Jejum intermitente em camundongos alimentados com dieta hiperlipídica ou dieta rica em frutose: analise do fígado, ilhota pancreática e tecido adiposo branco
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | |
Tipo de documento: | Tese |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações da UERJ |
Texto Completo: | http://www.bdtd.uerj.br/handle/1/21067 |
Resumo: | Objective: The study aimed to evaluate the effects on intermittent fasting (IF) on the liver (structure, steatosis, and metabolism), the pancreas (mass of beta cells, molecular markers), and subcutaneous white adipose tissue (WATs, beige adipocyte formation and thermogenic gene expression). Methodology: Male C57BL / 6 mice, aged three months, were fed control diet (C, 10% Kcal fat), high-fat diet (HF, 50% Kcal fat) or diet high in fructose (HFr, 50% Kcal fructose) for eight weeks. Then, half of each group was submitted to IF for an additional four weeks (feeding 24 h / fasting 24 h), forming six groups: C, C-IF, HF, HF-IF, HFr and HFr-IF. Results: The HF and HFr groups presented hyperglycemia, hyperinsulinemia, hyperleptinemia, hypoadiponectinemia, increased hepatic steatosis, and pancreatic islet hypertrophy with increased alpha and beta-cell mass, as well as adipocyte hypertrophy of WATs. Food intake on the day fed in groups with fast were not different between groups, but HF-IF and HFr-IF groups had a reduction in body mass, total cholesterol and triacylglycerol. The oral glucose tolerance test and insulinemia improved in the IF, regardless of the diet consumed, as well as decreased liver lipogenesis and increased beta-oxidation, resulting in reduced hepatic steatosis and inflammation. Insulin resistance increased in the HF group and was reduced in the HF-IF group. There was a decrease in the p-AKT / AKT (protein kinase B) ratio in the HF group, and IF increased this ratio in the HF-IF group. The p53 tumor suppressor increased in the HF group and IF decreased it in the HF-IF group. The IF led to a reduction in the size of the pancreatic islets and the mass of alpha and beta cells, in addition to improving insulin signaling and decreasing apoptosis. There was browning in WATs in the HF-IF animals and increased respiratory quotient (RQ) on the fed day. UCP (uncoupled protein) 1 increased in the groups with IF, which also decreased inflammatory markers and pro-apoptotic markers in the adipocytes of WATs. Conclusions: IF improved the metabolism of carbohydrates and hepatic pro-inflammatory markers, in addition to regulating the mass of alpha and beta cells and improving insulin signaling with decreased apoptosis, even with continued intake of the HF diet. The IF also promotes browning in WATs adipocytes, acting on thermogenesis and the adipoinsular axis, with improved response to leptin, insulin, and inflammatory markers |
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Lacerda, Márcia Barbosa Águila Mandarim dehttp://lattes.cnpq.br/0119459843172158Mandarim-de-Lacerda, Carlos Albertohttp://lattes.cnpq.br/2960155071929174Carvalho, Jorge José dehttp://lattes.cnpq.br/2608779267915272Dôres, Silvia Maria Custódio dashttp://lattes.cnpq.br/0407406842124499Texeira, Michelle Teixeirahttp://lattes.cnpq.br/5798390719855026http://lattes.cnpq.br/7650577915119496Marinho, Thatiany de Souzathatymarinho@gmail.com2024-02-08T20:33:16Z2020-03-14MARINHO, Thatiany de Souza. Efeitos do jejum intermitente no fígado, na ilhota pancreática e no adipócito de camundongos alimentados com dieta hiperlipídica ou dieta rica em frutose. 2020. 