Pancreatic islets isolated from β2 adrenergic receptor knockout mice show reduced insulin secretion in response to nutrients - doi: 10.4025/actascibiolsci.v35i3.15842
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | por eng |
Título da fonte: | Acta Scientiarum Biological Sciences |
Texto Completo: | http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/15842 |
Resumo: | Activation of β2 adrenergic receptors by catecholamine or catecholamine-mimetic substances may enhance insulin secretion. We herein investigated KCl- and nutrient-stimulated insulin secretion in pancreatic islets isolated from β2 knockout (β2KO) mice. β2KO mice showed reduced body weight, fasting hypoglycaemia associate to a similar fasting insulinemia compared to control. β2KO mice also showed reduced glucose tolerance despite the higher sensitivity to insulin. Glucose-induced insulin secretion was impaired in pancreatic islets isolated from β2KO mice. Leucine-induced (20mM) insulin secretion was diminished in pancreatic islets isolated from β2KO mice when compared to control one. The depolarizing effect of KCl on insulin secretion was also impaired in pancreatic islets from β2KO mice. These results suggested a possible role of β2 adrenergic receptors on nutrient-induced insulin secretion. |
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Pancreatic islets isolated from β2 adrenergic receptor knockout mice show reduced insulin secretion in response to nutrients - doi: 10.4025/actascibiolsci.v35i3.15842adrenergic receptorspancreatic beta cellsglucoseleucine(Citologia e Biologia Celular)(Fisiologia de órgãos e sistemas).Activation of β2 adrenergic receptors by catecholamine or catecholamine-mimetic substances may enhance insulin secretion. We herein investigated KCl- and nutrient-stimulated insulin secretion in pancreatic islets isolated from β2 knockout (β2KO) mice. β2KO mice showed reduced body weight, fasting hypoglycaemia associate to a similar fasting insulinemia compared to control. β2KO mice also showed reduced glucose tolerance despite the higher sensitivity to insulin. Glucose-induced insulin secretion was impaired in pancreatic islets isolated from β2KO mice. Leucine-induced (20mM) insulin secretion was diminished in pancreatic islets isolated from β2KO mice when compared to control one. The depolarizing effect of KCl on insulin secretion was also impaired in pancreatic islets from β2KO mice. These results suggested a possible role of β2 adrenergic receptors on nutrient-induced insulin secretion. Universidade Estadual De Maringá2013-02-28info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiondosagem do hormônio insulina ; parâmetros corporais ; teste de tolerância à glicose ; Teste de tolerância a insulinaapplication/pdfapplication/pdfapplication/pdfapplication/mswordapplication/mswordhttp://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/1584210.4025/actascibiolsci.v35i3.15842Acta Scientiarum. Biological Sciences; Vol 35 No 3 (2013); 437-443Acta Scientiarum. Biological Sciences; v. 35 n. 3 (2013); 437-4431807-863X1679-9283reponame:Acta Scientiarum Biological Sciencesinstname:Universidade Estadual de Maringá (UEM)instacron:UEMporenghttp://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/15842/pdfhttp://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/15842/pdf_1http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/15842/751375141488http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/15842/751375141492http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/15842/751375141493Marçal, Anderson CarlosDavel, Ana Paula CoutoCarpinelli, Angelo RafaelBrum, Patrícia ChakurRossoni, Luciana VenturiniCarvalho, Carla Roberta de Oliveirainfo:eu-repo/semantics/openAccess2022-11-23T17:34:09Zoai:periodicos.uem.br/ojs:article/15842Revistahttp://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSciPUBhttp://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/oai||actabiol@uem.br1807-863X1679-9283opendoar:2022-11-23T17:34:09Acta Scientiarum Biological Sciences - Universidade Estadual de Maringá (UEM)false |
dc.title.none.fl_str_mv |
Pancreatic islets isolated from β2 adrenergic receptor knockout mice show reduced insulin secretion in response to nutrients - doi: 10.4025/actascibiolsci.v35i3.15842 |
title |
Pancreatic islets isolated from β2 adrenergic receptor knockout mice show reduced insulin secretion in response to nutrients - doi: 10.4025/actascibiolsci.v35i3.15842 |
spellingShingle |
Pancreatic islets isolated from β2 adrenergic receptor knockout mice show reduced insulin secretion in response to nutrients - doi: 10.4025/actascibiolsci.v35i3.15842 Marçal, Anderson Carlos adrenergic receptors pancreatic beta cells glucose leucine (Citologia e Biologia Celular) (Fisiologia de órgãos e sistemas). |
