Continuous infusion of dipyrone in bitches in the intraoperative period: cardiorespiratory effects
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Semina. Ciências Agrárias (Online) |
Texto Completo: | https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/43742 |
Resumo: | Dipyrone is an effective analgesic for managing moderate or severe postoperative pain and can be used alone for mild pain or in combination with other analgesics for any type of pain. This study aimed to examine the administration of dipyrone by continuous infusion (CI) as an adjuvant analgesic in the intraoperative period for bitches undergoing elective ovariohysterectomy (OH) and its effect on these patients’ cardiorespiratory parameters. Twenty bitches underwent an elective OH procedure. The pre-anesthetic agent was a combination of acepromazine and morphine. Propofol was used to induce anesthesia, and isoflurane was used for maintenance. Subsequently, the animals were randomly allocated into two groups: the dipyrone group (DG) received a bolus dose of dipyrone (25 mg kg -1) by CI at a rate of 10 mg kg -1 h, and the control group (CG) received a bolus dose and a CI of 0.9% NaCl solution, both groups at a rate of 5 mL kg -1 h. The parametric variables were analyzed by ANOVA, followed by Tukey's test (p < 0.05). The paired t-test (p < 0.05) was used for comparison between the groups. Statistical differences were observed for heart rate, systolic, diastolic, and mean arterial pressure, respiratory rate, and blood glucose between the periods in both groups. There were differences only in the basal values of MAP between the groups; however, most values remained within the physiological range for the species. Using the drug as an adjuvant to anesthesia did not alter cardiorespiratory parameters, and it can be used as an adjuvant in analgesia during the intraoperative period of OH. |
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Continuous infusion of dipyrone in bitches in the intraoperative period: cardiorespiratory effectsInfusão continua transoperatória de dipirona em cadelas: efeitos cardiorrespiratórios e analgésicosAnesthesiaDogPainMetamizole.AnestesiaCãoDorMetamizol.Dipyrone is an effective analgesic for managing moderate or severe postoperative pain and can be used alone for mild pain or in combination with other analgesics for any type of pain. This study aimed to examine the administration of dipyrone by continuous infusion (CI) as an adjuvant analgesic in the intraoperative period for bitches undergoing elective ovariohysterectomy (OH) and its effect on these patients’ cardiorespiratory parameters. Twenty bitches underwent an elective OH procedure. The pre-anesthetic agent was a combination of acepromazine and morphine. Propofol was used to induce anesthesia, and isoflurane was used for maintenance. Subsequently, the animals were randomly allocated into two groups: the dipyrone group (DG) received a bolus dose of dipyrone (25 mg kg -1) by CI at a rate of 10 mg kg -1 h, and the control group (CG) received a bolus dose and a CI of 0.9% NaCl solution, both groups at a rate of 5 mL kg -1 h. The parametric variables were analyzed by ANOVA, followed by Tukey's test (p < 0.05). The paired t-test (p < 0.05) was used for comparison between the groups. Statistical differences were observed for heart rate, systolic, diastolic, and mean arterial pressure, respiratory rate, and blood glucose between the periods in both groups. There were differences only in the basal values of MAP between the groups; however, most values remained within the physiological range for the species. Using the drug as an adjuvant to anesthesia did not alter cardiorespiratory parameters, and it can be used as an adjuvant in analgesia during the intraoperative period of OH.A dipirona é um analgésico eficaz para o manejo da dor pós-operatória moderada ou grave, podendo ser utilizada isoladamente em dores leves ou associada a outros analgésicos em qualquer tipo de dor. O presente estudo teve como objetivo avaliar a utilização de infusão contínua (IC) de dipirona no período transoperatório de cadelas submetidas à Ovariohisterectomia (OH) eletiva como adjuvante analgésico, avaliando seu efeito sobre parâmetros cardiorrespiratórios desses pacientes. Para o estudo, 20 cadelas foram submetidas ao procedimento de OH eletiva. A medicação pré-anestésica foi composta pela associação de acepromazina e morfina, seguida da indução com propofol e manutenção com isofluorano. Posteriormente, os animais foram alocados, aleatoriamente, em dois grupos: dipirona (GD), que receberam bolus de dipirona (25 mg kg-1) seguido da IC do fármaco na taxa de 10 mg kg-1 h, e grupo controle (GC), cujos animais receberam o bolus e IC de solução de NaCl 0,9%, ambos os grupos na velocidade de 5 mL kg-1 h. Variáveis paramétricas foram analisadas pela ANOVA seguida pelo teste de Tukey (p < 0,05) e comparadas entre os grupos pelo teste t pareado (p < 0,05). Foram observadas diferenças estatísticas entre os momentos em ambos os grupos em relação à FC, FR, PAS, PAM, PAD e glicemia. Entre os grupos, houve apenas diferenças nos valores basais de PAM, no entanto, a maioria dos valores manteve-se dentro da faixa considerada fisiológica para a espécie. A utilização do fármaco como adjuvante a anestesia não alterou os parâmetros cardiorrespiratórios, podendo ser utilizado como adjuvante na analgesia durante o transoperatório de OH.UEL2022-02-25info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/4374210.5433/1679-0359.2022v43n2p827Semina: Ciências Agrárias; Vol. 43 No. 2 (2022); 827-840Semina: Ciências Agrárias; v. 43 n. 2 (2022); 827-8401679-03591676-546Xreponame:Semina. Ciências Agrárias (Online)instname:Universidade Estadual de Londrina (UEL)instacron:UELenghttps://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/43742/30802Copyright (c) 2021 Semina: Ciências Agráriashttp://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessGorczak, RochelleValandro, Marilia AvilaPereira, Bibiana WelterSegatto, ThalineBeckmann, Diego VilibaldoThiesen, Roberto2022-09-26T22:33:58Zoai:ojs.pkp.sfu.ca:article/43742Revistahttp://www.uel.br/revistas/uel/index.php/semagrariasPUBhttps://ojs.uel.br/revistas/uel/index.php/semagrarias/oaisemina.agrarias@uel.br1679-03591676-546Xopendoar:2022-09-26T22:33:58Semina. Ciências Agrárias (Online) - Universidade Estadual de Londrina (UEL)false |
