Annacardium occidentale stem bark extract can decrease the efficacy of antimicrobial drugs
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFBA |
Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/23068 |
Resumo: | Abstract Background: Due to the growing use of phytotherapy clinical strategies for infectious diseases, healthcare providers and patients must know the risks of interactions between such preparations and synthetic drugs. Cashew extracts are widely used in Brazil for complementary treatments of infectious diseases, and often are combined to antimicrobial drugs. However, the possible consequences of such combinations are unknown. Objective: To assess the interference of the Cashew stem bark hydroethanolic extract (CSBE) on certain antimicrobials against clinical isolates of staphylococcal species. Methodology: Antimicrobial susceptibility test and interference assays were performed using gentamycin, ampicilin, ciprofloxacin, G penicillin, neomycin, rifampicin and vancomycin disks. Results: Here we show that the CSBE might reduce the therapeutic activity of some antimicrobial drugs in Staphylococcal species. We found in controlled in vitro assays that the antagonistic effect was seen in all antimicrobial drugs tested for most of the strains and statistically significant differences were found when compared to the control antimicrobials. Our results also indicate the presence of tannins, flavonoids and saponins in the CSBE. Conclusion: Such combinations are suggested to be not adequate for clinical treatments. Further researches are needed for a better understating of such interactions at the molecular level. Keywords: Cashew. Interference. Antimicrobials. |
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Dias-Souza, Marcus ViníciusCaldoncelli, João LuisMonteiro, Andrea Souza2017-06-19T16:22:46Z2017-06-19T16:22:46Z2013-05Rev. Ciênc. Méd. Biol., Salvador, v.12, n.2, p.163-167, mai./ago. 20132236-5222http://repositorio.ufba.br/ri/handle/ri/23068v.12, n.2Abstract Background: Due to the growing use of phytotherapy clinical strategies for infectious diseases, healthcare providers and patients must know the risks of interactions between such preparations and synthetic drugs. Cashew extracts are widely used in Brazil for complementary treatments of infectious diseases, and often are combined to antimicrobial drugs. However, the possible consequences of such combinations are unknown. Objective: To assess the interference of the Cashew stem bark hydroethanolic extract (CSBE) on certain antimicrobials against clinical isolates of staphylococcal species. Methodology: Antimicrobial susceptibility test and interference assays were performed using gentamycin, ampicilin, ciprofloxacin, G penicillin, neomycin, rifampicin and vancomycin disks. Results: Here we show that the CSBE might reduce the therapeutic activity of some antimicrobial drugs in Staphylococcal species. We found in controlled in vitro assays that the antagonistic effect was seen in all antimicrobial drugs tested for most of the strains and statistically significant differences were found when compared to the control antimicrobials. Our results also indicate the presence of tannins, flavonoids and saponins in the CSBE. Conclusion: Such combinations are suggested to be not adequate for clinical treatments. Further researches are needed for a better understating of such interactions at the molecular level. Keywords: Cashew. Interference. Antimicrobials.Introdução: Com o aumento do uso de recursos fitoterápicos na clínica de doenças infecciosas, profissionais de saúde e pacientes devem ter ciência do risco das interações destes com preparações antimicrobianas sintéticas. Os extratos do cajueiro são amplamente utilizados no Brasil como recursos complementares no tratamento de doenças infecciosas, e em alguns casos, são associados a fármacos antimicrobianos, entretanto, pouco se conhece sobre as consequências destas associações. Objetivo: Avaliar possíveis interferências do extrato hidroetanólico da casca do cajueiro (EHCC) em alguns fármacos antimicrobianos de uso clínico sobre bactérias do gênero Staphylococcus. Metodologia: Testes de susceptibilidade antimicrobiana e interferência foram realizados com discos de gentamicina, ampicilina, ciprofloxacim, penicilina G, neomicina, rifampicina e vancomicina. Resultados: Demonstrou-se que o EHCC reduziu a atividade de alguns fármacos antimicrobianos. Ensaios in vitro indicaram que o efeito antagônico visto em todas as substâncias testadas na maioria das cepas microbianas teve diferença estatística em comparação às drogas testadas sem interação com o extrato. Foram detectados taninos, flavonoides e saponinas no EHCC. Conclusão: Os dados sugerem que as combinações avaliadas são inadequadas para uso clínico. Mais estudos são necessários para a caracterização das interações encontradas a nível molecular.Submitted by ROBERTO PAULO CORREIA DE ARAÚJO (ppgorgsistem@ufba.br) on 2017-06-19T16:22:46Z No. of bitstreams: 1 4_v.12_2.pdf: 318439 bytes, checksum: 59010950262cc3ad8e3377e0d2971ec8 (MD5)Made available in DSpace on 2017-06-19T16:22:46Z (GMT). No. of bitstreams: 1 4_v.12_2.pdf: 318439 bytes, checksum: 