Quantile regression for genomic selection of growth curves

• Autor(a) principal: Nascimento, Ana Carolina Campana
• Data de Publicação: 2023
• Outros Autores: Azevedo, Camila Ferreira, Barreto, Cynthia Aparecida Valiati, Oliveira, Gabriela França, Nascimento, Moysés
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Acta Scientiarum. Agronomy (Online)
• Texto Completo: http://www.periodicos.uem.br/ojs/index.php/ActaSciAgron/article/view/65081
• topic: conditional quantiles; genomic prediction; GWS; genetic breeding.; conditional quantiles; genomic prediction; GWS; genetic breeding.

This study evaluated the efficiency of genome-wide selection (GWS) based on regularized quantile regression (RQR) to obtain genomic growth curves based on genomic estimated breeding values (GEBV) of individuals with different probability distributions. The data were simulated and composed of 2,025 individuals from two generations and 435 markers randomly distributed across five chromosomes. The simulated phenotypes presented symmetrical, skewed, positive, and negative distributions. Data were analyzed using RQR considering nine quantiles (0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, and 0.9) and traditional methods of genomic selection (specifically, RR-BLUP, BLASSO, BayesA, and BayesB). In general, RQR-based estimation of the GEBV was efficient—at least for a quantile model, the results obtained were more accurate than those obtained by the other evaluated methodologies. Specifically, in the symmetrical-distribution scenario, the highest accuracy values were obtained for the parameters with the models RQR0.4, RQR0.3, and RQR0.4. For positive skewness, the models RQR0.2, RQR0.3, and RQR0.1 presented higher accuracy values, whereas for negative skewness, the best model was RQR0.9. Finally, the GEBV vectors obtained by RQR facilitated the construction of genomic growth curves at different levels of interest (quantiles), illustrating the weight–age relationship.