Estudo das propriedades biológicas, fitoquímicas e toxicológicas de Aspidosperma pyrifolium Mart
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações da UEPB |
Texto Completo: | http://tede.bc.uepb.edu.br/tede/jspui/handle/tede/2376 |
Resumo: | Aspidosperma pyrifolium Mart. is a species that occurs in the caatinga, being popularly known as Pereiro. This species is economically important to have multiple uses, primarily for use as an ornamental plant (even in recovery of riparian vegetation), as wood (carpentry, charcoal and firewood) and as fodder. Phytochemical studies revealed the presence of indole alkaloids, which were attributed hypotensive, antimicrobial, trypanosomicide and cytotoxic activities. The objective of this research was to realize a phytochemical, toxicological and biological study of A. pyrifolium Mart. The extracts were produced by different extraction techniques and by three different hydroalcoholic concentrations and of proportion of plant material. To perform the first biological activity a factorial design 3 3 was used to order to determine the extract of best antimicrobial action against the strains Escherichia coli (ATCC 25922) , Staphylococcus aureus (ATCC 25923), Pseudomonas aeruginosa (ATCC 27853) and Klebsiella pneumoniae (ATCC 4352). This extract was used in the realization of the other biological studies. The results showed that the best antimicrobial activity was obtained with the extract produced by turbólise using 30 g of plant material dissolved in solution of 90% ethanol/water. The phytochemical studies showed the presence of phenolic compounds and saponins. In pharmacological testing was observed that the extract, in the doses tested, exhibited an analgesic and anti-inflammatory potential, and although the crude extract has shown signs of toxicity, these were not evidenced in the pharmacological assays. |
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Medeiros, Ana Claudia Dantas de92956467468http://lattes.cnpq.br/0640671064146120Alves, Harley da Silva03103066473http://lattes.cnpq.br/2877008206355861Santos, Vanda Lúcia dos22242449420http://lattes.cnpq.br/3360729786561207Basílio, Ionaldo José Lima Diniz01299527450http://lattes.cnpq.br/931633805153863206226489421http://lattes.cnpq.br/5247340828896961Messiades, Davy Macgyver da Silva2016-07-22T15:02:24Z2014-06-06MESSIADES, D. M. da S. Estudo das propriedades biológicas, fitoquímicas e toxicológicas de Aspidosperma pyrifolium Mart. 2014. 137f. Dissertação (Programa de Pós-Graduação em Ciências Farmacêuticas - PPGCF)- Universidade Estadual da Paraíba, Campina Grande, 2014.http://tede.bc.uepb.edu.br/tede/jspui/handle/tede/2376Aspidosperma pyrifolium Mart. is a species that occurs in the caatinga, being popularly known as Pereiro. This species is economically important to have multiple uses, primarily for use as an ornamental plant (even in recovery of riparian vegetation), as wood (carpentry, charcoal and firewood) and as fodder. Phytochemical studies revealed the presence of indole alkaloids, which were attributed hypotensive, antimicrobial, trypanosomicide and cytotoxic activities. The objective of this research was to realize a phytochemical, toxicological and biological study of A. pyrifolium Mart. The extracts were produced by different extraction techniques and by three different hydroalcoholic concentrations and of proportion of plant material. To perform the first biological activity a factorial design 3 3 was used to order to determine the extract of best antimicrobial action against the strains Escherichia coli (ATCC 25922) , Staphylococcus aureus (ATCC 25923), Pseudomonas aeruginosa (ATCC 27853) and Klebsiella pneumoniae (ATCC 4352). This extract was used in the realization of the other biological studies. The results showed that the best antimicrobial activity was obtained with the extract produced by turbólise using 30 g of plant material dissolved in solution of 90% ethanol/water. The phytochemical studies showed the presence of phenolic compounds and saponins. In pharmacological testing was observed that the extract, in the doses tested, exhibited an analgesic and anti-inflammatory potential, and although the crude extract has shown signs of toxicity, these were not evidenced in the pharmacological assays.Aspidosperma pyrifolium Mart. é uma espécie que ocorre na caatinga, sendo popularmente conhecida como Pereiro. Essa espécie é economicamente importante por ter multiplicidade de usos, principalmente na utilização como planta ornamental (inclusive em processos de recuperação de mata ciliar), como madeira (carpintaria, carvão vegetal e lenha) e como forragem. Estudos fitoquímicos