Níveis séricos dos ácidos graxos poliinsaturados de cadeia longa em pacientes com doença periodontal

• Autor(a) principal: Martinez, Gisele Lago
• Data de Publicação: 2012
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Biblioteca Digital de Teses e Dissertações da UERJ
• Texto Completo: http://www.bdtd.uerj.br/handle/1/14205
• topic: Activity iflammatory process; Metabolism regulation; Periodontal disease; Polyunsaturated fatty acid; Ácidos graxos poliinsaturados; Atividade inflamatória; Doença periodontal; Metabolismo lipídico; CNPQ::CIENCIAS DA SAUDE::ODONTOLOGIA

Recent research has questioned whether the expression of polyunsaturated fatty acids (PUFAs) may be related to the pathogenesis of periodontal disease. PUFAs are affected by cyclooxygenases and lipoxygenases that may interfere with the production of eicosanoids and other oxidized derivatives can influence inflammation and immunity. Our goal was to analyze the serum levels of docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), docosapentaenóico acid (DPA) and arachidonic acid (AA) in patients with generalyzed chronic periodontitis and compare them to gingivitis subjects. Twenty-one patients with periodontitis (mean age of 46.0 ± 8.8 years) and 16 individuals with gingivitis (mean age 31.5 ± 7.5 years) were investigated. Clinical examination was performed with a computerized probe (Florida Probe®) to probing pocket depth (PPD), clinical attachment level (CAL), bleeding on probing (BOP) and plaque index (IPl). Blood samples were analyzed for triglycerides, total cholesterol, HDL-C, LDL-C, VLDL-C, hs-CRP, leukocytes, glycated hemoglobin, glucose, insulin and quantification of DHA, EPA, DPA and AA using gas chromatography. Differences between groups were calculated using Student's t test or Mann-Whitney and analysis of covariance (ANCOVA) adjusting for age and sex, and correlations by Pearson's correlation coefficient (rs). Patients with periodontitis had significantly higher levels of all long-chain polyunsaturated fatty acid (LC-PUFAs) compared to subjects with gingivitis (p < 0.05). No difference was found between groups for the ratios of n-6/n-3 LC-PUFAs. The levels of glycated hemoglobin and glucose were higher in the periodontitis group (p < 0.05). The others parameters blood did not differ significantly. PPD and CAL were positively correlated with LC-PUFAs n-6 and n-3, exception CAL and EPA. We conclude that serum levels of DHA, EPA, DPA and AA were signifcantly higher in patients with generalyzed chronic periodontitis when compared to gingivitis subjects, suggest that the increased level of LC-PUFAs n-3 and n-6, AA mainly, may be related to periodontal tissue destruction.