Análise do perfil e fatores relacionados a sobrevida de adultos jovens e idosos portadores de câncer oral
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações da UEFS |
Texto Completo: | http://tede2.uefs.br:8080/handle/tede/664 |
Resumo: | Oral cancer represents a major public health problem with widely varying incidence, mortality, and survival rates worldwide. The disease of multifactorial etiology develops because of the interaction of multiple genetic and environmental factors. The objective of this study was to investigate the profile of patients with oral cancer and to evaluate the influence of the factors related to the survival of these individuals in a high complexity Oncology unit of Feira de Santana, Bahia, Brazil, between 2010 and 2016. It is a hospital-based, retrospective cohort study where the population was composed of individuals with histopathological diagnosis of squamous cell carcinoma. Socio-demographic, life habits, lesion data, treatment, survival time and survival status variables were obtained by reviewing clinical records. Initially, a descriptive analysis of all variables was performed. Later, the Kaplan-Meier estimator was used to compute the survival probabilities at each time, with and without stratification. The log-rank test was used for the comparisons between the several curves. In order to estimate the effects of each variable on the survival of the individuals, the Cox models were adjusted for each of them and, from the significance of the relative risks at each time, the variables that entered the multivariable model were defined. The majority of cases occurred in male individuals, aged over 45 years, chronic smokers and alcoholics. Lesions predominantly localized in the tongue were diagnosed at an advanced stage of the disease. Surgical therapy associated with radiotherapy and chemotherapy was the most recommended for the young group and radiotherapy associated with chemotherapy for the old group. Results indicated that the only predictive factors for oral cancer were tumor staging and type of treatment, pointing out the need for strategies to reduce the main risk factors for the disease and the importance of early diagnosis, to increase the patients’ survival and the improvement of their quality of life. |
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Freitas, Valéria Souza5037833345305550161532http://lattes.cnpq.br/0628266911671801Amorim, Marília de Matos2018-07-16T20:18:40Z2018-03-08AMORIM, Marília de Matos. Análise do perfil e fatores relacionados a sobrevida de adultos jovens e idosos portadores de câncer oral. 2018. 132 f. Dissertação (Mestrado Acadêmico em Saúde Coletiva)- Universidade Estadual de Feira de Santana, Feira de Santana, 2018.http://tede2.uefs.br:8080/handle/tede/664Oral cancer represents a major public health problem with widely varying incidence, mortality, and survival rates worldwide. The disease of multifactorial etiology develops because of the interaction of multiple genetic and environmental factors. The objective of this study was to investigate the profile of patients with oral cancer and to evaluate the influence of the factors related to the survival of these individuals in a high complexity Oncology unit of Feira de Santana, Bahia, Brazil, between 2010 and 2016. It is a hospital-based, retrospective cohort study where the population was composed of individuals with histopathological diagnosis of squamous cell carcinoma. Socio-demographic, life habits, lesion data, treatment, survival time and survival status variables were obtained by reviewing clinical records. Initially, a descriptive analysis of all variables was performed. Later, the Kaplan-Meier estimator was used to compute the survival probabilities at each time, with and without stratification. The log-rank test was used for the comparisons between the several curves. In order to estimate the effects of each variable on the survival of the individuals, the Cox models were adjusted for each of them and, from the significance of the relative risks at each time, the variables that entered the multivariable model were defined. The majority of cases occurred in male individuals, aged over 45 years, chronic smokers and alcoholics. Lesions predominantly localized in the tongue were diagnosed at an advanced stage of the disease. Surgical therapy associated with radiotherapy and chemotherapy was the most recommended for the young group and radiotherapy associated with chemotherapy for the old group. Results indicated that the only predictive factors for oral cancer were tumor staging and type of treatment, pointing out the need for strategies