Sheep urinary tract architecture is not affected by acute urethral obstruction
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Semina. Ciências Agrárias (Online) |
Texto Completo: | https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/38390 |
Resumo: | Urolithiasis affects the urinary tract of small ruminants, thereby requiring the animal to prematurely terminate breeding. Morphometric study of organs can be used as a diagnostic method. Thus, this study aimed to describe the macroscopic, histopathological, and histomorphometric changes in the urinary tract of sheep with urolithiasis. For this purpose, 14 healthy male Santa Inês sheep, approximately 90 days old, were studied and fed an experimental diet. After the development of urolithiasis, the animals were reorganized into two groups, D1 (without urolithiasis) and D2 (with urolithiasis) for comparative data analysis. Sheep were necropsied to evaluate the pathological changes, followed by macroscopic morphometric analysis, and the histopathological and histomorphometric characteristics were described. Urethral necrosis and a full urinary bladder were observed in all animals that developed the disease. The comparison between sheep with and without urolithiasis showed no significant difference (P < 0.05) in the evaluated macroscopic morphometric variables, except for the right ureter width. Regarding the histopathological evaluation, multifocal areas of mild to moderate congestion within the glomerular tufts and protein in the tubular lumen of the kidneys were observed. In the liver, mild to moderate fatty degeneration was noted in the centrolobular regions, and an ulcerated focal area in the bladder mucosa was observed in only one animal. The present study demonstrated that the formulated diet was effective in inducing clinical disease. In acute obstructive urolithiasis in sheep tissue, lesions in the liver and urinary tract were observed, although there were no significant histomorphometric changes. |
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Sheep urinary tract architecture is not affected by acute urethral obstructionA arquitetura do trato urinário de ovinos não é afetada pela obstrução uretral agudaHistopathologyHydronephrosisMorphometryRamUrolith.HistopatologiaHidronefroseMorfometriaCarneiroUrólito.Urolithiasis affects the urinary tract of small ruminants, thereby requiring the animal to prematurely terminate breeding. Morphometric study of organs can be used as a diagnostic method. Thus, this study aimed to describe the macroscopic, histopathological, and histomorphometric changes in the urinary tract of sheep with urolithiasis. For this purpose, 14 healthy male Santa Inês sheep, approximately 90 days old, were studied and fed an experimental diet. After the development of urolithiasis, the animals were reorganized into two groups, D1 (without urolithiasis) and D2 (with urolithiasis) for comparative data analysis. Sheep were necropsied to evaluate the pathological changes, followed by macroscopic morphometric analysis, and the histopathological and histomorphometric characteristics were described. Urethral necrosis and a full urinary bladder were observed in all animals that developed the disease. The comparison between sheep with and without urolithiasis showed no significant difference (P < 0.05) in the evaluated macroscopic morphometric variables, except for the right ureter width. Regarding the histopathological evaluation, multifocal areas of mild to moderate congestion within the glomerular tufts and protein in the tubular lumen of the kidneys were observed. In the liver, mild to moderate fatty degeneration was noted in the centrolobular regions, and an ulcerated focal area in the bladder mucosa was observed in only one animal. The present study demonstrated that the formulated diet was effective in inducing clinical disease. In acute obstructive urolithiasis in sheep tissue, lesions in the liver and urinary tract were observed, although there were no significant histomorphometric changes.Urolitíase acomete o trato urinário de pequenos ruminantes causando a saída prematura de animais destinados à reprodução. O estudo morfométrico dos órgãos pode ser empregado como método de auxílio diagnóstico. Assim, este estudo objetivou descrever as alterações macroscópicas, histopatológicas e histomorfométricas do trato urinário de ovinos com urolitíase. Com esse fim, foram utilizados 14 ovinos hígidos, machos, da raça Santa Inês com idade aproximada de 90 dias, que receberam dieta experimental. Após o desenvolvimento da urolitíase os animais foram reorganizados em dois grupos experimentais distintos D1 (sem urolitíase) e D2 (com urolitíase) para a análise comparada dos dados. Os ovinos foram necropsiados para descrição das alterações patológicas, seguindo-se a análise morfométrica macroscópica e descrição quanto as características histopatológicas e histomorfométricas. Necrose de processo uretral e bexiga urinária repleta foram observados em todos os animais que desenvolveram a doença. Na comparação entre os ovinos com e sem urolitíase não houve diferença significativa (P < 0,05) nas variáveis morfométricas macroscópicas avaliadas, a exceção da largura do ureter direito. Quanto à avaliação histopatológica, foram observadas áreas multifocais de discreta a moderada congestão dos tufos glomerulares e proteína no lúmen tubular nos rins. No fígado, observou-se nas regiões centrolobulares, discreta a moderada degeneração gordurosa e apenas em um animal foi observada, macro e microscopicamente, área focal ulcerada na mucosa da bexiga. Os achados da presente pesquisa demonstraram que a dieta formulada foi eficaz na indução da doença clínica. Na urolitíase obstrutiva aguda em ovinos, lesões teciduais em fígado e trato urinário são observadas, mas não há alterações histomorfométricas significativas.UEL2021-03-19info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionRersearchapplication/pdfhttps://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/3839010.5433/1679-0359.2021v42n3p1111Semina: Ciências Agrárias; Vol. 