Evaluation of the effects of autohemotransfusion in arthritic rats induced by two doses of complete Freund´s adjuvant

Detalhes bibliográficos
Autor(a) principal: Lima, Mariana Machado
Data de Publicação: 2019
Outros Autores: Silva, Lorena Gimenes da, Dantas, Jailson Araújo, Amado, Ciomar Aparecida Bersani, Spack Junior, Miguel, Zanoni, Jacqueline Nelisis
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Scientiarum Biological Sciences
Texto Completo: http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/36978
Resumo:  The aim the study was to evaluate the effects of autohemotransfusion in adjuvant-induced arthritis model by injections of high and low doses of Complete Freund´s Adjuvant (CFA). Male Holtzman rats (200-230g) were distributed in six groups: control (C); control treated by autohemotransfusion (CT); CFA induced arthritis 0.5% w/v (AIA); CFA induced arthritis 0.5% w/v treated with autohemotransfusion (AIAT); CFA induced arthritis 0.1% w/v (AS) and CFA induced arthritis 0.1% w/v treated with autohemotransfusion (AST). The number of leukocytes, the weight of different organs and the paw volume were analyzed. The autohemotransfusion without erythrocytes promoted a reduction in the number of leukocytes in AIAT and AST when compared to AIA (p < 0.001). In the AST group an increase of the thymus weight (p < 0.05) was observed when compared to C, AIA and AIAT. The autohemotransfusion did not prevent the occurrence of paw edema in arthritic animals of AIAT and AST groups (p>0.05). The autohemotransfusion used in this work presented positive effects on AIA as they promoted a reduction in the number of leukocytes and an increase in thymus weight and body growth. However, other types of autohemotransfusion must be tested to determine the true efficacy of this alternative method of treatment.
id UEM-1_850a1bef02bb2da9c55f2ce6badb77af
oai_identifier_str oai:periodicos.uem.br/ojs:article/36978
network_acronym_str UEM-1
network_name_str Acta Scientiarum Biological Sciences
repository_id_str
spelling Evaluation of the effects of autohemotransfusion in arthritic rats induced by two doses of complete Freund´s adjuvantAdjuvant Immunologicratsinduced rheumatoid arthritis. The aim the study was to evaluate the effects of autohemotransfusion in adjuvant-induced arthritis model by injections of high and low doses of Complete Freund´s Adjuvant (CFA). Male Holtzman rats (200-230g) were distributed in six groups: control (C); control treated by autohemotransfusion (CT); CFA induced arthritis 0.5% w/v (AIA); CFA induced arthritis 0.5% w/v treated with autohemotransfusion (AIAT); CFA induced arthritis 0.1% w/v (AS) and CFA induced arthritis 0.1% w/v treated with autohemotransfusion (AST). The number of leukocytes, the weight of different organs and the paw volume were analyzed. The autohemotransfusion without erythrocytes promoted a reduction in the number of leukocytes in AIAT and AST when compared to AIA (p < 0.001). In the AST group an increase of the thymus weight (p < 0.05) was observed when compared to C, AIA and AIAT. The autohemotransfusion did not prevent the occurrence of paw edema in arthritic animals of AIAT and AST groups (p>0.05). The autohemotransfusion used in this work presented positive effects on AIA as they promoted a reduction in the number of leukocytes and an increase in thymus weight and body growth. However, other types of autohemotransfusion must be tested to determine the true efficacy of this alternative method of treatment.Universidade Estadual De Maringá2019-04-16info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/3697810.4025/actascibiolsci.v41i1.36978Acta Scientiarum. Biological Sciences; Vol 41 (2019): Publicação contínua; e36978Acta Scientiarum. Biological Sciences; v. 41 (2019): Publicação contínua; e369781807-863X1679-9283reponame:Acta Scientiarum Biological Sciencesinstname:Universidade Estadual de Maringá (UEM)instacron:UEMenghttp://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/36978/pdfCopyright (c) 2019 Acta Scientiarum. Biological Scienceshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessLima, Mariana MachadoSilva, Lorena Gimenes daDantas, Jailson AraújoAmado, Ciomar Aparecida BersaniSpack Junior, MiguelZanoni, Jacqueline Nelisis2022-02-20T21:59:41Zoai:periodicos.uem.br/ojs:article/36978Revistahttp://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSciPUBhttp://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/oai||actabiol@uem.br1807-863X1679-9283opendoar:2022-02-20T21:59:41Acta Scientiarum Biological Sciences - Universidade Estadual de Maringá (UEM)false
dc.title.none.fl_str_mv Evaluation of the effects of autohemotransfusion in arthritic rats induced by two doses of complete Freund´s adjuvant
title Evaluation of the effects of autohemotransfusion in arthritic rats induced by two doses of complete Freund´s adjuvant
spellingShingle Evaluation of the effects of autohemotransfusion in arthritic rats induced by two doses of complete Freund´s adjuvant
Lima, Mariana Machado
Adjuvant Immunologic
rats
induced rheumatoid arthritis.