to reduce the main risk factors for the disease and the importance of early diagnosis, to increase the patients’ survival and the improvement of their quality of life.O câncer oral representa um grande problema de saúde pública, com taxas de incidência, mortalidade e sobrevida bastante variáveis em todo o mundo. A doença de etiologia multifatorial desenvolve-se como resultado da interação de múltiplos fatores genéticos e ambientais. O objetivo deste estudo foi investigar o perfil de pacientes com câncer oral e avaliar a influência dos fatores relacionados à sobrevida destes indivíduos em uma unidade de alta complexidade em Oncologia de Feira de Santana, Bahia, no período 2010 a 2016. Trata-se de um estudo de coorte retrospectivo, de base hospitalar, onde a população foi composta por indivíduos com diagnóstico histopatológico de carcinoma de células escamosas. Variáveis sociodemográficas, de hábitos de vida, de dados da lesão, do tratamento, de tempo de sobrevida e de status de sobrevida foram obtidos através da revisão de prontuários clínicos. Inicialmente foi realizada uma análise descritiva de todas as variáveis. Posteriormente, para computar as probabilidades de sobrevida a cada tempo foi utilizado o estimador de Kaplan-Meier, sem e com estratificação. Para as comparações entre as diversas curvas foi utilizado o teste de log-rank. Com o objetivo de estimar os efeitos de cada variável na sobrevida dos indivíduos, foram ajustados os modelos de Cox para cada uma delas e, a partir da significância dos riscos relativos a cada tempo, foram definidas quais entraram no modelo multivariável. A maioria dos casos ocorreu em indivíduos do sexo masculino, com idade acima de 45 anos, tabagistas e etilistas crônicos. As lesões predominantemente localizadas em língua foram diagnosticadas em estágio avançado da doença. A terapia cirúrgica associada a radioterapia e quimioterapia foi a mais recomendada para o grupo jovem e a radioterapia associada a quimioterapia, para o grupo idoso. Os resultados indicaram que apenas o estadiamento do tumor e o tipo de tratamento foram fatores preditivos para o câncer oral, apontando a necessidade de estratégias para a redução dos principais fatores de risco para a doença e a importância do diagnóstico precoce, com vistas ao aumento da sobrevida e à melhoria da qualidade de vida dos pacientes.Submitted by Ricardo Cedraz Duque Moliterno (ricardo.moliterno@uefs.br) on 2018-07-16T20:18:40Z No. of bitstreams: 1 DISSERTACAO_FINAL_MARILIA_AMORIM.pdf: 2678188 bytes, checksum: dcefdbbe615be5ccd3ccf21e26697ed7 (MD5)Made available in DSpace on 2018-07-16T20:18:40Z (GMT). No. of bitstreams: 1 DISSERTACAO_FINAL_MARILIA_AMORIM.pdf: 2678188 bytes, checksum: dcefdbbe615be5ccd3ccf21e26697ed7 (MD5) Previous issue date: 2018-03-08Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESapplication/pdfporUniversidade Estadual de Feira de SantanaMestrado Acadêmico em Saúde ColetivaUEFSBrasilDEPARTAMENTO DE SAÚDENeoplasias bucaisAdulto jovemAnálise de sobrevidaOral neoplasmsYoung adultsSurvival analysisCIENCIAS DA SAUDE::SAUDE COLETIVAAnálise do perfil e fatores relacionados a sobrevida de adultos jovens e idosos portadores de câncer oralinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis-1219759018657228036006006006008549511740116106200-61731671037544951992075167498588264571info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da UEFSinstname:Universidade Estadual de Feira de Santana (UEFS)instacron:UEFSORIGINALDISSERTACAO_FINAL_MARILIA_AMORIM.pdfDISSERTACAO_FINAL_MARILIA_AMORIM.pdfapplication/pdf2678188http://tede2.uefs.br:8080/bitstream/tede/664/2/DISSERTACAO_FINAL_MARILIA_AMORIM.pdfdcefdbbe615be5ccd3ccf21e26697ed7MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82165http://tede2.uefs.br:8080/bitstream/tede/664/1/license.txtbd3efa91386c1718a7f26a329fdcb468MD51tede/6642018-07-16 17:18:40.408oai:tede2.uefs.br:8080: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Biblioteca Digital de Teses e Dissertaçõeshttp://tede2.uefs.br:8080/PUBhttp://tede2.uefs.br:8080/oai/requestbcuefs@uefs.br|| bcref@uefs.br||bcuefs@uefs.bropendoar:2018-07-16T20:18:40Biblioteca Digital de Teses e Dissertações da UEFS - Universidade Estadual de Feira de Santana (UEFS)false |
dc.title.por.fl_str_mv |
Análise do perfil e fatores relacionados a sobrevida de adultos jovens e idosos portadores de câncer oral |
title |
Análise do perfil e fatores relacionados a sobrevida de adultos jovens e idosos portadores de câncer oral |
spellingShingle |
Análise do perfil e fatores relacionados a sobrevida de adultos jovens e idosos portadores de câncer oral Amorim, Marília de Matos Neoplasias bucais Adulto jovem Análise de sobrevida Oral neoplasms Young adults Survival analysis CIENCIAS DA SAUDE::SAUDE COLETIVA |
