Atividade probiótica de Bifidobacterium animalis e Lactobacillus casei na imunomodulação e na aderência de Escherichia coli enteroagregativa (EAEC) em células intestinais Caco-2
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | |
Tipo de documento: | Tese |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações da UERJ |
Texto Completo: | http://www.bdtd.uerj.br/handle/1/20071 |
Resumo: | Enteroaggregative Escherichia coli (EAEC) is an E. coli pathotype that characteristically shows aggregative adhesion pattern on in vitro cultured cells, mainly related to persistent infant diarrhea cases. Probiotics are non-pathogenic living microorganisms that confer health benefits. These organisms usually provide protection against pathogens, living naturally in microbiota and are often found in fermented foods such as dairy products. Probiotic bacteria have activity against foodborne pathogens, being able to promote biofilm formation reduction, inhibition of adhesion and injury of in vitro cultured cells, in vivo models diarrhea prevention and also immunomodulation. In this study, two bacterial species probiotic activity on the virulence of EAEC strains was evaluated. Probiotic species Bifidobacterium animalis DN 173010 (Danone®) and Lactobacillus casei Shirota (Yakult®) were evaluated on immunomodulation ability and interference of EAEC 042, 1500, H92/3 and I49 strains adhesion in Caco-2 cells, under co-cultivation experiments. Caco-2 cells were submitted EAEC strains infection in presence and absence of both probiotics, separately and together. The EAEC strains substantially increased IL-8 production by infected Caco-2 cells, whereas it not occurs with other cytokines. In synergistic condition, probiotic strains proved to be able to modulate pro-inflammatory cytokines IL-1β, IL-6, IL-10 and TNF-α production of Caco-2 cells infected by EAEC. However, probiotic strains did not modulate IL-8 production. Increased TNF-α production by both infected and non-EAEC infected cells was induced by probiotics. Probiotics reestablished the anti-inflammatory cytokine IL-10 production in EAEC infection. EAEC strains showed diverse Caco-2 cell quantitative adherence numbers when co-cultivated with probiotics, which adhesion increased or decreased on differentiated and non-differentiated Caco-2 cells. Probiotic strains adhere similarly on differentiated and non-differentiated Caco-2 cells. These results suggest that probiotics presence may interfere in different ways on infection by distinct EAEC strains. This study helps to clarify the role that probiotic bacterial strains activity plays in EAEC infection. |
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Fonseca, Adenilson de Souza dahttp://lattes.cnpq.br/8838215858149851Mencalha, Andre Luizhttp://lattes.cnpq.br/2640957642674082Paoli, Flávia dehttp://lattes.cnpq.br/3197885404348516Trajano, Eduardo Tavares Limahttp://lattes.cnpq.br/1104445346920483http://lattes.cnpq.br/6309556867511284Lima, Andrezza Maria Côrtes Thoméandrezza_mct@hotmail.com2023-07-28T16:15:39Z2020-05-28FERREIRA, Andréa Fonseca. Atividade probiótica de Bifidobacterium animalis e Lactobacillus casei na imunomodulação e na aderência de Escherichia coli enteroagregativa (EAEC) em células intestinais Caco-2. 2019. 74 f. Tese (Doutorado em Microbiologia) – Faculdade de Ciências Médicas, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, 2019.http://www.bdtd.uerj.br/handle/1/20071Enteroaggregative Escherichia coli (EAEC) is an E. coli pathotype that characteristically shows aggregative adhesion pattern on in vitro cultured cells, mainly related to persistent infant diarrhea cases. Probiotics are non-pathogenic living microorganisms that confer health benefits. These organisms usually provide protection against pathogens, living naturally in microbiota and are often found in fermented foods such as dairy products. Probiotic bacteria have activity against foodborne pathogens, being able to promote biofilm formation reduction, inhibition of adhesion and injury of in vitro cultured cells, in vivo models diarrhea prevention and also immunomodulation. In this study, two bacterial species probiotic activity on the virulence of EAEC strains was evaluated. Probiotic species Bifidobacterium animalis DN 173010 (Danone®) and Lactobacillus casei Shirota (Yakult®) were evaluated on immunomodulation ability and interference of EAEC 042, 1500, H92/3 and I49 strains adhesion in Caco-2 cells, under co-cultivation experiments. Caco-2 cells were submitted EAEC strains infection in presence