115 f. Tese (Doutorado em Biologia Humana e Experimental) – Instituto de Biologia Roberto Alcântara Gomes, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, 2020.http://www.bdtd.uerj.br/handle/1/21067Objective: The study aimed to evaluate the effects on intermittent fasting (IF) on the liver (structure, steatosis, and metabolism), the pancreas (mass of beta cells, molecular markers), and subcutaneous white adipose tissue (WATs, beige adipocyte formation and thermogenic gene expression). Methodology: Male C57BL / 6 mice, aged three months, were fed control diet (C, 10% Kcal fat), high-fat diet (HF, 50% Kcal fat) or diet high in fructose (HFr, 50% Kcal fructose) for eight weeks. Then, half of each group was submitted to IF for an additional four weeks (feeding 24 h / fasting 24 h), forming six groups: C, C-IF, HF, HF-IF, HFr and HFr-IF. Results: The HF and HFr groups presented hyperglycemia, hyperinsulinemia, hyperleptinemia, hypoadiponectinemia, increased hepatic steatosis, and pancreatic islet hypertrophy with increased alpha and beta-cell mass, as well as adipocyte hypertrophy of WATs. Food intake on the day fed in groups with fast were not different between groups, but HF-IF and HFr-IF groups had a reduction in body mass, total cholesterol and triacylglycerol. The oral glucose tolerance test and insulinemia improved in the IF, regardless of the diet consumed, as well as decreased liver lipogenesis and increased beta-oxidation, resulting in reduced hepatic steatosis and inflammation. Insulin resistance increased in the HF group and was reduced in the HF-IF group. There was a decrease in the p-AKT / AKT (protein kinase B) ratio in the HF group, and IF increased this ratio in the HF-IF group. The p53 tumor suppressor increased in the HF group and IF decreased it in the HF-IF group. The IF led to a reduction in the size of the pancreatic islets and the mass of alpha and beta cells, in addition to improving insulin signaling and decreasing apoptosis. There was browning in WATs in the HF-IF animals and increased respiratory quotient (RQ) on the fed day. UCP (uncoupled protein) 1 increased in the groups with IF, which also decreased inflammatory markers and pro-apoptotic markers in the adipocytes of WATs. Conclusions: IF improved the metabolism of carbohydrates and hepatic pro-inflammatory markers, in addition to regulating the mass of alpha and beta cells and improving insulin signaling with decreased apoptosis, even with continued intake of the HF diet. The IF also promotes browning in WATs adipocytes, acting on thermogenesis and the adipoinsular axis, with improved response to leptin, insulin, and inflammatory markersObjetivo: O estudo avalia os efeitos no jejum intermitente (JI) no fígado (estrutura, esteatose e metabolismo), no pâncreas (massa de células beta, marcadores moleculares), e no tecido adiposo branco subcutâneo (TABs, formação de adipócitos bege e expressão de genes termogênicos). Metodologia: Camundongos machos C57BL/6, com três meses de idade, foram alimentados com dietas controle (C, 10% Kcal de gordura), hiperlipídica (HF, 50% Kcal de gordura) ou rica em frutose (HFr, 50% Kcal frutose) por oito semanas. Depois, metade de cada grupo foi submetido ao JI por quatro semanas adicionais (alimentação 24h / jejum 24h), formando seis grupos: C, C-JI, HF, HF-JI, HFr e HFr-JI. Resultados: Os grupos HF e HFr apresentaram hiperglicemia, hiperinsulinemia, hiperleptinemia, hipoadiponectinemia, aumento da esteatose hepática e hipertrofia das ilhotas pancreáticas com aumento da massa das células alfa e beta, bem como hipertrofia de adipócitos do TABs. A ingestão de alimentos no dia alimentado dos grupos com jejum não foi diferente entre os grupos, mas os grupos HF-JI e HFr-JI tiveram redução da massa corporal, do colesterol total e triacilglicerol. O teste oral de tolerância à glicose e a insulinemia melhoraram no JI, independentemente da dieta consumida, bem como diminuição da lipogênese hepática e aumento da beta-oxidação, resultando em redução da esteatose hepática e da inflamação. A resistência à insulina aumentou no grupo HF, e foi reduzida no grupo HF-JI. Houve diminuição da relação p-AKT/AKT (proteína quinase B) no grupo HF, e JI aumentou esta relação no grupo HF-JI. O supressor de tumor p53 aumentou no grupo HF e JI diminuiu no grupo HF-JI. O JI levou à redução do tamanho das ilhotas