Accumulative copper poisoning in buffaloes

• Autor(a) principal: Minervino, Antonio Humberto Hamad
• Data de Publicação: 2009
• Outros Autores: Barrêto Júnior, Raimundo Alves, Ferreira, Rodrigo Nogueira Fernandes, Saut, João Paulo Elsen, Meira Júnior, Enoch Brandão de Sousa, Rodrigues, Frederico Augusto Mazzocca Lopes, Nakagawa, Tizianne Larissa Duim Ribeiro, Headley, Selwyn Arlington, Ortolani, Enrico Lippi
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Semina. Ciências Agrárias (Online)
• Texto Completo: https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/2596
• topic: Copper; Clinical manifestations. liver; Buffaloes.; Cobre; Sintomas; Fígado; Búfalo.

The main objective of this study was to evaluate the clinical and hematological alterations, and the hepatic concentration of Cu in buffaloes with chronic copper poisoning (CCP). Ten buffalo yearling steers were randomly distributed into two groups: one copper supplemented (BUFCu; n = 6) and another control group (BUF; n = 4). The group BUFCu received, by ruminal fistula, 2 mg Cu/kgBW (as CuSO4.5H2O) daily during one week; after which 2 mg Cu/kgBW was added during each additional week, until the end of the experiment (105th day). Three liver biopsies were realized during the experiment (day zero, 45th, and 105th day) to determine the degree of copper accumulation. Alterations in body weight, clinical examination, and hematological values were monitored every 15 days. Two buffaloes supplemented with copper demonstrated clinical manifestations consistent with CCP, and died. Two distinct clinical manifestations were observed, one classical (n = 1) and another atypical (n = 1), characterized by remarkable high levels of liver copper, progressive hyporexia followed by anorexia, dehydration, severe apathy, decreased rumen movements, oliguria, and death. Some animals were resistant to CCP although high copper intake. In buffalos with clinical picture similar to the one described as atypical, CCP should be considered as a possible diagnostic even without presence of macroscopic hemoglobinuria.