Autosomal recessive inheritance of cutaneous asthenia in a dog - case report
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Semina. Ciências Agrárias (Online) |
Texto Completo: | https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/34980 |
Resumo: | Cutaneous asthenia (CA) or Ehlers-Danlos Syndrome, in dogs, is a rare hereditary syndrome caused by autosomal dominant inheritance that causes collagen synthesis failure and leads to hyperextensibility and cutaneous fragility. This report describes a clinical case of canine CA of hereditary recessive origin, hitherto proven for other species, in an animal born from inbreeding healthy parents. A one-year-old female Maltese dog received clinical and surgical care for a cutaneous wound after a hygienic bath. The clinical history revealed the occurrence of other injuries that were caused by minor trauma and the consanguinity of the patient. During wound cleaning, the trichotomy and removal of an adhesive tape that was fixed to the skin generated new lacerations, which led to clinical suspicion of CA. CA was confirmed by calculating the cutaneous extensibility index (CEI), which was 22%, higher than the normal limit for the species (14.5%). The skin biopsy confirmed the clinical diagnosis, and the wound of the animal was treated routinely and healed clinically. Both dominant and recessive patterns have been well documented in cats; however, in dogs, only the dominant form has been reported in the literature. Our findings demonstrate that canine CA may result from autosomal recessive inheritance, and CA must be considered during diagnostic clinical approaches and breeding selections. |
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Semina. Ciências Agrárias (Online) |
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Autosomal recessive inheritance of cutaneous asthenia in a dog - case reportAstenia cutânea autossômica recessiva em cão - relato de casoCollagenEhlers-Danlos SyndromeWounds.ColágenoFeridasSíndrome de Ehlers-Danlos.Cutaneous asthenia (CA) or Ehlers-Danlos Syndrome, in dogs, is a rare hereditary syndrome caused by autosomal dominant inheritance that causes collagen synthesis failure and leads to hyperextensibility and cutaneous fragility. This report describes a clinical case of canine CA of hereditary recessive origin, hitherto proven for other species, in an animal born from inbreeding healthy parents. A one-year-old female Maltese dog received clinical and surgical care for a cutaneous wound after a hygienic bath. The clinical history revealed the occurrence of other injuries that were caused by minor trauma and the consanguinity of the patient. During wound cleaning, the trichotomy and removal of an adhesive tape that was fixed to the skin generated new lacerations, which led to clinical suspicion of CA. CA was confirmed by calculating the cutaneous extensibility index (CEI), which was 22%, higher than the normal limit for the species (14.5%). The skin biopsy confirmed the clinical diagnosis, and the wound of the animal was treated routinely and healed clinically. Both dominant and recessive patterns have been well documented in cats; however, in dogs, only the dominant form has been reported in the literature. Our findings demonstrate that canine CA may result from autosomal recessive inheritance, and CA must be considered during diagnostic clinical approaches and breeding selections.A astenia cutânea (CA) ou Síndrome de Ehlers-Danlos, em cães, é uma síndrome hereditária rara, causada por gene autossômico dominante que resulta em falha na síntese de colágeno levando à hiperextensibilidade e à fragilidade cutâneas. O objetivo deste trabalho é relatar a existência de astenia cutânea canina de origem hereditária recessiva, até agora comprovada para outras espécies, a partir da descrição de um caso clínico de CA em um animal nascido de união consanguínea de pais saudáveis. Uma cadela Maltês, com um ano de idade, recebeu atendimento clínico-cirúrgico por apresentar uma ferida cutânea após um banho higiênico. A história clínica revelou a ocorrência de outros ferimentos provocados por pequenos traumas e a origem consanguínea da paciente. Durante a limpeza da ferida, a tricotomia e a remoção de uma fita adesiva fixada à pele geraram novas lacerações levantando à suspeita clínica de astenia cutânea, confirmada pelo cálculo do índice de extensibilidade cutânea (CEI) que resultou em 22%, valor superior ao limítrofe de normalidade para a espécie (14,5%). A biopsia cutânea confirmou o diagnóstico clínico. A ferida do animal foi tratada rotineiramente resultando em cura clínica. Tanto as formas dominante e recessiva foram bem documentadas em gatos; entretanto, em cães, somente a forma dominante havia sido descrita pela literatura. Concluiu-se que a astenia cutânea canina pode advir de herança autossômica recessiva e isto deve ser considerado durante a abordagem clínica visando o diagnóstico e a seleção racial.UEL2020-03-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionRelato de Casoinfo:eu-repo/semantics/otherapplication/pdfhttps://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/3498010.5433/1679-0359.2020v41n2p731Semina: Ciências Agrárias; Vol. 