and absence of both probiotics, separately and together. The EAEC strains substantially increased IL-8 production by infected Caco-2 cells, whereas it not occurs with other cytokines. In synergistic condition, probiotic strains proved to be able to modulate pro-inflammatory cytokines IL-1β, IL-6, IL-10 and TNF-α production of Caco-2 cells infected by EAEC. However, probiotic strains did not modulate IL-8 production. Increased TNF-α production by both infected and non-EAEC infected cells was induced by probiotics. Probiotics reestablished the anti-inflammatory cytokine IL-10 production in EAEC infection. EAEC strains showed diverse Caco-2 cell quantitative adherence numbers when co-cultivated with probiotics, which adhesion increased or decreased on differentiated and non-differentiated Caco-2 cells. Probiotic strains adhere similarly on differentiated and non-differentiated Caco-2 cells. These results suggest that probiotics presence may interfere in different ways on infection by distinct EAEC strains. This study helps to clarify the role that probiotic bacterial strains activity plays in EAEC infection.Escherichia coli enteroagregativa (EAEC) é um patotipo de E. coli que possui o padrão de aderência agregativo em células cultivadas in vitro, relacionado principalmente a casos de diarreia persistente infantil. Probióticos são microrganismos vivos não patogênicos que conferem benefícios à saúde. Estes organismos usualmente promovem proteção contra patógenos, vivendo naturalmente na microbiota e são comumente encontrados em alimentos fermentados, como em laticínios. Bactérias probióticas possuem atividade contra patógenos de origem alimentar, sendo capazes de promover redução da formação de biofilme, inibição de adesão e lesão em células cultivadas in vitro, prevenção de diarreia de modelos in vivo e também imunomodulação. No presente estudo foi avaliada a atividade probiótica de duas espécies bacterianas na virulência de cepas de EAEC. As espécies probióticas Bifidobacterium animalis DN 173010 (Danone®) e Lactobacillus casei Shirota (Yakult®) foram avaliadas quanto à capacidade de imunomodulação e interferência na aderência das cepas de EAEC 042, 1500, H92/3 e I49 em células da linhagem Caco-2, em ensaios de co-cultivo. As células Caco-2 foram submetidas à infecção por cepas de EAEC, na presença e na ausência de ambos os probióticos, separados e em conjunto. As cepas de EAEC estudadas induziram o intenso aumento da produção de IL-8 pelas células Caco-2 infectadas, o que não foi observado com as outras citocinas. Em condição de sinergismo, as cepas probióticas se mostraram capazes de modular a produção das citocinas pró-inflamatórias IL-1β, IL-6, TNF-α e IL-10 por células Caco-2 infectadas com EAEC. No entanto, as cepas probióticas não foram capazes de modular a produção de IL-8. O aumento da produção de TNF-α, tanto por células infectadas quanto por não infectadas com EAEC, foi induzido pelos probióticos. Os probióticos reestabeleceram a produção da citocina anti-inflamatória IL-10 na infecção por EAEC. As cepas de EAEC apresentaram números de aderência quantitativa a células Caco-2 variados quando em co-cultivo com probióticos juntos e separados, tendo sua aderência aumentada ou diminuída em tapetes celulares diferenciados e não diferenciados. As cepas probióticas foram capazes de aderir a células Caco-2 diferenciadas e não diferenciadas de maneira semelhante. Estes resultados sugerem que a presença de probióticos pode interferir de maneiras variadas na infecção por cepas de EAEC distintas. O presente estudo se mostrou importante para elucidar o papel que a atividade probiótica de cepas bacterianas exerce na infecção por EAEC.Submitted by Heloísa CB/A (helobdtd@gmail.com) on 2023-07-28T16:15:39Z No. of bitstreams: 1 Tese - Andrezza Maria Côrtes Thomé Lima - 2020 - Completa.pdf: 3609086 bytes, checksum: 705034b4f87aaa8db839d586c85908e4 (MD5)Made available in DSpace on 2023-07-28T16:15:39Z (GMT). No. of bitstreams: 1 Tese - Andrezza Maria Côrtes Thomé Lima - 2020 - Completa.pdf: 3609086 bytes, checksum: 705034b4f87aaa8db839d586c85908e4 (MD5) Previous issue date: 2020-05-28application/pdfporUniversidade do Estado do Rio de JaneiroPrograma de Pós-Graduação em BiociênciasUERJBrasilCentro Biomédico::Instituto de Biologia Roberto Alcantara GomesEscherichia coliEAECLactobacillusBifidobacteriumProbioticsImmunomodulationAdhesionCaco-2CytokinesEscherichia coliEAECLactobacillusBifidobacteriumProbióticosImunomodulaçãoAderênciaCaco-2CitocinasCIENCIAS DA SAUDE::FISIOTERAPIA E TERAPIA