Effect of colistin and tylosin used as feed additives on the performance, diarrhea incidence, and immune response of nursery pigs
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Semina. Ciências Agrárias (Online) |
Texto Completo: | https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/22590 |
Resumo: | For the last several decades, antimicrobial compounds have been used as feed additives to promote piglet growth at weaning, through the prevention of subclinical and clinical disease. However, few studies have assessed the influence of these antibiotics on the immune response of nursery pigs, as well as the relation between performance, health, and immunity of animals that receive feed additives. Therefore, the present study aimed to evaluate the effects of colistin and tylosin when used as feed additives on the performance, incidence of diarrhea, and immune response of nursery pigs. In this study, 72 weaned pigs (average age, 28 days) were allotted into one of three treatment groups: a control group (feed with no antibiotics), tylosin group (feed containing 22 ppm tylosin), and colistin group (feed containing 20 ppm colistin). Weekly, during a five week period, the average daily feed intake, average daily gain, and feed conversion ratio of the pigs were evaluated. Stools were scored daily, in accordance with a fecal texture scale. Blood samples were collected on the day of housing (d0) and on d7, d21, d28, and d35 for immune cell phenotyping. The results of this study showed that piglets in both the colistin and tylosin groups exhibited a significantly higher average daily feed intake, resulting in a higher body weight at the end of the experimental period (d35) when compared with piglets from the control group. Colistin and tylosin also significantly reduced the incidence of diarrhea. Colistin and tylosin modulated the piglets’ immune responses, particularly on d28, by changing the percentage of circulating B lymphocytes, CD4+CD8+ T cells, and the CD4:CD8 ratio. |
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Effect of colistin and tylosin used as feed additives on the performance, diarrhea incidence, and immune response of nursery pigsEfeito do uso da colistina e da tilosina como aditivos alimentares sobre o desempenho, incidência de diarreia e resposta imune de leitões na fase de crecheAntibioticsCell-mediated immunityGrowth promotersPigsWeaning.AntibióticosDesmameImunidade celularPromotores de crescimentoSuínos.For the last several decades, antimicrobial compounds have been used as feed additives to promote piglet growth at weaning, through the prevention of subclinical and clinical disease. However, few studies have assessed the influence of these antibiotics on the immune response of nursery pigs, as well as the relation between performance, health, and immunity of animals that receive feed additives. Therefore, the present study aimed to evaluate the effects of colistin and tylosin when used as feed additives on the performance, incidence of diarrhea, and immune response of nursery pigs. In this study, 72 weaned pigs (average age, 28 days) were allotted into one of three treatment groups: a control group (feed with no antibiotics), tylosin group (feed containing 22 ppm tylosin), and colistin group (feed containing 20 ppm colistin). Weekly, during a five week period, the average daily feed intake, average daily gain, and feed conversion ratio of the pigs were evaluated. Stools were scored daily, in accordance with a fecal texture scale. Blood samples were collected on the day of housing (d0) and on d7, d21, d28, and d35 for immune cell phenotyping. The results of this study showed that piglets in both the colistin and tylosin groups exhibited a significantly higher average daily feed intake, resulting in a higher body weight at the end of the experimental period (d35) when compared with piglets from the control group. Colistin and tylosin also significantly reduced the incidence of diarrhea. Colistin and tylosin modulated the piglets’ immune responses, particularly on d28, by changing the percentage of circulating B lymphocytes, CD4+CD8+ T cells, and the CD4:CD8 ratio.Nas últimas décadas, os compostos antimicrobianos têm sido utilizados como aditivos alimentares para promover o crescimento de leitões ao desmame, por meio da prevenção de doenças clínicas e subclínicas. No entanto, poucos estudos avaliaram a influência destes antibióticos sobre a resposta imune de leitões na fase de creche, bem como a relação entre o desempenho, a saúde e a imunidade dos animais com o uso destes aditivos. Sendo assim, o presente estudo teve como objetivo avaliar o efeito da colistina e da tilosina como aditivos na alimentação sobre o desempenho, incidência de diarreia e resposta imune de leitões na fase de creche. Para isso, foram utilizados 72 suínos recém-desmamados, com 28 dias de idade em media, divididos em três tratamentos: grupo controle (ração sem antibiótico), grupo tilosina (ração com 22 ppm de tilosina), grupo colistina (ração com 20 ppm de colistina). Semanalmente, durante cinco semanas, foi analisado o consumo deração diário, o ganho de peso diário e a conversão alimentar dos leitões. As fezes foram avaliadas diariamente, com a atribuição de escores relacionados à sua consistência. Amostras de sangue foram coletadas no momento do alojamento (d0) e aos d7, d21, d28 e d35, sendo submetidas à técnica de citometria de fluxo. Os resultados demonstraram que tanto o grupo colistina como o grupo tilosina promoveram aumento significativo no consumo de ração diário, o que se refletiu em maior peso ao final do estudo (d35), quando comparados ao grupo controle. A colistina e a tilosina também promoveram redução significativa na incidência de diarreia. A colistina e a tilosina modularam a atividade imune, principalmente aos 28 dias, alterando a porcentagem circulante de linfócitos B, células CD4+CD8+ e da razão entre CD4 e CD8.UEL2016-08-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPesquisa Empírica de Campoapplication/pdfhttps://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/2259010.5433/1679-0359.2016v37n4p1947Semina: Ciências Agrárias; Vol. 37 No. 4 (2016); 1947-1962Semina: Ciências Agrárias; v. 37 n. 4 (2016); 1947-19621679-03591676-546Xreponame:Semina. Ciências Agrárias (Online)instname:Universidade Estadual de Londrina (UEL)instacron:UELenghttps://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/22590/19638http://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessMazutti, KellyCosta, Leandro BatistaNascimento, Lígia ValériaFernandes Filho, TobiasBeirão, Breno Castello BrancoMachado Júnior, Pedro CelsoMaiorka, Alex2022-11-30T16:46:40Zoai:ojs.pkp.sfu.ca:article/22590Revistahttp://www.uel.br/revistas/uel/index.php/semagrariasPUBhttps://ojs.uel.br/revistas/uel/index.php/semagrarias/oaisemina.agrarias@uel.br1679-03591676-546Xopendoar:2022-11-30T16:46:40Semina. Ciências Agrárias (Online) - Universidade Estadual de Londrina (UEL)false |
