Pressure-induced left ventricular hypertrophy in canine model of aortic stenosis using nylon tie
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Acta Scientiarum Biological Sciences |
Texto Completo: | http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/48887 |
Resumo: | The aim of this study was to develop an experimentally-induced canine model of left ventricular hypertrophy through banding of the ascending aorta using nylon ties. Seven clinically normal dogs free of cardiovascular disease were used. Nylon tie was used in banding the mid-ascending aorta. Clinical, radiographic and echocardiographic evaluations were done at 1.5, 3 and 6 months. Dogs were euthanized at 6 months for post mortem and histopathological evaluation. Clinically, dogs did not exhibit any signs of cardiovascular disease at 1.5 or 3 months, while at 6 months two dogs (28.6 %) exhibited mild weight loss, exercise intolerance and heart murmurs. Radiographic evaluation revealed significant increase in cardiac size only at 6 months based on measurement of the cardiothoracic area evaluation. Echocardiography revealed increased left ventricular wall thickness starting from 1.5 month, although this increase was statistically significant at 3 and 6 months (p > 0.05). Left ventricular hypertrophy was confirmed by post mortem examination. Histopathological sections of left ventricle in all dogs demonstrated myocyte hypertrophy and interstitial fibrosis. This model simulates the naturally occurring ventricular hypertrophy using a rapid and economic technique. Such models are required to understand pathogenesis of heart disease and to develop effective treatment strategy. |
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Acta Scientiarum Biological Sciences |
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Pressure-induced left ventricular hypertrophy in canine model of aortic stenosis using nylon tiePressure-induced left ventricular hypertrophy in canine model of aortic stenosis using nylon tieheart; aorta; left ventricle; dog; enlargement; modelheart; aorta; left ventricle; dog; enlargement; modelThe aim of this study was to develop an experimentally-induced canine model of left ventricular hypertrophy through banding of the ascending aorta using nylon ties. Seven clinically normal dogs free of cardiovascular disease were used. Nylon tie was used in banding the mid-ascending aorta. Clinical, radiographic and echocardiographic evaluations were done at 1.5, 3 and 6 months. Dogs were euthanized at 6 months for post mortem and histopathological evaluation. Clinically, dogs did not exhibit any signs of cardiovascular disease at 1.5 or 3 months, while at 6 months two dogs (28.6 %) exhibited mild weight loss, exercise intolerance and heart murmurs. Radiographic evaluation revealed significant increase in cardiac size only at 6 months based on measurement of the cardiothoracic area evaluation. Echocardiography revealed increased left ventricular wall thickness starting from 1.5 month, although this increase was statistically significant at 3 and 6 months (p > 0.05). Left ventricular hypertrophy was confirmed by post mortem examination. Histopathological sections of left ventricle in all dogs demonstrated myocyte hypertrophy and interstitial fibrosis. This model simulates the naturally occurring ventricular hypertrophy using a rapid and economic technique. Such models are required to understand pathogenesis of heart disease and to develop effective treatment strategy.Universidade Estadual De Maringá2020-07-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/4888710.4025/actascibiolsci.v42i1.48887Acta Scientiarum. Biological Sciences; Vol 42 (2020): Publicação contínua; e48887Acta Scientiarum. Biological Sciences; v. 42 (2020): Publicação contínua; e488871807-863X1679-9283reponame:Acta Scientiarum Biological Sciencesinstname:Universidade Estadual de Maringá (UEM)instacron:UEMenghttp://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/48887/751375150229Copyright (c) 2020 Acta Scientiarum. Biological Scienceshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessShamaa, AshrafHanafy, Doaa Elgohary Khalifa, Tamer Farouk Salem, Mona Mahmoud Shehab, Gehan Gamil Aly, Nermin Mohamed Hassan, Elham2020-11-16T16:25:43Zoai:periodicos.uem.br/ojs:article/48887Revistahttp://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSciPUBhttp://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/oai||actabiol@uem.br1807-863X1679-9283opendoar:2020-11-16T16:25:43Acta Scientiarum Biological Sciences - Universidade Estadual de Maringá (UEM)false |
dc.title.none.fl_str_mv |
