Avaliação biológica e constituintes químicos dos frutos de Xanthium cavanillesii
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações da UEFS |
Texto Completo: | http://tede2.uefs.br:8080/handle/tede/1191 |
Resumo: | The genus Xanthium (Asteraceae), in Brazil, is found mainly in South and Southeast, authors described two species, X. strumarium and X. cavanillesii, this last one is popularly known as “carrapicho de carneiro”, “carrapichão” and “carrapicho grande”. This genus can produce sesquiterpene lactones, sulfonated compounds, diterpenes kauranes, essential oils, phenolic acids. In the X. cavanillesi previous studies had evaluated its antimicrobial, antifungic, diuretic, antiulcerative, topic antiflamatory properties. In other species also already its antimalarial property was studied. In order to study the secondary metabolites and the biological potential were a phytochemical studie of X. cavanillesii. Thus crude extracts of the aerial parts of X. cavanillesii had been gotten by maceration and bioassay front to Artemia salina (Brine Shrimp), by the cytotoxicity using mortality testing. As a result, the ethanolic and aqueous extracts showed biological activity and was testing antimalarial activity in vitro using the P. falciparum W2 clone. Following, the active extracts were fractionated using standard chromatographic methods (CC on silica gel and permeation by Sephadex LH-20). Analyses by HPLC-DAD, 1H and 13C NMR, MS, IR were used to characterize ferulic acid, caffeic acid, and a semi-purified diterpene kaurane. In addition, molecular docking studies were used to explain the mechanism of action against of PfATPase6 model. The results of in silico showed that caffeic acid is the most active of the phenolic acids extracted, while the ferulic acid is the less active compound against PfATPase6. |
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Taranto, Alex Gutterres94820635549http://lattes.cnpq.br/4166810899152932Costa, Sonia Carine Cova2020-06-26T16:20:11Z2010-02-24COSTA, Sonia Carine Cova. Avaliação biológica e constituintes químicos dos frutos de Xanthium cavanillesii. 2010. 112 f. Dissertação (Mestrado Acadêmico em Recursos Genéticos Vegetais)- Universidade Estadual de Feira de Santana, Feira de Santana, 2010.http://tede2.uefs.br:8080/handle/tede/1191The genus Xanthium (Asteraceae), in Brazil, is found mainly in South and Southeast, authors described two species, X. strumarium and X. cavanillesii, this last one is popularly known as “carrapicho de carneiro”, “carrapichão” and “carrapicho grande”. This genus can produce sesquiterpene lactones, sulfonated compounds, diterpenes kauranes, essential oils, phenolic acids. In the X. cavanillesi previous studies had evaluated its antimicrobial, antifungic, diuretic, antiulcerative, topic antiflamatory properties. In other species also already its antimalarial property was studied. In order to study the secondary metabolites and the biological potential were a phytochemical studie of X. cavanillesii. Thus crude extracts of the aerial parts of X. cavanillesii had been gotten by maceration and bioassay front to Artemia salina (Brine Shrimp), by the cytotoxicity using mortality testing. As a result, the ethanolic and aqueous extracts showed biological activity and was testing antimalarial activity in vitro using the P. falciparum W2 clone. Following, the active extracts were fractionated using standard chromatographic methods (CC on silica gel and permeation by Sephadex LH-20). Analyses by HPLC-DAD, 1H and 13C NMR, MS, IR were used to characterize ferulic acid, caffeic acid, and a semi-purified diterpene kaurane. In addition, molecular docking studies were used to explain the mechanism of action against of PfATPase6 model. The results of in silico showed that caffeic acid is the most active of the phenolic acids extracted, while the ferulic acid is the less active compound against PfATPase6.O gênero Xanthium (família Asteraceae) é encontrado principalmente nas regiões Sul e Sudeste, do Brasil, sendo descritas duas espécies, X. strumarium e X. cavanillesii, este último conhecido popularmente