pancreáticas e da massa das células alfa e beta, além de melhorar a sinalização da insulina e diminuir a apoptose. O grupo HF-JI teve escurecimento do TABs e quociente respiratório (RQ) aumentado no dia alimentado. UCP1 aumentou nos grupos com JI, que também diminuiu marcadores inflamatórios e marcadores pró-apoptóticos nos adipócitos do TABs. Conclusões: O JI melhorou o metabolismo de carboidratos e marcadores pró-inflamatórios hepáticos, além de regular a massa de células alfa e beta e melhorar a sinalização da insulina com diminuição de a apoptose, mesmo com a ingestão continuada de dieta HF. O JI também promove o escurecimento dos adipócitos do TABs, agindo na termogênese e no eixo adipoinsular, com melhora da resposta à leptina, insulina e marcadores inflamatóriosSubmitted by Felipe CB/A (felipebibliotecario@gmail.com) on 2024-02-08T20:33:16Z No. of bitstreams: 1 Tese - Thatiany de Souza Marinho - 2020 - Completa.pdf: 5117999 bytes, checksum: 72592984cc5ae0a69a5ec6b01e524b86 (MD5)Made available in DSpace on 2024-02-08T20:33:16Z (GMT). No. of bitstreams: 1 Tese - Thatiany de Souza Marinho - 2020 - Completa.pdf: 5117999 bytes, checksum: 72592984cc5ae0a69a5ec6b01e524b86 (MD5) Previous issue date: 2020-03-14Conselho Nacional de Desenvolvimento Científico e Tecnológico - CNPqCoordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESFundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro - FAPERJapplication/pdfporUniversidade do Estado do Rio de JaneiroPrograma de Pós-Graduação em Biologia Humana e ExperimentalUERJBrasilCentro Biomédico::Instituto de Biologia Roberto Alcantara GomesDietsIntermittent fastingInflammationSteatosisBeta-cell massThermogenesisDieta hiperlipídicaJejum intermitenteFrutoseGorduras na dietaInflamaçãoCamundongosDietasEsteatoseMassa de células betaTermogêneseCIENCIAS BIOLOGICAS::MORFOLOGIAJejum intermitente em camundongos alimentados com dieta hiperlipídica ou dieta rica em frutose: analise do fígado, ilhota pancreática e tecido adiposo brancoIntermittent fasting in mice feeding a hyperlipidic diet or a fructose-rich diet: analysis of liver, pancreatic island, and white adipose tissueinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisinfo:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da UERJinstname:Universidade do Estado do Rio de Janeiro (UERJ)instacron:UERJORIGINALTese - Thatiany de Souza Marinho - 2020 - Completa.pdfTese - Thatiany de Souza Marinho - 2020 - Completa.pdfapplication/pdf5117999http://www.bdtd.uerj.br/bitstream/1/21067/2/Tese+-+Thatiany+de+Souza+Marinho+-+2020+-+Completa.pdf72592984cc5ae0a69a5ec6b01e524b86MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82011http://www.bdtd.uerj.br/bitstream/1/21067/1/license.txtba23dde015e31ff1802d858071d990cdMD511/210672024-02-26 15:24:05.456oai:www.bdtd.uerj.br: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Biblioteca Digital de Teses e Dissertaçõeshttp://www.bdtd.uerj.br/PUBhttps://www.bdtd.uerj.br:8443/oai/requestbdtd.suporte@uerj.bropendoar:29032024-02-26T18:24:05Biblioteca Digital de Teses e Dissertações da UERJ - Universidade do Estado do Rio de Janeiro (UERJ)false |
dc.title.por.fl_str_mv |
Jejum intermitente em camundongos alimentados com dieta hiperlipídica ou dieta rica em frutose: analise do fígado, ilhota pancreática e tecido adiposo branco |
dc.title.alternative.eng.fl_str_mv |
Intermittent fasting in mice feeding a hyperlipidic diet or a fructose-rich diet: analysis of liver, pancreatic island, and white adipose tissue |
title |
Jejum intermitente em camundongos alimentados com dieta hiperlipídica ou dieta rica em frutose: analise do fígado, ilhota pancreática e tecido adiposo branco |
spellingShingle |
Jejum intermitente em camundongos alimentados com dieta hiperlipídica ou dieta rica em frutose: analise do fígado, ilhota pancreática e tecido adiposo branco Marinho, Thatiany de Souza Diets Intermittent fasting Inflammation Steatosis Beta-cell mass Thermogenesis Dieta hiperlipídica Jejum intermitente Frutose Gorduras na dieta Inflamação Camundongos Dietas Esteatose Massa de células beta Termogênese CIENCIAS BIOLOGICAS::MORFOLOGIA |
