Efeito do tratamento periodontal não-cirúrgico sobre o controle glicêmico, mediadores inflamatórios e adipocinas em pacientes com diabetes mellitus tipo 2 e periodontite crônica severa

• Autor(a) principal: Felipe, Maria Emília Mesquita Cansanção
• Data de Publicação: 2015
• Tipo de documento: Tese
• Idioma: por
• Título da fonte: Biblioteca Digital de Teses e Dissertações da UERJ
• Texto Completo: http://www.bdtd.uerj.br/handle/1/14054
• topic: Diabetes Mellitus; Periodontal disease; Inflammatory markers; Adipokines; Diabetes Mellitus; Doença Periodontal; Marcadores Inflamatórios; Adipocinas; CNPQ::CIENCIAS DA SAUDE::ODONTOLOGIA

The aim of this study was to evaluate the effects of non-surgical periodontal treatment on glycemic control, adipokines and systemic inflammatory mediators levels in patients with severe chronic periodontitis and diabetes mellitus type 2 (DM2). Fourty-one patients with severe chronic periodontitis and DM2 were randomly allocated in the test group (21 patients, mean age 58.1 ± 8.4 years, 11 men and 10 women) underwent nonsurgical periodontal treatment; and the control group (20 patients, mean age 54.1 ± 9.9 years, 14 men and 6 women) who remained untreated. The clinical parameters (probing depth - PD, clinical attachment level - CAL, BOP- bleeding on probing and plaque index - PI), laboratory (glycated hemoglobin - HbA1c, total cholesterol - TC, HDL, LDL and triglycerides) and inflammatory mediators (interleukin - 1β and -6, tumor necrosis factor-α, resistin, leptin and adiponectin) were evaluated at baseline and 90 days after periodontal therapy. After 90 days, there was a reduction in the% of sites with BOP, PI and sites with PD ≥ 6 mm in the test group. HbA1c levels, estimated glucose, IL-1β, TNF-α and resistin also significantly decreased in this group. There were no significant changes in the other markers in both groups. In conclusion, non-surgical periodontal treatment improved glycemic control in patients with severe chronic periodontitis and DM2. IL-1β, TNF-α and resistin levels decreased significantly after 3 months of the treatment.