dc.title.none.fl_str_mv |
Continuous infusion of dipyrone in bitches in the intraoperative period: cardiorespiratory effects Infusão continua transoperatória de dipirona em cadelas: efeitos cardiorrespiratórios e analgésicos |
title |
Continuous infusion of dipyrone in bitches in the intraoperative period: cardiorespiratory effects |
spellingShingle |
Continuous infusion of dipyrone in bitches in the intraoperative period: cardiorespiratory effects Gorczak, Rochelle Anesthesia Dog Pain Metamizole. Anestesia Cão Dor Metamizol. |
title_short |
Continuous infusion of dipyrone in bitches in the intraoperative period: cardiorespiratory effects |
title_full |
Continuous infusion of dipyrone in bitches in the intraoperative period: cardiorespiratory effects |
title_fullStr |
Continuous infusion of dipyrone in bitches in the intraoperative period: cardiorespiratory effects |
title_full_unstemmed |
Continuous infusion of dipyrone in bitches in the intraoperative period: cardiorespiratory effects |
title_sort |
Continuous infusion of dipyrone in bitches in the intraoperative period: cardiorespiratory effects |
author |
Gorczak, Rochelle |
author_facet |
Gorczak, Rochelle Valandro, Marilia Avila Pereira, Bibiana Welter Segatto, Thaline Beckmann, Diego Vilibaldo Thiesen, Roberto |
author_role |
author |
author2 |
Valandro, Marilia Avila Pereira, Bibiana Welter Segatto, Thaline Beckmann, Diego Vilibaldo Thiesen, Roberto |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Gorczak, Rochelle Valandro, Marilia Avila Pereira, Bibiana Welter Segatto, Thaline Beckmann, Diego Vilibaldo Thiesen, Roberto |
dc.subject.por.fl_str_mv |
Anesthesia Dog Pain Metamizole. Anestesia Cão Dor Metamizol. |
topic |
Anesthesia Dog Pain Metamizole. Anestesia Cão Dor Metamizol. |
description |
Dipyrone is an effective analgesic for managing moderate or severe postoperative pain and can be used alone for mild pain or in combination with other analgesics for any type of pain. This study aimed to examine the administration of dipyrone by continuous infusion (CI) as an adjuvant analgesic in the intraoperative period for bitches undergoing elective ovariohysterectomy (OH) and its effect on these patients’ cardiorespiratory parameters. Twenty bitches underwent an elective OH procedure. The pre-anesthetic agent was a combination of acepromazine and morphine. Propofol was used to induce anesthesia, and isoflurane was used for maintenance. Subsequently, the animals were randomly allocated into two groups: the dipyrone group (DG) received a bolus dose of dipyrone (25 mg kg -1) by CI at a rate of 10 mg kg -1 h, and the control group (CG) received a bolus dose and a CI of 0.9% NaCl solution, both groups at a rate of 5 mL kg -1 h. The parametric variables were analyzed by ANOVA, followed by Tukey's test (p < 0.05). The paired t-test (p < 0.05) was used for comparison between the groups. Statistical differences were observed for heart rate, systolic, diastolic, and mean arterial pressure, respiratory rate, and blood glucose between the periods in both groups. There were differences only in the basal values of MAP between the groups; however, most values remained within the physiological range for the species. Using the drug as an adjuvant to anesthesia did not alter cardiorespiratory parameters, and it can be used as an adjuvant in analgesia during the intraoperative period of OH. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-02-25 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/43742 10.5433/1679-0359.2022v43n2p827 |
url |
https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/43742 |
identifier_str_mv |
10.5433/1679-0359.2022v43n2p827 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/43742/30802 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2021 Semina: Ciências Agrárias http://creativecommons.org/licenses/by-nc/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2021 Semina: Ciências Agrárias http://creativecommons.org/licenses/by-nc/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
UEL |
publisher.none.fl_str_mv |
UEL |
dc.source.none.fl_str_mv |
Semina: Ciências Agrárias; Vol. 43 No. 2 (2022); 827-840 Semina: Ciências Agrárias; v. 43 n. 2 (2022); 827-840 1679-0359 1676-546X reponame:Semina. Ciências Agrárias (Online) instname:Universidade Estadual de Londrina (UEL) instacron:UEL |
instname_str |
Universidade Estadual de Londrina (UEL) |
instacron_str |
UEL |
institution |
UEL |
reponame_str |
Semina. Ciências Agrárias (Online) |
collection |
Semina. Ciências Agrárias (Online) |
repository.name.fl_str_mv |
Semina. Ciências Agrárias (Online) - Universidade Estadual de Londrina (UEL) |
repository.mail.fl_str_mv |
semina.agrarias@uel.br |
_version_ |
1799306085440421888 |