mostraram a presença de alcaloides indólicos, aos quais foram atribuídas atividades hipotensoras, antimicrobianas, tripanossomicidas e citotóxicas. Assim, o objetivo dessa pesquisa foi realizar um estudo fitoquímico, biológico e toxicológico da A. pyrifolium Mart. Os extratos foram produzidos por diferentes técnicas de extração e por três distintas concentrações hidroalcoólicas e de proporção de material vegetal. Para a realização da primeira atividade biológica foi utilizado um planejamento fatorial 3 3 , com a finalidade de se determinar o extrato de melhor ação antimicrobiana frente às cepas Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 25923), Pseudomonas aeruginosa (ATCC 27853) e klebsiella pneumoniae (ATCC 4352). Este extrato foi utilizado na realização dos demais estudos biológicos. Os resultados mostraram que a melhor atividade antimicrobiana foi obtida com o extrato produzido por turbólise, utilizando 30 g de material vegetal dissolvido em solução de 90% de etanol/água. O estudo fitoquímico mostrou a presença de compostos fenólicos e saponinas. Nos ensaios farmacológicos observou-se que o extrato, nas doses testadas, apresentou potencial analgésico e anti-inflamatório, e embora o extrato bruto tenha apresentado indícios de toxicidade, estes não foram evidenciados nos ensaios farmacológicos.Submitted by Jean Medeiros (jeanletras@uepb.edu.br) on 2016-03-18T11:49:47Z No. of bitstreams: 1 PDF - Davy Macgyver da Silva Messiades.pdf: 1230403 bytes, checksum: 455cb9c8a0edaf8b0d94fc14de70dee3 (MD5)Approved for entry into archive by Secta BC (secta.csu.bc@uepb.edu.br) on 2016-07-22T15:02:15Z (GMT) No. of bitstreams: 1 PDF - Davy Macgyver da Silva Messiades.pdf: 1230403 bytes, checksum: 455cb9c8a0edaf8b0d94fc14de70dee3 (MD5)Approved for entry into archive by Secta BC (secta.csu.bc@uepb.edu.br) on 2016-07-22T15:02:24Z (GMT) No. of bitstreams: 1 PDF - Davy Macgyver da Silva Messiades.pdf: 1230403 bytes, checksum: 455cb9c8a0edaf8b0d94fc14de70dee3 (MD5)Made available in DSpace on 2016-07-22T15:02:24Z (GMT). No. of bitstreams: 1 PDF - Davy Macgyver da Silva Messiades.pdf: 1230403 bytes, checksum: 455cb9c8a0edaf8b0d94fc14de70dee3 (MD5) Previous issue date: 2014-06-06application/pdfhttp://tede.bc.uepb.edu.br/jspui/retrieve/4887/PDF%20-%20Davy%20Macgyver%20da%20Silva%20Messiades.pdf.jpgporUniversidade Estadual da ParaíbaPrograma de Pós-Graduação em Ciências Farmacêuticas - PPGCFUEPBBrasilPró-Reitoria de Pós-Graduação e Pesquisa - PRPGPPereiroFitoquímicaMicrobiologiaToxicologiaMicrobiologyPhytochemistryToxicologyCIENCIAS DA SAUDE::FARMACIAEstudo das propriedades biológicas, fitoquímicas e toxicológicas de Aspidosperma pyrifolium Martinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis81579685552518768746006006005248714503811102786997636413449754996info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da UEPBinstname:Universidade Estadual da Paraíba (UEPB)instacron:UEPBTHUMBNAILPDF - Davy Macgyver da Silva Messiades.pdf.jpgPDF - Davy Macgyver da Silva Messiades.pdf.jpgimage/jpeg3665http://tede.bc.uepb.edu.br/jspui/bitstream/tede/2376/3/PDF+-+Davy+Macgyver+da+Silva+Messiades.pdf.jpgf1a164498575c4aac5b4a0cf4f79ac95MD53ORIGINALPDF - Davy Macgyver da Silva Messiades.pdfPDF - Davy Macgyver da Silva Messiades.pdfapplication/pdf1230403http://tede.bc.uepb.edu.br/jspui/bitstream/tede/2376/2/PDF+-+Davy+Macgyver+da+Silva+Messiades.pdf455cb9c8a0edaf8b0d94fc14de70dee3MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81960http://tede.bc.uepb.edu.br/jspui/bitstream/tede/2376/1/license.txt6052ae61e77222b2086e666b7ae213ceMD51tede/23762016-07-23 01:03:46.963oai:tede.bc.uepb.edu.br: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Biblioteca Digital de Teses e Dissertaçõeshttp://tede.bc.uepb.edu.br/jspui/PUBhttp://tede.bc.uepb.edu.br/oai/requestbc@uepb.edu.br||opendoar:2016-07-23T04:03:46Biblioteca Digital de Teses e Dissertações da UEPB - Universidade Estadual da Paraíba (UEPB)false |
dc.title.por.fl_str_mv |
Estudo das propriedades biológicas, fitoquímicas e toxicológicas de Aspidosperma pyrifolium Mart |
title |
Estudo das propriedades biológicas, fitoquímicas e toxicológicas de Aspidosperma pyrifolium Mart |
spellingShingle |
Estudo das propriedades biológicas, fitoquímicas e toxicológicas de Aspidosperma pyrifolium Mart Messiades, Davy Macgyver da Silva Pereiro Fitoquímica Microbiologia Toxicologia Microbiology Phytochemistry Toxicology CIENCIAS DA SAUDE::FARMACIA |
title_short |
Estudo das propriedades biológicas, fitoquímicas e toxicológicas de Aspidosperma pyrifolium Mart |
title_full |
Estudo das propriedades biológicas, fitoquímicas e toxicológicas de Aspidosperma pyrifolium Mart |
