Associação entre concentrações séricas de retinol e de hepcidina em crianças de 6 a 59 meses de idade
Autor(a) principal: | |
---|---|
Data de Publicação: | 2021 |
Outros Autores: | |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações da UERJ |
Texto Completo: | http://www.bdtd.uerj.br/handle/1/20502 |
Resumo: | Anemia is one of the main deficiency diseases in the world and the lack of vitamin A (VAD), usually determined by serum retinol concentrations, is one of the most important nutritional deficiencies in developing countries. Iron deficiency is believed to be one of the main causes of anemia, however, it can be determined by several factors. It is possible for a functional iron deficiency to develop due to changes in your homeostasis even when the iron stores are suitable. Systemically, iron homeostasis is controlled by the hormone hepcidin, which acts by reducing tissue mobilization and intestinal absorption of this mineral. Hepcidin synthesis is activated by the inflammation, but this activation mechanism has been poorly investigated in children. Additionally, it is known that VAD has been linked to inflammation. We aimed to evaluate the influence of serum retinol on hepcidin levels and anemia in children. This cross-sectional study included 312 children, aged 6–59 months, from Rio de Janeiro, Brazil. Multiple logistic regression was performed using anemia as the outcome and retinol and C-reactive protein (CRP) levels as predictive variables. The association between hepcidin and retinol levels, hematological parameters and body mass index (BMI) was analyzed using a generalized linear model with and without adjustment for CRP level. Logistic regression analysis was used to test anemia as an outcome and serum retinol level as a predictive variable using the odds ratio (OR) function. A total of 312 children were included in the study. Of them, about 67% were older than 24 months and 52% were male. Anemia was present in 14.6% of the children, 5.8% presented iron deficiency anemia and 9.6% had vitamin A deficiency. The increase in serum retinol levels reduced the chances of anemia (OR = 0.13; confidence interval = 0.29–0.59). When CRP level was not adjusted for in the multiple regression analyses, retinol level was a predictor of serum hepcidin levels, ferritin levels, and BMI/age (β = -3.36, 0.14, 1.02, respectively; p = 0.032). Accordingly, serum retinol levels were inversely associated with CRP levels (β = -0.025 and p = 0.000). Socioeconomic indicators were included and did not influence hepcidin levels in the studied population, suggesting a connection determined by biological factors. The association observed between retinol and hepcidin levels may explain why strategies to control anemia based on iron supplementation alone have limited impact on the overall prevalence of anemia. In the sample studied, anemia without iron deficiency was present in approximately two-thirds of the children with anemia, which could be explained by inflammation anemia and the need to improve the understanding of the relationship between vitamin A, hepcidin levels, and anemia in children. To our knowledge, this is the first study to assess the connection between serum retinol and hepcidin in children aged 6 to 59 months. Conclusions: The association between serum retinol and hepcidin levels in children aged 6–59 months seems to be dependent on inflammation. Taken together, these results reinforce the need for nutritional care and public policies to include vitamin A supplementation in anemia prevention and treatment regimens. |
id |
UERJ_536c1ed20b623f028cdf0e13ef29aa4c |
---|---|
oai_identifier_str |
oai:www.bdtd.uerj.br:1/20502 |
network_acronym_str |
UERJ |
network_name_str |
Biblioteca Digital de Teses e Dissertações da UERJ |
repository_id_str |
2903 |
spelling |
