The use of fluconazole associated with surgical excision in the treatment of equine cutaneous pythiosis
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Semina. Ciências Agrárias (Online) |
Texto Completo: | https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/35357 |
Resumo: | Cutaneous pythiosis is an important disease affecting horses raised in regions with a hot climate and water stagnation, occurring throughout all regions of Brazil. The disease progresses rapidly, and treatment for chronic lesions is challenging. The purpose of this study was to evaluate the efficacy of fluconazole after surgical excision and electrocauterization of cutaneous lesions in horses naturally infected with Pythium insidiosum. We treated 10 horses with cutaneous pythiosis, whose diagnoses were confirmed by histopathological and immunohistochemical examinations. After surgical debridement of lesion, animals received fluconazole orally for 21 days, in combination with topical treatment for the wounds. After 7 days of therapy, there was decreased serosanguineous secretion and no kunkers in the wounds in all horses. All lesions healed completely after therapy, and there were no recurrences 10 months after discharge. When associated with surgical excision, oral fluconazole therapy was an effective treatment in clinical cases of equine cutaneous pythiosis. |
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Semina. Ciências Agrárias (Online) |
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The use of fluconazole associated with surgical excision in the treatment of equine cutaneous pythiosisUso do flucozanol associado à excisão cirúrgica no tratamento da pitiose cutânea equinaTherapyAntifungal medicationSurgeryPythium insidiosum.TerapiaAntifúngicoCirurgiaPythium insidiosum.Cutaneous pythiosis is an important disease affecting horses raised in regions with a hot climate and water stagnation, occurring throughout all regions of Brazil. The disease progresses rapidly, and treatment for chronic lesions is challenging. The purpose of this study was to evaluate the efficacy of fluconazole after surgical excision and electrocauterization of cutaneous lesions in horses naturally infected with Pythium insidiosum. We treated 10 horses with cutaneous pythiosis, whose diagnoses were confirmed by histopathological and immunohistochemical examinations. After surgical debridement of lesion, animals received fluconazole orally for 21 days, in combination with topical treatment for the wounds. After 7 days of therapy, there was decreased serosanguineous secretion and no kunkers in the wounds in all horses. All lesions healed completely after therapy, and there were no recurrences 10 months after discharge. When associated with surgical excision, oral fluconazole therapy was an effective treatment in clinical cases of equine cutaneous pythiosis.Pitiose cutânea é uma enfermidade importante que acomete equinos criados em regiões de clima quente e com presença de água estagnada, sendo reportada em todas as regiões do Brasil. Possui evolução rápida e o tratamento de lesões crônicas ainda é considerado um desafio. O objetivo do presente trabalho foi a avaliação da eficácia do fluconazol após a excisão cirúrgica e termocauterização de feridas cutâneas de equinos naturalmente infectados por Pythium insidiosum. Para o estudo foram utilizados 10 equinos com pitiose cutânea, com diagnóstico confirmado por meio da avaliação histopatológica e da imuno-histoquímica. Após o desbridamento cirúrgico da lesão, os animais receberam fluconazol por via oral durante 21 dias, associado a tratamento tópico da ferida. Em todos os casos, após sete dias do início da terapia foi possível evidenciar diminuição da secreção serosanguinolenta, assim como ausência de kunkers na ferida. Todos os animais tiveram cicatrização completa das lesões após a terapia e não houve recidiva após dez meses da alta médica. A terapia com fluconazol administrado por via oral demonstrou ser um tratamento eficaz quando associado à excisão cirúrgica em casos clínicos de pitiose cutânea equina.UEL2019-09-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/3535710.5433/1679-0359.2019v40n6Supl2p3079Semina: Ciências Agrárias; Vol. 40 No. 6Supl2 (2019); 3079-3088Semina: Ciências Agrárias; v. 40 n. 6Supl2 (2019); 3079-30881679-03591676-546Xreponame:Semina. Ciências Agrárias (Online)instname:Universidade Estadual de Londrina (UEL)instacron:UELenghttps://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/35357/26204Copyright (c) 2019 Semina: Ciências Agráriashttp://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessCarvalho, Armando de MattosMunhoz, Thayanne Caroline PereiraToma, Hugo ShiseiSantos, Jéssica Pamela Velasco dosOliveira, Luiz Gustavo Schneider deBoabaid, Fabiana MarquesXavier, Andressa Batista da SilveiraKommers, Glaucia Denise2022-10-10T16:09:12Zoai:ojs.pkp.sfu.ca:article/35357Revistahttp://www.uel.br/revistas/uel/index.php/semagrariasPUBhttps://ojs.uel.br/revistas/uel/index.php/semagrarias/oaisemina.agrarias@uel.br1679-03591676-546Xopendoar:2022-10-10T16:09:12Semina. Ciências Agrárias (Online) - Universidade Estadual de Londrina (UEL)false |
