Effects of combined midazolam and propofol in anesthesia induction and recovery of cats undergoing ovariohisterectomy

Detalhes bibliográficos
Autor(a) principal: Castro, Diogo Gorayeb de
Data de Publicação: 2015
Outros Autores: Caldeira, Juliana de Araújo, Devito, Fernanda Corrêa, Melo, Samanta Rios, Cortopassi, Silvia Renata Gaido
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Semina. Ciências Agrárias (Online)
Texto Completo: https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/19955
Resumo: The objective of this study was to determine the effects of propofol and midazolam on induction of anesthesia in cats undergoing ovariohysterectomy, measured in terms of the quality of tracheal intubation, anesthesia induction, cardiorespiratory effects, and recuperation period. Thirty healthy adult cats were pretreated with acepromazine and morphine. After 30 min, they were divided into three groups: PG (n = 10), in which induction was performed with only intravenous propofol at doses required for intubation; MPG (n = 8), in which animals received intravenous midazolam (0.3 mg kg-1) administered over 30 s, followed by administration of propofol as in PG; and PMG (n = 9), in which propofol was first administered at a rate of 4 mg kg-1 min-1, after which midazolam was administered (0.3 mg/kg), followed by re-administration of propofol. In order to perform a blinded study, the PG and PMG received a 0.9% NaCl solution volume similar to the midazolam dose before induction (0.06 mL/kg). Similar to the other groups, the PG and MPG received (0.06 mL kg-1) saline 30 s after administration of propofol. In order to mimic the administration of midazolam, the saline solution was administered for 30s. The PG received 11.0 ± 1.38 mg kg-1 propofol, a greater dose than that administered to the PMG (p < 0.001) and MPG (p < 0.01), which received 7.9 ± 1.92 and 9.1 ± 2.20 mg kg-1, respectively. There were no differences in the intubation scores between groups. Previous use of midazolam did not affect agitation or excitement in cats; both sequences of propofol-midazolam administration are feasible, but the propofol-midazolam sequence was superior due to the lower propofol dose.
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spelling Effects of combined midazolam and propofol in anesthesia induction and recovery of cats undergoing ovariohisterectomyEfeitos do midazolam, associado ao propofol, na indução e recuperação da anestesia em gatas submetidas a ovariossalpingohisterectomiaBenzodiazepinesCastrationDogsFeline.BenzodiazepínicosCãesCastraçãoFelinos.The objective of this study was to determine the effects of propofol and midazolam on induction of anesthesia in cats undergoing ovariohysterectomy, measured in terms of the quality of tracheal intubation, anesthesia induction, cardiorespiratory effects, and recuperation period. Thirty healthy adult cats were pretreated with acepromazine and morphine. After 30 min, they were divided into three groups: PG (n = 10), in which induction was performed with only intravenous propofol at doses required for intubation; MPG (n = 8), in which animals received intravenous midazolam (0.3 mg kg-1) administered over 30 s, followed by administration of propofol as in PG; and PMG (n = 9), in which propofol was first administered at a rate of 4 mg kg-1 min-1, after which midazolam was administered (0.3 mg/kg), followed by re-administration of propofol. In order to perform a blinded study, the PG and PMG received a 0.9% NaCl solution volume similar to the midazolam dose before induction (0.06 mL/kg). Similar to the other groups, the PG and MPG received (0.06 mL kg-1) saline 30 s after administration of propofol. In order to mimic the administration of midazolam, the saline solution was administered for 30s. The PG received 11.0 ± 1.38 mg kg-1 propofol, a greater dose