Effects of the acute physical exercise on glycaemic and lipids levels in diabetic rats treated with metformin

Detalhes bibliográficos
Autor(a) principal: Queiroga, Marcos Roberto
Data de Publicação: 2008
Outros Autores: Silveira, Rafael Fernando, Oliveira, Maria Fernandes Mendes de, Crespilho, Daniel, Kokubun, Eduardo, Luciano, Eliete
Tipo de documento: Artigo
Idioma: por
Título da fonte: Journal of Physical Education (Maringá)
Texto Completo: https://periodicos.uem.br/ojs/index.php/RevEducFis/article/view/3337
Resumo: The aim of the study was to investigate the effects of the acute physical exercise on the glycaemic and lipids levels in diabetic rats treated with metformin. For the induction of the type 1 diabetes, the rats were maintained in fasting for 24 hours with free access to water. After anesthesia with ether, the rats received an intravenous injection of alloxan (32 mg / kg b.w.). Adult (130 days) male Wistar rats were divided in two groups: diabetics metformin (DM) and diabetics control (DC). The animals of the group DM received metformin in water (1,4 mg / ml) for 15 days. The blood samples were collected before and immediately after a swimming session (30 min) without additional load. The results revealed that the metformin administered (110 mg / kg / day) by itself or combined with the acute physical exercise didn't promote significant alterations in glucose, triglyceride and cholesterol concentrations in experimental diabetic rats. Other studies are necessary to test different metformin doses with regular sessions of physical exercise in type 1 diabetes.
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spelling Effects of the acute physical exercise on glycaemic and lipids levels in diabetic rats treated with metforminEFEITOS DO EXERCÍCIO FÍSICO AGUDO SOBRE A GLICEMIA E LIPIDEMIA DE RATOS DIABÉTICOS TRATADOS COM METFORMINADiabetes tipo 1MetforminaExercício Físico AgudoGlicemiaLipidemia4.09.00.00-2 Educação FísicaThe aim of the study was to investigate the effects of the acute physical exercise on the glycaemic and lipids levels in diabetic rats treated with metformin. For the induction of the type 1 diabetes, the rats were maintained in fasting for 24 hours with free access to water. After anesthesia with ether, the rats received an intravenous injection of alloxan (32 mg / kg b.w.). Adult (130 days) male Wistar rats were divided in two groups: diabetics metformin (DM) and diabetics control (DC). The animals of the group DM received metformin in water (1,4 mg / ml) for 15 days. The blood samples were collected before and immediately after a swimming session (30 min) without additional load. The results revealed that the metformin administered (110 mg / kg / day) by itself or combined with the acute physical exercise didn't promote significant alterations in glucose, triglyceride and cholesterol concentrations in experimental diabetic rats. Other studies are necessary to test different metformin doses with regular sessions of physical exercise in type 1 diabetes.O objetivo do estudo foi investigar os efeitos do exercício físico agudo sobre a glicemia e lipidemia de ratos diabéticos tratados com metformina. Para a indução do diabetes tipo 1, os ratos foram mantidos em jejum por 24 horas com livre acesso a água. Após anestesia com éter, os ratos receberam injeção de aloxana em salina (32 mg/kg), através da veia peniana. Ratos Wistar machos adultos (130 dias) foram divididos em dois grupos, diabéticos tratados com metformina (DM) e diabéticos controle (DC). Os animais do grupo DM receberam doses de metformina em água (1,4 mg/ml) durante 15 dias. As amostras sangüíneas foram coletadas antes e imediatamente após uma sessão de natação (30 min) sem carga adicional. Os resultados revelaram que a metformina administrada (110 mg/kg/dia) por si ou combinada com o exercício físico agudo não promoveu alterações significativas nas concentrações de glicose, triglicérides e colesterol em ratos diabéticos experimentais. Outros estudos são necessários para testar diferentes doses de metformina com sessões regulares de exercício físico no diabetes tipo 1.Department of Physical Education - State University of Maringá (UEM), Maringá-PR, Brazil2008-05-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://periodicos.uem.br/ojs/index.php/RevEducFis/article/view/3337Journal of Physical Education; Vol 17 No 2 (2006); 169-175Journal of Physical Education; Vol. 17 Núm. 2 (2006); 169-175Journal of Physical Education; v. 17 n. 2 (2006); 169-1752448-2455reponame:Journal of Physical Education (Maringá)instname:Universidade Estadual de Maringá (UEM)instacron:UEMporhttps://periodicos.uem.br/ojs/index.php/RevEducFis/article/view/3337/2410Queiroga, Marcos RobertoSilveira, Rafael FernandoOliveira, Maria Fernandes Mendes deCrespilho, DanielKokubun, EduardoLuciano, Elieteinfo:eu-repo/semantics/openAccess2023-01-10T15:37:09Zoai:periodicos.uem.br/ojs:article/3337Revistahttp://periodicos.uem.br/ojs/index.php/RevEducFis/indexPUBhttps://old.scielo.br/oai/scielo-oai.php||revdef@uem.br2448-24552448-2455opendoar:2023-01-10T15:37:09Journal of Physical Education (Maringá) - Universidade Estadual de Maringá (UEM)false
