Cytotoxic effect caused by cyclophosphamide in body mass and skeletal muscle tissue of trained rats - doi: 10.4025/reveducfis.v22i2.9933
Autor(a) principal: | |
---|---|
Data de Publicação: | 2011 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Journal of Physical Education (Maringá) |
Texto Completo: | https://periodicos.uem.br/ojs/index.php/RevEducFis/article/view/9933 |
Resumo: | The study examined the changes in body mass and skeletal muscle after a high dose of CF in trained rats. Twenty four Wistar male rats were divided into four groups. Half of the animals were subjected to swimming training lasting up to 40 minutes in moderate intensity for 21 days, the others were kept sedentary. After this period, half the animals in each group (exercise and sedentary) received a single dose of CF, while the other received saline. After seven days, the animals were sacrificed. There was less body mass for animals in the trained groups (227.7 ± 16.6 / 232.3 ± 19.7) compared with sedentary groups (254.6 ± 29.3 / 253.8 ± 29.8). There was no difference in absolute and relative weight of muscle, but a decrease in those areas and in the severity of injuries caused by CF in trained animals was observed. |
id |
UEM-9_d990792f7d4006c7e230fe667e92244a |
---|---|
oai_identifier_str |
oai:periodicos.uem.br/ojs:article/9933 |
network_acronym_str |
UEM-9 |
network_name_str |
Journal of Physical Education (Maringá) |
repository_id_str |
|
spelling |
Cytotoxic effect caused by cyclophosphamide in body mass and skeletal muscle tissue of trained rats - doi: 10.4025/reveducfis.v22i2.9933Efeito citotóxico provocado por ciclofosfamida na massa corporal e no tecido muscular estriado esquelético de ratos treinados. - doi: 10.4025/reveducfis.v22i2.9933CyclophosphamideExerciseBody mass.Cyclophosphamide. Exercise. Body mass.ciclofosfamidaexercício físicomassa corporal.The study examined the changes in body mass and skeletal muscle after a high dose of CF in trained rats. Twenty four Wistar male rats were divided into four groups. Half of the animals were subjected to swimming training lasting up to 40 minutes in moderate intensity for 21 days, the others were kept sedentary. After this period, half the animals in each group (exercise and sedentary) received a single dose of CF, while the other received saline. After seven days, the animals were sacrificed. There was less body mass for animals in the trained groups (227.7 ± 16.6 / 232.3 ± 19.7) compared with sedentary groups (254.6 ± 29.3 / 253.8 ± 29.8). There was no difference in absolute and relative weight of muscle, but a decrease in those areas and in the severity of injuries caused by CF in trained animals was observed.O objetivo do estudo foi verificar as alterações na massa corporal e no músculo esquelético de ratos, submetidos ou não à treinamento físico, após uma dose elevada de ciclofosfamida. Foram utilizados 24 ratos machos Wistar, alocados em quatro grupos. Metade dos animais foi submetida ao treinamento de natação com duração de até 40 minutos, intensidade moderada, por 21 dias, e os demais foram mantidos em sedentarismo. Após esse período, metade dos animais de cada grupo (exercício e sedentarismo) recebeu uma única dose de ciclofosfamida, enquanto os demais receberam solução fisiológica. Após sete dias, os animais foram sacrificados. Observou-se menor massa corporal para os animais dos grupos treinados (227,7±16,6/232,3±19,7) comparados aos grupos sedentários (254,6±29,3/253,8±29,8). Não houve diferença no peso absoluto e relativo do músculo, mas houve diminuição nas áreas e severidade das lesões provocadas por ciclofosfamida nos animais treinados. Esse protocolo de treinamento foi eficiente em controlar a massa corporal, e em proteger parcialmente o tecido contra a CF.Department of Physical Education - State University of Maringá (UEM), Maringá-PR, Brazil2011-07-14info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionExperimental ResearchPesquisa Experimentalapplication/pdfhttps://periodicos.uem.br/ojs/index.php/RevEducFis/article/view/9933Journal of Physical Education; Vol 22 No 2 (2011); 273-281Journal of Physical Education; Vol. 22 Núm. 2 (2011); 273-281Journal of Physical Education; v. 22 n. 2 (2011); 273-2812448-2455reponame:Journal of Physical Education (Maringá)instname:Universidade Estadual de Maringá (UEM)instacron:UEMporhttps://periodicos.uem.br/ojs/index.php/RevEducFis/article/view/9933/7652Goessler, Karla FabianaRuiz, Roberto JoséSimão, Andréa Name ColadoSiqueira, Cláudia Patrícia Cardoso MartinsRamos, Solange de PaulaPolito, Marcos Doederleininfo:eu-repo/semantics/openAccess2023-01-10T15:38:00Zoai:periodicos.uem.br/ojs:article/9933Revistahttp://periodicos.uem.br/ojs/index.php/RevEducFis/indexPUBhttps://old.scielo.br/oai/scielo-oai.php||revdef@uem.br2448-24552448-2455opendoar:2023-01-10T15:38Journal of Physical Education (Maringá) - Universidade Estadual de Maringá (UEM)false |
