et al. Plasmodium vivax clinical malaria is commonly observed in Duffy-negative Malagasy people. Proceedings of the National Academy of Sciences. 2010;107(13):5967-71. 54. Woolley I, Wood E, Sramkoski R, Zimmerman P, Miller J, Kazura J. Expression of Duffy antigen receptor for chemokines during reticulocyte maturation: using a CD71 flow cytometric technique to identify reticulocytes. Immunohematology. 2005;21(1):15-20. 55. 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