59010950262cc3ad8e3377e0d2971ec8 (MD5) Previous issue date: 2013-05SalvadorInstituto de Ciências da Saúde/ Universidade Federal da BahiaBrasilhttp://www.portalseer.ufba.br/index.php/cmbio/article/view/7043/6640reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBACajueiro.Interferência.Antimicrobianos.Annacardium occidentale stem bark extract can decrease the efficacy of antimicrobial drugsRevista de Ciências Médicas e Biológicasinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessporORIGINAL4_v.12_2.pdf4_v.12_2.pdfapplication/pdf318439https://repositorio.ufba.br/bitstream/ri/23068/1/4_v.12_2.pdf59010950262cc3ad8e3377e0d2971ec8MD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/23068/2/license.txtff6eaa8b858ea317fded99f125f5fcd0MD52TEXT4_v.12_2.pdf.txt4_v.12_2.pdf.txtExtracted texttext/plain19577https://repositorio.ufba.br/bitstream/ri/23068/3/4_v.12_2.pdf.txt0a99005919c49294182fa6a1f5e2cfa2MD53ri/230682022-03-10 14:07:11.917oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-03-10T17:07:11Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
dc.title.pt_BR.fl_str_mv |
Annacardium occidentale stem bark extract can decrease the efficacy of antimicrobial drugs |
dc.title.alternative.pt_BR.fl_str_mv |
Revista de Ciências Médicas e Biológicas |
title |
Annacardium occidentale stem bark extract can decrease the efficacy of antimicrobial drugs |
spellingShingle |
Annacardium occidentale stem bark extract can decrease the efficacy of antimicrobial drugs Dias-Souza, Marcus Vinícius Cajueiro. Interferência. Antimicrobianos. |
title_short |
Annacardium occidentale stem bark extract can decrease the efficacy of antimicrobial drugs |
title_full |
Annacardium occidentale stem bark extract can decrease the efficacy of antimicrobial drugs |
title_fullStr |
Annacardium occidentale stem bark extract can decrease the efficacy of antimicrobial drugs |
title_full_unstemmed |
Annacardium occidentale stem bark extract can decrease the efficacy of antimicrobial drugs |
title_sort |
Annacardium occidentale stem bark extract can decrease the efficacy of antimicrobial drugs |
author |
Dias-Souza, Marcus Vinícius |
author_facet |
Dias-Souza, Marcus Vinícius Caldoncelli, João Luis Monteiro, Andrea Souza |
author_role |
author |
author2 |
Caldoncelli, João Luis Monteiro, Andrea Souza |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Dias-Souza, Marcus Vinícius Caldoncelli, João Luis Monteiro, Andrea Souza |
dc.subject.por.fl_str_mv |
Cajueiro. Interferência. Antimicrobianos. |
topic |
Cajueiro. Interferência. Antimicrobianos. |
description |
Abstract Background: Due to the growing use of phytotherapy clinical strategies for infectious diseases, healthcare providers and patients must know the risks of interactions between such preparations and synthetic drugs. Cashew extracts are widely used in Brazil for complementary treatments of infectious diseases, and often are combined to antimicrobial drugs. However, the possible consequences of such combinations are unknown. Objective: To assess the interference of the Cashew stem bark hydroethanolic extract (CSBE) on certain antimicrobials against clinical isolates of staphylococcal species. Methodology: Antimicrobial susceptibility test and interference assays were performed using gentamycin, ampicilin, ciprofloxacin, G penicillin, neomycin, rifampicin and vancomycin disks. Results: Here we show that the CSBE might reduce the therapeutic activity of some antimicrobial drugs in Staphylococcal species. We found in controlled in vitro assays that the antagonistic effect was seen in all antimicrobial drugs tested for most of the strains and statistically significant differences were found when compared to the control antimicrobials. Our results also indicate the presence of tannins, flavonoids and saponins in the CSBE. Conclusion: Such combinations are suggested to be not adequate for clinical treatments. Further researches are needed for a better understating of such interactions at the molecular level. Keywords: Cashew. Interference. Antimicrobials. |
publishDate |
2013 |
dc.date.issued.fl_str_mv |
2013-05 |
dc.date.accessioned.fl_str_mv |
2017-06-19T16:22:46Z |
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2017-06-19T16:22:46Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Rev. Ciênc. Méd. Biol., Salvador, v.12, n.2, p.163-167, mai./ago. 2013 |
dc.identifier.uri.fl_str_mv |
http://repositorio.ufba.br/ri/handle/ri/23068 |
dc.identifier.issn.none.fl_str_mv |
2236-5222 |
dc.identifier.number.pt_BR.fl_str_mv |
v.12, n.2 |
identifier_str_mv |
Rev. Ciênc. Méd. Biol., Salvador, v.12, n.2, p.163-167, mai./ago. 2013 2236-5222 v.12, n.2 |
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http://repositorio.ufba.br/ri/handle/ri/23068 |
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Instituto de Ciências da Saúde/ Universidade Federal da Bahia |
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Brasil |
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Instituto de Ciências da Saúde/ Universidade Federal da Bahia |
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http://www.portalseer.ufba.br/index.php/cmbio/article/view/7043/6640 |
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