title_short |
Análise do perfil e fatores relacionados a sobrevida de adultos jovens e idosos portadores de câncer oral |
title_full |
Análise do perfil e fatores relacionados a sobrevida de adultos jovens e idosos portadores de câncer oral |
title_fullStr |
Análise do perfil e fatores relacionados a sobrevida de adultos jovens e idosos portadores de câncer oral |
title_full_unstemmed |
Análise do perfil e fatores relacionados a sobrevida de adultos jovens e idosos portadores de câncer oral |
title_sort |
Análise do perfil e fatores relacionados a sobrevida de adultos jovens e idosos portadores de câncer oral |
author |
Amorim, Marília de Matos |
author_facet |
Amorim, Marília de Matos |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Freitas, Valéria Souza |
dc.contributor.advisor1ID.fl_str_mv |
50378333453 |
dc.contributor.authorID.fl_str_mv |
05550161532 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/0628266911671801 |
dc.contributor.author.fl_str_mv |
Amorim, Marília de Matos |
contributor_str_mv |
Freitas, Valéria Souza |
dc.subject.por.fl_str_mv |
Neoplasias bucais Adulto jovem Análise de sobrevida |
topic |
Neoplasias bucais Adulto jovem Análise de sobrevida Oral neoplasms Young adults Survival analysis CIENCIAS DA SAUDE::SAUDE COLETIVA |
dc.subject.eng.fl_str_mv |
Oral neoplasms Young adults Survival analysis |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE::SAUDE COLETIVA |
description |
Oral cancer represents a major public health problem with widely varying incidence, mortality, and survival rates worldwide. The disease of multifactorial etiology develops because of the interaction of multiple genetic and environmental factors. The objective of this study was to investigate the profile of patients with oral cancer and to evaluate the influence of the factors related to the survival of these individuals in a high complexity Oncology unit of Feira de Santana, Bahia, Brazil, between 2010 and 2016. It is a hospital-based, retrospective cohort study where the population was composed of individuals with histopathological diagnosis of squamous cell carcinoma. Socio-demographic, life habits, lesion data, treatment, survival time and survival status variables were obtained by reviewing clinical records. Initially, a descriptive analysis of all variables was performed. Later, the Kaplan-Meier estimator was used to compute the survival probabilities at each time, with and without stratification. The log-rank test was used for the comparisons between the several curves. In order to estimate the effects of each variable on the survival of the individuals, the Cox models were adjusted for each of them and, from the significance of the relative risks at each time, the variables that entered the multivariable model were defined. The majority of cases occurred in male individuals, aged over 45 years, chronic smokers and alcoholics. Lesions predominantly localized in the tongue were diagnosed at an advanced stage of the disease. Surgical therapy associated with radiotherapy and chemotherapy was the most recommended for the young group and radiotherapy associated with chemotherapy for the old group. Results indicated that the only predictive factors for oral cancer were tumor staging and type of treatment, pointing out the need for strategies to reduce the main risk factors for the disease and the importance of early diagnosis, to increase the patients’ survival and the improvement of their quality of life. |
publishDate |
2018 |
dc.date.accessioned.fl_str_mv |
2018-07-16T20:18:40Z |
dc.date.issued.fl_str_mv |
2018-03-08 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
AMORIM, Marília de Matos. Análise do perfil e fatores relacionados a sobrevida de adultos jovens e idosos portadores de câncer oral. 2018. 132 f. Dissertação (Mestrado Acadêmico em Saúde Coletiva)- Universidade Estadual de Feira de Santana, Feira de Santana, 2018. |
dc.identifier.uri.fl_str_mv |
http://tede2.uefs.br:8080/handle/tede/664 |
identifier_str_mv |
AMORIM, Marília de Matos. Análise do perfil e fatores relacionados a sobrevida de adultos jovens e idosos portadores de câncer oral. 2018. 132 f. Dissertação (Mestrado Acadêmico em Saúde Coletiva)- Universidade Estadual de Feira de Santana, Feira de Santana, 2018. |
url |
http://tede2.uefs.br:8080/handle/tede/664 |
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por |
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Universidade Estadual de Feira de Santana |
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