dc.title.none.fl_str_mv |
The use of fluconazole associated with surgical excision in the treatment of equine cutaneous pythiosis Uso do flucozanol associado à excisão cirúrgica no tratamento da pitiose cutânea equina |
title |
The use of fluconazole associated with surgical excision in the treatment of equine cutaneous pythiosis |
spellingShingle |
The use of fluconazole associated with surgical excision in the treatment of equine cutaneous pythiosis Carvalho, Armando de Mattos Therapy Antifungal medication Surgery Pythium insidiosum. Terapia Antifúngico Cirurgia Pythium insidiosum. |
title_short |
The use of fluconazole associated with surgical excision in the treatment of equine cutaneous pythiosis |
title_full |
The use of fluconazole associated with surgical excision in the treatment of equine cutaneous pythiosis |
title_fullStr |
The use of fluconazole associated with surgical excision in the treatment of equine cutaneous pythiosis |
title_full_unstemmed |
The use of fluconazole associated with surgical excision in the treatment of equine cutaneous pythiosis |
title_sort |
The use of fluconazole associated with surgical excision in the treatment of equine cutaneous pythiosis |
author |
Carvalho, Armando de Mattos |
author_facet |
Carvalho, Armando de Mattos Munhoz, Thayanne Caroline Pereira Toma, Hugo Shisei Santos, Jéssica Pamela Velasco dos Oliveira, Luiz Gustavo Schneider de Boabaid, Fabiana Marques Xavier, Andressa Batista da Silveira Kommers, Glaucia Denise |
author_role |
author |
author2 |
Munhoz, Thayanne Caroline Pereira Toma, Hugo Shisei Santos, Jéssica Pamela Velasco dos Oliveira, Luiz Gustavo Schneider de Boabaid, Fabiana Marques Xavier, Andressa Batista da Silveira Kommers, Glaucia Denise |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Carvalho, Armando de Mattos Munhoz, Thayanne Caroline Pereira Toma, Hugo Shisei Santos, Jéssica Pamela Velasco dos Oliveira, Luiz Gustavo Schneider de Boabaid, Fabiana Marques Xavier, Andressa Batista da Silveira Kommers, Glaucia Denise |
dc.subject.por.fl_str_mv |
Therapy Antifungal medication Surgery Pythium insidiosum. Terapia Antifúngico Cirurgia Pythium insidiosum. |
topic |
Therapy Antifungal medication Surgery Pythium insidiosum. Terapia Antifúngico Cirurgia Pythium insidiosum. |
description |
Cutaneous pythiosis is an important disease affecting horses raised in regions with a hot climate and water stagnation, occurring throughout all regions of Brazil. The disease progresses rapidly, and treatment for chronic lesions is challenging. The purpose of this study was to evaluate the efficacy of fluconazole after surgical excision and electrocauterization of cutaneous lesions in horses naturally infected with Pythium insidiosum. We treated 10 horses with cutaneous pythiosis, whose diagnoses were confirmed by histopathological and immunohistochemical examinations. After surgical debridement of lesion, animals received fluconazole orally for 21 days, in combination with topical treatment for the wounds. After 7 days of therapy, there was decreased serosanguineous secretion and no kunkers in the wounds in all horses. All lesions healed completely after therapy, and there were no recurrences 10 months after discharge. When associated with surgical excision, oral fluconazole therapy was an effective treatment in clinical cases of equine cutaneous pythiosis. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-09-30 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/35357 10.5433/1679-0359.2019v40n6Supl2p3079 |
url |
https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/35357 |
identifier_str_mv |
10.5433/1679-0359.2019v40n6Supl2p3079 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/35357/26204 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2019 Semina: Ciências Agrárias http://creativecommons.org/licenses/by-nc/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2019 Semina: Ciências Agrárias http://creativecommons.org/licenses/by-nc/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
UEL |
publisher.none.fl_str_mv |
UEL |
dc.source.none.fl_str_mv |
Semina: Ciências Agrárias; Vol. 40 No. 6Supl2 (2019); 3079-3088 Semina: Ciências Agrárias; v. 40 n. 6Supl2 (2019); 3079-3088 1679-0359 1676-546X reponame:Semina. Ciências Agrárias (Online) instname:Universidade Estadual de Londrina (UEL) instacron:UEL |
instname_str |
Universidade Estadual de Londrina (UEL) |
instacron_str |
UEL |
institution |
UEL |
reponame_str |
Semina. Ciências Agrárias (Online) |
collection |
Semina. Ciências Agrárias (Online) |
repository.name.fl_str_mv |
Semina. Ciências Agrárias (Online) - Universidade Estadual de Londrina (UEL) |
repository.mail.fl_str_mv |
semina.agrarias@uel.br |
_version_ |
1799306081035354112 |