OCUPACIONALAtividade probiótica de Bifidobacterium animalis e Lactobacillus casei na imunomodulação e na aderência de Escherichia coli enteroagregativa (EAEC) em células intestinais Caco-2Bifidobacterium animalis and Lactobacillus casei probiotic activity on immunomodulation and enteroaggregative Escherichia coli (EAEC) adhesion on Caco-2 intestinal cellsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisinfo:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da UERJinstname:Universidade do Estado do Rio de Janeiro (UERJ)instacron:UERJORIGINALTese - Andrezza Maria Côrtes Thomé Lima - 2020 - Completa.pdfTese - Andrezza Maria Côrtes Thomé Lima - 2020 - Completa.pdfapplication/pdf3609086http://www.bdtd.uerj.br/bitstream/1/20071/2/Tese+-+Andrezza+Maria+C%C3%B4rtes+Thom%C3%A9+Lima+-+2020+-+Completa.pdf705034b4f87aaa8db839d586c85908e4MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82123http://www.bdtd.uerj.br/bitstream/1/20071/1/license.txte5502652da718045d7fcd832b79fca29MD511/200712024-02-26 11:25:03.924oai:www.bdtd.uerj.br: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Biblioteca Digital de Teses e Dissertaçõeshttp://www.bdtd.uerj.br/PUBhttps://www.bdtd.uerj.br:8443/oai/requestbdtd.suporte@uerj.bropendoar:29032024-02-26T14:25:03Biblioteca Digital de Teses e Dissertações da UERJ - Universidade do Estado do Rio de Janeiro (UERJ)false |
dc.title.por.fl_str_mv |
Atividade probiótica de Bifidobacterium animalis e Lactobacillus casei na imunomodulação e na aderência de Escherichia coli enteroagregativa (EAEC) em células intestinais Caco-2 |
dc.title.alternative.eng.fl_str_mv |
Bifidobacterium animalis and Lactobacillus casei probiotic activity on immunomodulation and enteroaggregative Escherichia coli (EAEC) adhesion on Caco-2 intestinal cells |
title |
Atividade probiótica de Bifidobacterium animalis e Lactobacillus casei na imunomodulação e na aderência de Escherichia coli enteroagregativa (EAEC) em células intestinais Caco-2 |
spellingShingle |
Atividade probiótica de Bifidobacterium animalis e Lactobacillus casei na imunomodulação e na aderência de Escherichia coli enteroagregativa (EAEC) em células intestinais Caco-2 Lima, Andrezza Maria Côrtes Thomé Escherichia coli EAEC Lactobacillus Bifidobacterium Probiotics Immunomodulation Adhesion Caco-2 Cytokines Escherichia coli EAEC Lactobacillus Bifidobacterium Probióticos Imunomodulação Aderência Caco-2 Citocinas CIENCIAS DA SAUDE::FISIOTERAPIA E TERAPIA OCUPACIONAL |
title_short |
Atividade probiótica de Bifidobacterium animalis e Lactobacillus casei na imunomodulação e na aderência de Escherichia coli enteroagregativa (EAEC) em células intestinais Caco-2 |
title_full |
Atividade probiótica de Bifidobacterium animalis e Lactobacillus casei na imunomodulação e na aderência de Escherichia coli enteroagregativa (EAEC) em células intestinais Caco-2 |
title_fullStr |
Atividade probiótica de Bifidobacterium animalis e Lactobacillus casei na imunomodulação e na aderência de Escherichia coli enteroagregativa (EAEC) em células intestinais Caco-2 |
title_full_unstemmed |
Atividade probiótica de Bifidobacterium animalis e Lactobacillus casei na imunomodulação e na aderência de Escherichia coli enteroagregativa (EAEC) em células intestinais Caco-2 |
title_sort |
Atividade probiótica de Bifidobacterium animalis e Lactobacillus casei na imunomodulação e na aderência de Escherichia coli enteroagregativa (EAEC) em células intestinais Caco-2 |
author |
Lima, Andrezza Maria Côrtes Thomé |
author_facet |
Lima, Andrezza Maria Côrtes Thomé andrezza_mct@hotmail.com |
author_role |
author |
author2 |
andrezza_mct@hotmail.com |
author2_role |
author |
dc.contributor.advisor1.fl_str_mv |
Fonseca, Adenilson de Souza da |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/8838215858149851 |
dc.contributor.referee1.fl_str_mv |
Mencalha, Andre Luiz |
dc.contributor.referee1Lattes.fl_str_mv |
http://lattes.cnpq.br/2640957642674082 |
dc.contributor.referee2.fl_str_mv |
Paoli, Flávia de |
dc.contributor.referee2Lattes.fl_str_mv |
http://lattes.cnpq.br/3197885404348516 |
dc.contributor.referee3.fl_str_mv |
Trajano, Eduardo Tavares Lima |
dc.contributor.referee3Lattes.fl_str_mv |
http://lattes.cnpq.br/1104445346920483 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/6309556867511284 |
dc.contributor.author.fl_str_mv |
Lima, Andrezza Maria Côrtes Thomé andrezza_mct@hotmail.com |
contributor_str_mv |
Fonseca, Adenilson de Souza da Mencalha, Andre Luiz Paoli, Flávia de Trajano, Eduardo Tavares Lima |
dc.subject.eng.fl_str_mv |
