Preoperative epidural administration of lidocaine-methadone or lidocaine-fentanyl in female dogs undergoing elective ovariohysterectomy
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Semina. Ciências Agrárias (Online) |
Texto Completo: | https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/22084 |
Resumo: | We compared the analgesia and cardiopulmonary changes induced by epidural methadone or fentanyl in combination with lidocaine in female dogs undergoing elective ovariohysterectomy and anesthetized with propofol. Eighteen female dogs were randomly assigned to two groups and given either methadone (0.3 mg kg?¹) + 2% lidocaine without vasoconstrictor (LM) or fentanyl (5 µg kg?¹) + 2% lidocaine without vasoconstrictor (LF). The drugs were administered epidurally in a volume of 0.25 ml kg?¹. Heart rate (HR), respiratory rate (RR), rectal temperature (RT), systolic blood pressure (SBP), and blood glucose levels were recorded before and 15 minutes after premedication (T0 and T1); 15 minutes after epidural administration (T2); five minutes after dermotomy (T3); five minutes after clamping of the ovarian pedicle (T4); five minutes and 1, 3, 6, 12, 18, and 24 hours (T5, T6, T7, T8, T9, T10, and T11, respectively) after surgery. The number of additional propofol injections and total propofol dose (mg kg?¹) were recorded. Analgesia was assessed using a numerical descriptive scale. SBP and HR were similar in both groups, but hypotension was detected in animals from both groups at different times. Respiratory rate decreased significantly at T6 in the LF group and was lower than in the LM group. Hypothermia was observed in animals from both groups, but RT was significantly lower than baseline values only at T4 in the LM group. Blood glucose levels increased significantly only in the LF group at T4, T7, and T8. All animals in the LF group and eight animals in the LM group required additional propofol injections at T4, but no significant differences were detected in the number of propofol injections and total propofol dose between the LF (3 ± 1 injections, 7.5 ± 4.5 mg kg?¹) and LM (2 ± 2 injections, 4.5 ± 3.4 mg kg?¹) groups. The latency period, anesthetic period, and the duration of surgery were similar in both groups. No animals required rescue analgesia. The lidocaine-methadone and lidocaine-fentanyl combinations caused minimal cardiorespiratory changes, but did not abolish pain at the time of handling of the ovarian pedicle. |
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Preoperative epidural administration of lidocaine-methadone or lidocaine-fentanyl in female dogs undergoing elective ovariohysterectomyAdministração epidural pré-operatória de lidocaína-metadona ou lidocaína-fentanil em cadelas submetidas à ovário-histerectomia eletivaAnesthesiaAnalgesiaOpioidEpidural.AnestesiaAnalgesiaOpioidePeridural.We compared the analgesia and cardiopulmonary changes induced by epidural methadone or fentanyl in combination with lidocaine in female dogs undergoing elective ovariohysterectomy and anesthetized with propofol. Eighteen female dogs were randomly assigned to two groups and given either methadone (0.3 mg kg?¹) + 2% lidocaine without vasoconstrictor (LM) or fentanyl (5 µg kg?¹) + 2% lidocaine without vasoconstrictor (LF). The drugs were administered epidurally in a volume of 0.25 ml kg?¹. Heart rate (HR), respiratory rate (RR), rectal temperature (RT), systolic blood pressure (SBP), and blood glucose levels were recorded before and 15 minutes after premedication (T0 and T1); 15 minutes after epidural administration (T2); five minutes after dermotomy (T3); five minutes after clamping of the ovarian pedicle (T4); five minutes and 1, 3, 6, 12, 18, and 24 hours (T5, T6, T7, T8, T9, T10, and T11, respectively) after surgery. The number of additional propofol injections and total propofol dose (mg kg?¹) were recorded. Analgesia was assessed using a numerical descriptive scale. SBP and HR were similar in both groups, but hypotension was detected in animals from both groups at different times. Respiratory rate decreased significantly at T6 in the LF group and was lower than in the LM group. Hypothermia was observed in animals from both groups, but RT was significantly lower than baseline values only at T4 in the LM group. Blood glucose levels increased significantly only in the LF group at T4, T7, and T8. All animals in the LF group and eight animals in the LM group required additional propofol injections at T4, but no significant differences were detected in the number of propofol injections and total propofol dose between the LF (3 ± 1 injections, 7.5 ± 4.5 mg kg?¹) and LM (2 ± 2 injections, 4.5 ± 3.4 mg kg?