dc.title.none.fl_str_mv |
Cytotoxic effect caused by cyclophosphamide in body mass and skeletal muscle tissue of trained rats - doi: 10.4025/reveducfis.v22i2.9933 Efeito citotóxico provocado por ciclofosfamida na massa corporal e no tecido muscular estriado esquelético de ratos treinados. - doi: 10.4025/reveducfis.v22i2.9933 |
title |
Cytotoxic effect caused by cyclophosphamide in body mass and skeletal muscle tissue of trained rats - doi: 10.4025/reveducfis.v22i2.9933 |
spellingShingle |
Cytotoxic effect caused by cyclophosphamide in body mass and skeletal muscle tissue of trained rats - doi: 10.4025/reveducfis.v22i2.9933 Goessler, Karla Fabiana Cyclophosphamide Exercise Body mass. Cyclophosphamide. Exercise. Body mass. ciclofosfamida exercício físico massa corporal. |
title_short |
Cytotoxic effect caused by cyclophosphamide in body mass and skeletal muscle tissue of trained rats - doi: 10.4025/reveducfis.v22i2.9933 |
title_full |
Cytotoxic effect caused by cyclophosphamide in body mass and skeletal muscle tissue of trained rats - doi: 10.4025/reveducfis.v22i2.9933 |
title_fullStr |
Cytotoxic effect caused by cyclophosphamide in body mass and skeletal muscle tissue of trained rats - doi: 10.4025/reveducfis.v22i2.9933 |
title_full_unstemmed |
Cytotoxic effect caused by cyclophosphamide in body mass and skeletal muscle tissue of trained rats - doi: 10.4025/reveducfis.v22i2.9933 |
title_sort |
Cytotoxic effect caused by cyclophosphamide in body mass and skeletal muscle tissue of trained rats - doi: 10.4025/reveducfis.v22i2.9933 |
author |
Goessler, Karla Fabiana |
author_facet |
Goessler, Karla Fabiana Ruiz, Roberto José Simão, Andréa Name Colado Siqueira, Cláudia Patrícia Cardoso Martins Ramos, Solange de Paula Polito, Marcos Doederlein |
author_role |
author |
author2 |
Ruiz, Roberto José Simão, Andréa Name Colado Siqueira, Cláudia Patrícia Cardoso Martins Ramos, Solange de Paula Polito, Marcos Doederlein |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Goessler, Karla Fabiana Ruiz, Roberto José Simão, Andréa Name Colado Siqueira, Cláudia Patrícia Cardoso Martins Ramos, Solange de Paula Polito, Marcos Doederlein |
dc.subject.por.fl_str_mv |
Cyclophosphamide Exercise Body mass. Cyclophosphamide. Exercise. Body mass. ciclofosfamida exercício físico massa corporal. |
topic |
Cyclophosphamide Exercise Body mass. Cyclophosphamide. Exercise. Body mass. ciclofosfamida exercício físico massa corporal. |
description |
The study examined the changes in body mass and skeletal muscle after a high dose of CF in trained rats. Twenty four Wistar male rats were divided into four groups. Half of the animals were subjected to swimming training lasting up to 40 minutes in moderate intensity for 21 days, the others were kept sedentary. After this period, half the animals in each group (exercise and sedentary) received a single dose of CF, while the other received saline. After seven days, the animals were sacrificed. There was less body mass for animals in the trained groups (227.7 ± 16.6 / 232.3 ± 19.7) compared with sedentary groups (254.6 ± 29.3 / 253.8 ± 29.8). There was no difference in absolute and relative weight of muscle, but a decrease in those areas and in the severity of injuries caused by CF in trained animals was observed. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-07-14 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Experimental Research Pesquisa Experimental |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://periodicos.uem.br/ojs/index.php/RevEducFis/article/view/9933 |
url |
https://periodicos.uem.br/ojs/index.php/RevEducFis/article/view/9933 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://periodicos.uem.br/ojs/index.php/RevEducFis/article/view/9933/7652 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Department of Physical Education - State University of Maringá (UEM), Maringá-PR, Brazil |
publisher.none.fl_str_mv |
Department of Physical Education - State University of Maringá (UEM), Maringá-PR, Brazil |
dc.source.none.fl_str_mv |
Journal of Physical Education; Vol 22 No 2 (2011); 273-281 Journal of Physical Education; Vol. 22 Núm. 2 (2011); 273-281 Journal of Physical Education; v. 22 n. 2 (2011); 273-281 2448-2455 reponame:Journal of Physical Education (Maringá) instname:Universidade Estadual de Maringá (UEM) instacron:UEM |
instname_str |
Universidade Estadual de Maringá (UEM) |
instacron_str |
UEM |
institution |
UEM |
reponame_str |
Journal of Physical Education (Maringá) |
collection |
Journal of Physical Education (Maringá) |
repository.name.fl_str_mv |
Journal of Physical Education (Maringá) - Universidade Estadual de Maringá (UEM) |
repository.mail.fl_str_mv |
||revdef@uem.br |
_version_ |
1754732542934646784 |