Exercício físico de baixa intensidade altera adiposidade da prole de 21 dias provenientes de mães alimentadas com dieta de cafeteria

• Autor(a) principal: Andrade, Maynara Lucca
• Data de Publicação: 2014
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Repositório Institucional da Universidade Estadual de Maringá (RI-UEM)
• Texto Completo: http://repositorio.uem.br:8080/jspui/handle/1/2213
• topic: Exercício físico; Dieta; Programação metabólica; Tecido adiposo; Ciências da Saúde; Educação Física

Studies regarding the fetal programming of obesity have shown that maternal nutrition during pregnancy may promote significant changes related to fetal development and metabolic programming however the influence of exercise during this period as a protector attenuator of the deleterious effects caused by maternal malnutrition remain unknown. Thus, we investigated the effects of a light physical activity program on the damage caused by the cafeteria diet during gestation and lactation on changes in several parameters related to adiposity in male pups, 21 days old. To this end, we used male rats from female rats, 70 days old. At the beginning of pregnancy and throughout the whole period of exercise and lactation the female rats received the cafeteria diet. After birth, the following groups were randomly formed: Sedentary Control Pups (FSC), Trained Control Pups (FTC), Sedentary Cafeteria Pups (FSCA) and Trained Cafeteria Pups (FTCA). At weaning, 21 full days, pups were euthanized and several adipose tissue fat padswere collected and weighed. The subcutaneous and periepididymal pads were treated with collagenase and adipocytes isolated. Brown adipose tissue (BAT) histological analysis was performed in order to verify changes in the adipocyte area lipid droplet area. The data obtained in our experimental model indicate a related imprinting characteristic of adiposity, such as changes in body weight of offspring for the diet accompanied by weight changes in fat pads, which also suffered the influence of physical exercise. Furthermore, the diameter of periepydidimal adipocytes increased significantly in FSCA with concomitant decrease in cellularity. On the other hand,FSCA and FTCA subcutaneous adipocytes showed an increase in diameter but a reduction on cellularity only in FSCA. In BAT, adipocyte and lipid droplet areas were higherin FSCA and FTCA. In summary, we conclude exercise performed by mothers during pregnancy contributed to the improvement in cellularity of white adipocytes but did not revert the deleterious effects of cafeteria diet on brown adipose tissue morphology.