The use of fluconazole associated with surgical excision in the treatment of equine cutaneous pythiosis

Detalhes bibliográficos
Autor(a) principal: Carvalho, Armando de Mattos
Data de Publicação: 2019
Outros Autores: Munhoz, Thayanne Caroline Pereira, Toma, Hugo Shisei, Santos, Jéssica Pamela Velasco dos, Oliveira, Luiz Gustavo Schneider de, Boabaid, Fabiana Marques, Xavier, Andressa Batista da Silveira, Kommers, Glaucia Denise
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Semina. Ciências Agrárias (Online)
Texto Completo: https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/35357
Resumo: Cutaneous pythiosis is an important disease affecting horses raised in regions with a hot climate and water stagnation, occurring throughout all regions of Brazil. The disease progresses rapidly, and treatment for chronic lesions is challenging. The purpose of this study was to evaluate the efficacy of fluconazole after surgical excision and electrocauterization of cutaneous lesions in horses naturally infected with Pythium insidiosum. We treated 10 horses with cutaneous pythiosis, whose diagnoses were confirmed by histopathological and immunohistochemical examinations. After surgical debridement of lesion, animals received fluconazole orally for 21 days, in combination with topical treatment for the wounds. After 7 days of therapy, there was decreased serosanguineous secretion and no kunkers in the wounds in all horses. All lesions healed completely after therapy, and there were no recurrences 10 months after discharge. When associated with surgical excision, oral fluconazole therapy was an effective treatment in clinical cases of equine cutaneous pythiosis.
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spelling The use of fluconazole associated with surgical excision in the treatment of equine cutaneous pythiosisUso do flucozanol associado à excisão cirúrgica no tratamento da pitiose cutânea equinaTherapyAntifungal medicationSurgeryPythium insidiosum.TerapiaAntifúngicoCirurgiaPythium insidiosum.Cutaneous pythiosis is an important disease affecting horses raised in regions with a hot climate and water stagnation, occurring throughout all regions of Brazil. The disease progresses rapidly, and treatment for chronic lesions is challenging. The purpose of this study was to evaluate the efficacy of fluconazole after surgical excision and electrocauterization of cutaneous lesions in horses naturally infected with Pythium insidiosum. We treated 10 horses with cutaneous pythiosis, whose diagnoses were confirmed by histopathological and immunohistochemical examinations. After surgical debridement of lesion, animals received fluconazole orally for 21 days, in combination with topical treatment for the wounds. After 7 days of therapy, there was decreased serosanguineous secretion and no kunkers in the wounds in all horses. All lesions healed completely after therapy, and there were no recurrences 10 months after discharge. When associated with surgical excision, oral fluconazole therapy was an effective treatment in clinical cases of equine cutaneous pythiosis.Pitiose cutânea é uma enfermidade importante que acomete equinos criados em regiões de clima quente e com presença de água estagnada, sendo reportada em todas as regiões do Brasil. Possui evolução rápida e o tratamento de lesões crônicas ainda é considerado um desafio. O objetivo do presente trabalho foi a avaliação da eficácia do fluconazol após a excisão cirúrgica e termocauterização de feridas cutâneas de equinos naturalmente infectados por Pythium insidiosum. Para o estudo foram utilizados 10 equinos com pitiose cutânea, com diagnóstico confirmado por meio da avaliação histopatológica e da imuno-histoquímica. Após o desbridamento cirúrgico da lesão, os animais receberam fluconazol por via oral durante 21 dias, associado a tratamento tópico da ferida. Em todos os casos, após sete dias do início da terapia foi possível evidenciar diminuição da secreção serosanguinolenta, assim como ausência de kunkers na ferida. Todos os animais tiveram cicatrização completa das lesões após a terapia e não houve recidiva após dez meses da alta médica. A terapia com fluconazol administrado por via oral demonstrou ser um tratamento eficaz quando associado à excisão cirúrgica em casos clínicos de pitiose cutânea equina.UEL2019-09-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/3535710.5433/1679-0359.2019v40n6Supl2p3079Semina: Ciências Agrárias; Vol. 40 No. 6Supl2 (2019); 3079-3088Semina: Ciências Agrárias; v. 40 n. 6Supl2 (2019); 3079-30881679-03591676-546Xreponame:Semina. Ciências Agrárias (Online)instname:Universidade Estadual de Londrina (UEL)instacron:UELenghttps://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/35357/26204Copyright (c) 2019 Semina: Ciências Agráriashttp://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessCarvalho, Armando de MattosMunhoz, Thayanne Caroline PereiraToma, Hugo ShiseiSantos, Jéssica Pamela Velasco dosOliveira, Luiz Gustavo Schneider deBoabaid, Fabiana MarquesXavier, Andressa Batista da SilveiraKommers, Glaucia Denise2022-10-10T16:09:12Zoai:ojs.pkp.sfu.ca:article/35357Revistahttp://www.uel.br/revistas/uel/index.php/semagrariasPUBhttps://ojs.uel.br/revistas/uel/index.php/semagrarias/oaisemina.agrarias@uel.br1679-03591676-546Xopendoar:2022-10-10T16:09:12Semina. Ciências Agrárias (Online) - Universidade Estadual de Londrina (UEL)false
dc.title.none.fl_str_mv The use of fluconazole associated with surgical excision in the treatment of equine cutaneous pythiosis
Uso do flucozanol associado à excisão cirúrgica no tratamento da pitiose cutânea equina
title The use of fluconazole associated with surgical excision in the treatment of equine cutaneous pythiosis
spellingShingle The use of fluconazole associated with surgical excision in the treatment of equine cutaneous pythiosis
Carvalho, Armando de Mattos
Therapy
Antifungal medication
Surgery
Pythium insidiosum.
