CTZ and Calcium Hydroxide Pastes Did Not Cause Hepatic and Renal Alterations in Mice

Detalhes bibliográficos
Autor(a) principal: Lima, Cacilda Castelo Branco
Data de Publicação: 2024
Outros Autores: Lima, Marina de Deus Moura, Rizzo, Marcia dos Santos, Oliveira, Caroline Barros, Conde Júnior, Airton Mendes, de Moura, Marcoeli Silva, Moura, Lúcia de Fátima Almeida de Deus
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Pesquisa Brasileira em Odontopediatria e Clínica Integrada (Online)
Texto Completo: https://revista.uepb.edu.br/PBOCI/article/view/3376
Resumo: Objective: To evaluate the possible renal and hepatic alteration by root canal filling pastes in mice. Material and Methods: Fifty-four mice were divided into nine groups and received one polyethylene tube implant containing two filling pastes (CTZ or calcium hydroxide pastes). Empty polyethylene tubes were used as a negative control. All tubes were implanted subcutaneously in the back of the mice. After time intervals of 7, 21, and 63 days, 1.5 mL of blood was collected by cardiac puncture, and serum samples were used for serological testing. Urea, creatinine, aspartate transferase (AST), alanine transferase (ALT), alkaline phosphatase (ALP), and gamma-glutamyltransferase (GGT) were evaluated. Data were analyzed by 2-way ANOVA (p<0.05). Results: When comparing CTZ and calcium hydroxide pastes and empty tubes and experimental time intervals, no significant differences in the results were found for any of the biochemical parameters analyzed (p>0.05). No differences were observed in the interactions (material*experimental time intervals) and the biochemical parameters analyzed (p>0.05). Conclusion: CTZ and calcium hydroxide pastes did not cause hepatic and renal alterations in mice, demonstrating the pastes' safety.
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spelling CTZ and Calcium Hydroxide Pastes Did Not Cause Hepatic and Renal Alterations in MiceCalcium HydroxidePediatric DentistryRoot Canal Filling MaterialsSubcutaneous TissueObjective: To evaluate the possible renal and hepatic alteration by root canal filling pastes in mice. Material and Methods: Fifty-four mice were divided into nine groups and received one polyethylene tube implant containing two filling pastes (CTZ or calcium hydroxide pastes). Empty polyethylene tubes were used as a negative control. All tubes were implanted subcutaneously in the back of the mice. After time intervals of 7, 21, and 63 days, 1.5 mL of blood was collected by cardiac puncture, and serum samples were used for serological testing. Urea, creatinine, aspartate transferase (AST), alanine transferase (ALT), alkaline phosphatase (ALP), and gamma-glutamyltransferase (GGT) were evaluated. Data were analyzed by 2-way ANOVA (p<0.05). Results: When comparing CTZ and calcium hydroxide pastes and empty tubes and experimental time intervals, no significant differences in the results were found for any of the biochemical parameters analyzed (p>0.05). No differences were observed in the interactions (material*experimental time intervals) and the biochemical parameters analyzed (p>0.05). Conclusion: CTZ and calcium hydroxide pastes did not cause hepatic and renal alterations in mice, demonstrating the pastes' safety.EDUEPB - EDITORA DA UNIVERSIDADE ESTADUAL DA PARAÍBA2024-04-29info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://revista.uepb.edu.br/PBOCI/article/view/3376Pesquisa Brasileira em Odontopediatria e Clínica Integrada; Vol. 24 (2024); e230122Pesquisa Brasileira em Odontopediatria e Clínica Integrada; v. 24 (2024); e2301221983-46321519-0501reponame:Pesquisa Brasileira em Odontopediatria e Clínica Integrada (Online)instname:Universidade Estadual da Paraíba (UEPB)instacron:UEPBenghttps://revista.uepb.edu.br/PBOCI/article/view/3376/2374Copyright (c) 2023 Pesquisa Brasileira em Odontopediatria e Clínica Integradahttps://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessLima, Cacilda Castelo BrancoLima, Marina de Deus MouraRizzo, Marcia dos SantosOliveira, Caroline BarrosConde Júnior, Airton Mendesde Moura, Marcoeli SilvaMoura, Lúcia de Fátima Almeida de Deus2024-04-29T07:30:23Zoai:ojs.pkp.sfu.ca:article/3376Revistahttps://revista.uepb.edu.br/PBOCI/PUBhttps://revista.uepb.edu.br/PBOCI/oaipboci.editoria@gmail.com || alessandrouepb@gmail.com1983-46321519-0501opendoar:2024-04-29T07:30:23Pesquisa Brasileira em Odontopediatria e Clínica Integrada (Online) - Universidade Estadual da Paraíba (UEPB)false
dc.title.none.fl_str_mv CTZ and Calcium Hydroxide Pastes Did Not Cause Hepatic and Renal Alterations in Mice
