Mitotic and meiotic instability produced by an informational suppressor in Aspergillus nidulans

Detalhes bibliográficos
Autor(a) principal: Franzoni, Melissa Gracite de Melo
Data de Publicação: 2008
Outros Autores: Prado, Marialba Avezum Alves Castro
Tipo de documento: Artigo
Idioma: por
Título da fonte: Acta Scientiarum Biological Sciences
Texto Completo: http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/2810
Resumo: The genetic instability induced by the informational suppressor suO1 in Aspergillus nidulans is described. suO1 was selected through the properties of coreversion of several physiologically unrelated mutations. This mutation decreased the conidia and ascospores viability of the suppressor strains. These strains were unstable at mitosis and meiosis, producing improved derivatives, phenotypically different from the original strains. Meiotic crosses, heterozygous for the suppressor mutation, produced barren cleistothecia. suO1 was unstable in the restoration of the genetic alterations present in the genome of M-15 mutant, producing more than 25.0% unsuppressed progeny in heterozygous crosses for auxotrophyc mutations (for instance, su, ribo x su+, ribo+) . Our results suggested that suO1 altered the fidelity of the translation process, inducing mistranslation of normal and mutant mRNAs
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spelling Mitotic and meiotic instability produced by an informational suppressor in Aspergillus nidulansInstabilidade mitótica e meiótica produzida por um supressor informacional em Aspergillus nidulansAspergillus nidulansinstabilidade mitóticainstabilidade meióticagene supressor2.00.00.00-6 Ciências BiológicasThe genetic instability induced by the informational suppressor suO1 in Aspergillus nidulans is described. suO1 was selected through the properties of coreversion of several physiologically unrelated mutations. This mutation decreased the conidia and ascospores viability of the suppressor strains. These strains were unstable at mitosis and meiosis, producing improved derivatives, phenotypically different from the original strains. Meiotic crosses, heterozygous for the suppressor mutation, produced barren cleistothecia. suO1 was unstable in the restoration of the genetic alterations present in the genome of M-15 mutant, producing more than 25.0% unsuppressed progeny in heterozygous crosses for auxotrophyc mutations (for instance, su, ribo x su+, ribo+) . Our results suggested that suO1 altered the fidelity of the translation process, inducing mistranslation of normal and mutant mRNAsA instabilidade genética de linhagens de Aspergillus nidulans, portadoras de um supressor informacional (suO1), foi estudada no presente trabalho. suO1 foi selecionado através de sua capacidade de suprimir várias mutações auxotróficas e de coloração de conídios, presentes no genoma do mutante M-15. Este supressor mostrou-se também capaz de reduzir a fertilidade e a viabilidade conidial das linhagens suprimidas. Estas linhagens mostraram-se instáveis na mitose, produzindo espontaneamente setores mitóticos fenotipicamente distintos da linhagem original, e na meiose, produzindo cleistotécios contendo reduzido número de ascósporos viáveis. Em cruzamentos heterozigotos (su, ribo x su+, ribo+) mais de 25.0% da progênie exibiu o fenótipo mutante ribo, destacando a baixa eficiência da mutação suO1. Nossos resultados sugerem que suO1 induz erros na tradução de mRNAs selvagens e mutantesUniversidade Estadual De Maringá2008-05-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/281010.4025/actascibiolsci.v22i0.2810Acta Scientiarum. Biological Sciences; Vol 22 (2000); 263-268Acta Scientiarum. Biological Sciences; v. 22 (2000); 263-2681807-863X1679-9283reponame:Acta Scientiarum Biological Sciencesinstname:Universidade Estadual de Maringá (UEM)instacron:UEMporhttp://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/2810/2087Franzoni, Melissa Gracite de MeloPrado, Marialba Avezum Alves Castroinfo:eu-repo/semantics/openAccess2022-11-23T17:33:30Zoai:periodicos.uem.br/ojs:article/2810Revistahttp://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSciPUBhttp://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/oai||actabiol@uem.br1807-863X1679-9283opendoar:2022-11-23T17:33:30Acta Scientiarum Biological Sciences - Universidade Estadual de Maringá (UEM)false
