Volumetria de vias aéreas através da tomografia computadorizada e associação com função pulmonar em pacientes com acromegalia

• Autor(a) principal: Camilo, Gustavo Bittencourt
• Data de Publicação: 2017
• Tipo de documento: Tese
• Idioma: por
• Título da fonte: Biblioteca Digital de Teses e Dissertações da UERJ
• Texto Completo: http://www.bdtd.uerj.br/handle/1/8613
• topic: Acromegaly; X-Ray - Computed tomography; Pulmonary -Function tests; Trachea; Tracheobronchomegaly; Airway obstruction; Diagnostic imaging; Acromegalia; Tomografia computadorizada por raios X; Testes de função pulmonar; Traqueia; Traqueobroncomegalia; Obstrução das vias respiratórias; Diagnóstico por imagem; Vias aéreas (Medicina) Doenças Imagem; Acromegalia Complicações e sequelas; Traqueia Imagem; Testes funcionais dos pulmões; Tomografia computadorizada por raios X; Diagnóstico por imagem; Traqueostomia Imagem; CNPQ::CIENCIAS DA SAUDE::MEDICINA::RADIOLOGIA MEDICA

Acromegaly is a rare, insidious and slowly progressive disease caused by chronic increase of growth hormone and insulin-like growth factor type I. To date, there have been no studies in the literature that have evaluated the use of airway volume through computed tomography (CT) in patients with acromegaly. The objectives of this study were to identify the main findings in the lower airways through CT in patients with acromegaly and to determine the type and extent of lower airway involvement. Two cross-sectional studies, a case series model, were performed with patients with acromegaly recruited at the Clementino Fraga Filho University Hospital and the Federal Hospital of Bonsucesso. The first study involved 20 patients with acromegaly and a control group composed of 20 paired individuals with respect to age, gender, height and weight. As a result of the first study, acromegalic patients presented higher proportions of forced expiratory flow and forced inspiratory flow at 50% of forced vital capacity (FEF50%/FIF50%) (2.05 vs. 1.06, p = 0.0001) compared to controls. The second study involved 28 patients with acromegaly and a control group composed of 15 paired individuals with respect to age, gender, height and weight. As a result of the second study, it was observed that, compared to the controls, patients with acromegaly had larger diameters in the trachea, right main bronchus and left main bronchus. As a conclusion, patients with acromegaly have tracheal structural alterations that are associated with functional indicators of obstruction of large airways, but not with clinical data. In addition, they present tracheobronchial gyrus, sinuosity and tracheal stenosis, as well as associations between the results of airway lumen volumetry and hormonal levels and functional parameters of the obstruction of the large airways.