title_short Evaluation of the effects of autohemotransfusion in arthritic rats induced by two doses of complete Freund´s adjuvant
title_full Evaluation of the effects of autohemotransfusion in arthritic rats induced by two doses of complete Freund´s adjuvant
title_fullStr Evaluation of the effects of autohemotransfusion in arthritic rats induced by two doses of complete Freund´s adjuvant
title_full_unstemmed Evaluation of the effects of autohemotransfusion in arthritic rats induced by two doses of complete Freund´s adjuvant
title_sort Evaluation of the effects of autohemotransfusion in arthritic rats induced by two doses of complete Freund´s adjuvant
author Lima, Mariana Machado
author_facet Lima, Mariana Machado
Silva, Lorena Gimenes da
Dantas, Jailson Araújo
Amado, Ciomar Aparecida Bersani
Spack Junior, Miguel
Zanoni, Jacqueline Nelisis
author_role author
author2 Silva, Lorena Gimenes da
Dantas, Jailson Araújo
Amado, Ciomar Aparecida Bersani
Spack Junior, Miguel
Zanoni, Jacqueline Nelisis
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Lima, Mariana Machado
Silva, Lorena Gimenes da
Dantas, Jailson Araújo
Amado, Ciomar Aparecida Bersani
Spack Junior, Miguel
Zanoni, Jacqueline Nelisis
dc.subject.por.fl_str_mv Adjuvant Immunologic
rats
induced rheumatoid arthritis.
topic Adjuvant Immunologic
rats
induced rheumatoid arthritis.
description  The aim the study was to evaluate the effects of autohemotransfusion in adjuvant-induced arthritis model by injections of high and low doses of Complete Freund´s Adjuvant (CFA). Male Holtzman rats (200-230g) were distributed in six groups: control (C); control treated by autohemotransfusion (CT); CFA induced arthritis 0.5% w/v (AIA); CFA induced arthritis 0.5% w/v treated with autohemotransfusion (AIAT); CFA induced arthritis 0.1% w/v (AS) and CFA induced arthritis 0.1% w/v treated with autohemotransfusion (AST). The number of leukocytes, the weight of different organs and the paw volume were analyzed. The autohemotransfusion without erythrocytes promoted a reduction in the number of leukocytes in AIAT and AST when compared to AIA (p < 0.001). In the AST group an increase of the thymus weight (p < 0.05) was observed when compared to C, AIA and AIAT. The autohemotransfusion did not prevent the occurrence of paw edema in arthritic animals of AIAT and AST groups (p>0.05). The autohemotransfusion used in this work presented positive effects on AIA as they promoted a reduction in the number of leukocytes and an increase in thymus weight and body growth. However, other types of autohemotransfusion must be tested to determine the true efficacy of this alternative method of treatment.
publishDate 2019
dc.date.none.fl_str_mv 2019-04-16
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/36978
10.4025/actascibiolsci.v41i1.36978
url http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/36978
identifier_str_mv 10.4025/actascibiolsci.v41i1.36978
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/36978/pdf
dc.rights.driver.fl_str_mv Copyright (c) 2019 Acta Scientiarum. Biological Sciences
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2019 Acta Scientiarum. Biological Sciences
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Estadual De Maringá
publisher.none.fl_str_mv Universidade Estadual De Maringá
dc.source.none.fl_str_mv Acta Scientiarum. Biological Sciences; Vol 41 (2019): Publicação contínua; e36978
Acta Scientiarum. Biological Sciences; v. 41 (2019): Publicação contínua; e36978
1807-863X
1679-9283
reponame:Acta Scientiarum Biological Sciences
instname:Universidade Estadual de Maringá (UEM)
instacron:UEM
instname_str Universidade Estadual de Maringá (UEM)
instacron_str UEM
institution UEM
reponame_str Acta Scientiarum Biological Sciences
collection Acta Scientiarum Biological Sciences
repository.name.fl_str_mv Acta Scientiarum Biological Sciences - Universidade Estadual de Maringá (UEM)
repository.mail.fl_str_mv ||actabiol@uem.br
_version_ 1799317396972896256