Efeitos benéficos da rosuvastatina no remodelamento da parede da aorta em ratos deficientes em óxido nítrico

• Autor(a) principal: Ferreira, Rodrigo Neto
• Data de Publicação: 2008
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Biblioteca Digital de Teses e Dissertações da UERJ
• Texto Completo: http://www.bdtd.uerj.br/handle/1/16084
• topic: Arterial hypertension; Nitric oxide; L-NAME; Vascular remodelling; Hipertensão arterial; Òxido nítrico; L-NAME; Remodelamento vascular; NG-Nitroarginina Metil Éster; Aorta; Óxido nítrico; Hipertensão arterial; CNPQ::CIENCIAS BIOLOGICAS::MORFOLOGIA

The excessive adiposity and increased blood pressure, beginning in hildhood, together with accelerated adverse longitudinal changes in risk variables of metabolic syndrome throughout young adulthood characterized the early natural history of hypertension. The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, or statins, affect the endothelial function independently of its hypolipemiant capacity and, additionally, could have importance in the control of the blood pressure due to their pleiotropic effects. This study aimed at evaluating the beneficial effects of Rosuvastatin upon structural and ultrastructural aortic remodeling in a model of hypertension induced by NO synthase blockade in rats. Wistar rats were divided into 4 groups: Control group (C), normotensive untreated; control treated group (CR), normotensive treated with Rosuvastatin (20mg/kg/day); L-NAME group (LN), hypertensive that received L-NAME (40mg/kg/day); and L-NAME treated group (LNR), which received L-NAME and Rosuvastatin in the same doses. Animals were deeply anaesthetized and killed after 5 weeks of drugs administration. The L-NAME administration yielded higher blood pressure (BP) values in LN and LNR groups. The concomitant treatment with L-NAME and Rosuvastatin showed efficacy in reducing BP levels in comparison with the hypertensive group. It was observed thicker internal and media tunics of thoracic aorta in LN group, but not in LNR group. All in all, the administration of Rosuvastatin to NO deficient animals provoked by chronic L-NAME administration during five weeks proved to have beneficial effects on BP, improved the endothelial dysfunction, and attenuated the adverse structural remodeling of the aortic wall