Cytotoxic effect caused by cyclophosphamide in body mass and skeletal muscle tissue of trained rats - doi: 10.4025/reveducfis.v22i2.9933

Detalhes bibliográficos
Autor(a) principal: Goessler, Karla Fabiana
Data de Publicação: 2011
Outros Autores: Ruiz, Roberto José, Simão, Andréa Name Colado, Siqueira, Cláudia Patrícia Cardoso Martins, Ramos, Solange de Paula, Polito, Marcos Doederlein
Tipo de documento: Artigo
Idioma: por
Título da fonte: Journal of Physical Education (Maringá)
Texto Completo: https://periodicos.uem.br/ojs/index.php/RevEducFis/article/view/9933
Resumo: The study examined the changes in body mass and skeletal muscle after a high dose of CF in trained rats. Twenty four Wistar male rats were divided into four groups. Half of the animals were subjected to swimming training lasting up to 40 minutes in moderate intensity for 21 days, the others were kept sedentary. After this period, half the animals in each group (exercise and sedentary) received a single dose of CF, while the other received saline. After seven days, the animals were sacrificed. There was less body mass for animals in the trained groups (227.7 ± 16.6 / 232.3 ± 19.7) compared with sedentary groups (254.6 ± 29.3 / 253.8 ± 29.8). There was no difference in absolute and relative weight of muscle, but a decrease in those areas and in the severity of injuries caused by CF in trained animals was observed.
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spelling Cytotoxic effect caused by cyclophosphamide in body mass and skeletal muscle tissue of trained rats - doi: 10.4025/reveducfis.v22i2.9933Efeito citotóxico provocado por ciclofosfamida na massa corporal e no tecido muscular estriado esquelético de ratos treinados. - doi: 10.4025/reveducfis.v22i2.9933CyclophosphamideExerciseBody mass.Cyclophosphamide. Exercise. Body mass.ciclofosfamidaexercício físicomassa corporal.The study examined the changes in body mass and skeletal muscle after a high dose of CF in trained rats. Twenty four Wistar male rats were divided into four groups. Half of the animals were subjected to swimming training lasting up to 40 minutes in moderate intensity for 21 days, the others were kept sedentary. After this period, half the animals in each group (exercise and sedentary) received a single dose of CF, while the other received saline. After seven days, the animals were sacrificed. There was less body mass for animals in the trained groups (227.7 ± 16.6 / 232.3 ± 19.7) compared with sedentary groups (254.6 ± 29.3 / 253.8 ± 29.8). There was no difference in absolute and relative weight of muscle, but a decrease in those areas and in the severity of injuries caused by CF in trained animals was observed.O objetivo do estudo foi verificar as alterações na massa corporal e no músculo esquelético de ratos, submetidos ou não à treinamento físico, após uma dose elevada de ciclofosfamida. Foram utilizados 24 ratos machos Wistar, alocados em quatro grupos. Metade dos animais foi submetida ao treinamento de natação com duração de até 40 minutos, intensidade moderada, por 21 dias, e os demais foram mantidos em sedentarismo. Após esse período, metade dos animais de cada grupo (exercício e sedentarismo) recebeu uma única dose de ciclofosfamida, enquanto os demais receberam solução fisiológica. Após sete dias, os animais foram sacrificados. Observou-se menor massa corporal para os animais dos grupos treinados (227,7±16,6/232,3±19,7) comparados aos grupos sedentários (254,6±29,3/253,8±29,8). Não houve diferença no peso absoluto e relativo do músculo, mas houve diminuição nas áreas e severidade das lesões provocadas por ciclofosfamida nos animais treinados. Esse protocolo de treinamento foi eficiente em controlar a massa corporal, e em proteger parcialmente o tecido contra a CF.Department of Physical Education - State University of Maringá (UEM), Maringá-PR, Brazil2011-07-14info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionExperimental ResearchPesquisa Experimentalapplication/pdfhttps://periodicos.uem.br/ojs/index.php/RevEducFis/article/view/9933Journal of Physical Education; Vol 22 No 2 (2011); 273-281Journal of Physical Education; Vol. 22 Núm. 2 (2011); 273-281Journal of Physical Education; v. 22 n. 2 (2011); 273-2812448-2455reponame:Journal of Physical Education (Maringá)instname:Universidade Estadual de Maringá (UEM)instacron:UEMporhttps://periodicos.uem.br/ojs/index.php/RevEducFis/article/view/9933/7652Goessler, Karla FabianaRuiz, Roberto JoséSimão, Andréa Name ColadoSiqueira, Cláudia Patrícia Cardoso MartinsRamos, Solange de PaulaPolito, Marcos Doederleininfo:eu-repo/semantics/openAccess2023-01-10T15:38:00Zoai:periodicos.uem.br/ojs:article/9933Revistahttp://periodicos.uem.br/ojs/index.php/RevEducFis/indexPUBhttps://old.scielo.br/oai/scielo-oai.php||revdef@uem.br2448-24552448-2455opendoar:2023-01-10T15:38Journal of Physical Education (Maringá) - Universidade Estadual de Maringá (UEM)false
dc.title.none.fl_str_mv Cytotoxic effect caused by cyclophosphamide in body mass and skeletal muscle tissue of trained rats - doi: 10.4025/reveducfis.v22i2.9933
Efeito citotóxico provocado por ciclofosfamida na massa corporal e no tecido muscular estriado esquelético de ratos treinados. - doi: 10.4025/reveducfis.v22i2.9933
title Cytotoxic effect caused by cyclophosphamide in body mass and skeletal muscle tissue of trained rats - doi: 10.4025/reveducfis.v22i2.9933
spellingShingle Cytotoxic effect caused by cyclophosphamide in body mass and skeletal muscle tissue of trained rats - doi: 10.4025/reveducfis.v22i2.9933
Goessler, Karla Fabiana
Cyclophosphamide
Exercise
Body mass.
