Clinical responses to acute blood loss in goats

Detalhes bibliográficos
Autor(a) principal: Argolo, Erick Paiva
Data de Publicação: 2018
Outros Autores: Firmino, Paulo Ricardo, Soares, Jaqueline Oliveira, Nunes, Talyta Lins, Abrantes, Maria Rociene, Sousa, Rejane Santos, Oliveira, Francisco Leonardo Costa, Paula, Valeria Veras, Ortolani, Enrico Lippi, Minervino, Antonio Humberto Hamad, Barrêto-Júnior, Raimundo Alves
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Semina. Ciências Agrárias (Online)
Texto Completo: https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/27609
Resumo: The response to blood loss is directly related to the degree of hemorrhage, but for the caprine species some aspects still need to be investigated. Therefore, the present study aimed to assess the clinical and hemodynamic effects of acute blood loss in goats. Eight healthy, adult male crossbred goats were subjected to external jugular puncture to remove 30% of the total blood volume. A physical examination and blood gas, biochemical, and hematologic analyses were performed at baseline, before blood loss (T0), and after one (T1h), six (T6h), 12 (T12h), 24 (T24h) and 72 (T72h) hours, and eight (T8d), 16 (T16d), 24 (T24d) and 32 (T32d) days after the acute blood loss event. The goats presented with tachycardia, tachypnea, and hyperthermia one hour after blood loss with a return to normal physiological values at T6h. Packed cell volume was decreased at T1h and red cell counts at T12h, both returning to baseline at T24d. There was a reduction in total protein and albumin levels at T1h, both remained below baseline levels until T16d and T8d, respectively. The serum calcium concentration decreased over the period T1h to T24h and glucose increased over the period T1h to T6h. The values of pH, TCO2, bicarbonate, and base excess were lower at T1h, while lactate increased markedly at this time. The pCO2 value only was reduced at T24h. Systolic (PS), diastolic (PD), and mean (PM) pressures were decreased at T1h. Acute loss of 30% of blood volume in goats caused changes in clinical, blood gas, and biochemical parameters, which were restored over a six-hour period, while hematologic changes were more persistent, with baseline values restored only after 24 days.
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spelling Clinical responses to acute blood loss in goatsRespostas clínicas à perda sanguínea aguda em caprinosShockBlood gasHypovolemiaBlood.ChoqueHemogasometriaHipovolemiaSangue.The response to blood loss is directly related to the degree of hemorrhage, but for the caprine species some aspects still need to be investigated. Therefore, the present study aimed to assess the clinical and hemodynamic effects of acute blood loss in goats. Eight healthy, adult male crossbred goats were subjected to external jugular puncture to remove 30% of the total blood volume. A physical examination and blood gas, biochemical, and hematologic analyses were performed at baseline, before blood loss (T0), and after one (T1h), six (T6h), 12 (T12h), 24 (T24h) and 72 (T72h) hours, and eight (T8d), 16 (T16d), 24 (T24d) and 32 (T32d) days after the acute blood loss event. The goats presented with tachycardia, tachypnea, and hyperthermia one hour after blood loss with a return to normal physiological values at T6h. Packed cell volume was decreased at T1h and red cell counts at T12h, both returning to baseline at T24d. There was a reduction in total protein and albumin levels at T1h, both remained below baseline levels until T16d and T8d, respectively. The serum calcium concentration decreased over the period T1h to T24h and glucose increased over the period T1h to T6h. The values of pH, TCO2, bicarbonate, and base excess