Effect of strength training versus raloxifene on bone weight, blood glucose, lipid and antioxidant profile in ovariectomized rats
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Acta Scientiarum Biological Sciences |
Texto Completo: | https://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/59835 |
Resumo: | We compared the effect of the treatment with strength training (ST) and raloxifene (RALOX) on bone weight, blood glucose, lipid, and antioxidant profile in ovariectomized rats. Twenty-four Wistar rats were distributed into four groups: ovariectomy + VEHICLE (control); ovariectomy + RALOX; ovariectomy + ST; ovariectomy + RALOX + ST. Thirty days after ovariectomy, the animals underwent the treatment with RALOX (750 μcg day-1) and/or ST (three sessions week-1). Thirty days after, all groups were scarified, tibia and femur were weighed, and the blood was collected for analysis of the lipid profile, glucose, and antioxidants catalase (CAT) and glutathione (GSH). The ST group showed greater femur weight (0.82 ± 0.18 g) and RALOX + ST had greater tibia weight (0.61 ± 0.17 g) than CONTROL with femur weight of 0.65 ± 0.08 g and tibia of 0.49 ± 0.08 g with no differences between treatments (p > 0.05). ST group showed significantly higher catalase (181.7 ± 15.4 μM g-1) compared to the other groups. In contrast, the GSH value was lower in ST group (89.2 ± 8.1 μM g-1) compared to RALOX (175.9 ± 17.1 μM g-1) and RALOX + ST (162.8 ± 12.1 μM g-1), but the values of these two groups did not differ from CONTROL (115.3 ± 21.1 μM g-1). Total cholesterol did not differ between groups (p > 0.05), but exercise alone (54.3 ± 2.5 mg dL-1) or with RALOX (53.0 ± 1.5 mg dL-1) resulted in higher HDL cholesterol than CONTROL (45.5 ± 2.5 mg dL-1). Only RALOX+ST presented lower glucose (140.3 ± 9.7 mg dL-1) values than CONTROL (201.7 ± 30.6 mg dL-1). In conclusion, ST promotes similar benefits on bone and metabolic parameters compared to pharmacological treatment in ovariectomized rats. |
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Effect of strength training versus raloxifene on bone weight, blood glucose, lipid and antioxidant profile in ovariectomized ratsEffect of strength training versus raloxifene on bone weight, blood glucose, lipid and antioxidant profile in ovariectomized ratshormonal reposition; ovariectomy; strength training.hormonal reposition; ovariectomy; strength training.We compared the effect of the treatment with strength training (ST) and raloxifene (RALOX) on bone weight, blood glucose, lipid, and antioxidant profile in ovariectomized rats. Twenty-four Wistar rats were distributed into four groups: ovariectomy + VEHICLE (control); ovariectomy + RALOX; ovariectomy + ST; ovariectomy + RALOX + ST. Thirty days after ovariectomy, the animals underwent the treatment with RALOX (750 μcg day-1) and/or ST (three sessions week-1). Thirty days after, all groups were scarified, tibia and femur were weighed, and the blood was collected for analysis of the lipid profile, glucose, and antioxidants catalase (CAT) and glutathione (GSH). The ST group showed greater femur weight (0.82 ± 0.18 g) and RALOX + ST had greater tibia weight (0.61 ± 0.17 g) than CONTROL with femur weight of 0.65 ± 0.08 g and tibia of 0.49 ± 0.08 g with no differences between treatments (p > 0.05). ST group showed significantly higher catalase (181.7 ± 15.4 μM g-1) compared to the other groups. In contrast, the GSH value was lower in ST group (89.2 ± 8.1 μM g-1) compared to RALOX (175.9 ± 17.1 μM g-1) and RALOX + ST (162.8 ± 12.1 μM g-1), but the values of these two groups did not differ from CONTROL (115.3 ± 21.1 μM g-1). Total cholesterol did not differ between groups (p > 0.05), but exercise alone (54.3 ± 2.5 mg dL-1) or with RALOX (53.0 ± 1.5 mg dL-1) resulted in higher HDL cholesterol than CONTROL (45.5 ± 2.5 mg dL-1). Only RALOX+ST presented lower glucose (140.3 ± 9.7 mg dL-1) values than CONTROL (201.7 ± 30.6 mg dL-1). In conclusion, ST promotes similar benefits on bone and metabolic parameters compared to pharmacological treatment in ovariectomized rats.We