dc.title.none.fl_str_mv Mitotic and meiotic instability produced by an informational suppressor in Aspergillus nidulans
Instabilidade mitótica e meiótica produzida por um supressor informacional em Aspergillus nidulans
title Mitotic and meiotic instability produced by an informational suppressor in Aspergillus nidulans
spellingShingle Mitotic and meiotic instability produced by an informational suppressor in Aspergillus nidulans
Franzoni, Melissa Gracite de Melo
Aspergillus nidulans
instabilidade mitótica
instabilidade meiótica
gene supressor
2.00.00.00-6 Ciências Biológicas
title_short Mitotic and meiotic instability produced by an informational suppressor in Aspergillus nidulans
title_full Mitotic and meiotic instability produced by an informational suppressor in Aspergillus nidulans
title_fullStr Mitotic and meiotic instability produced by an informational suppressor in Aspergillus nidulans
title_full_unstemmed Mitotic and meiotic instability produced by an informational suppressor in Aspergillus nidulans
title_sort Mitotic and meiotic instability produced by an informational suppressor in Aspergillus nidulans
author Franzoni, Melissa Gracite de Melo
author_facet Franzoni, Melissa Gracite de Melo
Prado, Marialba Avezum Alves Castro
author_role author
author2 Prado, Marialba Avezum Alves Castro
author2_role author
dc.contributor.author.fl_str_mv Franzoni, Melissa Gracite de Melo
Prado, Marialba Avezum Alves Castro
dc.subject.por.fl_str_mv Aspergillus nidulans
instabilidade mitótica
instabilidade meiótica
gene supressor
2.00.00.00-6 Ciências Biológicas
topic Aspergillus nidulans
instabilidade mitótica
instabilidade meiótica
gene supressor
2.00.00.00-6 Ciências Biológicas
description The genetic instability induced by the informational suppressor suO1 in Aspergillus nidulans is described. suO1 was selected through the properties of coreversion of several physiologically unrelated mutations. This mutation decreased the conidia and ascospores viability of the suppressor strains. These strains were unstable at mitosis and meiosis, producing improved derivatives, phenotypically different from the original strains. Meiotic crosses, heterozygous for the suppressor mutation, produced barren cleistothecia. suO1 was unstable in the restoration of the genetic alterations present in the genome of M-15 mutant, producing more than 25.0% unsuppressed progeny in heterozygous crosses for auxotrophyc mutations (for instance, su, ribo x su+, ribo+) . Our results suggested that suO1 altered the fidelity of the translation process, inducing mistranslation of normal and mutant mRNAs
publishDate 2008
dc.date.none.fl_str_mv 2008-05-09
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/2810
10.4025/actascibiolsci.v22i0.2810
url http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/2810
identifier_str_mv 10.4025/actascibiolsci.v22i0.2810
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/2810/2087
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Estadual De Maringá
publisher.none.fl_str_mv Universidade Estadual De Maringá
dc.source.none.fl_str_mv Acta Scientiarum. Biological Sciences; Vol 22 (2000); 263-268
Acta Scientiarum. Biological Sciences; v. 22 (2000); 263-268
1807-863X
1679-9283
reponame:Acta Scientiarum Biological Sciences
instname:Universidade Estadual de Maringá (UEM)
instacron:UEM
instname_str Universidade Estadual de Maringá (UEM)
instacron_str UEM
institution UEM
reponame_str Acta Scientiarum Biological Sciences
collection Acta Scientiarum Biological Sciences
repository.name.fl_str_mv Acta Scientiarum Biological Sciences - Universidade Estadual de Maringá (UEM)
repository.mail.fl_str_mv ||actabiol@uem.br
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