Avaliação das alterações microcirculatórias renais secundárias ao uso de ivabradina em um modelo experimental de sepse em hamsters

• Autor(a) principal: Ferro, Ariana Gayer
• Data de Publicação: 2018
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Biblioteca Digital de Teses e Dissertações da UERJ
• Texto Completo: http://www.bdtd.uerj.br/handle/1/12716
• topic: Ivabradine; Sepsis; Renal microcirculation; Ivabradina; Sepse; Microcirculação renal; Ivabradina; Sepse; Microcirculação renal; CNPQ::CIENCIAS DA SAUDE

Ivabradine, an If current inhibitor in the sinoatrial node, has already been used in septic patients although few studies have examined its effects on microcirculatory renal function. Therefore, we have designed a controlled experimental study to characterize the microcirculatory effects of ivabradine on a murine model of abdominal sepsis that allows in vivo studies of microcirculation. Twenty-eight golden Syrian hamsters were allocated in groups: sham-operated; non-treated septic animals; septic animals treated with saline; septic animals treated with ivabradine (2.0 mg.kg-1 intravenous bolus + 0.5 mg.kg-1.h-1). The laser Doppler at left kidney allowed quantitative analysis of microvascular variables. Arterial blood pressure, heart rate, arterial blood gases, and hematological and biochemical parameters were documented. Sepsis decreased renal perfusion and was associated with organ dysfunction and metabolic acidosis. Ivabradine significantly attenuated these responses: compared with septic animals treated with saline, those treated with ivabradine had better organ and renal endothelial function. Thus, ivabradine was effective in reducing organ dysfunction and microvascular derangements evoked by experimental sepsis. These results suggest that ivabradine yields beneficial effects on septic animals renal microcirculation.