Análise comparativa dos métodos de citologia convencional e citologia em base líquida para amostras cérvico-vaginais no Hospital Naval Marcílio Dias

• Autor(a) principal: Oliveira, Antônio Carlos Almeida de
• Data de Publicação: 2020
• Outros Autores: [e-mail]
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Biblioteca Digital de Teses e Dissertações da UERJ
• Texto Completo: http://www.bdtd.uerj.br/handle/1/19585
• topic: Cervical cancer screening; Liquid-based cytology; Conventional cytology; Papanicolaou; Citologia em base líquida; Citologia convencional; CIENCIAS DA SAUDE::MEDICINA

Cervical cancer screening is an important tool in public health. Liquid-based cytology (LBC) has been performed at the studied hospital for 7 years. The present study compares the performance of two LBC techniques to conventional cytology. Our objective is to verify the sensitivity for the detection of neoplastic and pre- neoplastic epithelial atypia, as well as the positive predictive value of the three methodologies. We analyzed retrospectively 24,529 cases and evaluated the conventional cytology, ThinPrep®, and BD SurePath® performance categorizing the results according to the Brazilian Nomenclature for cervical reports, derived from Bethesda System (TBS). We also compared the level of unsatisfactory samples, the presence of elements from the squamocolumnar junction (SCJ) and organisms. ThinPrep® (1.43%) showed superior sensitivity over BD SurePath® (0.91) and conventional cytology (0.71) in terms of the detection of high- grade lesions, however, in terms of squamous atypia as a whole (ASC-US +), BD SurePath® (6.44%) proved to be more sensitive than conventional cytology (5.28%) and ThinPrep® (3.73%). The results show the advantage of implementing LBC in routine screening for cervical lesions. In this study, BD SurePath® achieved best the overall performance considering the studied variables.