Necrotizing leukoencephalitis in a Yorkshire dog from Brazil
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Semina. Ciências Agrárias (Online) |
Texto Completo: | https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/36187 |
Resumo: | Necrotizing leukoencephalitis (NLE) is an uncommon inflammatory condition of brain of dogs, and was described in dogs from North America, Europe, and Asia. Cases of NLE from South America were not located when major data bases were examined. Consequently, this report describes the findings associated with NLE in a Brazilian 3.5-year-old female Yorkshire dog with neurological findings related to the myelencephalon; the dog died, besides medical treatment, and was submitted for autopsy exam and histopathological evaluation. Lesions were restricted to the encephalon and characterized as leukoencephalomalacia with severe non-suppurative inflammation with extensive perivascular cuffing; the non-suppurative inflammation was characterized by influx of lymphocytes and histiocytes, and occasionally plasma cells, and gitter cells. Infectious disease agents were not identified by molecular techniques or visualized with histochemical stains. This report represents the first definitive diagnose of NLE in Brazil, suggesting that this disease may be present in South America dogs suffering from neurological conditions. This knowledge may be useful for veterinarians in Brazil, taking into account that this disease should be considered as a differential diagnosis when infectious causes are excluded. |
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Semina. Ciências Agrárias (Online) |
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Necrotizing leukoencephalitis in a Yorkshire dog from BrazilLeucoencefalite necrosante em um cão Yorkshire do BrasilNecrotizing encephalitisDogNeuropathology.Encefalite necrosanteCãoNeuropatologia.Necrotizing leukoencephalitis (NLE) is an uncommon inflammatory condition of brain of dogs, and was described in dogs from North America, Europe, and Asia. Cases of NLE from South America were not located when major data bases were examined. Consequently, this report describes the findings associated with NLE in a Brazilian 3.5-year-old female Yorkshire dog with neurological findings related to the myelencephalon; the dog died, besides medical treatment, and was submitted for autopsy exam and histopathological evaluation. Lesions were restricted to the encephalon and characterized as leukoencephalomalacia with severe non-suppurative inflammation with extensive perivascular cuffing; the non-suppurative inflammation was characterized by influx of lymphocytes and histiocytes, and occasionally plasma cells, and gitter cells. Infectious disease agents were not identified by molecular techniques or visualized with histochemical stains. This report represents the first definitive diagnose of NLE in Brazil, suggesting that this disease may be present in South America dogs suffering from neurological conditions. This knowledge may be useful for veterinarians in Brazil, taking into account that this disease should be considered as a differential diagnosis when infectious causes are excluded.Leucoencefalite necrosante (LEN) é uma condição inflamatória encefálica incomum. A NLE foi descrita em cães da América do Norte, Europa e Ásia, mas, de acordo com o conhecimento dos autores, não há diagnóstico definitivo dessa doença na América do Sul. O objetivo do presente relato foi descrever um caso de leucoencefalite necrosante diagnosticado em um cão do Brasil. A doença é descrita em um cão Yorkshire fêmea de 3,5 anos com apresentação neurológica afetando principalmente o mielencéfalo; o animal veio a óbito, apesar do tratamento médico, e foi submetida a autopsia e avaliação histopatológica. As lesões estavam restritas ao encéfalo e foram caracterizadas por necrose da substância branca e extensa inflamação não-supurativa do neurópilo e presença de grandes manguitos perivasculares; a resposta inflamatória não-supurativa foi caracterizada principalmente por infiltração de linfócitos e histiócitos, e ocasionais plasmócitos e células gitter. Agentes infecciosos não foram detectados por técnicas moleculares e também não foram identificados por colorações histológicas. Este relato representa o primeiro caso de LEN com diagnóstico anatomopatológico no Brasil, demonstrando que esta doença está presente em cães Sul Americanos que sofrem de condições neurológicas. Esta informação é útil para os médicos veterinários no Brasil, levando em consideração que esta doença deve ser considerada como um diagnóstico diferencial quando as causas infecciosas forem excluídas.UEL2019-09-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/otherapplication/pdfhttps://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/3618710.5433/1679-0359.2019v40n6Supl2p3321Semina: Ciências Agrárias; Vol. 40 No. 6Supl2 (2019); 3321-3326Semina: Ciências Agrárias; v. 40 n. 6Supl2 (2019); 3321-33261679-03591676-546Xreponame:Semina. Ciências Agrárias (Online)instname:Universidade Estadual de Londrina (UEL)instacron:UELenghttps://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/36187/26153Copyright (c) 2019 Semina: Ciências Agráriashttp://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessAmude, Alexandre MendesArias, Mônica Vicky BahrHeadley, Selwyn ArlingtonBracarense, Ana Paula Frederico Rodrigues LoureiroSilva, Natalino FranciscoAlfieri, Amauri Alcindo2022-10-10T16:35:23Zoai:ojs.pkp.sfu.ca:article/36187Revistahttp://www.uel.br/revistas/uel/index.php/semagrariasPUBhttps://ojs.uel.br/revistas/uel/index.php/semagrarias/oaisemina.agrarias@uel.br1679-03591676-546Xopendoar:2022-10-10T16:35:23Semina. Ciências Agrárias (Online) - Universidade Estadual de Londrina (UEL)false |