¹) groups. The latency period, anesthetic period, and the duration of surgery were similar in both groups. No animals required rescue analgesia. The lidocaine-methadone and lidocaine-fentanyl combinations caused minimal cardiorespiratory changes, but did not abolish pain at the time of handling of the ovarian pedicle.Comparou-se a analgesia e alterações cardiopulmonares promovidas pela metadona ou fentanil, associados à lidocaína, por via epidural, em cadelas submetidas à ovário-histerectomia eletiva e mantidas anestesiadas pelo propofol. Foram utilizadas 18 cadelas, distribuídas em dois grupos: LM - metadona (0,3 mg kg-1) + lidocaína 2% sem vasoconstrictor; e LF - fentanil 5 ?g kg-1 + lidocaína 2% sem vasoconstrictor. Os fármacos foram administrados por via epidural, num volume de 0,25 mL kg-1. Registraram-se: frequências cardíaca (FC) e respiratória (f), temperatura retal (TR), pressão arterial sistólica (PAS) e glicemia, antes e 15 minutos após a medicação pré-anestésica (T0 e T1); 15 minutos após a epidural (T2); cinco minutos após a dermotomia (T3); cinco minutos após o pinçamento dos pedículos ovarianos (T4); cinco minutos, uma, 3, 6, 12, 18 e 24 horas (T5, T6, T7, T8, T9, T10 e T11, respectivamente) após o término da cirurgia. Mensuraram-se ainda o número de repiques de propofol e o consumo total, em mg kg-1. Avaliou-se a analgesia através de escala descritiva numérica. Não houve diferença significativa na PAS e na FC entre os grupos, porém ocorreu hipotensão em alguns momentos em ambos os grupos. Ocorreu redução significativa na frequência respiratória no momento T6 no grupo LF, sendo esta menor que no grupo LM. Ocorreu hipotermia em ambos os grupos, porém houve diferença estatística, em relação ao valor basal, apenas no momento T4 no grupo LF. A glicemia aumentou significativamente apenas no grupo LF, nos momentos T4, T7 e T8. Todos os animais do grupo LF e oito animais do grupo LM necessitaram de repique de propofol no T4, porém não houve diferença significativa quanto ao número de repiques e ao consumo total de propofol entre os grupos LF (3 ± 1 repiques; 7,5 ± 4,5 mg kg-1) e LM (2 ± 2 repiques; 4,5 ± 3,4 mg kg-1). Os períodos de latência e hábil anestésico e de duração do procedimento cirúrgico foram semelhantes em ambos os grupos. Nenhum animal necessitou de analgesia de resgate. As associações lidocaína-metadona ou lidocaína-fentanil promovem mínimas alterações cardiorrespiratórias, porém não são suficientes para abolir a dor no momento da manipulação do pedículo ovariano.UEL2017-06-13info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPesquisa Científicaapplication/pdfhttps://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/2208410.5433/1679-0359.2017v38n3p1303Semina: Ciências Agrárias; Vol. 38 No. 3 (2017); 1303-1312Semina: Ciências Agrárias; v. 38 n. 3 (2017); 1303-13121679-03591676-546Xreponame:Semina. Ciências Agrárias (Online)instname:Universidade Estadual de Londrina (UEL)instacron:UELenghttps://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/22084/21001http://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessOliveira, Kalyne Danielly Silva deHenrique, Fernanda VieiraFelipe, Gracineide da CostaMedeiros, Lyllian Karlla Gomes deRego, Renato Otaviano doAlves, Alane PereiraParentoni, Roberta NunesSouza, Almir Pereira deNóbrega Neto, Pedro Isidro da2022-10-24T13:27:13Zoai:ojs.pkp.sfu.ca:article/22084Revistahttp://www.uel.br/revistas/uel/index.php/semagrariasPUBhttps://ojs.uel.br/revistas/uel/index.php/semagrarias/oaisemina.agrarias@uel.br1679-03591676-546Xopendoar:2022-10-24T13:27:13Semina. Ciências Agrárias (Online) - Universidade Estadual de Londrina (UEL)false |
dc.title.none.fl_str_mv |
Preoperative epidural administration of lidocaine-methadone or lidocaine-fentanyl in female dogs undergoing elective ovariohysterectomy Administração epidural pré-operatória de lidocaína-metadona ou lidocaína-fentanil em cadelas submetidas à ovário-histerectomia eletiva |
title |
Preoperative epidural administration of lidocaine-methadone or lidocaine-fentanyl in female dogs undergoing elective ovariohysterectomy |
spellingShingle |
Preoperative epidural administration of lidocaine-methadone or lidocaine-fentanyl in female dogs undergoing elective ovariohysterectomy Oliveira, Kalyne Danielly Silva de Anesthesia Analgesia Opioid Epidural. Anestesia Analgesia Opioide Peridural. |
title_short |
Preoperative epidural administration of lidocaine-methadone or lidocaine-fentanyl in female dogs undergoing elective ovariohysterectomy |
title_full |
Preoperative epidural administration of lidocaine-methadone or lidocaine-fentanyl in female dogs undergoing elective ovariohysterectomy |
title_fullStr |
Preoperative epidural administration of lidocaine-methadone or lidocaine-fentanyl in female dogs undergoing elective ovariohysterectomy |
title_full_unstemmed |