were lower at T1h, while lactate increased markedly at this time. The pCO2 value only was reduced at T24h. Systolic (PS), diastolic (PD), and mean (PM) pressures were decreased at T1h. Acute loss of 30% of blood volume in goats caused changes in clinical, blood gas, and biochemical parameters, which were restored over a six-hour period, while hematologic changes were more persistent, with baseline values restored only after 24 days.A resposta clínica à perda de sangue está diretamente relacionada ao grau de hemorragia, mas para a espécie caprinas alguns aspectos ainda precisam ser investigados. Deste modo o presente estudo teve como objetivo avaliar os efeitos clínicos e hemodinâmicos da perda aguda de sangue em caprinos. Oito caprinos adultos, mestiços, hígidos, foram submetidas a punção jugular externa para remoção de 30% do volume total de sangue. Foi realizado exame clínico e análises hematológicas, hemogasométricas e bioquímicas no momento basal, antes da perda de sangue (T0), e uma (T1h), seis (T6h), 12 (T12h), 24 (T24h) e 72 (T72h) horas e oito (T8d), 16 (T16d), 24 (T24d) e 32 (T32d) dias após. As cabras apresentaram taquicardia, taquipneia e hipertermia uma hora após a perda de sangue com retorno aos valores fisiológicos em T6h. O volume globular diminuiu em T1h e a contagem de células vermelhas em T12h, ambos retornando valores basais em T24d. Houve uma redução nos níveis de proteína totais e albumina em T1h, e ambos permaneceram abaixo dos níveis basais até T16d e T8d, respectivamente. A concentração sérica de cálcio diminuiu durante o período T1h para T24h e a glicose aumentou no período T1h a T6h. Os valores de pH, TCO2, bicarbonato e excesso de base foram menores em T1h, enquanto o lactato aumentou acentuadamente neste momento. O pCO2 foi reduzida somente em T24h. As pressões sistólica (PS), diastólica (PD) e média (PM) diminuíram em T1h. A perda aguda de 30% do volume sangüíneo em cabras causou alterações nos parâmetros clínicos, hemogasométricos e bioquímicos, que foram restaurados ao longo de um período de seis horas, enquanto que as alterações hematológicas foram mais persistentes, com valores basais restaurados somente após 24 dias.UEL2018-03-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionEstudo clínico experimentalapplication/pdfhttps://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/2760910.5433/1679-0359.2018v39n2p583Semina: Ciências Agrárias; Vol. 39 No. 2 (2018); 583-592Semina: Ciências Agrárias; v. 39 n. 2 (2018); 583-5921679-03591676-546Xreponame:Semina. Ciências Agrárias (Online)instname:Universidade Estadual de Londrina (UEL)instacron:UELenghttps://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/27609/23191Copyright (c) 2018 Semina: Ciências Agráriashttp://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessArgolo, Erick PaivaFirmino, Paulo RicardoSoares, Jaqueline OliveiraNunes, Talyta LinsAbrantes, Maria RocieneSousa, Rejane SantosOliveira, Francisco Leonardo CostaPaula, Valeria VerasOrtolani, Enrico LippiMinervino, Antonio Humberto HamadBarrêto-Júnior, Raimundo Alves2022-10-20T21:26:24Zoai:ojs.pkp.sfu.ca:article/27609Revistahttp://www.uel.br/revistas/uel/index.php/semagrariasPUBhttps://ojs.uel.br/revistas/uel/index.php/semagrarias/oaisemina.agrarias@uel.br1679-03591676-546Xopendoar:2022-10-20T21:26:24Semina. Ciências Agrárias (Online) - Universidade Estadual de Londrina (UEL)false
dc.title.none.fl_str_mv Clinical responses to acute blood loss in goats
Respostas clínicas à perda sanguínea aguda em caprinos
title Clinical responses to acute blood loss in goats
spellingShingle Clinical responses to acute blood loss in goats
Argolo, Erick Paiva
Shock
Blood gas
Hypovolemia
Blood.
Choque
Hemogasometria
Hipovolemia
Sangue.