dc.title.none.fl_str_mv |
Necrotizing leukoencephalitis in a Yorkshire dog from Brazil Leucoencefalite necrosante em um cão Yorkshire do Brasil |
title |
Necrotizing leukoencephalitis in a Yorkshire dog from Brazil |
spellingShingle |
Necrotizing leukoencephalitis in a Yorkshire dog from Brazil Amude, Alexandre Mendes Necrotizing encephalitis Dog Neuropathology. Encefalite necrosante Cão Neuropatologia. |
title_short |
Necrotizing leukoencephalitis in a Yorkshire dog from Brazil |
title_full |
Necrotizing leukoencephalitis in a Yorkshire dog from Brazil |
title_fullStr |
Necrotizing leukoencephalitis in a Yorkshire dog from Brazil |
title_full_unstemmed |
Necrotizing leukoencephalitis in a Yorkshire dog from Brazil |
title_sort |
Necrotizing leukoencephalitis in a Yorkshire dog from Brazil |
author |
Amude, Alexandre Mendes |
author_facet |
Amude, Alexandre Mendes Arias, Mônica Vicky Bahr Headley, Selwyn Arlington Bracarense, Ana Paula Frederico Rodrigues Loureiro Silva, Natalino Francisco Alfieri, Amauri Alcindo |
author_role |
author |
author2 |
Arias, Mônica Vicky Bahr Headley, Selwyn Arlington Bracarense, Ana Paula Frederico Rodrigues Loureiro Silva, Natalino Francisco Alfieri, Amauri Alcindo |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Amude, Alexandre Mendes Arias, Mônica Vicky Bahr Headley, Selwyn Arlington Bracarense, Ana Paula Frederico Rodrigues Loureiro Silva, Natalino Francisco Alfieri, Amauri Alcindo |
dc.subject.por.fl_str_mv |
Necrotizing encephalitis Dog Neuropathology. Encefalite necrosante Cão Neuropatologia. |
topic |
Necrotizing encephalitis Dog Neuropathology. Encefalite necrosante Cão Neuropatologia. |
description |
Necrotizing leukoencephalitis (NLE) is an uncommon inflammatory condition of brain of dogs, and was described in dogs from North America, Europe, and Asia. Cases of NLE from South America were not located when major data bases were examined. Consequently, this report describes the findings associated with NLE in a Brazilian 3.5-year-old female Yorkshire dog with neurological findings related to the myelencephalon; the dog died, besides medical treatment, and was submitted for autopsy exam and histopathological evaluation. Lesions were restricted to the encephalon and characterized as leukoencephalomalacia with severe non-suppurative inflammation with extensive perivascular cuffing; the non-suppurative inflammation was characterized by influx of lymphocytes and histiocytes, and occasionally plasma cells, and gitter cells. Infectious disease agents were not identified by molecular techniques or visualized with histochemical stains. This report represents the first definitive diagnose of NLE in Brazil, suggesting that this disease may be present in South America dogs suffering from neurological conditions. This knowledge may be useful for veterinarians in Brazil, taking into account that this disease should be considered as a differential diagnosis when infectious causes are excluded. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-09-30 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/other |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/36187 10.5433/1679-0359.2019v40n6Supl2p3321 |
url |
https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/36187 |
identifier_str_mv |
10.5433/1679-0359.2019v40n6Supl2p3321 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/36187/26153 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2019 Semina: Ciências Agrárias http://creativecommons.org/licenses/by-nc/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2019 Semina: Ciências Agrárias http://creativecommons.org/licenses/by-nc/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
UEL |
publisher.none.fl_str_mv |
UEL |
dc.source.none.fl_str_mv |
Semina: Ciências Agrárias; Vol. 40 No. 6Supl2 (2019); 3321-3326 Semina: Ciências Agrárias; v. 40 n. 6Supl2 (2019); 3321-3326 1679-0359 1676-546X reponame:Semina. Ciências Agrárias (Online) instname:Universidade Estadual de Londrina (UEL) instacron:UEL |
instname_str |
Universidade Estadual de Londrina (UEL) |
instacron_str |
UEL |
institution |
UEL |
reponame_str |
Semina. Ciências Agrárias (Online) |
collection |
Semina. Ciências Agrárias (Online) |
repository.name.fl_str_mv |
Semina. Ciências Agrárias (Online) - Universidade Estadual de Londrina (UEL) |
repository.mail.fl_str_mv |
semina.agrarias@uel.br |
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1799306081469464576 |