title_short |
Jejum intermitente em camundongos alimentados com dieta hiperlipídica ou dieta rica em frutose: analise do fígado, ilhota pancreática e tecido adiposo branco |
title_full |
Jejum intermitente em camundongos alimentados com dieta hiperlipídica ou dieta rica em frutose: analise do fígado, ilhota pancreática e tecido adiposo branco |
title_fullStr |
Jejum intermitente em camundongos alimentados com dieta hiperlipídica ou dieta rica em frutose: analise do fígado, ilhota pancreática e tecido adiposo branco |
title_full_unstemmed |
Jejum intermitente em camundongos alimentados com dieta hiperlipídica ou dieta rica em frutose: analise do fígado, ilhota pancreática e tecido adiposo branco |
title_sort |
Jejum intermitente em camundongos alimentados com dieta hiperlipídica ou dieta rica em frutose: analise do fígado, ilhota pancreática e tecido adiposo branco |
author |
Marinho, Thatiany de Souza |
author_facet |
Marinho, Thatiany de Souza thatymarinho@gmail.com |
author_role |
author |
author2 |
thatymarinho@gmail.com |
author2_role |
author |
dc.contributor.advisor1.fl_str_mv |
Lacerda, Márcia Barbosa Águila Mandarim de |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/0119459843172158 |
dc.contributor.referee1.fl_str_mv |
Mandarim-de-Lacerda, Carlos Alberto |
dc.contributor.referee1Lattes.fl_str_mv |
http://lattes.cnpq.br/2960155071929174 |
dc.contributor.referee2.fl_str_mv |
Carvalho, Jorge José de |
dc.contributor.referee2Lattes.fl_str_mv |
http://lattes.cnpq.br/2608779267915272 |
dc.contributor.referee3.fl_str_mv |
Dôres, Silvia Maria Custódio das |
dc.contributor.referee3Lattes.fl_str_mv |
http://lattes.cnpq.br/0407406842124499 |
dc.contributor.referee4.fl_str_mv |
Texeira, Michelle Teixeira |
dc.contributor.referee4Lattes.fl_str_mv |
http://lattes.cnpq.br/5798390719855026 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/7650577915119496 |
dc.contributor.author.fl_str_mv |
Marinho, Thatiany de Souza thatymarinho@gmail.com |
contributor_str_mv |
Lacerda, Márcia Barbosa Águila Mandarim de Mandarim-de-Lacerda, Carlos Alberto Carvalho, Jorge José de Dôres, Silvia Maria Custódio das Texeira, Michelle Teixeira |
dc.subject.eng.fl_str_mv |
Diets Intermittent fasting Inflammation Steatosis Beta-cell mass Thermogenesis |
topic |
Diets Intermittent fasting Inflammation Steatosis Beta-cell mass Thermogenesis Dieta hiperlipídica Jejum intermitente Frutose Gorduras na dieta Inflamação Camundongos Dietas Esteatose Massa de células beta Termogênese CIENCIAS BIOLOGICAS::MORFOLOGIA |
dc.subject.por.fl_str_mv |
Dieta hiperlipídica Jejum intermitente Frutose Gorduras na dieta Inflamação Camundongos Dietas Esteatose Massa de células beta Termogênese |
dc.subject.cnpq.fl_str_mv |
CIENCIAS BIOLOGICAS::MORFOLOGIA |
description |
Objective: The study aimed to evaluate the effects on intermittent fasting (IF) on the liver (structure, steatosis, and metabolism), the pancreas (mass of beta cells, molecular markers), and subcutaneous white adipose tissue (WATs, beige adipocyte formation and thermogenic gene expression). Methodology: Male C57BL / 6 mice, aged three months, were fed control diet (C, 10% Kcal fat), high-fat diet (HF, 50% Kcal fat) or diet high in fructose (HFr, 50% Kcal fructose) for eight weeks. Then, half of each group was submitted to IF for an additional four weeks (feeding 24 h / fasting 24 h), forming six groups: C, C-IF, HF, HF-IF, HFr and HFr-IF. Results: The HF and HFr groups presented hyperglycemia, hyperinsulinemia, hyperleptinemia, hypoadiponectinemia, increased hepatic steatosis, and pancreatic islet hypertrophy with increased alpha and beta-cell mass, as well as adipocyte hypertrophy of WATs. Food intake on the day fed in groups with fast were not different between groups, but HF-IF and HFr-IF groups had