como carrapicho de carneiro, carrapichão e carrapicho grande. Esta espécie bioproduz lactonas sesquiterpênicas, diterpenos da classe dos cauranos, óleos essenciais, ácidos fenólicos. No X. cavanillesi estudos anteriores avaliaram suas propriedades antimicrobiana, antifúngica, diurética, anti-ulcerativa e antiinflamatória-tópica. Em outras espécies também já foi estudada sua propriedade antimalárica. Com o objetivo de conhecer potencial biológico antimalárico e os metabólitos secundários correspondentes foi realizado um estudo fitoquímico do X. cavanillesii. Assim extratos das partes aéreas de X. cavanillesii foram obtidos por maceração e testados frente a A. salina, quanto à toxicidade empregando teste de mortalidade. Os extratos etanólico e aquoso foram testados in vitro contra cepas W2 do P. falciparum. O extrato etanólico apresentou atividade superior ao quanto comparado ao extrato aquoso, sendo em seguida fracionado utilizando-se métodos cromatográficos usuais (CC em sílica e permeação em gel de Sephadex LH-20). Análises das frações por CLAE, RMN 1H e 13C, EM, IV, permitiram a caracterização dos ácidos ferúlico, caféico e um diterpeno caurano, este composto foi semi-purificado. Estudos de ancoargem molecular foram utilizados para explicar o mecanismo de ação contra o modelo do receptor PfATPase6. Como resultado do ensaio in sílico, o ácido caféico foi o mais ativo da série de ácidos fenólicos estudados, e o ácido ferúlico menos ativo contra PfATPase6.Submitted by Bruno Matos Nascimento (brunomatos@uefs.br) on 2020-06-26T16:20:11Z No. of bitstreams: 1 DISSETAÇÃO SÔNIA CARINE COVA COSTA.pdf: 2760029 bytes, checksum: f3f0a97d0ff9cef4aca47af14f360941 (MD5)Made available in DSpace on 2020-06-26T16:20:11Z (GMT). No. of bitstreams: 1 DISSETAÇÃO SÔNIA CARINE COVA COSTA.pdf: 2760029 bytes, checksum: f3f0a97d0ff9cef4aca47af14f360941 (MD5) Previous issue date: 2010-02-24application/pdfporUniversidade Estadual de Feira de SantanaMestrado Acadêmico em Recursos Genéticos VegetaisUEFSBrasilDEPARTAMENTO DE CIÊNCIAS BIOLÓGICASXanthium cavanillesiácido fenólicomaláriaantimaláricoancoragem molecularPfATPase6phenolic acidsmalariaantimalarialmolecular dockingCIENCIAS AGRARIASCIENCIAS BIOLOGICASAvaliação biológica e constituintes químicos dos frutos de Xanthium cavanillesiiinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis814664648162224187460060060060050261233834505892827828424726906663919-3439178843068202161info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da UEFSinstname:Universidade Estadual de Feira de Santana (UEFS)instacron:UEFSORIGINALDISSETAÇÃO SÔNIA CARINE COVA COSTA.pdfDISSETAÇÃO SÔNIA CARINE COVA COSTA.pdfapplication/pdf2760029http://tede2.uefs.br:8080/bitstream/tede/1191/2/DISSETA%C3%87%C3%83O+S%C3%94NIA+CARINE+COVA+COSTA.pdff3f0a97d0ff9cef4aca47af14f360941MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82089http://tede2.uefs.br:8080/bitstream/tede/1191/1/license.txt7b5ba3d2445355f386edab96125d42b7MD51tede/11912020-06-26 13:20:11.14oai:tede2.uefs.br:8080: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Biblioteca Digital de Teses e Dissertaçõeshttp://tede2.uefs.br:8080/PUBhttp://tede2.uefs.br:8080/oai/requestbcuefs@uefs.br|| bcref@uefs.br||bcuefs@uefs.bropendoar:2020-06-26T16:20:11Biblioteca Digital de Teses e Dissertações da UEFS - Universidade Estadual de Feira de Santana (UEFS)false |
dc.title.por.fl_str_mv |
Avaliação biológica e constituintes químicos dos frutos de Xanthium cavanillesii |
title |
Avaliação biológica e constituintes químicos dos frutos de Xanthium cavanillesii |
spellingShingle |
Avaliação biológica e constituintes químicos dos frutos de Xanthium cavanillesii Costa, Sonia Carine Cova Xanthium cavanillesi ácido fenólico malária antimalárico ancoragem molecular PfATPase6 phenolic acids malaria antimalarial molecular docking CIENCIAS AGRARIAS CIENCIAS BIOLOGICAS |
title_short |
Avaliação biológica e constituintes químicos dos frutos de Xanthium cavanillesii |
title_full |
Avaliação biológica e constituintes químicos dos frutos de Xanthium cavanillesii |
title_fullStr |
Avaliação biológica e constituintes químicos dos frutos de Xanthium cavanillesii |
