Evaluation of the effects of autohemotransfusion in arthritic rats induced by two doses of complete Freund´s adjuvant
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Acta Scientiarum Biological Sciences |
Texto Completo: | http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/36978 |
Resumo: | The aim the study was to evaluate the effects of autohemotransfusion in adjuvant-induced arthritis model by injections of high and low doses of Complete Freund´s Adjuvant (CFA). Male Holtzman rats (200-230g) were distributed in six groups: control (C); control treated by autohemotransfusion (CT); CFA induced arthritis 0.5% w/v (AIA); CFA induced arthritis 0.5% w/v treated with autohemotransfusion (AIAT); CFA induced arthritis 0.1% w/v (AS) and CFA induced arthritis 0.1% w/v treated with autohemotransfusion (AST). The number of leukocytes, the weight of different organs and the paw volume were analyzed. The autohemotransfusion without erythrocytes promoted a reduction in the number of leukocytes in AIAT and AST when compared to AIA (p < 0.001). In the AST group an increase of the thymus weight (p < 0.05) was observed when compared to C, AIA and AIAT. The autohemotransfusion did not prevent the occurrence of paw edema in arthritic animals of AIAT and AST groups (p>0.05). The autohemotransfusion used in this work presented positive effects on AIA as they promoted a reduction in the number of leukocytes and an increase in thymus weight and body growth. However, other types of autohemotransfusion must be tested to determine the true efficacy of this alternative method of treatment. |
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Acta Scientiarum Biological Sciences |
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Evaluation of the effects of autohemotransfusion in arthritic rats induced by two doses of complete Freund´s adjuvantAdjuvant Immunologicratsinduced rheumatoid arthritis. The aim the study was to evaluate the effects of autohemotransfusion in adjuvant-induced arthritis model by injections of high and low doses of Complete Freund´s Adjuvant (CFA). Male Holtzman rats (200-230g) were distributed in six groups: control (C); control treated by autohemotransfusion (CT); CFA induced arthritis 0.5% w/v (AIA); CFA induced arthritis 0.5% w/v treated with autohemotransfusion (AIAT); CFA induced arthritis 0.1% w/v (AS) and CFA induced arthritis 0.1% w/v treated with autohemotransfusion (AST). The number of leukocytes, the weight of different organs and the paw volume were analyzed. The autohemotransfusion without erythrocytes promoted a reduction in the number of leukocytes in AIAT and AST when compared to AIA (p < 0.001). In the AST group an increase of the thymus weight (p < 0.05) was observed when compared to C, AIA and AIAT. The autohemotransfusion did not prevent the occurrence of paw edema in arthritic animals of AIAT and AST groups (p>0.05). The autohemotransfusion used in this work presented positive effects on AIA as they promoted a reduction in the number of leukocytes and an increase in thymus weight and body growth. However, other types of autohemotransfusion must be tested to determine the true efficacy of this alternative method of treatment.Universidade Estadual De Maringá2019-04-16info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/3697810.4025/actascibiolsci.v41i1.36978Acta Scientiarum. Biological Sciences; Vol 41 (2019): Publicação contínua; e36978Acta Scientiarum. Biological Sciences; v. 41 (2019): Publicação contínua; e369781807-863X1679-9283reponame:Acta Scientiarum Biological Sciencesinstname:Universidade Estadual de Maringá (UEM)instacron:UEMenghttp://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/36978/pdfCopyright (c) 2019 Acta Scientiarum. Biological Scienceshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessLima, Mariana MachadoSilva, Lorena Gimenes daDantas, Jailson AraújoAmado, Ciomar Aparecida BersaniSpack Junior, MiguelZanoni, Jacqueline Nelisis2022-02-20T21:59:41Zoai:periodicos.uem.br/ojs:article/36978Revistahttp://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSciPUBhttp://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/oai||actabiol@uem.br1807-863X1679-9283opendoar:2022-02-20T21:59:41Acta Scientiarum Biological Sciences - Universidade Estadual de Maringá (UEM)false |
dc.title.none.fl_str_mv |
Evaluation of the effects of autohemotransfusion in arthritic rats induced by two doses of complete Freund´s adjuvant |