dc.title.none.fl_str_mv |
Effect of colistin and tylosin used as feed additives on the performance, diarrhea incidence, and immune response of nursery pigs Efeito do uso da colistina e da tilosina como aditivos alimentares sobre o desempenho, incidência de diarreia e resposta imune de leitões na fase de creche |
title |
Effect of colistin and tylosin used as feed additives on the performance, diarrhea incidence, and immune response of nursery pigs |
spellingShingle |
Effect of colistin and tylosin used as feed additives on the performance, diarrhea incidence, and immune response of nursery pigs Mazutti, Kelly Antibiotics Cell-mediated immunity Growth promoters Pigs Weaning. Antibióticos Desmame Imunidade celular Promotores de crescimento Suínos. |
title_short |
Effect of colistin and tylosin used as feed additives on the performance, diarrhea incidence, and immune response of nursery pigs |
title_full |
Effect of colistin and tylosin used as feed additives on the performance, diarrhea incidence, and immune response of nursery pigs |
title_fullStr |
Effect of colistin and tylosin used as feed additives on the performance, diarrhea incidence, and immune response of nursery pigs |
title_full_unstemmed |
Effect of colistin and tylosin used as feed additives on the performance, diarrhea incidence, and immune response of nursery pigs |
title_sort |
Effect of colistin and tylosin used as feed additives on the performance, diarrhea incidence, and immune response of nursery pigs |
author |
Mazutti, Kelly |
author_facet |
Mazutti, Kelly Costa, Leandro Batista Nascimento, Lígia Valéria Fernandes Filho, Tobias Beirão, Breno Castello Branco Machado Júnior, Pedro Celso Maiorka, Alex |
author_role |
author |
author2 |
Costa, Leandro Batista Nascimento, Lígia Valéria Fernandes Filho, Tobias Beirão, Breno Castello Branco Machado Júnior, Pedro Celso Maiorka, Alex |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Mazutti, Kelly Costa, Leandro Batista Nascimento, Lígia Valéria Fernandes Filho, Tobias Beirão, Breno Castello Branco Machado Júnior, Pedro Celso Maiorka, Alex |
dc.subject.por.fl_str_mv |
Antibiotics Cell-mediated immunity Growth promoters Pigs Weaning. Antibióticos Desmame Imunidade celular Promotores de crescimento Suínos. |
topic |
Antibiotics Cell-mediated immunity Growth promoters Pigs Weaning. Antibióticos Desmame Imunidade celular Promotores de crescimento Suínos. |
description |
For the last several decades, antimicrobial compounds have been used as feed additives to promote piglet growth at weaning, through the prevention of subclinical and clinical disease. However, few studies have assessed the influence of these antibiotics on the immune response of nursery pigs, as well as the relation between performance, health, and immunity of animals that receive feed additives. Therefore, the present study aimed to evaluate the effects of colistin and tylosin when used as feed additives on the performance, incidence of diarrhea, and immune response of nursery pigs. In this study, 72 weaned pigs (average age, 28 days) were allotted into one of three treatment groups: a control group (feed with no antibiotics), tylosin group (feed containing 22 ppm tylosin), and colistin group (feed containing 20 ppm colistin). Weekly, during a five week period, the average daily feed intake, average daily gain, and feed conversion ratio of the pigs were evaluated. Stools were scored daily, in accordance with a fecal texture scale. Blood samples were collected on the day of housing (d0) and on d7, d21, d28, and d35 for immune cell phenotyping. The results of this study showed that piglets in both the colistin and tylosin groups exhibited a significantly higher average daily feed intake, resulting in a higher body weight at the end of the experimental period (d35) when compared with piglets from the control group. Colistin and tylosin also significantly reduced the incidence of diarrhea. Colistin and tylosin modulated the piglets’ immune responses, particularly on d28, by changing the percentage of circulating B lymphocytes, CD4+CD8+ T cells, and the CD4:CD8 ratio. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-08-30 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Pesquisa Empírica de Campo |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/22590 10.5433/1679-0359.2016v37n4p1947 |
url |
https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/22590 |
identifier_str_mv |
10.5433/1679-0359.2016v37n4p1947 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/22590/19638 |
dc.rights.driver.fl_str_mv |
http://creativecommons.org/licenses/by-nc/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by-nc/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
UEL |
publisher.none.fl_str_mv |
UEL |
dc.source.none.fl_str_mv |
Semina: Ciências Agrárias; Vol. 37 No. 4 (2016); 1947-1962 Semina: Ciências Agrárias; v. 37 n. 4 (2016); 1947-1962 1679-0359 1676-546X reponame:Semina. Ciências Agrárias (Online) instname:Universidade Estadual de Londrina (UEL) instacron:UEL |
instname_str |
Universidade Estadual de Londrina (UEL) |
instacron_str |
UEL |
institution |
UEL |
reponame_str |
Semina. Ciências Agrárias (Online) |
collection |
Semina. Ciências Agrárias (Online) |
repository.name.fl_str_mv |
Semina. Ciências Agrárias (Online) - Universidade Estadual de Londrina (UEL) |
repository.mail.fl_str_mv |
semina.agrarias@uel.br |
_version_ |
1799306074494337024 |