Reis, Marta Citelli doshttp://lattes.cnpq.br/1136248028072284Pereira, Alessandra da Silvahttp://lattes.cnpq.br/4947624998243616Castro, Inês Rugani Ribeiro dehttp://lattes.cnpq.br/7156846059999820Mocellin, Michel Carloshttp://lattes.cnpq.br/8112062034560158http://lattes.cnpq.br/6189408291474360Silva, Amanda de Paulaamanda.de.paula@hotmail.com2023-10-24T16:07:27Z2021-06-18SILVA, Amanda de Paula. Associação entre concentrações séricas de retinol e de hepcidina em crianças de 6 a 59 meses de idade. 2021. 64 f. Dissertação (Mestrado em Alimentação, Nutrição e Saúde) – Instituto de Nutrição, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, 2021.http://www.bdtd.uerj.br/handle/1/20502Anemia is one of the main deficiency diseases in the world and the lack of vitamin A (VAD), usually determined by serum retinol concentrations, is one of the most important nutritional deficiencies in developing countries. Iron deficiency is believed to be one of the main causes of anemia, however, it can be determined by several factors. It is possible for a functional iron deficiency to develop due to changes in your homeostasis even when the iron stores are suitable. Systemically, iron homeostasis is controlled by the hormone hepcidin, which acts by reducing tissue mobilization and intestinal absorption of this mineral. Hepcidin synthesis is activated by the inflammation, but this activation mechanism has been poorly investigated in children. Additionally, it is known that VAD has been linked to inflammation. We aimed to evaluate the influence of serum retinol on hepcidin levels and anemia in children. This cross-sectional study included 312 children, aged 6–59 months, from Rio de Janeiro, Brazil. Multiple logistic regression was performed using anemia as the outcome and retinol and C-reactive protein (CRP) levels as predictive variables. The association between hepcidin and retinol levels, hematological parameters and body mass index (BMI) was analyzed using a generalized linear model with and without adjustment for CRP level. Logistic regression analysis was used to test anemia as an outcome and serum retinol level as a predictive variable using the odds ratio (OR) function. A total of 312 children were included in the study. Of them, about 67% were older than 24 months and 52% were male. Anemia was present in 14.6% of the children, 5.8% presented iron deficiency anemia and 9.6% had vitamin A deficiency. The increase in serum retinol levels reduced the chances of anemia (OR = 0.13; confidence interval = 0.29–0.59). When CRP level was not adjusted for in the multiple regression analyses, retinol level was a predictor of serum hepcidin levels, ferritin levels, and BMI/age (β = -3.36, 0.14, 1.02, respectively; p = 0.032). Accordingly, serum retinol levels were inversely associated with CRP levels (β = -0.025 and p = 0.000). Socioeconomic indicators were included and did not influence hepcidin levels in the studied population, suggesting a connection determined by biological factors. The association observed between retinol and hepcidin levels may explain why strategies to control anemia based on iron supplementation alone have limited impact on the overall prevalence of anemia. In the sample studied, anemia without iron deficiency was present in approximately two-thirds of the children with anemia, which could be explained by inflammation anemia and the need to improve the understanding of the relationship between vitamin A, hepcidin levels, and anemia in children. To our knowledge, this is the first study to assess the connection between serum retinol and hepcidin in children aged 6 to 59 months. Conclusions: The association between serum retinol and hepcidin levels in children aged 6–59 months seems to be dependent on inflammation. Taken together, these results reinforce the need for nutritional care and public policies to include vitamin A supplementation in anemia prevention and treatment regimens.A anemia é uma das principais doenças carenciais no mundo e a deficiência de vitamina A (DVA), usualmente determinada pelas concentrações séricas de retinol, é uma das mais importantes deficiências nutricionais dos países em desenvolvimento. Acredita-se que a deficiência de ferro seja uma das principais causas de anemia, porém, esta pode ser determinada por diversos fatores. É possível que uma deficiência funcional de ferro se desenvolva por alterações na sua homeostase mesmo quando as reservas de ferro estejam adequadas. De forma sistêmica, a homeostase de ferro é controlada pelo hormônio hepcidina, que atua reduzindo a mobilização tecidual e absorção intestinal deste mineral. A síntese de hepcidina é ativada pela inflamação, mas este mecanismo de ativação