Técnica de oscilações forçadas na análise da função pulmonar de indivíduos com asma relacionada ao trabalho

• Autor(a) principal: Tuza, Fábio Augusto D Alegria
• Data de Publicação: 2020
• Outros Autores: [e-mail]
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Biblioteca Digital de Teses e Dissertações da UERJ
• Texto Completo: http://www.bdtd.uerj.br/handle/1/18721
• topic: Work-related asthma; Forced Oscillation Technique; Asma relacionada ao trabalho; Técnica de Oscilações Forçadas; Mecânica respiratória; Asma ocupacional – Fisiopatologia; Oscilometria; Testes de função pulmonar; Respiratory mechanics; CIENCIAS BIOLOGICAS::FISIOLOGIA::FISIOLOGIA DE ORGAOS E SISTEMAS::FISIOLOGIA DA RESPIRACAO

Work-related asthma (WRA) is characterized by obstructive airway hyperresponsiveness due to conditions in the work environment and not by stimuli outside the workplace. The forced oscillation technique (FOT) ) is a simple, non-invasive method, performed with spontaneous ventilation. It only requires passive cooperation, with no need for forced expiratory maneuvers. In this study, we used the parameters obtained from the multifrequency FOT and eRIC model. In this context, the objectives of the present study were: To analyze changes in respiratory mechanics in individuals with WRA; Evaluate the ability of FOT to detect changes in lung function resulting from WRA. This is a cross-sectional controlled study, in which 62 individuals were evaluated: 31 healthy and 31 with WRA. In the clinical evaluation, a questionnaire on respiratory symptoms and the Asthma Control Test (ACT) questionnaire were applied, in addition to the pulmonary function tests: spirometry, plethysmography and FOT (before and after use of bronchodilator. Through the analysis of the ROC curve from the comparison between the control group and the WRA group, the traditional parameter of FOT with greater accuracy (AUC = 0.92) was Fr (Resonance Frequency), where as the parameter of the eRIC model was RpeRIC (AUC = 0.79). in the ROC curve between WRA pre and post bronchodilation, Z4 was the best traditional parameter (AUC 0.72). In general, the spirometric and plethysmographic parameters showed reasonable correlations with FOT. FOT showed changes in resistive and reactive properties, in agreement with the pathophysiology of WRA. After bronchodilator administration, we noticed positive responses in all parameters of the FOT, except in IeRIC, configuring a reduction in and improvement of respiratory system compliance. X4, Cdin, R4 and Z4 allowed to adequately identify the effects of bronchodilation. Therefore, FOT can be useful as a complementary analysis in the study of the bronchodilator response in individuals with WRA. In addition, FOT has a simple and easy-to-apply methodology, which can be an adequate alternative both for longitudinal assessment and for the early identification of the disease and impaired lung function in individuals with WRA.