title_short Clinical responses to acute blood loss in goats
title_full Clinical responses to acute blood loss in goats
title_fullStr Clinical responses to acute blood loss in goats
title_full_unstemmed Clinical responses to acute blood loss in goats
title_sort Clinical responses to acute blood loss in goats
author Argolo, Erick Paiva
author_facet Argolo, Erick Paiva
Firmino, Paulo Ricardo
Soares, Jaqueline Oliveira
Nunes, Talyta Lins
Abrantes, Maria Rociene
Sousa, Rejane Santos
Oliveira, Francisco Leonardo Costa
Paula, Valeria Veras
Ortolani, Enrico Lippi
Minervino, Antonio Humberto Hamad
Barrêto-Júnior, Raimundo Alves
author_role author
author2 Firmino, Paulo Ricardo
Soares, Jaqueline Oliveira
Nunes, Talyta Lins
Abrantes, Maria Rociene
Sousa, Rejane Santos
Oliveira, Francisco Leonardo Costa
Paula, Valeria Veras
Ortolani, Enrico Lippi
Minervino, Antonio Humberto Hamad
Barrêto-Júnior, Raimundo Alves
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Argolo, Erick Paiva
Firmino, Paulo Ricardo
Soares, Jaqueline Oliveira
Nunes, Talyta Lins
Abrantes, Maria Rociene
Sousa, Rejane Santos
Oliveira, Francisco Leonardo Costa
Paula, Valeria Veras
Ortolani, Enrico Lippi
Minervino, Antonio Humberto Hamad
Barrêto-Júnior, Raimundo Alves
dc.subject.por.fl_str_mv Shock
Blood gas
Hypovolemia
Blood.
Choque
Hemogasometria
Hipovolemia
Sangue.
topic Shock
Blood gas
Hypovolemia
Blood.
Choque
Hemogasometria
Hipovolemia
Sangue.
description The response to blood loss is directly related to the degree of hemorrhage, but for the caprine species some aspects still need to be investigated. Therefore, the present study aimed to assess the clinical and hemodynamic effects of acute blood loss in goats. Eight healthy, adult male crossbred goats were subjected to external jugular puncture to remove 30% of the total blood volume. A physical examination and blood gas, biochemical, and hematologic analyses were performed at baseline, before blood loss (T0), and after one (T1h), six (T6h), 12 (T12h), 24 (T24h) and 72 (T72h) hours, and eight (T8d), 16 (T16d), 24 (T24d) and 32 (T32d) days after the acute blood loss event. The goats presented with tachycardia, tachypnea, and hyperthermia one hour after blood loss with a return to normal physiological values at T6h. Packed cell volume was decreased at T1h and red cell counts at T12h, both returning to baseline at T24d. There was a reduction in total protein and albumin levels at T1h, both remained below baseline levels until T16d and T8d, respectively. The serum calcium concentration decreased over the period T1h to T24h and glucose increased over the period T1h to T6h. The values of pH, TCO2, bicarbonate, and base excess were lower at T1h, while lactate increased markedly at this time. The pCO2 value only was reduced at T24h. Systolic (PS), diastolic (PD), and mean (PM) pressures were decreased at T1h. Acute loss of 30% of blood volume in goats caused changes in clinical, blood gas, and biochemical parameters, which were restored over a six-hour period, while hematologic changes were more persistent, with baseline values restored only after 24 days.
publishDate 2018
dc.date.none.fl_str_mv 2018-03-15
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Estudo clínico experimental
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/27609
10.5433/1679-0359.2018v39n2p583
url https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/27609
identifier_str_mv 10.5433/1679-0359.2018v39n2p583
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/27609/23191
dc.rights.driver.fl_str_mv Copyright (c) 2018 Semina: Ciências Agrárias
http://creativecommons.org/licenses/by-nc/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2018 Semina: Ciências Agrárias
http://creativecommons.org/licenses/by-nc/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv UEL
publisher.none.fl_str_mv UEL
dc.source.none.fl_str_mv Semina: Ciências Agrárias; Vol. 39 No. 2 (2018); 583-592
Semina: Ciências Agrárias; v. 39 n. 2 (2018); 583-592
1679-0359
1676-546X
reponame:Semina. Ciências Agrárias (Online)
instname:Universidade Estadual de Londrina (UEL)
instacron:UEL
instname_str Universidade Estadual de Londrina (UEL)
instacron_str UEL
institution UEL
reponame_str Semina. Ciências Agrárias (Online)
collection Semina. Ciências Agrárias (Online)
repository.name.fl_str_mv Semina. Ciências Agrárias (Online) - Universidade Estadual de Londrina (UEL)
repository.mail.fl_str_mv semina.agrarias@uel.br
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