a reduction in body mass, total cholesterol and triacylglycerol. The oral glucose tolerance test and insulinemia improved in the IF, regardless of the diet consumed, as well as decreased liver lipogenesis and increased beta-oxidation, resulting in reduced hepatic steatosis and inflammation. Insulin resistance increased in the HF group and was reduced in the HF-IF group. There was a decrease in the p-AKT / AKT (protein kinase B) ratio in the HF group, and IF increased this ratio in the HF-IF group. The p53 tumor suppressor increased in the HF group and IF decreased it in the HF-IF group. The IF led to a reduction in the size of the pancreatic islets and the mass of alpha and beta cells, in addition to improving insulin signaling and decreasing apoptosis. There was browning in WATs in the HF-IF animals and increased respiratory quotient (RQ) on the fed day. UCP (uncoupled protein) 1 increased in the groups with IF, which also decreased inflammatory markers and pro-apoptotic markers in the adipocytes of WATs. Conclusions: IF improved the metabolism of carbohydrates and hepatic pro-inflammatory markers, in addition to regulating the mass of alpha and beta cells and improving insulin signaling with decreased apoptosis, even with continued intake of the HF diet. The IF also promotes browning in WATs adipocytes, acting on thermogenesis and the adipoinsular axis, with improved response to leptin, insulin, and inflammatory markers |
publishDate |
2020 |
dc.date.issued.fl_str_mv |
2020-03-14 |
dc.date.accessioned.fl_str_mv |
2024-02-08T20:33:16Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/doctoralThesis |
format |
doctoralThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
MARINHO, Thatiany de Souza. Efeitos do jejum intermitente no fígado, na ilhota pancreática e no adipócito de camundongos alimentados com dieta hiperlipídica ou dieta rica em frutose. 2020. 115 f. Tese (Doutorado em Biologia Humana e Experimental) – Instituto de Biologia Roberto Alcântara Gomes, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, 2020. |
dc.identifier.uri.fl_str_mv |
http://www.bdtd.uerj.br/handle/1/21067 |
identifier_str_mv |
MARINHO, Thatiany de Souza. Efeitos do jejum intermitente no fígado, na ilhota pancreática e no adipócito de camundongos alimentados com dieta hiperlipídica ou dieta rica em frutose. 2020. 115 f. Tese (Doutorado em Biologia Humana e Experimental) – Instituto de Biologia Roberto Alcântara Gomes, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, 2020. |
url |
http://www.bdtd.uerj.br/handle/1/21067 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade do Estado do Rio de Janeiro |
dc.publisher.program.fl_str_mv |
Programa de Pós-Graduação em Biologia Humana e Experimental |
dc.publisher.initials.fl_str_mv |
UERJ |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Centro Biomédico::Instituto de Biologia Roberto Alcantara Gomes |
publisher.none.fl_str_mv |
Universidade do Estado do Rio de Janeiro |
dc.source.none.fl_str_mv |
reponame:Biblioteca Digital de Teses e Dissertações da UERJ instname:Universidade do Estado do Rio de Janeiro (UERJ) instacron:UERJ |
instname_str |
Universidade do Estado do Rio de Janeiro (UERJ) |
instacron_str |
UERJ |
institution |
UERJ |
reponame_str |
Biblioteca Digital de Teses e Dissertações da UERJ |
collection |
Biblioteca Digital de Teses e Dissertações da UERJ |
bitstream.url.fl_str_mv |
http://www.bdtd.uerj.br/bitstream/1/21067/2/Tese+-+Thatiany+de+Souza+Marinho+-+2020+-+Completa.pdf http://www.bdtd.uerj.br/bitstream/1/21067/1/license.txt |
bitstream.checksum.fl_str_mv |
72592984cc5ae0a69a5ec6b01e524b86 ba23dde015e31ff1802d858071d990cd |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
repository.name.fl_str_mv |
Biblioteca Digital de Teses e Dissertações da UERJ - Universidade do Estado do Rio de Janeiro (UERJ) |
repository.mail.fl_str_mv |
bdtd.suporte@uerj.br |
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1811728747576950784 |