compared the effect of the treatment with strength training (ST) and raloxifene (RALOX) on bone weight, blood glucose, lipid, and antioxidant profile in ovariectomized rats. Twenty-four Wistar rats were distributed into four groups: ovariectomy + VEHICLE (control); ovariectomy + RALOX; ovariectomy + ST; ovariectomy + RALOX + ST. Thirty days after ovariectomy, the animals underwent the treatment with RALOX (750 μcg day-1) and/or ST (three sessions week-1). Thirty days after, all groups were scarified, tibia and femur were weighed, and the blood was collected for analysis of the lipid profile, glucose, and antioxidants catalase (CAT) and glutathione (GSH). The ST group showed greater femur weight (0.82 ± 0.18 g) and RALOX + ST had greater tibia weight (0.61 ± 0.17 g) than CONTROL with femur weight of 0.65 ± 0.08 g and tibia of 0.49 ± 0.08 g with no differences between treatments (p > 0.05). ST group showed significantly higher catalase (181.7 ± 15.4 μM g-1) compared to the other groups. In contrast, the GSH value was lower in ST group (89.2 ± 8.1 μM g-1) compared to RALOX (175.9 ± 17.1 μM g-1) and RALOX + ST (162.8 ± 12.1 μM g-1), but the values of these two groups did not differ from CONTROL (115.3 ± 21.1 μM g-1). Total cholesterol did not differ between groups (p > 0.05), but exercise alone (54.3 ± 2.5 mg dL-1) or with RALOX (53.0 ± 1.5 mg dL-1) resulted in higher HDL cholesterol than CONTROL (45.5 ± 2.5 mg dL-1). Only RALOX+ST presented lower glucose (140.3 ± 9.7 mg dL-1) values than CONTROL (201.7 ± 30.6 mg dL-1). In conclusion, ST promotes similar benefits on bone and metabolic parameters compared to pharmacological treatment in ovariectomized rats.Universidade Estadual De Maringá2023-03-22info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/5983510.4025/actascibiolsci.v45i1.59835Acta Scientiarum. Biological Sciences; Vol 45 (2023): Publicação contínua; e59835Acta Scientiarum. Biological Sciences; v. 45 (2023): Publicação contínua; e598351807-863X1679-9283reponame:Acta Scientiarum Biological Sciencesinstname:Universidade Estadual de Maringá (UEM)instacron:UEMenghttps://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/59835/751375155620Copyright (c) 2023 Acta Scientiarum. Biological Scienceshttp://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSantos, Marcos Antônio Pereira dos Martins, Maria do Carmo de Carvalho e Silva, Raquel Suelen Brito da Lopes, Carolina Farias de Arruda Silva, Alexandre Sérgio 2023-05-25T13:47:19Zoai:periodicos.uem.br/ojs:article/59835Revistahttps://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/PUBhttps://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/oai||actabiol@uem.br1807-863X1679-9283opendoar:2023-05-25T13:47:19Acta Scientiarum Biological Sciences - Universidade Estadual de Maringá (UEM)false |
dc.title.none.fl_str_mv |
Effect of strength training versus raloxifene on bone weight, blood glucose, lipid and antioxidant profile in ovariectomized rats Effect of strength training versus raloxifene on bone weight, blood glucose, lipid and antioxidant profile in ovariectomized rats |
title |
Effect of strength training versus raloxifene on bone weight, blood glucose, lipid and antioxidant profile in ovariectomized rats |
spellingShingle |
Effect of strength training versus raloxifene on bone weight, blood glucose, lipid and antioxidant profile in ovariectomized rats Santos, Marcos Antônio Pereira dos hormonal reposition; ovariectomy; strength training. hormonal reposition; ovariectomy; strength training. |
title_short |
Effect of strength training versus raloxifene on bone weight, blood glucose, lipid and antioxidant profile in ovariectomized rats |
title_full |
Effect of strength training versus raloxifene on bone weight, blood glucose, lipid and antioxidant profile in ovariectomized rats |
title_fullStr |
Effect of strength training versus raloxifene on bone weight, blood glucose, lipid and antioxidant profile in ovariectomized rats |
title_full_unstemmed |
Effect of strength training versus raloxifene on bone weight, blood glucose, lipid and antioxidant profile in ovariectomized rats |