Pressure-induced left ventricular hypertrophy in canine model of aortic stenosis using nylon tie Pressure-induced left ventricular hypertrophy in canine model of aortic stenosis using nylon tie |
title |
Pressure-induced left ventricular hypertrophy in canine model of aortic stenosis using nylon tie |
spellingShingle |
Pressure-induced left ventricular hypertrophy in canine model of aortic stenosis using nylon tie Shamaa, Ashraf heart; aorta; left ventricle; dog; enlargement; model heart; aorta; left ventricle; dog; enlargement; model |
title_short |
Pressure-induced left ventricular hypertrophy in canine model of aortic stenosis using nylon tie |
title_full |
Pressure-induced left ventricular hypertrophy in canine model of aortic stenosis using nylon tie |
title_fullStr |
Pressure-induced left ventricular hypertrophy in canine model of aortic stenosis using nylon tie |
title_full_unstemmed |
Pressure-induced left ventricular hypertrophy in canine model of aortic stenosis using nylon tie |
title_sort |
Pressure-induced left ventricular hypertrophy in canine model of aortic stenosis using nylon tie |
author |
Shamaa, Ashraf |
author_facet |
Shamaa, Ashraf Hanafy, Doaa Elgohary Khalifa, Tamer Farouk Salem, Mona Mahmoud Shehab, Gehan Gamil Aly, Nermin Mohamed Hassan, Elham |
author_role |
author |
author2 |
Hanafy, Doaa Elgohary Khalifa, Tamer Farouk Salem, Mona Mahmoud Shehab, Gehan Gamil Aly, Nermin Mohamed Hassan, Elham |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Shamaa, Ashraf Hanafy, Doaa Elgohary Khalifa, Tamer Farouk Salem, Mona Mahmoud Shehab, Gehan Gamil Aly, Nermin Mohamed Hassan, Elham |
dc.subject.por.fl_str_mv |
heart; aorta; left ventricle; dog; enlargement; model heart; aorta; left ventricle; dog; enlargement; model |
topic |
heart; aorta; left ventricle; dog; enlargement; model heart; aorta; left ventricle; dog; enlargement; model |
description |
The aim of this study was to develop an experimentally-induced canine model of left ventricular hypertrophy through banding of the ascending aorta using nylon ties. Seven clinically normal dogs free of cardiovascular disease were used. Nylon tie was used in banding the mid-ascending aorta. Clinical, radiographic and echocardiographic evaluations were done at 1.5, 3 and 6 months. Dogs were euthanized at 6 months for post mortem and histopathological evaluation. Clinically, dogs did not exhibit any signs of cardiovascular disease at 1.5 or 3 months, while at 6 months two dogs (28.6 %) exhibited mild weight loss, exercise intolerance and heart murmurs. Radiographic evaluation revealed significant increase in cardiac size only at 6 months based on measurement of the cardiothoracic area evaluation. Echocardiography revealed increased left ventricular wall thickness starting from 1.5 month, although this increase was statistically significant at 3 and 6 months (p > 0.05). Left ventricular hypertrophy was confirmed by post mortem examination. Histopathological sections of left ventricle in all dogs demonstrated myocyte hypertrophy and interstitial fibrosis. This model simulates the naturally occurring ventricular hypertrophy using a rapid and economic technique. Such models are required to understand pathogenesis of heart disease and to develop effective treatment strategy. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-07-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/48887 10.4025/actascibiolsci.v42i1.48887 |
url |
http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/48887 |
identifier_str_mv |
10.4025/actascibiolsci.v42i1.48887 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/48887/751375150229 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2020 Acta Scientiarum. Biological Sciences https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2020 Acta Scientiarum. Biological Sciences https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Estadual De Maringá |
publisher.none.fl_str_mv |
Universidade Estadual De Maringá |
dc.source.none.fl_str_mv |
Acta Scientiarum. Biological Sciences; Vol 42 (2020): Publicação contínua; e48887 Acta Scientiarum. Biological Sciences; v. 42 (2020): Publicação contínua; e48887 1807-863X 1679-9283 reponame:Acta Scientiarum Biological Sciences instname:Universidade Estadual de Maringá (UEM) instacron:UEM |
instname_str |
Universidade Estadual de Maringá (UEM) |
instacron_str |
UEM |
institution |
UEM |
reponame_str |
Acta Scientiarum Biological Sciences |
collection |
Acta Scientiarum Biological Sciences |
repository.name.fl_str_mv |
Acta Scientiarum Biological Sciences - Universidade Estadual de Maringá (UEM) |
repository.mail.fl_str_mv |
||actabiol@uem.br |
_version_ |
1799317397504524288 |