than that administered to the PMG (p < 0.001) and MPG (p < 0.01), which received 7.9 ± 1.92 and 9.1 ± 2.20 mg kg-1, respectively. There were no differences in the intubation scores between groups. Previous use of midazolam did not affect agitation or excitement in cats; both sequences of propofol-midazolam administration are feasible, but the propofol-midazolam sequence was superior due to the lower propofol dose.O objetivo deste estudo foi determinar os efeitos de propofol e midazolam na indução da anestesia em gatas submetidas a ovariossalpingohisterectomia quanto a qualidade da intubação orotraqueal e da indução da anestesia, efeitos cardiorrespiratórios e períodos de recuperação. Foram utilizadas 27 gatas adultas e hígidas que foram pré-tratadas com acepromazina e morfina. Decorridos 30 minutos, foram distribuídas em três grupos: no GP (n=10), a indução foi realizada somente com propofol por via intravenosa na dose necessária para intubação orotraqueal; no GMP (n=8), os animais receberam midazolam (0,3 mg/kg) administrado pela via intravenosa em 30s, e em seguida o propofol foi administrado segundo os critérios do grupo propofol; no GPM (n=9), administrou-se, inicialmente, propofol na velocidade de 4 mg/kg/min; posteriormente, administrou-se midazolam (0,3 mg/kg), e o restante da indução foi realizado com propofol. Para que o estudo fosse cego, os animais dos grupos GP e GPM receberam solução salina no volume similar à dose de midazolam antes da indução (0,06 ml/kg). Da mesma forma, os grupos GP e GMP receberam solução de NaCl a 0,9% (0,06 ml/kg) após 30s de administração de propofol. Com objetivo de mimetizar a administração do midazolam, a solução salina foi administrada em 30s. O GP recebeu 11,0±1,38 mg/kg de propofol, sendo superior a dose dos grupos GPM (p<0,001) e GMP (p<0,01) que receberam 7,9±1,92 mg/kg e 9,1±2,20 mg/kg, respectivamente. Em relação aos escores de intubação não houve diferença entre os grupos. O uso prévio de midazolam não determinou agitação, tampouco excitação nas gatas; ambas as sequências de administração da associação propofol-midazolam são factíveis, porém a sequência propofol-midazolam se mostrou superior devido a menor dose empregada de propofol.UEL2015-12-16info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArtigo Científicoapplication/pdfhttps://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/1995510.5433/1679-0359.2015v36n6Supl2p4269Semina: Ciências Agrárias; Vol. 36 No. 6Supl2 (2015); 4269-4276Semina: Ciências Agrárias; v. 36 n. 6Supl2 (2015); 4269-42761679-03591676-546Xreponame:Semina. Ciências Agrárias (Online)instname:Universidade Estadual de Londrina (UEL)instacron:UELenghttps://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/19955/17547http://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessCastro, Diogo Gorayeb deCaldeira, Juliana de AraújoDevito, Fernanda CorrêaMelo, Samanta RiosCortopassi, Silvia Renata Gaido2022-12-02T14:57:09Zoai:ojs.pkp.sfu.ca:article/19955Revistahttp://www.uel.br/revistas/uel/index.php/semagrariasPUBhttps://ojs.uel.br/revistas/uel/index.php/semagrarias/oaisemina.agrarias@uel.br1679-03591676-546Xopendoar:2022-12-02T14:57:09Semina. Ciências Agrárias (Online) - Universidade Estadual de Londrina (UEL)false
dc.title.none.fl_str_mv Effects of combined midazolam and propofol in anesthesia induction and recovery of cats undergoing ovariohisterectomy
Efeitos do midazolam, associado ao propofol, na indução e recuperação da anestesia em gatas submetidas a ovariossalpingohisterectomia
title Effects of combined midazolam and propofol in anesthesia induction and recovery of cats undergoing ovariohisterectomy
spellingShingle Effects of combined midazolam and propofol in anesthesia induction and recovery of cats undergoing ovariohisterectomy
Castro, Diogo Gorayeb de
Benzodiazepines
Castration
Dogs
Feline.
