Estudos dos Polimorfismos dos Genes da Apolipoproteína E (APOE) e do Receptor de LDL (RLDL - A370T) em Indivíduos Jovens Pertencentes ao Estudo do Rio de Janeiro em Seguimento de 28 Anos
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações da UERJ |
Texto Completo: | http://www.bdtd.uerj.br/handle/1/17308 |
Resumo: | Studies have shown the association of changes in the apolipoprotein E (ApoE) and LDL receptor (LDLR) with the occurrence of cardiovascular diseases and dyslipidemia. The objective of this study was to investigate the association between different ApoE genotypes and LDLR with the persistence of changes in lipid variables in young individuals followed-up 28 years in the study of Rio de Janeiro (ERJ). Through a longitudinal study cohort, 56 subjects (35M) in A1(13.30 ± 1.53 years), A2(22.09 ± 1.91 years) and A3(31.23 ± 1.99) were investigated. On all three occasions clinical evaluation was conducted. In A2 and A3: total cholesterol, HDL, LDL and triglycerides. In A3 was added to the study of genetic polymorphisms of the ApoE and LDLR. The fragments of interest in this study were amplified by PCR (polymerase chain reaction) and the genotypes were identified by reaction with the restriction enzyme HhaI and HaeIII for ApoE and LDLR polymorphisms, respectively. ApoE genotypes were identified as ε3/ε3 (62.5%), ε3/ε4 (25%), ε2/ε3 (5.4%), ε2/ε4 (5.4%) and ε4/ε4 (1.8%) and the LDLR genotypes identified as AA (85.7%), AT (12.5%) and TT (1.8%). ε2/ε2 genotype was not observed. The analysis of the distribution of ApoE and LDLR genotypes according to the permanence of the dyslipidemia in the study sample showed that all individuals with the ApoE genotype ε2/ε4 and ε4/ε4 kept at least one lipid changes in A2 and A3 and all individuals ApoE genotype ε2/ε3 had not altered lipids in A2 and A3, while for RLDL genotype no difference was found. When analyzed individually, no lipid variable altered in A2 and/or A3, associated with these genotypes, were found. The ApoE gene polymorphism was associated with the permanence of dyslipidemia in young individuals in a longitudinal follow-up study. |
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Silva, Dayse Aparecida daMagalhães, Maria Eliane CamposCarvalho, Elizeu FagundesNogueira, Armando da RochaFreitas, Rossana Ghessa Andrade de2022-03-16T17:18:37Z2011-08-23FREITAS, Rossana Ghessa Andrade de. Estudos dos Polimorfismos dos Genes da Apolipoproteína E (APOE) e do Receptor de LDL (RLDL - A370T) em Indivíduos Jovens Pertencentes ao Estudo do Rio de Janeiro em Seguimento de 28 Anos. 2011. 65 f. Dissertação (Mestrado em Biologia Humana e Experimental) - Instituto Roberto Alcantara Gomes, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, 2011http://www.bdtd.uerj.br/handle/1/17308Studies have shown the association of changes in the apolipoprotein E (ApoE) and LDL receptor (LDLR) with the occurrence of cardiovascular diseases and dyslipidemia. The objective of this study was to investigate the association between different ApoE genotypes and LDLR with the persistence of changes in lipid variables in young individuals followed-up 28 years in the study of Rio de Janeiro (ERJ). Through a longitudinal study cohort, 56 subjects (35M) in A1(13.30 ± 1.53 years), A2(22.09 ± 1.91 years) and A3(31.23 ± 1.99) were investigated. On all three occasions clinical evaluation was conducted. In A2 and A3: total cholesterol, HDL, LDL and triglycerides. In A3 was added to the study of genetic polymorphisms of the ApoE and LDLR. The fragments of interest in this study were amplified by PCR (polymerase chain reaction) and the genotypes were identified by reaction with the restriction enzyme HhaI and HaeIII for ApoE and LDLR polymorphisms, respectively. ApoE genotypes were identified as ε3/ε3 (62.5%), ε3/ε4 (25%), ε2/ε3 (5.4%), ε2/ε4 (5.4%) and ε4/ε4 (1.8%) and the LDLR genotypes identified as AA (85.7%), AT (12.5%) and TT (1.8%). ε2/ε2 genotype was not observed. The analysis of the distribution of ApoE and LDLR genotypes according to the permanence of the dyslipidemia in the study sample showed that all individuals with the ApoE genotype ε2/ε4 and ε4/ε4 kept at least one lipid changes in A2 and A3 and all individuals ApoE genotype ε2/ε3 had not altered lipids in A2 and A3, while for RLDL genotype no difference was found. When analyzed individually, no lipid variable altered in A2 and/or A3, associated with these genotypes, were found. The ApoE gene polymorphism was associated with the permanence of dyslipidemia in young individuals in a longitudinal follow-up study.Studies have shown the association of changes in the apolipoprotein E (ApoE) and LDL receptor (LDLR) with the occurrence of cardiovascular diseases and dyslipidemia. The objective of this study was to investigate the association between different ApoE genotypes and LDLR with the persistence of changes in lipid variables in young individuals followed-up 28 years in the study of Rio de Janeiro (ERJ). Through a longitudinal study cohort, 56 subjects (35M) in A1(13.30 ± 1.53 years), A2(22.09 ± 1.91 years) and A3(31.23 ± 1.99) were investigated. On all three occasions clinical evaluation was conducted. In A2 and A3: total cholesterol, HDL, LDL and triglycerides. In A3 was added to the study of genetic polymorphisms of the ApoE and LDLR. The fragments of interest in this study were amplified by PCR (polymerase chain reaction) and the genotypes were identified by reaction with the restriction enzyme HhaI and HaeIII for ApoE and LDLR polymorphisms, respectively. ApoE genotypes were identified as ε3/ε3 (62.5%), ε3/ε4 (25%), ε2/ε3 (5.4%), ε2/ε4 (5.4%) and ε4/ε4 (1.8%) and the LDLR genotypes identified as AA (85.7%), AT (12.5%) and TT (1.8%). ε2/ε2 genotype was not observed. The analysis of the distribution of ApoE and LDLR genotypes according to the permanence of the dyslipidemia in the study sample showed that all individuals with the ApoE genotype ε2/ε4 and ε4/ε4 kept at least one lipid changes in A2 and A3 and all individuals ApoE genotype ε2/ε3 had not altered lipids in A2 and A3, while for RLDL genotype no difference was found. When analyzed individually, no lipid variable altered in A2 and/or A3, associated with these genotypes, were found. The ApoE gene polymorphism was associated with the permanence of dyslipidemia in young individuals in a longitudinal follow-up study.Submitted by Thais Vieira NPROTEC (thaisvieira.uerj@gmail.com) on 2022-03-16T17:18:37Z No. of bitstreams: 1 Dissertaçao - Rossana Ghessa Andrade de Freitas -Completa - 2011.pdf: 859632 bytes, checksum: 4b40a76bcb50b3c5237bbb7bc6aebdf2 (MD5)Made available in DSpace on 2022-03-16T17:18:37Z (GMT). No. of bitstreams: 1 Dissertaçao - Rossana Ghessa Andrade de Freitas -Completa - 2011.pdf: 859632 bytes, checksum: 4b40a76bcb50b3c5237bbb7bc6aebdf2 (MD5) Previous issue date: 2011-08-23Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESapplication/pdfporUniversidade do Estado do Rio de JaneiroPrograma de Pós-Graduação em Biologia Humana e ExperimentalUERJBrasilCentro Biomédico::Instituto de Biologia Roberto Alcantara GomesPolimorfisnmo (Genética)Sistema CardiovascularGene polymorphismsCardiovascular diseasesCIENCIAS BIOLOGICAS::FISIOLOGIA::FISIOLOGIA DE ORGAOS E SISTEMAS::FISIOLOGIA CARDIOVASCULAREstudos dos Polimorfismos dos Genes da Apolipoproteína E (APOE) e do Receptor de LDL (RLDL - A370T) em Indivíduos Jovens Pertencentes ao Estudo do Rio de Janeiro em Seguimento de 28 AnosStudies of Apolipoprotein E (APOE) and LDL Receptor (LDL - A370T) Gene Polymorphisms in Young Individuals Belonging to the Rio de Janeiro Study in a 28-Year