Escherichia coli EAEC Lactobacillus Bifidobacterium Probiotics Immunomodulation Adhesion Caco-2 Cytokines |
topic |
Escherichia coli EAEC Lactobacillus Bifidobacterium Probiotics Immunomodulation Adhesion Caco-2 Cytokines Escherichia coli EAEC Lactobacillus Bifidobacterium Probióticos Imunomodulação Aderência Caco-2 Citocinas CIENCIAS DA SAUDE::FISIOTERAPIA E TERAPIA OCUPACIONAL |
dc.subject.por.fl_str_mv |
Escherichia coli EAEC Lactobacillus Bifidobacterium Probióticos Imunomodulação Aderência Caco-2 Citocinas |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE::FISIOTERAPIA E TERAPIA OCUPACIONAL |
description |
Enteroaggregative Escherichia coli (EAEC) is an E. coli pathotype that characteristically shows aggregative adhesion pattern on in vitro cultured cells, mainly related to persistent infant diarrhea cases. Probiotics are non-pathogenic living microorganisms that confer health benefits. These organisms usually provide protection against pathogens, living naturally in microbiota and are often found in fermented foods such as dairy products. Probiotic bacteria have activity against foodborne pathogens, being able to promote biofilm formation reduction, inhibition of adhesion and injury of in vitro cultured cells, in vivo models diarrhea prevention and also immunomodulation. In this study, two bacterial species probiotic activity on the virulence of EAEC strains was evaluated. Probiotic species Bifidobacterium animalis DN 173010 (Danone®) and Lactobacillus casei Shirota (Yakult®) were evaluated on immunomodulation ability and interference of EAEC 042, 1500, H92/3 and I49 strains adhesion in Caco-2 cells, under co-cultivation experiments. Caco-2 cells were submitted EAEC strains infection in presence and absence of both probiotics, separately and together. The EAEC strains substantially increased IL-8 production by infected Caco-2 cells, whereas it not occurs with other cytokines. In synergistic condition, probiotic strains proved to be able to modulate pro-inflammatory cytokines IL-1β, IL-6, IL-10 and TNF-α production of Caco-2 cells infected by EAEC. However, probiotic strains did not modulate IL-8 production. Increased TNF-α production by both infected and non-EAEC infected cells was induced by probiotics. Probiotics reestablished the anti-inflammatory cytokine IL-10 production in EAEC infection. EAEC strains showed diverse Caco-2 cell quantitative adherence numbers when co-cultivated with probiotics, which adhesion increased or decreased on differentiated and non-differentiated Caco-2 cells. Probiotic strains adhere similarly on differentiated and non-differentiated Caco-2 cells. These results suggest that probiotics presence may interfere in different ways on infection by distinct EAEC strains. This study helps to clarify the role that probiotic bacterial strains activity plays in EAEC infection. |
publishDate |
2020 |
dc.date.issued.fl_str_mv |
2020-05-28 |
dc.date.accessioned.fl_str_mv |
2023-07-28T16:15:39Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/doctoralThesis |
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doctoralThesis |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
FERREIRA, Andréa Fonseca. Atividade probiótica de Bifidobacterium animalis e Lactobacillus casei na imunomodulação e na aderência de Escherichia coli enteroagregativa (EAEC) em células intestinais Caco-2. 2019. 74 f. Tese (Doutorado em Microbiologia) – Faculdade de Ciências Médicas, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, 2019. |
dc.identifier.uri.fl_str_mv |
http://www.bdtd.uerj.br/handle/1/20071 |
identifier_str_mv |
FERREIRA, Andréa Fonseca. Atividade probiótica de Bifidobacterium animalis e Lactobacillus casei na imunomodulação e na aderência de Escherichia coli enteroagregativa (EAEC) em células intestinais Caco-2. 2019. 74 f. Tese (Doutorado em Microbiologia) – Faculdade de Ciências Médicas, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, 2019. |
url |
http://www.bdtd.uerj.br/handle/1/20071 |
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Universidade do Estado do Rio de Janeiro |
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Programa de Pós-Graduação em Biociências |
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UERJ |
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Brasil |
dc.publisher.department.fl_str_mv |
Centro Biomédico::Instituto de Biologia Roberto Alcantara Gomes |
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Universidade do Estado do Rio de Janeiro |
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