Benzodiazepínicos
Cães
Castração
Felinos.
title_short Effects of combined midazolam and propofol in anesthesia induction and recovery of cats undergoing ovariohisterectomy
title_full Effects of combined midazolam and propofol in anesthesia induction and recovery of cats undergoing ovariohisterectomy
title_fullStr Effects of combined midazolam and propofol in anesthesia induction and recovery of cats undergoing ovariohisterectomy
title_full_unstemmed Effects of combined midazolam and propofol in anesthesia induction and recovery of cats undergoing ovariohisterectomy
title_sort Effects of combined midazolam and propofol in anesthesia induction and recovery of cats undergoing ovariohisterectomy
author Castro, Diogo Gorayeb de
author_facet Castro, Diogo Gorayeb de
Caldeira, Juliana de Araújo
Devito, Fernanda Corrêa
Melo, Samanta Rios
Cortopassi, Silvia Renata Gaido
author_role author
author2 Caldeira, Juliana de Araújo
Devito, Fernanda Corrêa
Melo, Samanta Rios
Cortopassi, Silvia Renata Gaido
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Castro, Diogo Gorayeb de
Caldeira, Juliana de Araújo
Devito, Fernanda Corrêa
Melo, Samanta Rios
Cortopassi, Silvia Renata Gaido
dc.subject.por.fl_str_mv Benzodiazepines
Castration
Dogs
Feline.
Benzodiazepínicos
Cães
Castração
Felinos.
topic Benzodiazepines
Castration
Dogs
Feline.
Benzodiazepínicos
Cães
Castração
Felinos.
description The objective of this study was to determine the effects of propofol and midazolam on induction of anesthesia in cats undergoing ovariohysterectomy, measured in terms of the quality of tracheal intubation, anesthesia induction, cardiorespiratory effects, and recuperation period. Thirty healthy adult cats were pretreated with acepromazine and morphine. After 30 min, they were divided into three groups: PG (n = 10), in which induction was performed with only intravenous propofol at doses required for intubation; MPG (n = 8), in which animals received intravenous midazolam (0.3 mg kg-1) administered over 30 s, followed by administration of propofol as in PG; and PMG (n = 9), in which propofol was first administered at a rate of 4 mg kg-1 min-1, after which midazolam was administered (0.3 mg/kg), followed by re-administration of propofol. In order to perform a blinded study, the PG and PMG received a 0.9% NaCl solution volume similar to the midazolam dose before induction (0.06 mL/kg). Similar to the other groups, the PG and MPG received (0.06 mL kg-1) saline 30 s after administration of propofol. In order to mimic the administration of midazolam, the saline solution was administered for 30s. The PG received 11.0 ± 1.38 mg kg-1 propofol, a greater dose than that administered to the PMG (p < 0.001) and MPG (p < 0.01), which received 7.9 ± 1.92 and 9.1 ± 2.20 mg kg-1, respectively. There were no differences in the intubation scores between groups. Previous use of midazolam did not affect agitation or excitement in cats; both sequences of propofol-midazolam administration are feasible, but the propofol-midazolam sequence was superior due to the lower propofol dose.
publishDate 2015
dc.date.none.fl_str_mv 2015-12-16
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Artigo Científico
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/19955
10.5433/1679-0359.2015v36n6Supl2p4269
url https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/19955
identifier_str_mv 10.5433/1679-0359.2015v36n6Supl2p4269
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/19955/17547
dc.rights.driver.fl_str_mv http://creativecommons.org/licenses/by-nc/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv UEL
publisher.none.fl_str_mv UEL
dc.source.none.fl_str_mv Semina: Ciências Agrárias; Vol. 36 No. 6Supl2 (2015); 4269-4276
Semina: Ciências Agrárias; v. 36 n. 6Supl2 (2015); 4269-4276
1679-0359
1676-546X
reponame:Semina. Ciências Agrárias (Online)
instname:Universidade Estadual de Londrina (UEL)
instacron:UEL
instname_str Universidade Estadual de Londrina (UEL)
instacron_str UEL
institution UEL
reponame_str Semina. Ciências Agrárias (Online)
collection Semina. Ciências Agrárias (Online)
repository.name.fl_str_mv Semina. Ciências Agrárias (Online) - Universidade Estadual de Londrina (UEL)
repository.mail.fl_str_mv semina.agrarias@uel.br
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