Characterization and qualification of diclofenac sodium as a secondary standard - doi: 10.4025/actascitechnol.v34i1.11654

Detalhes bibliográficos
Autor(a) principal: Stoef, Paulo Roberto
Data de Publicação: 2011
Outros Autores: Guzzi, Silvane, Carletto, Marla Suzane, Lobo, Viviane da Silva, Rosa, Mauricio Ferreira da
Tipo de documento: Artigo
Idioma: por
Título da fonte: Acta scientiarum. Technology (Online)
Texto Completo: http://www.periodicos.uem.br/ojs/index.php/ActaSciTechnol/article/view/11654
Resumo: This paper aimed to characterize and qualify a secondary standard of diclofenac sodium as a reference standard in the quality control of medicines. The identity of the candidate was confirmed through infrared spectroscopy and the content (99.63%) determined by high performance liquid chromatography (HPLC) by comparing with the compendial primary standard. The quality of the secondary standard was also supported by redox titration in non-aqueous media, related substances and UV spectrum by HPLC. 
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spelling Characterization and qualification of diclofenac sodium as a secondary standard - doi: 10.4025/actascitechnol.v34i1.11654Caracterização e qualificação de diclofenaco de sódio como padrão secundário - doi: 10.4025/actascitechnol.v34i1.11654infrared spectroscopyreference standardHPLCQuímicaespectroscopia de infravermelhopadrão de referênciaCLAEQuímicaThis paper aimed to characterize and qualify a secondary standard of diclofenac sodium as a reference standard in the quality control of medicines. The identity of the candidate was confirmed through infrared spectroscopy and the content (99.63%) determined by high performance liquid chromatography (HPLC) by comparing with the compendial primary standard. The quality of the secondary standard was also supported by redox titration in non-aqueous media, related substances and UV spectrum by HPLC. O objetivo deste artigo é caracterizar e qualificar um padrão secundário de diclofenaco de sódio como padrão de referência no controle de qualidade de medicamentos. A identidade do candidato foi confirmada por espectroscopia na região do infravermelho e sua pureza (99,63%) determinada por cromatografia líquida de alta eficiência (CLAE) por comparação com padrão primário. A qualidade do padrão secundário também foi suportada por titulação redox em meio não-aquoso, espectroscopia na região do UV-visível. Universidade Estadual De Maringá2011-07-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://www.periodicos.uem.br/ojs/index.php/ActaSciTechnol/article/view/1165410.4025/actascitechnol.v34i1.11654Acta Scientiarum. Technology; Vol 34 No 1 (2012); 89-95Acta Scientiarum. Technology; v. 34 n. 1 (2012); 89-951806-25631807-8664reponame:Acta scientiarum. Technology (Online)instname:Universidade Estadual de Maringá (UEM)instacron:UEMporhttp://www.periodicos.uem.br/ojs/index.php/ActaSciTechnol/article/view/11654/11654aStoef, Paulo RobertoGuzzi, SilvaneCarletto, Marla SuzaneLobo, Viviane da SilvaRosa, Mauricio Ferreira dainfo:eu-repo/semantics/openAccess2024-05-17T13:03:19Zoai:periodicos.uem.br/ojs:article/11654Revistahttps://www.periodicos.uem.br/ojs/index.php/ActaSciTechnol/indexPUBhttps://www.periodicos.uem.br/ojs/index.php/ActaSciTechnol/oai||actatech@uem.br1807-86641806-2563opendoar:2024-05-17T13:03:19Acta scientiarum. Technology (Online) - Universidade Estadual de Maringá (UEM)false
dc.title.none.fl_str_mv Characterization and qualification of diclofenac sodium as a secondary standard - doi: 10.4025/actascitechnol.v34i1.11654
Caracterização e qualificação de diclofenaco de sódio como padrão secundário - doi: 10.4025/actascitechnol.v34i1.11654
title Characterization and qualification of diclofenac sodium as a secondary standard - doi: 10.4025/actascitechnol.v34i1.11654
spellingShingle Characterization and qualification of diclofenac sodium as a secondary standard - doi: 10.4025/actascitechnol.v34i1.11654
Stoef, Paulo Roberto
infrared spectroscopy
reference standard
HPLC
Química
espectroscopia de infravermelho
padrão de referência
CLAE
Química
title_short Characterization and qualification of diclofenac sodium as a secondary standard - doi: 10.4025/actascitechnol.v34i1.11654
title_full Characterization and qualification of diclofenac sodium as a secondary standard - doi: 10.4025/actascitechnol.v34i1.11654
title_fullStr Characterization and qualification of diclofenac sodium as a secondary standard - doi: 10.4025/actascitechnol.v34i1.11654
title_full_unstemmed Characterization and qualification of diclofenac sodium as a secondary standard - doi: 10.4025/actascitechnol.v34i1.11654
title_sort Characterization and qualification of diclofenac sodium as a secondary standard - doi: 10.4025/actascitechnol.v34i1.11654
author Stoef, Paulo Roberto
author_facet Stoef, Paulo Roberto
Guzzi, Silvane
Carletto, Marla Suzane
Lobo, Viviane da Silva
Rosa, Mauricio Ferreira da
author_role author
author2 Guzzi, Silvane
Carletto, Marla Suzane
Lobo, Viviane da Silva
Rosa, Mauricio Ferreira da
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Stoef, Paulo Roberto
Guzzi, Silvane
Carletto, Marla Suzane
Lobo, Viviane da Silva
Rosa, Mauricio Ferreira da
dc.subject.por.fl_str_mv infrared spectroscopy
reference standard
HPLC
Química
espectroscopia de infravermelho
padrão de referência
CLAE
Química
topic infrared spectroscopy
reference standard
HPLC
Química
espectroscopia de infravermelho
padrão de referência
CLAE
Química
description This paper aimed to characterize and qualify a secondary standard of diclofenac sodium as a reference standard in the quality control of medicines. The identity of the candidate was confirmed through infrared spectroscopy and the content (99.63%) determined by high performance liquid chromatography (HPLC) by comparing with the compendial primary standard. The quality of the secondary standard was also supported by redox titration in non-aqueous media, related substances and UV spectrum by HPLC. 
publishDate 2011
dc.date.none.fl_str_mv 2011-07-08
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.periodicos.uem.br/ojs/index.php/ActaSciTechnol/article/view/11654
10.4025/actascitechnol.v34i1.11654
url http://www.periodicos.uem.br/ojs/index.php/ActaSciTechnol/article/view/11654
identifier_str_mv 10.4025/actascitechnol.v34i1.11654
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv http://www.periodicos.uem.br/ojs/index.php/ActaSciTechnol/article/view/11654/11654a
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Estadual De Maringá
publisher.none.fl_str_mv Universidade Estadual De Maringá
dc.source.none.fl_str_mv Acta Scientiarum. Technology; Vol 34 No 1 (2012); 89-95
Acta Scientiarum. Technology; v. 34 n. 1 (2012); 89-95
1806-2563
1807-8664
reponame:Acta scientiarum. Technology (Online)
instname:Universidade Estadual de Maringá (UEM)
instacron:UEM
instname_str Universidade Estadual de Maringá (UEM)
instacron_str UEM
institution UEM
reponame_str Acta scientiarum. Technology (Online)
collection Acta scientiarum. Technology (Online)
repository.name.fl_str_mv Acta scientiarum. Technology (Online) - Universidade Estadual de Maringá (UEM)
repository.mail.fl_str_mv ||actatech@uem.br
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