Hyperglycemia induced by acute central fluoxetine administration: role of the central CRH system and 5-HT3 receptors

Detalhes bibliográficos
Autor(a) principal: Carvalho, F.
Data de Publicação: 2004
Outros Autores: Barros, D., Silva, J., Rezende, E., Soares, M., Fregoneze, J., Silva, E. De Castro e
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/7543
Resumo: Texto completo:acesso restrito. p. 98-105
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spelling Carvalho, F.Barros, D.Silva, J.Rezende, E.Soares, M.Fregoneze, J.Silva, E. De Castro eCarvalho, F.Barros, D.Silva, J.Rezende, E.Soares, M.Fregoneze, J.Silva, E. De Castro e2012-12-14T14:23:42Z20040143-4179http://www.repositorio.ufba.br/ri/handle/ri/7543v. 38, n. 2-3Texto completo:acesso restrito. p. 98-105Brain serotonin and CRH systems participate in the control of blood glucose levels. We have previously demonstrated that the pharmacological stimulation of central 5-HT3 receptors, the target for several therapeutic agents used as antiemetics in the course of chemotherapy, induces hyperglycemia. The aim of the present study was to investigate the participation of the brain CRH component and 5-HT3 receptors in basal blood glucose levels as well as in the hyperglycemia induced by third ventricle injections of fluoxetine, a serotonin reuptake inhibitor with a broad range of clinical use. In this study, we used fasted adult Wistar male rats (220 20 g) whose third ventricles were cannulated 7 days prior to the experiments. Acute third ventricle injections of fluoxetine caused a significant increase in plasma glucose levels throughout the experiment. Pretreatment with a-helical CRH, a selective CRH antagonist, significantly blunted fluoxetine-induced hyperglycemia. Also, pretreatment with two distinct selective 5-HT3 receptor antagonists (LY-278,584 and ondansetron) significantly impaired the rise in plasma glucose levels observed in fluoxetine-treated animals pretreated with isotonic saline solution. None of these antagonists was able to modify blood glucose levels when injected alone into the third ventricle. Animals receiving third ventricle injections of fluoxetine, in spite of being hyperglycemic, presented plasma insulin levels similar to those displayed by normoglycemic, saline-treated controls. It is suggested that the acute increase in brain serotonergic activity caused by third ventricle injections of fluoxetine induces a hyperglycemic response that requires the functional integrity of the brain CRH system and 5-HT3 receptors. Also, it is proposed that the absence of a compensatory increase in plasma insulin levels may contribute to the generation of a hyperglycemic response after central fluoxetine administrationSubmitted by JURANDI DE SOUZA SILVA (jssufba@hotmail.com) on 2012-12-14T14:23:42Z No. of bitstreams: 1 1-s2.0-S0143417904000289-main.pdf: 297117 bytes, checksum: cba339d6b67eb3423f8d9b938f2595bb (MD5)Made available in DSpace on 2012-12-14T14:23:42Z (GMT). No. of bitstreams: 1 1-s2.0-S0143417904000289-main.pdf: 297117 bytes, checksum: cba339d6b67eb3423f8d9b938f2595bb (MD5) Previous issue date: 2004Elservierhttp://dx.doi.org/10.1016/j.npep.2004.04.004reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBASerotoninCRH5-HT3 receptorsLY-278584OndansetronInsulinHyperglycemia induced by acute central fluoxetine administration: role of the central CRH system and 5-HT3 receptorsNeuropeptidesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessORIGINAL1-s2.0-S0143417904000289-main.pdf1-s2.0-S0143417904000289-main.pdfapplication/pdf297117https://repositorio.ufba.br/bitstream/ri/7543/1/1-s2.0-S0143417904000289-main.pdfcba339d6b67eb3423f8d9b938f2595bbMD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/7543/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXT1-s2.0-S0143417904000289-main.pdf.txt1-s2.0-S0143417904000289-main.pdf.txtExtracted texttext/plain43423https://repositorio.ufba.br/bitstream/ri/7543/3/1-s2.0-S0143417904000289-main.pdf.txt7d4d545f1192d4a22ecf9eebf0587946MD53ri/75432022-07-05 14:03:19.696oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:19Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Hyperglycemia induced by acute central fluoxetine administration: role of the central CRH system and 5-HT3 receptors
dc.title.alternative.pt_BR.fl_str_mv Neuropeptides
title Hyperglycemia induced by acute central fluoxetine administration: role of the central CRH system and 5-HT3 receptors
spellingShingle Hyperglycemia induced by acute central fluoxetine administration: role of the central CRH system and 5-HT3 receptors
Carvalho, F.
Serotonin
CRH
5-HT3 receptors
LY-278
584
Ondansetron
Insulin
title_short Hyperglycemia induced by acute central fluoxetine administration: role of the central CRH system and 5-HT3 receptors
title_full Hyperglycemia induced by acute central fluoxetine administration: role of the central CRH system and 5-HT3 receptors
title_fullStr Hyperglycemia induced by acute central fluoxetine administration: role of the central CRH system and 5-HT3 receptors
title_full_unstemmed Hyperglycemia induced by acute central fluoxetine administration: role of the central CRH system and 5-HT3 receptors
title_sort Hyperglycemia induced by acute central fluoxetine administration: role of the central CRH system and 5-HT3 receptors
author Carvalho, F.
author_facet Carvalho, F.
Barros, D.
Silva, J.
Rezende, E.
Soares, M.
Fregoneze, J.
Silva, E. De Castro e
author_role author
author2 Barros, D.
Silva, J.
Rezende, E.
Soares, M.
Fregoneze, J.
Silva, E. De Castro e
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Carvalho, F.
Barros, D.
Silva, J.
Rezende, E.
Soares, M.
Fregoneze, J.
Silva, E. De Castro e
Carvalho, F.
Barros, D.
Silva, J.
Rezende, E.
Soares, M.
Fregoneze, J.
Silva, E. De Castro e
dc.subject.por.fl_str_mv Serotonin
CRH
5-HT3 receptors
LY-278
584
Ondansetron
Insulin
topic Serotonin
CRH
5-HT3 receptors
LY-278
584
Ondansetron
Insulin
description Texto completo:acesso restrito. p. 98-105
publishDate 2004
dc.date.issued.fl_str_mv 2004
dc.date.accessioned.fl_str_mv 2012-12-14T14:23:42Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/7543
dc.identifier.issn.none.fl_str_mv 0143-4179
dc.identifier.number.pt_BR.fl_str_mv v. 38, n. 2-3
identifier_str_mv 0143-4179
v. 38, n. 2-3
url http://www.repositorio.ufba.br/ri/handle/ri/7543
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elservier
publisher.none.fl_str_mv Elservier
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1016/j.npep.2004.04.004
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
instname_str Universidade Federal da Bahia (UFBA)
instacron_str UFBA
institution UFBA
reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
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