foi pouco investigado em crianças. Adicionalmente, sabe-se que DVA tem sido associada à inflamação. O objetivo foi estudar a associação da vitamina A com anemia e concentrações séricas de hepcidina em crianças menores de cinco anos. Estudo transversal com 312 crianças de 6 a 59 meses usuárias do Sistema Único de Saúde no Rio de Janeiro, Brasil. Foi realizada uma regressão logística múltipla, testando anemia como desfecho, retinol e proteína C reativa (PCR) como variáveis preditivas. A associação entre hepcidina e retinol séricos, parâmetros hematológicos (ferritina, hemoglobina, hematócrito, VCM, HCM e CHCM) e índice de massa corporal/idade (IMC/I) foi analisada pelo modelo linear generalizado (GLM) com e sem ajuste para PCR. Além disso, a análise de regressão logística foi usada para testar a anemia como desfecho e o retinol sérico como variável preditiva, usando a função de razão de chance. As análises foram ajustadas para sexo, idade, escolaridade materna e renda familiar. Foram incluídas no estudo 312 crianças. Destas, aproximadamente 67% tinham mais de 24 meses e 52% eram do sexo masculino. A prevalência de anemia foi 14,6%, a de anemia ferropriva foi 5,8%e a de deficiência de vitamina A foi 9,6%. O aumento das concentrações séricas de retinol sérico reduziu as chances de anemia (OR = 0,13; intervalo de confiança = 0,29-0,59). Quando não ajustado para PCR, no GLM, retinol foi um preditor de hepcidina sérica, juntamente com ferritina e IMC/I (β = -3,36, 0,14, 1,02, respectivamente; p= 0,032). O retinol sérico associou-se inversamente à PCR (β = -0,025; p= 0,000). Indicadores socioeconômicos foram incluídos e não influenciaram os níveis de hepcidina na população estudada, sugerindo uma associação determinada por fatores biológicos. A associação observada entre os níveis de retinol e hepcidina pode explicar porque as estratégias para controlar a anemia baseadas apenas na suplementação de ferro têm um impacto limitado na prevalência geral da anemia. Na amostra estudada, a anemia sem deficiência de ferro estava presente em aproximadamente dois terços das crianças com anemia, o que poderia ser explicado pela anemia de inflamação e a necessidade de melhorar a compreensão da relação entre vitamina A, níveis de hepcidina e anemia em crianças. Até onde sabemos, este é o primeiro estudo a avaliar a associação entre retinol sérico e hepcidina em crianças de 6 a 59 meses. Conclusões: A associação entre as concentrações séricas de retinol e hepcidina em crianças de 6 a 59 meses parece ser dependente de inflamação. Tomados em conjunto, os resultados reforçam a necessidade do desenvolvimento de novos estudos para melhor compreender a relação entre a vitamina A e a anemia de inflamação.Submitted by Barbara Marques CEH/A (barbara_marques@id.uff.br) on 2023-10-24T16:07:27Z No. of bitstreams: 1 Dissertação - Amanda de Paula Silva - 2021 - Completa.pdf: 655930 bytes, checksum: 7873fc81b3ddd5a5f99b175de0f1b67c (MD5)Made available in DSpace on 2023-10-24T16:07:27Z (GMT). No. of bitstreams: 1 Dissertação - Amanda de Paula Silva - 2021 - Completa.pdf: 655930 bytes, checksum: 7873fc81b3ddd5a5f99b175de0f1b67c (MD5) Previous issue date: 2021-06-18application/pdfporUniversidade do Estado do Rio de JaneiroPrograma de Pós-Graduação em Alimentação, Nutrição e SaúdeUERJBrasilCentro Biomédico::Instituto de NutriçãoRetinolAnemiaInflammationHepcidinChildrenRetinolAnemiaInflamaçãoHepcidinaCriançasCIENCIAS DA SAUDE::NUTRICAO::BIOQUIMICA DA NUTRICAOAssociação entre concentrações séricas de retinol e de hepcidina em crianças de 6 a 59 meses de idadeInfluence of vitamin A on anemia and serum hepcidin levels in children aged 6 to 59 monthsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da UERJinstname:Universidade do Estado do Rio de Janeiro (UERJ)instacron:UERJORIGINALDissertação - Amanda de Paula Silva - 2021 - Completa.pdfDissertação - Amanda de Paula Silva - 2021 - Completa.pdfapplication/pdf655930http://www.bdtd.uerj.br/bitstream/1/20502/2/Disserta%C3%A7%C3%A3o+-+Amanda+de+Paula+Silva+-+2021+-+Completa.pdf7873fc81b3ddd5a5f99b175de0f1b67cMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82123http://www.bdtd.uerj.br/bitstream/1/20502/1/license.txte5502652da718045d7fcd832b79fca29MD511/205022024-02-23 16:32:20.351oai:www.bdtd.uerj.br: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Biblioteca Digital de Teses e Dissertaçõeshttp://www.bdtd.uerj.br/PUBhttps://www.bdtd.uerj.br:8443/oai/requestbdtd.suporte@uerj.bropendoar:29032024-02-23T19:32:20Biblioteca Digital de Teses e Dissertações da UERJ - Universidade do Estado do Rio de Janeiro (UERJ)false |