dc.title.none.fl_str_mv Effects of the acute physical exercise on glycaemic and lipids levels in diabetic rats treated with metformin
EFEITOS DO EXERCÍCIO FÍSICO AGUDO SOBRE A GLICEMIA E LIPIDEMIA DE RATOS DIABÉTICOS TRATADOS COM METFORMINA
title Effects of the acute physical exercise on glycaemic and lipids levels in diabetic rats treated with metformin
spellingShingle Effects of the acute physical exercise on glycaemic and lipids levels in diabetic rats treated with metformin
Queiroga, Marcos Roberto
Diabetes tipo 1
Metformina
Exercício Físico Agudo
Glicemia
Lipidemia
4.09.00.00-2 Educação Física
title_short Effects of the acute physical exercise on glycaemic and lipids levels in diabetic rats treated with metformin
title_full Effects of the acute physical exercise on glycaemic and lipids levels in diabetic rats treated with metformin
title_fullStr Effects of the acute physical exercise on glycaemic and lipids levels in diabetic rats treated with metformin
title_full_unstemmed Effects of the acute physical exercise on glycaemic and lipids levels in diabetic rats treated with metformin
title_sort Effects of the acute physical exercise on glycaemic and lipids levels in diabetic rats treated with metformin
author Queiroga, Marcos Roberto
author_facet Queiroga, Marcos Roberto
Silveira, Rafael Fernando
Oliveira, Maria Fernandes Mendes de
Crespilho, Daniel
Kokubun, Eduardo
Luciano, Eliete
author_role author
author2 Silveira, Rafael Fernando
Oliveira, Maria Fernandes Mendes de
Crespilho, Daniel
Kokubun, Eduardo
Luciano, Eliete
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Queiroga, Marcos Roberto
Silveira, Rafael Fernando
Oliveira, Maria Fernandes Mendes de
Crespilho, Daniel
Kokubun, Eduardo
Luciano, Eliete
dc.subject.por.fl_str_mv Diabetes tipo 1
Metformina
Exercício Físico Agudo
Glicemia
Lipidemia
4.09.00.00-2 Educação Física
topic Diabetes tipo 1
Metformina
Exercício Físico Agudo
Glicemia
Lipidemia
4.09.00.00-2 Educação Física
description The aim of the study was to investigate the effects of the acute physical exercise on the glycaemic and lipids levels in diabetic rats treated with metformin. For the induction of the type 1 diabetes, the rats were maintained in fasting for 24 hours with free access to water. After anesthesia with ether, the rats received an intravenous injection of alloxan (32 mg / kg b.w.). Adult (130 days) male Wistar rats were divided in two groups: diabetics metformin (DM) and diabetics control (DC). The animals of the group DM received metformin in water (1,4 mg / ml) for 15 days. The blood samples were collected before and immediately after a swimming session (30 min) without additional load. The results revealed that the metformin administered (110 mg / kg / day) by itself or combined with the acute physical exercise didn't promote significant alterations in glucose, triglyceride and cholesterol concentrations in experimental diabetic rats. Other studies are necessary to test different metformin doses with regular sessions of physical exercise in type 1 diabetes.
publishDate 2008
dc.date.none.fl_str_mv 2008-05-15
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicos.uem.br/ojs/index.php/RevEducFis/article/view/3337
url https://periodicos.uem.br/ojs/index.php/RevEducFis/article/view/3337
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://periodicos.uem.br/ojs/index.php/RevEducFis/article/view/3337/2410
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Department of Physical Education - State University of Maringá (UEM), Maringá-PR, Brazil
publisher.none.fl_str_mv Department of Physical Education - State University of Maringá (UEM), Maringá-PR, Brazil
dc.source.none.fl_str_mv Journal of Physical Education; Vol 17 No 2 (2006); 169-175
Journal of Physical Education; Vol. 17 Núm. 2 (2006); 169-175
Journal of Physical Education; v. 17 n. 2 (2006); 169-175
2448-2455
reponame:Journal of Physical Education (Maringá)
instname:Universidade Estadual de Maringá (UEM)
instacron:UEM
instname_str Universidade Estadual de Maringá (UEM)
instacron_str UEM
institution UEM
reponame_str Journal of Physical Education (Maringá)
collection Journal of Physical Education (Maringá)
repository.name.fl_str_mv Journal of Physical Education (Maringá) - Universidade Estadual de Maringá (UEM)
repository.mail.fl_str_mv ||revdef@uem.br
_version_ 1754732540925575168

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