title_sort |
Effect of strength training versus raloxifene on bone weight, blood glucose, lipid and antioxidant profile in ovariectomized rats |
author |
Santos, Marcos Antônio Pereira dos |
author_facet |
Santos, Marcos Antônio Pereira dos Martins, Maria do Carmo de Carvalho e Silva, Raquel Suelen Brito da Lopes, Carolina Farias de Arruda Silva, Alexandre Sérgio |
author_role |
author |
author2 |
Martins, Maria do Carmo de Carvalho e Silva, Raquel Suelen Brito da Lopes, Carolina Farias de Arruda Silva, Alexandre Sérgio |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Santos, Marcos Antônio Pereira dos Martins, Maria do Carmo de Carvalho e Silva, Raquel Suelen Brito da Lopes, Carolina Farias de Arruda Silva, Alexandre Sérgio |
dc.subject.por.fl_str_mv |
hormonal reposition; ovariectomy; strength training. hormonal reposition; ovariectomy; strength training. |
topic |
hormonal reposition; ovariectomy; strength training. hormonal reposition; ovariectomy; strength training. |
description |
We compared the effect of the treatment with strength training (ST) and raloxifene (RALOX) on bone weight, blood glucose, lipid, and antioxidant profile in ovariectomized rats. Twenty-four Wistar rats were distributed into four groups: ovariectomy + VEHICLE (control); ovariectomy + RALOX; ovariectomy + ST; ovariectomy + RALOX + ST. Thirty days after ovariectomy, the animals underwent the treatment with RALOX (750 μcg day-1) and/or ST (three sessions week-1). Thirty days after, all groups were scarified, tibia and femur were weighed, and the blood was collected for analysis of the lipid profile, glucose, and antioxidants catalase (CAT) and glutathione (GSH). The ST group showed greater femur weight (0.82 ± 0.18 g) and RALOX + ST had greater tibia weight (0.61 ± 0.17 g) than CONTROL with femur weight of 0.65 ± 0.08 g and tibia of 0.49 ± 0.08 g with no differences between treatments (p > 0.05). ST group showed significantly higher catalase (181.7 ± 15.4 μM g-1) compared to the other groups. In contrast, the GSH value was lower in ST group (89.2 ± 8.1 μM g-1) compared to RALOX (175.9 ± 17.1 μM g-1) and RALOX + ST (162.8 ± 12.1 μM g-1), but the values of these two groups did not differ from CONTROL (115.3 ± 21.1 μM g-1). Total cholesterol did not differ between groups (p > 0.05), but exercise alone (54.3 ± 2.5 mg dL-1) or with RALOX (53.0 ± 1.5 mg dL-1) resulted in higher HDL cholesterol than CONTROL (45.5 ± 2.5 mg dL-1). Only RALOX+ST presented lower glucose (140.3 ± 9.7 mg dL-1) values than CONTROL (201.7 ± 30.6 mg dL-1). In conclusion, ST promotes similar benefits on bone and metabolic parameters compared to pharmacological treatment in ovariectomized rats. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-03-22 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/59835 10.4025/actascibiolsci.v45i1.59835 |
url |
https://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/59835 |
identifier_str_mv |
10.4025/actascibiolsci.v45i1.59835 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/59835/751375155620 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2023 Acta Scientiarum. Biological Sciences http://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2023 Acta Scientiarum. Biological Sciences http://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Estadual De Maringá |
publisher.none.fl_str_mv |
Universidade Estadual De Maringá |
dc.source.none.fl_str_mv |
Acta Scientiarum. Biological Sciences; Vol 45 (2023): Publicação contínua; e59835 Acta Scientiarum. Biological Sciences; v. 45 (2023): Publicação contínua; e59835 1807-863X 1679-9283 reponame:Acta Scientiarum Biological Sciences instname:Universidade Estadual de Maringá (UEM) instacron:UEM |
instname_str |
Universidade Estadual de Maringá (UEM) |
instacron_str |
UEM |
institution |
UEM |
reponame_str |
Acta Scientiarum Biological Sciences |
collection |
Acta Scientiarum Biological Sciences |
repository.name.fl_str_mv |
Acta Scientiarum Biological Sciences - Universidade Estadual de Maringá (UEM) |
repository.mail.fl_str_mv |
||actabiol@uem.br |
_version_ |
1799317390361624576 |