dc.title.por.fl_str_mv |
Associação entre concentrações séricas de retinol e de hepcidina em crianças de 6 a 59 meses de idade |
dc.title.alternative.eng.fl_str_mv |
Influence of vitamin A on anemia and serum hepcidin levels in children aged 6 to 59 months |
title |
Associação entre concentrações séricas de retinol e de hepcidina em crianças de 6 a 59 meses de idade |
spellingShingle |
Associação entre concentrações séricas de retinol e de hepcidina em crianças de 6 a 59 meses de idade Silva, Amanda de Paula Retinol Anemia Inflammation Hepcidin Children Retinol Anemia Inflamação Hepcidina Crianças CIENCIAS DA SAUDE::NUTRICAO::BIOQUIMICA DA NUTRICAO |
title_short |
Associação entre concentrações séricas de retinol e de hepcidina em crianças de 6 a 59 meses de idade |
title_full |
Associação entre concentrações séricas de retinol e de hepcidina em crianças de 6 a 59 meses de idade |
title_fullStr |
Associação entre concentrações séricas de retinol e de hepcidina em crianças de 6 a 59 meses de idade |
title_full_unstemmed |
Associação entre concentrações séricas de retinol e de hepcidina em crianças de 6 a 59 meses de idade |
title_sort |
Associação entre concentrações séricas de retinol e de hepcidina em crianças de 6 a 59 meses de idade |
author |
Silva, Amanda de Paula |
author_facet |
Silva, Amanda de Paula amanda.de.paula@hotmail.com |
author_role |
author |
author2 |
amanda.de.paula@hotmail.com |
author2_role |
author |
dc.contributor.advisor1.fl_str_mv |
Reis, Marta Citelli dos |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/1136248028072284 |
dc.contributor.advisor-co1.fl_str_mv |
Pereira, Alessandra da Silva |
dc.contributor.advisor-co1Lattes.fl_str_mv |
http://lattes.cnpq.br/4947624998243616 |
dc.contributor.referee1.fl_str_mv |
Castro, Inês Rugani Ribeiro de |
dc.contributor.referee1Lattes.fl_str_mv |
http://lattes.cnpq.br/7156846059999820 |
dc.contributor.referee2.fl_str_mv |
Mocellin, Michel Carlos |
dc.contributor.referee2Lattes.fl_str_mv |
http://lattes.cnpq.br/8112062034560158 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/6189408291474360 |
dc.contributor.author.fl_str_mv |
Silva, Amanda de Paula amanda.de.paula@hotmail.com |
contributor_str_mv |
Reis, Marta Citelli dos Pereira, Alessandra da Silva Castro, Inês Rugani Ribeiro de Mocellin, Michel Carlos |
dc.subject.eng.fl_str_mv |
Retinol Anemia Inflammation Hepcidin Children |
topic |
Retinol Anemia Inflammation Hepcidin Children Retinol Anemia Inflamação Hepcidina Crianças CIENCIAS DA SAUDE::NUTRICAO::BIOQUIMICA DA NUTRICAO |
dc.subject.por.fl_str_mv |
Retinol Anemia Inflamação Hepcidina Crianças |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE::NUTRICAO::BIOQUIMICA DA NUTRICAO |
description |
Anemia is one of the main deficiency diseases in the world and the lack of vitamin A (VAD), usually determined by serum retinol concentrations, is one of the most important nutritional deficiencies in developing countries. Iron deficiency is believed to be one of the main causes of anemia, however, it can be determined by several factors. It is possible for a functional iron deficiency to develop due to changes in your homeostasis even when the iron stores are suitable. Systemically, iron homeostasis is controlled by the hormone hepcidin, which acts by reducing tissue mobilization and intestinal absorption of this mineral. Hepcidin synthesis is activated by the inflammation, but this activation mechanism has been poorly investigated in children. Additionally, it is known that VAD has been linked to inflammation. We aimed to evaluate the influence of serum retinol on hepcidin levels and anemia in children. This cross-sectional study included 312 children, aged 6–59 months, from Rio de Janeiro, Brazil. Multiple logistic regression was performed using anemia as the outcome and retinol and C-reactive protein (CRP) levels as predictive variables. The association between hepcidin and retinol