41 No. 2 (2020); 731-736Semina: Ciências Agrárias; v. 41 n. 2 (2020); 731-7361679-03591676-546Xreponame:Semina. Ciências Agrárias (Online)instname:Universidade Estadual de Londrina (UEL)instacron:UELenghttps://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/34980/26889Copyright (c) 2020 Semina: Ciências Agráriashttp://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessSaigali, Pedro Henrique FrançaJardim, Paulo Henrique de AffonsecaRondon, Eric Schmidt2022-10-10T14:10:42Zoai:ojs.pkp.sfu.ca:article/34980Revistahttp://www.uel.br/revistas/uel/index.php/semagrariasPUBhttps://ojs.uel.br/revistas/uel/index.php/semagrarias/oaisemina.agrarias@uel.br1679-03591676-546Xopendoar:2022-10-10T14:10:42Semina. Ciências Agrárias (Online) - Universidade Estadual de Londrina (UEL)false |
dc.title.none.fl_str_mv |
Autosomal recessive inheritance of cutaneous asthenia in a dog - case report Astenia cutânea autossômica recessiva em cão - relato de caso |
title |
Autosomal recessive inheritance of cutaneous asthenia in a dog - case report |
spellingShingle |
Autosomal recessive inheritance of cutaneous asthenia in a dog - case report Saigali, Pedro Henrique França Collagen Ehlers-Danlos Syndrome Wounds. Colágeno Feridas Síndrome de Ehlers-Danlos. |
title_short |
Autosomal recessive inheritance of cutaneous asthenia in a dog - case report |
title_full |
Autosomal recessive inheritance of cutaneous asthenia in a dog - case report |
title_fullStr |
Autosomal recessive inheritance of cutaneous asthenia in a dog - case report |
title_full_unstemmed |
Autosomal recessive inheritance of cutaneous asthenia in a dog - case report |
title_sort |
Autosomal recessive inheritance of cutaneous asthenia in a dog - case report |
author |
Saigali, Pedro Henrique França |
author_facet |
Saigali, Pedro Henrique França Jardim, Paulo Henrique de Affonseca Rondon, Eric Schmidt |
author_role |
author |
author2 |
Jardim, Paulo Henrique de Affonseca Rondon, Eric Schmidt |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Saigali, Pedro Henrique França Jardim, Paulo Henrique de Affonseca Rondon, Eric Schmidt |
dc.subject.por.fl_str_mv |
Collagen Ehlers-Danlos Syndrome Wounds. Colágeno Feridas Síndrome de Ehlers-Danlos. |
topic |
Collagen Ehlers-Danlos Syndrome Wounds. Colágeno Feridas Síndrome de Ehlers-Danlos. |
description |
Cutaneous asthenia (CA) or Ehlers-Danlos Syndrome, in dogs, is a rare hereditary syndrome caused by autosomal dominant inheritance that causes collagen synthesis failure and leads to hyperextensibility and cutaneous fragility. This report describes a clinical case of canine CA of hereditary recessive origin, hitherto proven for other species, in an animal born from inbreeding healthy parents. A one-year-old female Maltese dog received clinical and surgical care for a cutaneous wound after a hygienic bath. The clinical history revealed the occurrence of other injuries that were caused by minor trauma and the consanguinity of the patient. During wound cleaning, the trichotomy and removal of an adhesive tape that was fixed to the skin generated new lacerations, which led to clinical suspicion of CA. CA was confirmed by calculating the cutaneous extensibility index (CEI), which was 22%, higher than the normal limit for the species (14.5%). The skin biopsy confirmed the clinical diagnosis, and the wound of the animal was treated routinely and healed clinically. Both dominant and recessive patterns have been well documented in cats; however, in dogs, only the dominant form has been reported in the literature. Our findings demonstrate that canine CA may result from autosomal recessive inheritance, and CA must be considered during diagnostic clinical approaches and breeding selections. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-03-06 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Relato de Caso info:eu-repo/semantics/other |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/34980 10.5433/1679-0359.2020v41n2p731 |
url |
https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/34980 |
identifier_str_mv |
10.5433/1679-0359.2020v41n2p731 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/34980/26889 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2020 Semina: Ciências Agrárias http://creativecommons.org/licenses/by-nc/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2020 Semina: Ciências Agrárias http://creativecommons.org/licenses/by-nc/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
UEL |
publisher.none.fl_str_mv |
UEL |
dc.source.none.fl_str_mv |
Semina: Ciências Agrárias; Vol. 41 No. 2 (2020); 731-736 Semina: Ciências Agrárias; v. 41 n. 2 (2020); 731-736 1679-0359 1676-546X reponame:Semina. Ciências Agrárias (Online) instname:Universidade Estadual de Londrina (UEL) instacron:UEL |
instname_str |
Universidade Estadual de Londrina (UEL) |
instacron_str |
UEL |
institution |
UEL |
reponame_str |
Semina. Ciências Agrárias (Online) |
collection |
Semina. Ciências Agrárias (Online) |
repository.name.fl_str_mv |
Semina. Ciências Agrárias (Online) - Universidade Estadual de Londrina (UEL) |
repository.mail.fl_str_mv |
semina.agrarias@uel.br |
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1799306080932593664 |