Follow-upinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da UERJinstname:Universidade do Estado do Rio de Janeiro (UERJ)instacron:UERJORIGINALDissertaçao - Rossana Ghessa Andrade de Freitas -Completa - 2011.pdfDissertaçao - Rossana Ghessa Andrade de Freitas -Completa - 2011.pdfapplication/pdf859632http://www.bdtd.uerj.br/bitstream/1/17308/2/Disserta%C3%A7ao+-+Rossana+Ghessa+Andrade+de+Freitas+-Completa+-+2011.pdf4b40a76bcb50b3c5237bbb7bc6aebdf2MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82123http://www.bdtd.uerj.br/bitstream/1/17308/1/license.txte5502652da718045d7fcd832b79fca29MD511/173082022-03-16 14:51:59.452oai:www.bdtd.uerj.br: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Biblioteca Digital de Teses e Dissertaçõeshttp://www.bdtd.uerj.br/PUBhttps://www.bdtd.uerj.br:8443/oai/requestbdtd.suporte@uerj.bropendoar:29032022-03-16T17:51:59Biblioteca Digital de Teses e Dissertações da UERJ - Universidade do Estado do Rio de Janeiro (UERJ)false |
dc.title.por.fl_str_mv |
Estudos dos Polimorfismos dos Genes da Apolipoproteína E (APOE) e do Receptor de LDL (RLDL - A370T) em Indivíduos Jovens Pertencentes ao Estudo do Rio de Janeiro em Seguimento de 28 Anos |
dc.title.alternative.eng.fl_str_mv |
Studies of Apolipoprotein E (APOE) and LDL Receptor (LDL - A370T) Gene Polymorphisms in Young Individuals Belonging to the Rio de Janeiro Study in a 28-Year Follow-up |
title |
Estudos dos Polimorfismos dos Genes da Apolipoproteína E (APOE) e do Receptor de LDL (RLDL - A370T) em Indivíduos Jovens Pertencentes ao Estudo do Rio de Janeiro em Seguimento de 28 Anos |
spellingShingle |
Estudos dos Polimorfismos dos Genes da Apolipoproteína E (APOE) e do Receptor de LDL (RLDL - A370T) em Indivíduos Jovens Pertencentes ao Estudo do Rio de Janeiro em Seguimento de 28 Anos Freitas, Rossana Ghessa Andrade de Polimorfisnmo (Genética) Sistema Cardiovascular Gene polymorphisms Cardiovascular diseases CIENCIAS BIOLOGICAS::FISIOLOGIA::FISIOLOGIA DE ORGAOS E SISTEMAS::FISIOLOGIA CARDIOVASCULAR |
title_short |
Estudos dos Polimorfismos dos Genes da Apolipoproteína E (APOE) e do Receptor de LDL (RLDL - A370T) em Indivíduos Jovens Pertencentes ao Estudo do Rio de Janeiro em Seguimento de 28 Anos |
title_full |
Estudos dos Polimorfismos dos Genes da Apolipoproteína E (APOE) e do Receptor de LDL (RLDL - A370T) em Indivíduos Jovens Pertencentes ao Estudo do Rio de Janeiro em Seguimento de 28 Anos |
title_fullStr |
Estudos dos Polimorfismos dos Genes da Apolipoproteína E (APOE) e do Receptor de LDL (RLDL - A370T) em Indivíduos Jovens Pertencentes ao Estudo do Rio de Janeiro em Seguimento de 28 Anos |
title_full_unstemmed |
Estudos dos Polimorfismos dos Genes da Apolipoproteína E (APOE) e do Receptor de LDL (RLDL - A370T) em Indivíduos Jovens Pertencentes ao Estudo do Rio de Janeiro em Seguimento de 28 Anos |
title_sort |
Estudos dos Polimorfismos dos Genes da Apolipoproteína E (APOE) e do Receptor de LDL (RLDL - A370T) em Indivíduos Jovens Pertencentes ao Estudo do Rio de Janeiro em Seguimento de 28 Anos |
author |
Freitas, Rossana Ghessa Andrade de |
author_facet |
Freitas, Rossana Ghessa Andrade de |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Silva, Dayse Aparecida da |
dc.contributor.advisor-co1.fl_str_mv |
Magalhães, Maria Eliane Campos |
dc.contributor.referee1.fl_str_mv |
Carvalho, Elizeu Fagundes |
dc.contributor.referee2.fl_str_mv |
Nogueira, Armando da Rocha |
dc.contributor.author.fl_str_mv |
Freitas, Rossana Ghessa Andrade de |
contributor_str_mv |
Silva, Dayse Aparecida da Magalhães, Maria Eliane Campos Carvalho, Elizeu Fagundes Nogueira, Armando da Rocha |
dc.subject.por.fl_str_mv |
Polimorfisnmo (Genética) Sistema Cardiovascular |
topic |
