Periodontite crônica severa está associada à disfunção endotelial em pacientes sistemicamente saudáveis

• Autor(a) principal: Galhardo, Thaiana Sanches Campos
• Data de Publicação: 2014
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Biblioteca Digital de Teses e Dissertações da UERJ
• Texto Completo: http://www.bdtd.uerj.br/handle/1/14200
• topic: Aterosclerosis; Cardiovascular disease; Chronic periodontitis; Endothelium; Aterosclerose; Doenças cardiovasculares; Endotélio; Periodontite crônica; CNPQ::CIENCIAS DA SAUDE::ODONTOLOGIA

Periodontitis is a chronic inflammatory disease characterized by the destruction of the supporting tissues of the teeth in susceptible subjects. Studies indicated that periodontal disease is associated with increased risk of development of cardiovascular disease, but the mechanism is still not fully understood. The aim of this study was to evaluate the association between severe chronic periodontitis and endothelial dysfunction in systemically healthy patients. Eighteen non-smoking, non-obese, systemically healthy patients who did not use continuous medication and had not undergone periodontal treatment in the 6 months prior to baseline were evaluated. Ten patients were diagnosed with severe chronic periodontitis (median age [interquartile range] 46 years [12.3]) and were assigned to the test group, while the remaining 8 presented no clinical signs of periodontal inflammation, and were assigned to the group control (34.5 years [12.8]). The assessment of endothelial function in both groups was performed with the technique of peripheral arterial tonometry with Endo-PAT device. Blood analysis included measurements of high density lipoprotein (HDL), low density lipoprotein (LDL), triglycerides, total cholesterol, glycated hemoglobin, glucose, C-reactive protein (CRP) and fibrinogen. Among the patients in the test group, 70 % had endothelial dysfunction, whereas no patients in the control group showed endothelial dysfunction (p = 0.002). The reactive hyperemia index was significantly lower in the test group as compared with the control (1.52 [0.5] vs 2.10 [0.4]; P=0.001). This association remained significant after adjustment for age (p = 0.01). In conclusion, severe chronic periodontitis was associated with endothelial dysfunction in systemically healthy patients.