Cyclophosphamide. Exercise. Body mass.
ciclofosfamida
exercício físico
massa corporal.
title_short Cytotoxic effect caused by cyclophosphamide in body mass and skeletal muscle tissue of trained rats - doi: 10.4025/reveducfis.v22i2.9933
title_full Cytotoxic effect caused by cyclophosphamide in body mass and skeletal muscle tissue of trained rats - doi: 10.4025/reveducfis.v22i2.9933
title_fullStr Cytotoxic effect caused by cyclophosphamide in body mass and skeletal muscle tissue of trained rats - doi: 10.4025/reveducfis.v22i2.9933
title_full_unstemmed Cytotoxic effect caused by cyclophosphamide in body mass and skeletal muscle tissue of trained rats - doi: 10.4025/reveducfis.v22i2.9933
title_sort Cytotoxic effect caused by cyclophosphamide in body mass and skeletal muscle tissue of trained rats - doi: 10.4025/reveducfis.v22i2.9933
author Goessler, Karla Fabiana
author_facet Goessler, Karla Fabiana
Ruiz, Roberto José
Simão, Andréa Name Colado
Siqueira, Cláudia Patrícia Cardoso Martins
Ramos, Solange de Paula
Polito, Marcos Doederlein
author_role author
author2 Ruiz, Roberto José
Simão, Andréa Name Colado
Siqueira, Cláudia Patrícia Cardoso Martins
Ramos, Solange de Paula
Polito, Marcos Doederlein
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Goessler, Karla Fabiana
Ruiz, Roberto José
Simão, Andréa Name Colado
Siqueira, Cláudia Patrícia Cardoso Martins
Ramos, Solange de Paula
Polito, Marcos Doederlein
dc.subject.por.fl_str_mv Cyclophosphamide
Exercise
Body mass.
Cyclophosphamide. Exercise. Body mass.
ciclofosfamida
exercício físico
massa corporal.
topic Cyclophosphamide
Exercise
Body mass.
Cyclophosphamide. Exercise. Body mass.
ciclofosfamida
exercício físico
massa corporal.
description The study examined the changes in body mass and skeletal muscle after a high dose of CF in trained rats. Twenty four Wistar male rats were divided into four groups. Half of the animals were subjected to swimming training lasting up to 40 minutes in moderate intensity for 21 days, the others were kept sedentary. After this period, half the animals in each group (exercise and sedentary) received a single dose of CF, while the other received saline. After seven days, the animals were sacrificed. There was less body mass for animals in the trained groups (227.7 ± 16.6 / 232.3 ± 19.7) compared with sedentary groups (254.6 ± 29.3 / 253.8 ± 29.8). There was no difference in absolute and relative weight of muscle, but a decrease in those areas and in the severity of injuries caused by CF in trained animals was observed.
publishDate 2011
dc.date.none.fl_str_mv 2011-07-14
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Experimental Research
Pesquisa Experimental
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicos.uem.br/ojs/index.php/RevEducFis/article/view/9933
url https://periodicos.uem.br/ojs/index.php/RevEducFis/article/view/9933
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://periodicos.uem.br/ojs/index.php/RevEducFis/article/view/9933/7652
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Department of Physical Education - State University of Maringá (UEM), Maringá-PR, Brazil
publisher.none.fl_str_mv Department of Physical Education - State University of Maringá (UEM), Maringá-PR, Brazil
dc.source.none.fl_str_mv Journal of Physical Education; Vol 22 No 2 (2011); 273-281
Journal of Physical Education; Vol. 22 Núm. 2 (2011); 273-281
Journal of Physical Education; v. 22 n. 2 (2011); 273-281
2448-2455
reponame:Journal of Physical Education (Maringá)
instname:Universidade Estadual de Maringá (UEM)
instacron:UEM
instname_str Universidade Estadual de Maringá (UEM)
instacron_str UEM
institution UEM
reponame_str Journal of Physical Education (Maringá)
collection Journal of Physical Education (Maringá)
repository.name.fl_str_mv Journal of Physical Education (Maringá) - Universidade Estadual de Maringá (UEM)
repository.mail.fl_str_mv ||revdef@uem.br
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