title CTZ and Calcium Hydroxide Pastes Did Not Cause Hepatic and Renal Alterations in Mice
spellingShingle CTZ and Calcium Hydroxide Pastes Did Not Cause Hepatic and Renal Alterations in Mice
Lima, Cacilda Castelo Branco
Calcium Hydroxide
Pediatric Dentistry
Root Canal Filling Materials
Subcutaneous Tissue
title_short CTZ and Calcium Hydroxide Pastes Did Not Cause Hepatic and Renal Alterations in Mice
title_full CTZ and Calcium Hydroxide Pastes Did Not Cause Hepatic and Renal Alterations in Mice
title_fullStr CTZ and Calcium Hydroxide Pastes Did Not Cause Hepatic and Renal Alterations in Mice
title_full_unstemmed CTZ and Calcium Hydroxide Pastes Did Not Cause Hepatic and Renal Alterations in Mice
title_sort CTZ and Calcium Hydroxide Pastes Did Not Cause Hepatic and Renal Alterations in Mice
author Lima, Cacilda Castelo Branco
author_facet Lima, Cacilda Castelo Branco
Lima, Marina de Deus Moura
Rizzo, Marcia dos Santos
Oliveira, Caroline Barros
Conde Júnior, Airton Mendes
de Moura, Marcoeli Silva
Moura, Lúcia de Fátima Almeida de Deus
author_role author
author2 Lima, Marina de Deus Moura
Rizzo, Marcia dos Santos
Oliveira, Caroline Barros
Conde Júnior, Airton Mendes
de Moura, Marcoeli Silva
Moura, Lúcia de Fátima Almeida de Deus
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Lima, Cacilda Castelo Branco
Lima, Marina de Deus Moura
Rizzo, Marcia dos Santos
Oliveira, Caroline Barros
Conde Júnior, Airton Mendes
de Moura, Marcoeli Silva
Moura, Lúcia de Fátima Almeida de Deus
dc.subject.por.fl_str_mv Calcium Hydroxide
Pediatric Dentistry
Root Canal Filling Materials
Subcutaneous Tissue
topic Calcium Hydroxide
Pediatric Dentistry
Root Canal Filling Materials
Subcutaneous Tissue
description Objective: To evaluate the possible renal and hepatic alteration by root canal filling pastes in mice. Material and Methods: Fifty-four mice were divided into nine groups and received one polyethylene tube implant containing two filling pastes (CTZ or calcium hydroxide pastes). Empty polyethylene tubes were used as a negative control. All tubes were implanted subcutaneously in the back of the mice. After time intervals of 7, 21, and 63 days, 1.5 mL of blood was collected by cardiac puncture, and serum samples were used for serological testing. Urea, creatinine, aspartate transferase (AST), alanine transferase (ALT), alkaline phosphatase (ALP), and gamma-glutamyltransferase (GGT) were evaluated. Data were analyzed by 2-way ANOVA (p<0.05). Results: When comparing CTZ and calcium hydroxide pastes and empty tubes and experimental time intervals, no significant differences in the results were found for any of the biochemical parameters analyzed (p>0.05). No differences were observed in the interactions (material*experimental time intervals) and the biochemical parameters analyzed (p>0.05). Conclusion: CTZ and calcium hydroxide pastes did not cause hepatic and renal alterations in mice, demonstrating the pastes' safety.
publishDate 2024
dc.date.none.fl_str_mv 2024-04-29
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://revista.uepb.edu.br/PBOCI/article/view/3376
url https://revista.uepb.edu.br/PBOCI/article/view/3376
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://revista.uepb.edu.br/PBOCI/article/view/3376/2374
dc.rights.driver.fl_str_mv Copyright (c) 2023 Pesquisa Brasileira em Odontopediatria e Clínica Integrada
https://creativecommons.org/licenses/by-nc/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2023 Pesquisa Brasileira em Odontopediatria e Clínica Integrada
https://creativecommons.org/licenses/by-nc/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv EDUEPB - EDITORA DA UNIVERSIDADE ESTADUAL DA PARAÍBA
publisher.none.fl_str_mv EDUEPB - EDITORA DA UNIVERSIDADE ESTADUAL DA PARAÍBA
dc.source.none.fl_str_mv Pesquisa Brasileira em Odontopediatria e Clínica Integrada; Vol. 24 (2024); e230122
Pesquisa Brasileira em Odontopediatria e Clínica Integrada; v. 24 (2024); e230122
1983-4632
1519-0501
reponame:Pesquisa Brasileira em Odontopediatria e Clínica Integrada (Online)
instname:Universidade Estadual da Paraíba (UEPB)
instacron:UEPB
instname_str Universidade Estadual da Paraíba (UEPB)
instacron_str UEPB
institution UEPB
reponame_str Pesquisa Brasileira em Odontopediatria e Clínica Integrada (Online)
collection Pesquisa Brasileira em Odontopediatria e Clínica Integrada (Online)
repository.name.fl_str_mv Pesquisa Brasileira em Odontopediatria e Clínica Integrada (Online) - Universidade Estadual da Paraíba (UEPB)
repository.mail.fl_str_mv pboci.editoria@gmail.com || alessandrouepb@gmail.com
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