levels, hematological parameters and body mass index (BMI) was analyzed using a generalized linear model with and without adjustment for CRP level. Logistic regression analysis was used to test anemia as an outcome and serum retinol level as a predictive variable using the odds ratio (OR) function. A total of 312 children were included in the study. Of them, about 67% were older than 24 months and 52% were male. Anemia was present in 14.6% of the children, 5.8% presented iron deficiency anemia and 9.6% had vitamin A deficiency. The increase in serum retinol levels reduced the chances of anemia (OR = 0.13; confidence interval = 0.29–0.59). When CRP level was not adjusted for in the multiple regression analyses, retinol level was a predictor of serum hepcidin levels, ferritin levels, and BMI/age (β = -3.36, 0.14, 1.02, respectively; p = 0.032). Accordingly, serum retinol levels were inversely associated with CRP levels (β = -0.025 and p = 0.000). Socioeconomic indicators were included and did not influence hepcidin levels in the studied population, suggesting a connection determined by biological factors. The association observed between retinol and hepcidin levels may explain why strategies to control anemia based on iron supplementation alone have limited impact on the overall prevalence of anemia. In the sample studied, anemia without iron deficiency was present in approximately two-thirds of the children with anemia, which could be explained by inflammation anemia and the need to improve the understanding of the relationship between vitamin A, hepcidin levels, and anemia in children. To our knowledge, this is the first study to assess the connection between serum retinol and hepcidin in children aged 6 to 59 months. Conclusions: The association between serum retinol and hepcidin levels in children aged 6–59 months seems to be dependent on inflammation. Taken together, these results reinforce the need for nutritional care and public policies to include vitamin A supplementation in anemia prevention and treatment regimens. |
publishDate |
2021 |
dc.date.issued.fl_str_mv |
2021-06-18 |
dc.date.accessioned.fl_str_mv |
2023-10-24T16:07:27Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SILVA, Amanda de Paula. Associação entre concentrações séricas de retinol e de hepcidina em crianças de 6 a 59 meses de idade. 2021. 64 f. Dissertação (Mestrado em Alimentação, Nutrição e Saúde) – Instituto de Nutrição, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, 2021. |
dc.identifier.uri.fl_str_mv |
http://www.bdtd.uerj.br/handle/1/20502 |
identifier_str_mv |
SILVA, Amanda de Paula. Associação entre concentrações séricas de retinol e de hepcidina em crianças de 6 a 59 meses de idade. 2021. 64 f. Dissertação (Mestrado em Alimentação, Nutrição e Saúde) – Instituto de Nutrição, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, 2021. |
url |
http://www.bdtd.uerj.br/handle/1/20502 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade do Estado do Rio de Janeiro |
dc.publisher.program.fl_str_mv |
Programa de Pós-Graduação em Alimentação, Nutrição e Saúde |
dc.publisher.initials.fl_str_mv |
UERJ |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Centro Biomédico::Instituto de Nutrição |
publisher.none.fl_str_mv |
Universidade do Estado do Rio de Janeiro |
dc.source.none.fl_str_mv |
reponame:Biblioteca Digital de Teses e Dissertações da UERJ instname:Universidade do Estado do Rio de Janeiro (UERJ) instacron:UERJ |
instname_str |
Universidade do Estado do Rio de Janeiro (UERJ) |
instacron_str |
UERJ |
institution |
UERJ |
reponame_str |
Biblioteca Digital de Teses e Dissertações da UERJ |
collection |
Biblioteca Digital de Teses e Dissertações da UERJ |
bitstream.url.fl_str_mv |
http://www.bdtd.uerj.br/bitstream/1/20502/2/Disserta%C3%A7%C3%A3o+-+Amanda+de+Paula+Silva+-+2021+-+Completa.pdf http://www.bdtd.uerj.br/bitstream/1/20502/1/license.txt |
bitstream.checksum.fl_str_mv |
7873fc81b3ddd5a5f99b175de0f1b67c e5502652da718045d7fcd832b79fca29 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
repository.name.fl_str_mv |
Biblioteca Digital de Teses e Dissertações da UERJ - Universidade do Estado do Rio de Janeiro (UERJ) |
repository.mail.fl_str_mv |
bdtd.suporte@uerj.br |
_version_ |
1792352389371527168 |