Terapia
Antifúngico
Cirurgia
Pythium insidiosum.
title_short The use of fluconazole associated with surgical excision in the treatment of equine cutaneous pythiosis
title_full The use of fluconazole associated with surgical excision in the treatment of equine cutaneous pythiosis
title_fullStr The use of fluconazole associated with surgical excision in the treatment of equine cutaneous pythiosis
title_full_unstemmed The use of fluconazole associated with surgical excision in the treatment of equine cutaneous pythiosis
title_sort The use of fluconazole associated with surgical excision in the treatment of equine cutaneous pythiosis
author Carvalho, Armando de Mattos
author_facet Carvalho, Armando de Mattos
Munhoz, Thayanne Caroline Pereira
Toma, Hugo Shisei
Santos, Jéssica Pamela Velasco dos
Oliveira, Luiz Gustavo Schneider de
Boabaid, Fabiana Marques
Xavier, Andressa Batista da Silveira
Kommers, Glaucia Denise
author_role author
author2 Munhoz, Thayanne Caroline Pereira
Toma, Hugo Shisei
Santos, Jéssica Pamela Velasco dos
Oliveira, Luiz Gustavo Schneider de
Boabaid, Fabiana Marques
Xavier, Andressa Batista da Silveira
Kommers, Glaucia Denise
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Carvalho, Armando de Mattos
Munhoz, Thayanne Caroline Pereira
Toma, Hugo Shisei
Santos, Jéssica Pamela Velasco dos
Oliveira, Luiz Gustavo Schneider de
Boabaid, Fabiana Marques
Xavier, Andressa Batista da Silveira
Kommers, Glaucia Denise
dc.subject.por.fl_str_mv Therapy
Antifungal medication
Surgery
Pythium insidiosum.
Terapia
Antifúngico
Cirurgia
Pythium insidiosum.
topic Therapy
Antifungal medication
Surgery
Pythium insidiosum.
Terapia
Antifúngico
Cirurgia
Pythium insidiosum.
description Cutaneous pythiosis is an important disease affecting horses raised in regions with a hot climate and water stagnation, occurring throughout all regions of Brazil. The disease progresses rapidly, and treatment for chronic lesions is challenging. The purpose of this study was to evaluate the efficacy of fluconazole after surgical excision and electrocauterization of cutaneous lesions in horses naturally infected with Pythium insidiosum. We treated 10 horses with cutaneous pythiosis, whose diagnoses were confirmed by histopathological and immunohistochemical examinations. After surgical debridement of lesion, animals received fluconazole orally for 21 days, in combination with topical treatment for the wounds. After 7 days of therapy, there was decreased serosanguineous secretion and no kunkers in the wounds in all horses. All lesions healed completely after therapy, and there were no recurrences 10 months after discharge. When associated with surgical excision, oral fluconazole therapy was an effective treatment in clinical cases of equine cutaneous pythiosis.
publishDate 2019
dc.date.none.fl_str_mv 2019-09-30
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/35357
10.5433/1679-0359.2019v40n6Supl2p3079
url https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/35357
identifier_str_mv 10.5433/1679-0359.2019v40n6Supl2p3079
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/35357/26204
dc.rights.driver.fl_str_mv Copyright (c) 2019 Semina: Ciências Agrárias
http://creativecommons.org/licenses/by-nc/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2019 Semina: Ciências Agrárias
http://creativecommons.org/licenses/by-nc/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv UEL
publisher.none.fl_str_mv UEL
dc.source.none.fl_str_mv Semina: Ciências Agrárias; Vol. 40 No. 6Supl2 (2019); 3079-3088
Semina: Ciências Agrárias; v. 40 n. 6Supl2 (2019); 3079-3088
1679-0359
1676-546X
reponame:Semina. Ciências Agrárias (Online)
instname:Universidade Estadual de Londrina (UEL)
instacron:UEL
instname_str Universidade Estadual de Londrina (UEL)
instacron_str UEL
institution UEL
reponame_str Semina. Ciências Agrárias (Online)
collection Semina. Ciências Agrárias (Online)
repository.name.fl_str_mv Semina. Ciências Agrárias (Online) - Universidade Estadual de Londrina (UEL)
repository.mail.fl_str_mv semina.agrarias@uel.br
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