title_fullStr |
Estudo das propriedades biológicas, fitoquímicas e toxicológicas de Aspidosperma pyrifolium Mart |
title_full_unstemmed |
Estudo das propriedades biológicas, fitoquímicas e toxicológicas de Aspidosperma pyrifolium Mart |
title_sort |
Estudo das propriedades biológicas, fitoquímicas e toxicológicas de Aspidosperma pyrifolium Mart |
author |
Messiades, Davy Macgyver da Silva |
author_facet |
Messiades, Davy Macgyver da Silva |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Medeiros, Ana Claudia Dantas de |
dc.contributor.advisor1ID.fl_str_mv |
92956467468 |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/0640671064146120 |
dc.contributor.advisor-co1.fl_str_mv |
Alves, Harley da Silva |
dc.contributor.advisor-co1ID.fl_str_mv |
03103066473 |
dc.contributor.advisor-co1Lattes.fl_str_mv |
http://lattes.cnpq.br/2877008206355861 |
dc.contributor.referee1.fl_str_mv |
Santos, Vanda Lúcia dos |
dc.contributor.referee1ID.fl_str_mv |
22242449420 |
dc.contributor.referee1Lattes.fl_str_mv |
http://lattes.cnpq.br/3360729786561207 |
dc.contributor.referee2.fl_str_mv |
Basílio, Ionaldo José Lima Diniz |
dc.contributor.referee2ID.fl_str_mv |
01299527450 |
dc.contributor.referee2Lattes.fl_str_mv |
http://lattes.cnpq.br/9316338051538632 |
dc.contributor.authorID.fl_str_mv |
06226489421 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/5247340828896961 |
dc.contributor.author.fl_str_mv |
Messiades, Davy Macgyver da Silva |
contributor_str_mv |
Medeiros, Ana Claudia Dantas de Alves, Harley da Silva Santos, Vanda Lúcia dos Basílio, Ionaldo José Lima Diniz |
dc.subject.por.fl_str_mv |
Pereiro Fitoquímica Microbiologia Toxicologia |
topic |
Pereiro Fitoquímica Microbiologia Toxicologia Microbiology Phytochemistry Toxicology CIENCIAS DA SAUDE::FARMACIA |
dc.subject.eng.fl_str_mv |
Microbiology Phytochemistry Toxicology |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE::FARMACIA |
description |
Aspidosperma pyrifolium Mart. is a species that occurs in the caatinga, being popularly known as Pereiro. This species is economically important to have multiple uses, primarily for use as an ornamental plant (even in recovery of riparian vegetation), as wood (carpentry, charcoal and firewood) and as fodder. Phytochemical studies revealed the presence of indole alkaloids, which were attributed hypotensive, antimicrobial, trypanosomicide and cytotoxic activities. The objective of this research was to realize a phytochemical, toxicological and biological study of A. pyrifolium Mart. The extracts were produced by different extraction techniques and by three different hydroalcoholic concentrations and of proportion of plant material. To perform the first biological activity a factorial design 3 3 was used to order to determine the extract of best antimicrobial action against the strains Escherichia coli (ATCC 25922) , Staphylococcus aureus (ATCC 25923), Pseudomonas aeruginosa (ATCC 27853) and Klebsiella pneumoniae (ATCC 4352). This extract was used in the realization of the other biological studies. The results showed that the best antimicrobial activity was obtained with the extract produced by turbólise using 30 g of plant material dissolved in solution of 90% ethanol/water. The phytochemical studies showed the presence of phenolic compounds and saponins. In pharmacological testing was observed that the extract, in the doses tested, exhibited an analgesic and anti-inflammatory potential, and although the crude extract has shown signs of toxicity, these were not evidenced in the pharmacological assays. |
publishDate |
2014 |
dc.date.issued.fl_str_mv |
2014-06-06 |
dc.date.accessioned.fl_str_mv |
2016-07-22T15:02:24Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/masterThesis |
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masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
MESSIADES, D. M. da S. Estudo das propriedades biológicas, fitoquímicas e toxicológicas de Aspidosperma pyrifolium Mart. 2014. 137f. Dissertação (Programa de Pós-Graduação em Ciências Farmacêuticas - PPGCF)- Universidade Estadual da Paraíba, Campina Grande, 2014. |
dc.identifier.uri.fl_str_mv |
http://tede.bc.uepb.edu.br/tede/jspui/handle/tede/2376 |
identifier_str_mv |
MESSIADES, D. M. da S. Estudo das propriedades biológicas, fitoquímicas e toxicológicas de Aspidosperma pyrifolium Mart. 2014. 137f. Dissertação (Programa de Pós-Graduação em Ciências Farmacêuticas - PPGCF)- Universidade Estadual da Paraíba, Campina Grande, 2014. |
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http://tede.bc.uepb.edu.br/tede/jspui/handle/tede/2376 |
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