title |
Evaluation of the effects of autohemotransfusion in arthritic rats induced by two doses of complete Freund´s adjuvant |
spellingShingle |
Evaluation of the effects of autohemotransfusion in arthritic rats induced by two doses of complete Freund´s adjuvant Lima, Mariana Machado Adjuvant Immunologic rats induced rheumatoid arthritis. |
title_short |
Evaluation of the effects of autohemotransfusion in arthritic rats induced by two doses of complete Freund´s adjuvant |
title_full |
Evaluation of the effects of autohemotransfusion in arthritic rats induced by two doses of complete Freund´s adjuvant |
title_fullStr |
Evaluation of the effects of autohemotransfusion in arthritic rats induced by two doses of complete Freund´s adjuvant |
title_full_unstemmed |
Evaluation of the effects of autohemotransfusion in arthritic rats induced by two doses of complete Freund´s adjuvant |
title_sort |
Evaluation of the effects of autohemotransfusion in arthritic rats induced by two doses of complete Freund´s adjuvant |
author |
Lima, Mariana Machado |
author_facet |
Lima, Mariana Machado Silva, Lorena Gimenes da Dantas, Jailson Araújo Amado, Ciomar Aparecida Bersani Spack Junior, Miguel Zanoni, Jacqueline Nelisis |
author_role |
author |
author2 |
Silva, Lorena Gimenes da Dantas, Jailson Araújo Amado, Ciomar Aparecida Bersani Spack Junior, Miguel Zanoni, Jacqueline Nelisis |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Lima, Mariana Machado Silva, Lorena Gimenes da Dantas, Jailson Araújo Amado, Ciomar Aparecida Bersani Spack Junior, Miguel Zanoni, Jacqueline Nelisis |
dc.subject.por.fl_str_mv |
Adjuvant Immunologic rats induced rheumatoid arthritis. |
topic |
Adjuvant Immunologic rats induced rheumatoid arthritis. |
description |
The aim the study was to evaluate the effects of autohemotransfusion in adjuvant-induced arthritis model by injections of high and low doses of Complete Freund´s Adjuvant (CFA). Male Holtzman rats (200-230g) were distributed in six groups: control (C); control treated by autohemotransfusion (CT); CFA induced arthritis 0.5% w/v (AIA); CFA induced arthritis 0.5% w/v treated with autohemotransfusion (AIAT); CFA induced arthritis 0.1% w/v (AS) and CFA induced arthritis 0.1% w/v treated with autohemotransfusion (AST). The number of leukocytes, the weight of different organs and the paw volume were analyzed. The autohemotransfusion without erythrocytes promoted a reduction in the number of leukocytes in AIAT and AST when compared to AIA (p < 0.001). In the AST group an increase of the thymus weight (p < 0.05) was observed when compared to C, AIA and AIAT. The autohemotransfusion did not prevent the occurrence of paw edema in arthritic animals of AIAT and AST groups (p>0.05). The autohemotransfusion used in this work presented positive effects on AIA as they promoted a reduction in the number of leukocytes and an increase in thymus weight and body growth. However, other types of autohemotransfusion must be tested to determine the true efficacy of this alternative method of treatment. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-04-16 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/36978 10.4025/actascibiolsci.v41i1.36978 |
url |
http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/36978 |
identifier_str_mv |
10.4025/actascibiolsci.v41i1.36978 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/36978/pdf |
dc.rights.driver.fl_str_mv |
Copyright (c) 2019 Acta Scientiarum. Biological Sciences https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2019 Acta Scientiarum. Biological Sciences https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Estadual De Maringá |
publisher.none.fl_str_mv |
Universidade Estadual De Maringá |
dc.source.none.fl_str_mv |
Acta Scientiarum. Biological Sciences; Vol 41 (2019): Publicação contínua; e36978 Acta Scientiarum. Biological Sciences; v. 41 (2019): Publicação contínua; e36978 1807-863X 1679-9283 reponame:Acta Scientiarum Biological Sciences instname:Universidade Estadual de Maringá (UEM) instacron:UEM |
instname_str |
Universidade Estadual de Maringá (UEM) |
instacron_str |
UEM |
institution |
UEM |
reponame_str |
Acta Scientiarum Biological Sciences |
collection |
Acta Scientiarum Biological Sciences |
repository.name.fl_str_mv |
Acta Scientiarum Biological Sciences - Universidade Estadual de Maringá (UEM) |
repository.mail.fl_str_mv |
||actabiol@uem.br |
_version_ |
1799317396972896256 |