A comparison of detomidine in combination with saline, morphine or methadone in horses submitted to experimental oral stimuli
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Semina. Ciências Agrárias (Online) |
Texto Completo: | https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/19769 |
Resumo: | This study aimed to compare the sedative and cardiopulmonary effects of detomidine in combination with saline, morphine or methadone and to determine whether the addition of these opioids increases the degree of sedation in horses submitted to experimental oral stimuli. In a blinded, randomized, experimental study, six adult mares were evaluated using a crossover design with at least 15 days between trials: 10?g/kg detomidine in combination with saline (D/SAL), 0.1mg/kg morphine (D/ MORPH) or 0.1mg/kg methadone (D/METH). The degree of sedation, response to oral stimuli and cardiopulmonary parameters were monitored for 120 minutes. Parametric data were analyzed using the ANOVA and Tukey’s tests, and non- parametric data were analyzed with the Kruskal-Wallis and Friedman’s tests with the post-Dunn test (P<0.05). The degree of sedation was significantly greater for the D/SAL than for the D/MORPH and D/METH treatments at 30 min. The horses´ responses to the oral stimuli decreased significantly following all treatments at 5 and 30 min from baseline values. The heart rate, respiratory rate, arterial pH and blood gas variables were all similar among the treatment groups. Mean arterial blood pressure was significantly higher in the D/MORPH group when compared with the D/SAL group between 75 and 120 min. It was concluded that all treatments provided sedative effects with mild cardiopulmonary changes. However the addition of morphine or methadone to detomidine did not improve the degree of sedation in horses submitted to experimental oral stimuli. |
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Semina. Ciências Agrárias (Online) |
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A comparison of detomidine in combination with saline, morphine or methadone in horses submitted to experimental oral stimuliComparação entre a associação da detomidina à solução salina, à morfina ou à metadona em cavalos submetidos aos estímulos experimentais na cavidade oralAlpha2 adrenoreceptor agonistsDentalEquineOpioids.This study aimed to compare the sedative and cardiopulmonary effects of detomidine in combination with saline, morphine or methadone and to determine whether the addition of these opioids increases the degree of sedation in horses submitted to experimental oral stimuli. In a blinded, randomized, experimental study, six adult mares were evaluated using a crossover design with at least 15 days between trials: 10?g/kg detomidine in combination with saline (D/SAL), 0.1mg/kg morphine (D/ MORPH) or 0.1mg/kg methadone (D/METH). The degree of sedation, response to oral stimuli and cardiopulmonary parameters were monitored for 120 minutes. Parametric data were analyzed using the ANOVA and Tukey’s tests, and non- parametric data were analyzed with the Kruskal-Wallis and Friedman’s tests with the post-Dunn test (P<0.05). The degree of sedation was significantly greater for the D/SAL than for the D/MORPH and D/METH treatments at 30 min. The horses´ responses to the oral stimuli decreased significantly following all treatments at 5 and 30 min from baseline values. The heart rate, respiratory rate, arterial pH and blood gas variables were all similar among the treatment groups. Mean arterial blood pressure was significantly higher in the D/MORPH group when compared with the D/SAL group between 75 and 120 min. It was concluded that all treatments provided sedative effects with mild cardiopulmonary changes. However the addition of morphine or methadone to detomidine did not improve the degree of sedation in horses submitted to experimental oral stimuli.Objetivou-se comparar os efeitos sedativos e cardiorrespiratórios da detomidina associada à solução salina, à morfina ou à metadona e determinar se a associação desses opioides poderia incrementar o grau de sedação em cavalos submetidos aos estímulos na cavidade oral. Em estudo cego, com delineamento aleatório foram avaliadas 06 éguas, com intervalo mínimo de 15 dias entre cada avaliação, sendo submetidos aos protocolos de sedação com detomidina (10mg/kg, IV) associada à solução salina (D/SAL), a 0,1mg/kg (IV) de morfina (D/MORF) ou a 0,1mg/kg (IV) de metadona (D/MET). Foram avaliados, durante 120 minutos: grau de sedação, resposta aos estímulos orais e parâmetros cardiorrespiratórios. A estatística foi realizada com análise de variância, teste de Tukey e análise de medidas repetidas, para as variáveis paramétricas. Para as variáveis não paramétricas foram empregados os testes de Kruskal-Wallis e de Friedman com contrastes pelo método de Dunn (P<0,05). O efeito sedativo foi significativamente superior no D/SAL em relação ao D/MORF e D/MET aos 30 minutos após a administração dos fármacos. A resposta dos animais perante os estímulos feitos na cavidade oral diminuiu significativamente aos 5 e 30 minutos em relação ao basal em todos os tratamentos. A frequência cardíaca e respiratória, bem como as variáveis hemogasométricas não diferiram entre os grupos. Valores superiores de pressão arterial foram observados no grupo D/MORF em relação ao D/ SAL dos 75 aos 120 minutos. Conclui-se que os três tratamentos determinaram discretas alterações nos parâmetros cardiorrespiratórios, além de efeito sedativo. Contudo, a adição dos opioides à detomidina não incrementou o grau de sedação em cavalos submetidos aos estímulos na cavidade oral. UEL2015-12-16info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPesquisa Empírica de CampoAdrenorreceptores agonistas ?2; Opioides; Odontologia; Eqüino.application/pdfhttps://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/1976910.5433/1679-0359.2015v36n6Supl2p4225Semina: Ciências Agrárias; Vol. 36 No. 6Supl2 (2015); 4225-4236Semina: Ciências Agrárias; v. 36 n. 6Supl2 (2015); 4225-42361679-03591676-546Xreponame:Semina. Ciências Agrárias (Online)instname:Universidade Estadual de Londrina (UEL)instacron:UELenghttps://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/19769/17543http://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessGuilhen, Rafael CostaCassu, Renata NavarroDiniz, Miriely SteimGiuffrida, RogérioDuarte, Rodrigo Rolim2022-12-02T14:50:25Zoai:ojs.pkp.sfu.ca:article/19769Revistahttp://www.uel.br/revistas/uel/index.php/semagrariasPUBhttps://ojs.uel.br/revistas/uel/index.php/semagrarias/oaisemina.agrarias@uel.br1679-03591676-546Xopendoar:2022-12-02T14:50:25Semina. Ciências Agrárias (Online) - Universidade Estadual de Londrina (UEL)false |
dc.title.none.fl_str_mv |
A comparison of detomidine in combination with saline, morphine or methadone in horses submitted to experimental oral stimuli Comparação entre a associação da detomidina à solução salina, à morfina ou à metadona em cavalos submetidos aos estímulos experimentais na cavidade oral |
title |
A comparison of detomidine in combination with saline, morphine or methadone in horses submitted to experimental oral stimuli |
spellingShingle |
A comparison of detomidine in combination with saline, morphine or methadone in horses submitted to experimental oral stimuli Guilhen, Rafael Costa Alpha2 adrenoreceptor agonists Dental Equine Opioids. |
title_short |
A comparison of detomidine in combination with saline, morphine or methadone in horses submitted to experimental oral stimuli |
title_full |
A comparison of detomidine in combination with saline, morphine or methadone in horses submitted to experimental oral stimuli |
title_fullStr |
A comparison of detomidine in combination with saline, morphine or methadone in horses submitted to experimental oral stimuli |
title_full_unstemmed |
A comparison of detomidine in combination with saline, morphine or methadone in horses submitted to experimental oral stimuli |
title_sort |
A comparison of detomidine in combination with saline, morphine or methadone in horses submitted to experimental oral stimuli |
author |
Guilhen, Rafael Costa |
author_facet |
Guilhen, Rafael Costa Cassu, Renata Navarro Diniz, Miriely Steim Giuffrida, Rogério Duarte, Rodrigo Rolim |
author_role |
author |
author2 |
Cassu, Renata Navarro Diniz, Miriely Steim Giuffrida, Rogério Duarte, Rodrigo Rolim |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Guilhen, Rafael Costa Cassu, Renata Navarro Diniz, Miriely Steim Giuffrida, Rogério Duarte, Rodrigo Rolim |
dc.subject.por.fl_str_mv |
Alpha2 adrenoreceptor agonists Dental Equine Opioids. |
topic |
Alpha2 adrenoreceptor agonists Dental Equine Opioids. |
description |
This study aimed to compare the sedative and cardiopulmonary effects of detomidine in combination with saline, morphine or methadone and to determine whether the addition of these opioids increases the degree of sedation in horses submitted to experimental oral stimuli. In a blinded, randomized, experimental study, six adult mares were evaluated using a crossover design with at least 15 days between trials: 10?g/kg detomidine in combination with saline (D/SAL), 0.1mg/kg morphine (D/ MORPH) or 0.1mg/kg methadone (D/METH). The degree of sedation, response to oral stimuli and cardiopulmonary parameters were monitored for 120 minutes. Parametric data were analyzed using the ANOVA and Tukey’s tests, and non- parametric data were analyzed with the Kruskal-Wallis and Friedman’s tests with the post-Dunn test (P<0.05). The degree of sedation was significantly greater for the D/SAL than for the D/MORPH and D/METH treatments at 30 min. The horses´ responses to the oral stimuli decreased significantly following all treatments at 5 and 30 min from baseline values. The heart rate, respiratory rate, arterial pH and blood gas variables were all similar among the treatment groups. Mean arterial blood pressure was significantly higher in the D/MORPH group when compared with the D/SAL group between 75 and 120 min. It was concluded that all treatments provided sedative effects with mild cardiopulmonary changes. However the addition of morphine or methadone to detomidine did not improve the degree of sedation in horses submitted to experimental oral stimuli. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-12-16 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Pesquisa Empírica de Campo Adrenorreceptores agonistas ?2; Opioides; Odontologia; Eqüino. |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/19769 10.5433/1679-0359.2015v36n6Supl2p4225 |
url |
https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/19769 |
identifier_str_mv |
10.5433/1679-0359.2015v36n6Supl2p4225 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/19769/17543 |
dc.rights.driver.fl_str_mv |
http://creativecommons.org/licenses/by-nc/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by-nc/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
UEL |
publisher.none.fl_str_mv |
UEL |
dc.source.none.fl_str_mv |
Semina: Ciências Agrárias; Vol. 36 No. 6Supl2 (2015); 4225-4236 Semina: Ciências Agrárias; v. 36 n. 6Supl2 (2015); 4225-4236 1679-0359 1676-546X reponame:Semina. Ciências Agrárias (Online) instname:Universidade Estadual de Londrina (UEL) instacron:UEL |
instname_str |
Universidade Estadual de Londrina (UEL) |
instacron_str |
UEL |
institution |
UEL |
reponame_str |
Semina. Ciências Agrárias (Online) |
collection |
Semina. Ciências Agrárias (Online) |
repository.name.fl_str_mv |
Semina. Ciências Agrárias (Online) - Universidade Estadual de Londrina (UEL) |
repository.mail.fl_str_mv |
semina.agrarias@uel.br |
_version_ |
1799306072799838208 |