Polimorfisnmo (Genética) Sistema Cardiovascular Gene polymorphisms Cardiovascular diseases CIENCIAS BIOLOGICAS::FISIOLOGIA::FISIOLOGIA DE ORGAOS E SISTEMAS::FISIOLOGIA CARDIOVASCULAR |
dc.subject.eng.fl_str_mv |
Gene polymorphisms Cardiovascular diseases |
dc.subject.cnpq.fl_str_mv |
CIENCIAS BIOLOGICAS::FISIOLOGIA::FISIOLOGIA DE ORGAOS E SISTEMAS::FISIOLOGIA CARDIOVASCULAR |
description |
Studies have shown the association of changes in the apolipoprotein E (ApoE) and LDL receptor (LDLR) with the occurrence of cardiovascular diseases and dyslipidemia. The objective of this study was to investigate the association between different ApoE genotypes and LDLR with the persistence of changes in lipid variables in young individuals followed-up 28 years in the study of Rio de Janeiro (ERJ). Through a longitudinal study cohort, 56 subjects (35M) in A1(13.30 ± 1.53 years), A2(22.09 ± 1.91 years) and A3(31.23 ± 1.99) were investigated. On all three occasions clinical evaluation was conducted. In A2 and A3: total cholesterol, HDL, LDL and triglycerides. In A3 was added to the study of genetic polymorphisms of the ApoE and LDLR. The fragments of interest in this study were amplified by PCR (polymerase chain reaction) and the genotypes were identified by reaction with the restriction enzyme HhaI and HaeIII for ApoE and LDLR polymorphisms, respectively. ApoE genotypes were identified as ε3/ε3 (62.5%), ε3/ε4 (25%), ε2/ε3 (5.4%), ε2/ε4 (5.4%) and ε4/ε4 (1.8%) and the LDLR genotypes identified as AA (85.7%), AT (12.5%) and TT (1.8%). ε2/ε2 genotype was not observed. The analysis of the distribution of ApoE and LDLR genotypes according to the permanence of the dyslipidemia in the study sample showed that all individuals with the ApoE genotype ε2/ε4 and ε4/ε4 kept at least one lipid changes in A2 and A3 and all individuals ApoE genotype ε2/ε3 had not altered lipids in A2 and A3, while for RLDL genotype no difference was found. When analyzed individually, no lipid variable altered in A2 and/or A3, associated with these genotypes, were found. The ApoE gene polymorphism was associated with the permanence of dyslipidemia in young individuals in a longitudinal follow-up study. |
publishDate |
2011 |
dc.date.issued.fl_str_mv |
2011-08-23 |
dc.date.accessioned.fl_str_mv |
2022-03-16T17:18:37Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
FREITAS, Rossana Ghessa Andrade de. Estudos dos Polimorfismos dos Genes da Apolipoproteína E (APOE) e do Receptor de LDL (RLDL - A370T) em Indivíduos Jovens Pertencentes ao Estudo do Rio de Janeiro em Seguimento de 28 Anos. 2011. 65 f. Dissertação (Mestrado em Biologia Humana e Experimental) - Instituto Roberto Alcantara Gomes, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, 2011 |
dc.identifier.uri.fl_str_mv |
http://www.bdtd.uerj.br/handle/1/17308 |
identifier_str_mv |
FREITAS, Rossana Ghessa Andrade de. Estudos dos Polimorfismos dos Genes da Apolipoproteína E (APOE) e do Receptor de LDL (RLDL - A370T) em Indivíduos Jovens Pertencentes ao Estudo do Rio de Janeiro em Seguimento de 28 Anos. 2011. 65 f. Dissertação (Mestrado em Biologia Humana e Experimental) - Instituto Roberto Alcantara Gomes, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, 2011 |
url |
http://www.bdtd.uerj.br/handle/1/17308 |
dc.language.iso.fl_str_mv |
por |
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por |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
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Universidade do Estado do Rio de Janeiro |
dc.publisher.program.fl_str_mv |
Programa de Pós-Graduação em Biologia Humana e Experimental |
dc.publisher.initials.fl_str_mv |
UERJ |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Centro Biomédico::Instituto de Biologia Roberto Alcantara Gomes |
publisher.none.fl_str_mv |
Universidade do Estado do Rio de Janeiro |
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