Pressure-induced left ventricular hypertrophy in canine model of aortic stenosis using nylon tie

Detalhes bibliográficos
Autor(a) principal: Shamaa, Ashraf
Data de Publicação: 2020
Outros Autores: Hanafy, Doaa Elgohary, Khalifa, Tamer Farouk, Salem, Mona Mahmoud, Shehab, Gehan Gamil, Aly, Nermin Mohamed, Hassan, Elham
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Scientiarum Biological Sciences
Texto Completo: http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/48887
Resumo: The aim of this study was to develop an experimentally-induced canine model of left ventricular hypertrophy through banding of the ascending aorta using nylon ties. Seven clinically normal dogs free of cardiovascular disease were used. Nylon tie was used in banding the mid-ascending aorta. Clinical, radiographic and echocardiographic evaluations were done at 1.5, 3 and 6 months. Dogs were euthanized at 6 months for post mortem and histopathological evaluation. Clinically, dogs did not exhibit any signs of cardiovascular disease at 1.5 or 3 months, while at 6 months two dogs (28.6 %) exhibited mild weight loss, exercise intolerance and heart murmurs. Radiographic evaluation revealed significant increase in cardiac size only at 6 months based on measurement of the cardiothoracic area evaluation. Echocardiography revealed increased left ventricular wall thickness starting from 1.5 month, although this increase was statistically significant at 3 and 6 months (p > 0.05). Left ventricular hypertrophy was confirmed by post mortem examination. Histopathological sections of left ventricle in all dogs demonstrated myocyte hypertrophy and interstitial fibrosis. This model simulates the naturally occurring ventricular hypertrophy using a rapid and economic technique. Such models are required to understand pathogenesis of heart disease and to develop effective treatment strategy.
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spelling Pressure-induced left ventricular hypertrophy in canine model of aortic stenosis using nylon tiePressure-induced left ventricular hypertrophy in canine model of aortic stenosis using nylon tieheart; aorta; left ventricle; dog; enlargement; modelheart; aorta; left ventricle; dog; enlargement; modelThe aim of this study was to develop an experimentally-induced canine model of left ventricular hypertrophy through banding of the ascending aorta using nylon ties. Seven clinically normal dogs free of cardiovascular disease were used. Nylon tie was used in banding the mid-ascending aorta. Clinical, radiographic and echocardiographic evaluations were done at 1.5, 3 and 6 months. Dogs were euthanized at 6 months for post mortem and histopathological evaluation. Clinically, dogs did not exhibit any signs of cardiovascular disease at 1.5 or 3 months, while at 6 months two dogs (28.6 %) exhibited mild weight loss, exercise intolerance and heart murmurs. Radiographic evaluation revealed significant increase in cardiac size only at 6 months based on measurement of the cardiothoracic area evaluation. Echocardiography revealed increased left ventricular wall thickness starting from 1.5 month, although this increase was statistically significant at 3 and 6 months (p > 0.05). Left ventricular hypertrophy was confirmed by post mortem examination. Histopathological sections of left ventricle in all dogs demonstrated myocyte hypertrophy and interstitial fibrosis. This model simulates the naturally occurring ventricular hypertrophy using a rapid and economic technique. Such models are required to understand pathogenesis of heart disease and to develop effective treatment strategy.Universidade Estadual De Maringá2020-07-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/4888710.4025/actascibiolsci.v42i1.48887Acta Scientiarum. Biological Sciences; Vol 42 (2020): Publicação contínua; e48887Acta Scientiarum. Biological Sciences; v. 42 (2020): Publicação contínua; e488871807-863X1679-9283reponame:Acta Scientiarum Biological Sciencesinstname:Universidade Estadual de Maringá (UEM)instacron:UEMenghttp://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/48887/751375150229Copyright (c) 2020 Acta Scientiarum. Biological Scienceshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessShamaa, AshrafHanafy, Doaa Elgohary Khalifa, Tamer Farouk Salem, Mona Mahmoud Shehab, Gehan Gamil Aly, Nermin Mohamed Hassan, Elham2020-11-16T16:25:43Zoai:periodicos.uem.br/ojs:article/48887Revistahttp://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSciPUBhttp://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/oai||actabiol@uem.br1807-863X1679-9283opendoar:2020-11-16T16:25:43Acta Scientiarum Biological Sciences - Universidade Estadual de Maringá (UEM)false