42 No. 3 (2021); 1111-1128Semina: Ciências Agrárias; v. 42 n. 3 (2021); 1111-11281679-03591676-546Xreponame:Semina. Ciências Agrárias (Online)instname:Universidade Estadual de Londrina (UEL)instacron:UELenghttps://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/38390/29161Copyright (c) 2021 Semina: Ciências Agráriashttp://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessMaciel, Thiago ArcoverdeOliveira, Clédson Calixto deFirmino, Millena de OliveiraNascimento-Hama, Lismara Castro doMathias, Luis AntonioArtoni, Silvana Martinez BaraldiOliveira, DanielaAmoroso, Lizandra2022-10-04T12:48:39Zoai:ojs.pkp.sfu.ca:article/38390Revistahttp://www.uel.br/revistas/uel/index.php/semagrariasPUBhttps://ojs.uel.br/revistas/uel/index.php/semagrarias/oaisemina.agrarias@uel.br1679-03591676-546Xopendoar:2022-10-04T12:48:39Semina. Ciências Agrárias (Online) - Universidade Estadual de Londrina (UEL)false |
dc.title.none.fl_str_mv |
Sheep urinary tract architecture is not affected by acute urethral obstruction A arquitetura do trato urinário de ovinos não é afetada pela obstrução uretral aguda |
title |
Sheep urinary tract architecture is not affected by acute urethral obstruction |
spellingShingle |
Sheep urinary tract architecture is not affected by acute urethral obstruction Maciel, Thiago Arcoverde Histopathology Hydronephrosis Morphometry Ram Urolith. Histopatologia Hidronefrose Morfometria Carneiro Urólito. |
title_short |
Sheep urinary tract architecture is not affected by acute urethral obstruction |
title_full |
Sheep urinary tract architecture is not affected by acute urethral obstruction |
title_fullStr |
Sheep urinary tract architecture is not affected by acute urethral obstruction |
title_full_unstemmed |
Sheep urinary tract architecture is not affected by acute urethral obstruction |
title_sort |
Sheep urinary tract architecture is not affected by acute urethral obstruction |
author |
Maciel, Thiago Arcoverde |
author_facet |
Maciel, Thiago Arcoverde Oliveira, Clédson Calixto de Firmino, Millena de Oliveira Nascimento-Hama, Lismara Castro do Mathias, Luis Antonio Artoni, Silvana Martinez Baraldi Oliveira, Daniela Amoroso, Lizandra |
author_role |
author |
author2 |
Oliveira, Clédson Calixto de Firmino, Millena de Oliveira Nascimento-Hama, Lismara Castro do Mathias, Luis Antonio Artoni, Silvana Martinez Baraldi Oliveira, Daniela Amoroso, Lizandra |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Maciel, Thiago Arcoverde Oliveira, Clédson Calixto de Firmino, Millena de Oliveira Nascimento-Hama, Lismara Castro do Mathias, Luis Antonio Artoni, Silvana Martinez Baraldi Oliveira, Daniela Amoroso, Lizandra |
dc.subject.por.fl_str_mv |
Histopathology Hydronephrosis Morphometry Ram Urolith. Histopatologia Hidronefrose Morfometria Carneiro Urólito. |
topic |
Histopathology Hydronephrosis Morphometry Ram Urolith. Histopatologia Hidronefrose Morfometria Carneiro Urólito. |
description |
Urolithiasis affects the urinary tract of small ruminants, thereby requiring the animal to prematurely terminate breeding. Morphometric study of organs can be used as a diagnostic method. Thus, this study aimed to describe the macroscopic, histopathological, and histomorphometric changes in the urinary tract of sheep with urolithiasis. For this purpose, 14 healthy male Santa Inês sheep, approximately 90 days old, were studied and fed an experimental diet. After the development of urolithiasis, the animals were reorganized into two groups, D1 (without urolithiasis) and D2 (with urolithiasis) for comparative data analysis. Sheep were necropsied to evaluate the pathological changes, followed by macroscopic morphometric analysis, and the histopathological and histomorphometric characteristics were described. Urethral necrosis and a full urinary bladder were observed in all animals that developed the disease. The comparison between sheep with and without urolithiasis showed no significant difference (P < 0.05) in the evaluated macroscopic morphometric variables, except for the right ureter width. Regarding the histopathological evaluation, multifocal areas of mild to moderate congestion within the glomerular tufts and protein in the tubular lumen of the kidneys were observed. In the liver, mild to moderate fatty degeneration was noted in the centrolobular regions, and an ulcerated focal area in the bladder mucosa was observed in only one animal. The present study demonstrated that the formulated diet was effective in inducing clinical disease. In acute obstructive urolithiasis in sheep tissue, lesions in the liver and urinary tract were observed, although there were no significant histomorphometric changes. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-03-19 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Rersearch |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/38390 10.5433/1679-0359.2021v42n3p1111 |
url |
https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/38390 |
identifier_str_mv |
10.5433/1679-0359.2021v42n3p1111 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/38390/29161 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2021 Semina: Ciências Agrárias http://creativecommons.org/licenses/by-nc/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2021 Semina: Ciências Agrárias http://creativecommons.org/licenses/by-nc/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
UEL |
publisher.none.fl_str_mv |
UEL |
dc.source.none.fl_str_mv |
Semina: Ciências Agrárias; Vol. 42 No. 3 (2021); 1111-1128 Semina: Ciências Agrárias; v. 42 n. 3 (2021); 1111-1128 1679-0359 1676-546X reponame:Semina. Ciências Agrárias (Online) instname:Universidade Estadual de Londrina (UEL) instacron:UEL |
instname_str |
Universidade Estadual de Londrina (UEL) |
instacron_str |
UEL |
institution |
UEL |
reponame_str |
Semina. Ciências Agrárias (Online) |
collection |
Semina. Ciências Agrárias (Online) |
repository.name.fl_str_mv |
Semina. Ciências Agrárias (Online) - Universidade Estadual de Londrina (UEL) |
repository.mail.fl_str_mv |
semina.agrarias@uel.br |
_version_ |
1799306082287353856 |