Preoperative epidural administration of lidocaine-methadone or lidocaine-fentanyl in female dogs undergoing elective ovariohysterectomy |
title_sort |
Preoperative epidural administration of lidocaine-methadone or lidocaine-fentanyl in female dogs undergoing elective ovariohysterectomy |
author |
Oliveira, Kalyne Danielly Silva de |
author_facet |
Oliveira, Kalyne Danielly Silva de Henrique, Fernanda Vieira Felipe, Gracineide da Costa Medeiros, Lyllian Karlla Gomes de Rego, Renato Otaviano do Alves, Alane Pereira Parentoni, Roberta Nunes Souza, Almir Pereira de Nóbrega Neto, Pedro Isidro da |
author_role |
author |
author2 |
Henrique, Fernanda Vieira Felipe, Gracineide da Costa Medeiros, Lyllian Karlla Gomes de Rego, Renato Otaviano do Alves, Alane Pereira Parentoni, Roberta Nunes Souza, Almir Pereira de Nóbrega Neto, Pedro Isidro da |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Oliveira, Kalyne Danielly Silva de Henrique, Fernanda Vieira Felipe, Gracineide da Costa Medeiros, Lyllian Karlla Gomes de Rego, Renato Otaviano do Alves, Alane Pereira Parentoni, Roberta Nunes Souza, Almir Pereira de Nóbrega Neto, Pedro Isidro da |
dc.subject.por.fl_str_mv |
Anesthesia Analgesia Opioid Epidural. Anestesia Analgesia Opioide Peridural. |
topic |
Anesthesia Analgesia Opioid Epidural. Anestesia Analgesia Opioide Peridural. |
description |
We compared the analgesia and cardiopulmonary changes induced by epidural methadone or fentanyl in combination with lidocaine in female dogs undergoing elective ovariohysterectomy and anesthetized with propofol. Eighteen female dogs were randomly assigned to two groups and given either methadone (0.3 mg kg?¹) + 2% lidocaine without vasoconstrictor (LM) or fentanyl (5 µg kg?¹) + 2% lidocaine without vasoconstrictor (LF). The drugs were administered epidurally in a volume of 0.25 ml kg?¹. Heart rate (HR), respiratory rate (RR), rectal temperature (RT), systolic blood pressure (SBP), and blood glucose levels were recorded before and 15 minutes after premedication (T0 and T1); 15 minutes after epidural administration (T2); five minutes after dermotomy (T3); five minutes after clamping of the ovarian pedicle (T4); five minutes and 1, 3, 6, 12, 18, and 24 hours (T5, T6, T7, T8, T9, T10, and T11, respectively) after surgery. The number of additional propofol injections and total propofol dose (mg kg?¹) were recorded. Analgesia was assessed using a numerical descriptive scale. SBP and HR were similar in both groups, but hypotension was detected in animals from both groups at different times. Respiratory rate decreased significantly at T6 in the LF group and was lower than in the LM group. Hypothermia was observed in animals from both groups, but RT was significantly lower than baseline values only at T4 in the LM group. Blood glucose levels increased significantly only in the LF group at T4, T7, and T8. All animals in the LF group and eight animals in the LM group required additional propofol injections at T4, but no significant differences were detected in the number of propofol injections and total propofol dose between the LF (3 ± 1 injections, 7.5 ± 4.5 mg kg?¹) and LM (2 ± 2 injections, 4.5 ± 3.4 mg kg?¹) groups. The latency period, anesthetic period, and the duration of surgery were similar in both groups. No animals required rescue analgesia. The lidocaine-methadone and lidocaine-fentanyl combinations caused minimal cardiorespiratory changes, but did not abolish pain at the time of handling of the ovarian pedicle. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-06-13 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Pesquisa Científica |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/22084 10.5433/1679-0359.2017v38n3p1303 |
url |
https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/22084 |
identifier_str_mv |
10.5433/1679-0359.2017v38n3p1303 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/22084/21001 |
dc.rights.driver.fl_str_mv |
http://creativecommons.org/licenses/by-nc/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by-nc/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
UEL |
publisher.none.fl_str_mv |
UEL |
dc.source.none.fl_str_mv |
Semina: Ciências Agrárias; Vol. 38 No. 3 (2017); 1303-1312 Semina: Ciências Agrárias; v. 38 n. 3 (2017); 1303-1312 1679-0359 1676-546X reponame:Semina. Ciências Agrárias (Online) instname:Universidade Estadual de Londrina (UEL) instacron:UEL |
instname_str |
Universidade Estadual de Londrina (UEL) |
instacron_str |
UEL |
institution |
UEL |
reponame_str |
Semina. Ciências Agrárias (Online) |
collection |
Semina. Ciências Agrárias (Online) |
repository.name.fl_str_mv |
Semina. Ciências Agrárias (Online) - Universidade Estadual de Londrina (UEL) |
repository.mail.fl_str_mv |
semina.agrarias@uel.br |
_version_ |
1799306074066518016 |