dc.title.none.fl_str_mv Pressure-induced left ventricular hypertrophy in canine model of aortic stenosis using nylon tie
Pressure-induced left ventricular hypertrophy in canine model of aortic stenosis using nylon tie
title Pressure-induced left ventricular hypertrophy in canine model of aortic stenosis using nylon tie
spellingShingle Pressure-induced left ventricular hypertrophy in canine model of aortic stenosis using nylon tie
Shamaa, Ashraf
heart; aorta; left ventricle; dog; enlargement; model
heart; aorta; left ventricle; dog; enlargement; model
title_short Pressure-induced left ventricular hypertrophy in canine model of aortic stenosis using nylon tie
title_full Pressure-induced left ventricular hypertrophy in canine model of aortic stenosis using nylon tie
title_fullStr Pressure-induced left ventricular hypertrophy in canine model of aortic stenosis using nylon tie
title_full_unstemmed Pressure-induced left ventricular hypertrophy in canine model of aortic stenosis using nylon tie
title_sort Pressure-induced left ventricular hypertrophy in canine model of aortic stenosis using nylon tie
author Shamaa, Ashraf
author_facet Shamaa, Ashraf
Hanafy, Doaa Elgohary
Khalifa, Tamer Farouk
Salem, Mona Mahmoud
Shehab, Gehan Gamil
Aly, Nermin Mohamed
Hassan, Elham
author_role author
author2 Hanafy, Doaa Elgohary
Khalifa, Tamer Farouk
Salem, Mona Mahmoud
Shehab, Gehan Gamil
Aly, Nermin Mohamed
Hassan, Elham
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Shamaa, Ashraf
Hanafy, Doaa Elgohary
Khalifa, Tamer Farouk
Salem, Mona Mahmoud
Shehab, Gehan Gamil
Aly, Nermin Mohamed
Hassan, Elham
dc.subject.por.fl_str_mv heart; aorta; left ventricle; dog; enlargement; model
heart; aorta; left ventricle; dog; enlargement; model
topic heart; aorta; left ventricle; dog; enlargement; model
heart; aorta; left ventricle; dog; enlargement; model
description The aim of this study was to develop an experimentally-induced canine model of left ventricular hypertrophy through banding of the ascending aorta using nylon ties. Seven clinically normal dogs free of cardiovascular disease were used. Nylon tie was used in banding the mid-ascending aorta. Clinical, radiographic and echocardiographic evaluations were done at 1.5, 3 and 6 months. Dogs were euthanized at 6 months for post mortem and histopathological evaluation. Clinically, dogs did not exhibit any signs of cardiovascular disease at 1.5 or 3 months, while at 6 months two dogs (28.6 %) exhibited mild weight loss, exercise intolerance and heart murmurs. Radiographic evaluation revealed significant increase in cardiac size only at 6 months based on measurement of the cardiothoracic area evaluation. Echocardiography revealed increased left ventricular wall thickness starting from 1.5 month, although this increase was statistically significant at 3 and 6 months (p > 0.05). Left ventricular hypertrophy was confirmed by post mortem examination. Histopathological sections of left ventricle in all dogs demonstrated myocyte hypertrophy and interstitial fibrosis. This model simulates the naturally occurring ventricular hypertrophy using a rapid and economic technique. Such models are required to understand pathogenesis of heart disease and to develop effective treatment strategy.
publishDate 2020
dc.date.none.fl_str_mv 2020-07-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/48887
10.4025/actascibiolsci.v42i1.48887
url http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/48887
identifier_str_mv 10.4025/actascibiolsci.v42i1.48887
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/48887/751375150229
dc.rights.driver.fl_str_mv Copyright (c) 2020 Acta Scientiarum. Biological Sciences
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2020 Acta Scientiarum. Biological Sciences
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Estadual De Maringá
publisher.none.fl_str_mv Universidade Estadual De Maringá
dc.source.none.fl_str_mv Acta Scientiarum. Biological Sciences; Vol 42 (2020): Publicação contínua; e48887
Acta Scientiarum. Biological Sciences; v. 42 (2020): Publicação contínua; e48887
1807-863X
1679-9283
reponame:Acta Scientiarum Biological Sciences
instname:Universidade Estadual de Maringá (UEM)
instacron:UEM
instname_str Universidade Estadual de Maringá (UEM)
instacron_str UEM
institution UEM
reponame_str Acta Scientiarum Biological Sciences
collection Acta Scientiarum Biological Sciences
repository.name.fl_str_mv Acta Scientiarum Biological Sciences - Universidade Estadual de Maringá (UEM)
repository.mail.fl_str_mv ||actabiol@uem.br
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