title_full_unstemmed |
Avaliação biológica e constituintes químicos dos frutos de Xanthium cavanillesii |
title_sort |
Avaliação biológica e constituintes químicos dos frutos de Xanthium cavanillesii |
author |
Costa, Sonia Carine Cova |
author_facet |
Costa, Sonia Carine Cova |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Taranto, Alex Gutterres |
dc.contributor.authorID.fl_str_mv |
94820635549 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/4166810899152932 |
dc.contributor.author.fl_str_mv |
Costa, Sonia Carine Cova |
contributor_str_mv |
Taranto, Alex Gutterres |
dc.subject.por.fl_str_mv |
Xanthium cavanillesi ácido fenólico malária antimalárico ancoragem molecular PfATPase6 |
topic |
Xanthium cavanillesi ácido fenólico malária antimalárico ancoragem molecular PfATPase6 phenolic acids malaria antimalarial molecular docking CIENCIAS AGRARIAS CIENCIAS BIOLOGICAS |
dc.subject.eng.fl_str_mv |
phenolic acids malaria antimalarial molecular docking |
dc.subject.cnpq.fl_str_mv |
CIENCIAS AGRARIAS CIENCIAS BIOLOGICAS |
description |
The genus Xanthium (Asteraceae), in Brazil, is found mainly in South and Southeast, authors described two species, X. strumarium and X. cavanillesii, this last one is popularly known as “carrapicho de carneiro”, “carrapichão” and “carrapicho grande”. This genus can produce sesquiterpene lactones, sulfonated compounds, diterpenes kauranes, essential oils, phenolic acids. In the X. cavanillesi previous studies had evaluated its antimicrobial, antifungic, diuretic, antiulcerative, topic antiflamatory properties. In other species also already its antimalarial property was studied. In order to study the secondary metabolites and the biological potential were a phytochemical studie of X. cavanillesii. Thus crude extracts of the aerial parts of X. cavanillesii had been gotten by maceration and bioassay front to Artemia salina (Brine Shrimp), by the cytotoxicity using mortality testing. As a result, the ethanolic and aqueous extracts showed biological activity and was testing antimalarial activity in vitro using the P. falciparum W2 clone. Following, the active extracts were fractionated using standard chromatographic methods (CC on silica gel and permeation by Sephadex LH-20). Analyses by HPLC-DAD, 1H and 13C NMR, MS, IR were used to characterize ferulic acid, caffeic acid, and a semi-purified diterpene kaurane. In addition, molecular docking studies were used to explain the mechanism of action against of PfATPase6 model. The results of in silico showed that caffeic acid is the most active of the phenolic acids extracted, while the ferulic acid is the less active compound against PfATPase6. |
publishDate |
2010 |
dc.date.issued.fl_str_mv |
2010-02-24 |
dc.date.accessioned.fl_str_mv |
2020-06-26T16:20:11Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
COSTA, Sonia Carine Cova. Avaliação biológica e constituintes químicos dos frutos de Xanthium cavanillesii. 2010. 112 f. Dissertação (Mestrado Acadêmico em Recursos Genéticos Vegetais)- Universidade Estadual de Feira de Santana, Feira de Santana, 2010. |
dc.identifier.uri.fl_str_mv |
http://tede2.uefs.br:8080/handle/tede/1191 |
identifier_str_mv |
COSTA, Sonia Carine Cova. Avaliação biológica e constituintes químicos dos frutos de Xanthium cavanillesii. 2010. 112 f. Dissertação (Mestrado Acadêmico em Recursos Genéticos Vegetais)- Universidade Estadual de Feira de Santana, Feira de Santana, 2010. |
url |
http://tede2.uefs.br:8080/handle/tede/1191 |
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por |
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por |
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openAccess |
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Universidade Estadual de Feira de Santana |
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Mestrado Acadêmico em Recursos Genéticos Vegetais |
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UEFS |
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Universidade Estadual de Feira de Santana |
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