title_short |
Pancreatic islets isolated from β2 adrenergic receptor knockout mice show reduced insulin secretion in response to nutrients - doi: 10.4025/actascibiolsci.v35i3.15842 |
title_full |
Pancreatic islets isolated from β2 adrenergic receptor knockout mice show reduced insulin secretion in response to nutrients - doi: 10.4025/actascibiolsci.v35i3.15842 |
title_fullStr |
Pancreatic islets isolated from β2 adrenergic receptor knockout mice show reduced insulin secretion in response to nutrients - doi: 10.4025/actascibiolsci.v35i3.15842 |
title_full_unstemmed |
Pancreatic islets isolated from β2 adrenergic receptor knockout mice show reduced insulin secretion in response to nutrients - doi: 10.4025/actascibiolsci.v35i3.15842 |
title_sort |
Pancreatic islets isolated from β2 adrenergic receptor knockout mice show reduced insulin secretion in response to nutrients - doi: 10.4025/actascibiolsci.v35i3.15842 |
author |
Marçal, Anderson Carlos |
author_facet |
Marçal, Anderson Carlos Davel, Ana Paula Couto Carpinelli, Angelo Rafael Brum, Patrícia Chakur Rossoni, Luciana Venturini Carvalho, Carla Roberta de Oliveira |
author_role |
author |
author2 |
Davel, Ana Paula Couto Carpinelli, Angelo Rafael Brum, Patrícia Chakur Rossoni, Luciana Venturini Carvalho, Carla Roberta de Oliveira |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Marçal, Anderson Carlos Davel, Ana Paula Couto Carpinelli, Angelo Rafael Brum, Patrícia Chakur Rossoni, Luciana Venturini Carvalho, Carla Roberta de Oliveira |
dc.subject.por.fl_str_mv |
adrenergic receptors pancreatic beta cells glucose leucine (Citologia e Biologia Celular) (Fisiologia de órgãos e sistemas). |
topic |
adrenergic receptors pancreatic beta cells glucose leucine (Citologia e Biologia Celular) (Fisiologia de órgãos e sistemas). |
description |
Activation of β2 adrenergic receptors by catecholamine or catecholamine-mimetic substances may enhance insulin secretion. We herein investigated KCl- and nutrient-stimulated insulin secretion in pancreatic islets isolated from β2 knockout (β2KO) mice. β2KO mice showed reduced body weight, fasting hypoglycaemia associate to a similar fasting insulinemia compared to control. β2KO mice also showed reduced glucose tolerance despite the higher sensitivity to insulin. Glucose-induced insulin secretion was impaired in pancreatic islets isolated from β2KO mice. Leucine-induced (20mM) insulin secretion was diminished in pancreatic islets isolated from β2KO mice when compared to control one. The depolarizing effect of KCl on insulin secretion was also impaired in pancreatic islets from β2KO mice. These results suggested a possible role of β2 adrenergic receptors on nutrient-induced insulin secretion. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-02-28 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion dosagem do hormônio insulina ; parâmetros corporais ; teste de tolerância à glicose ; Teste de tolerância a insulina |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/15842 10.4025/actascibiolsci.v35i3.15842 |
url |
http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/15842 |
identifier_str_mv |
10.4025/actascibiolsci.v35i3.15842 |
dc.language.iso.fl_str_mv |
por eng |
language |
por eng |
dc.relation.none.fl_str_mv |
http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/15842/pdf http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/15842/pdf_1 http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/15842/751375141488 http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/15842/751375141492 http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/15842/751375141493 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/msword application/msword |
dc.publisher.none.fl_str_mv |
Universidade Estadual De Maringá |
publisher.none.fl_str_mv |
Universidade Estadual De Maringá |
dc.source.none.fl_str_mv |
Acta Scientiarum. Biological Sciences; Vol 35 No 3 (2013); 437-443 Acta Scientiarum. Biological Sciences; v. 35 n. 3 (2013); 437-443 1807-863X 1679-9283 reponame:Acta Scientiarum Biological Sciences instname:Universidade Estadual de Maringá (UEM) instacron:UEM |
instname_str |
Universidade Estadual de Maringá (UEM) |
instacron_str |
UEM |
institution |
UEM |
reponame_str |
Acta Scientiarum Biological Sciences |
collection |
Acta Scientiarum Biological Sciences |
repository.name.fl_str_mv |
Acta Scientiarum Biological Sciences - Universidade Estadual de Maringá (UEM) |
repository.mail.fl_str_mv |
||actabiol@uem.br |
_version_ |
1799317395546832896 |