Serum kinetics of crotoxin from Crotalus durissus terrificus venom in mice: evidence for a rapid clearance

Detalhes bibliográficos
Autor(a) principal: Barral-Netto, Manoel
Data de Publicação: 1991
Outros Autores: Von Sohsten, R. L.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/7515
Resumo: Texto completo: acesso restrito. p. 527–531
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spelling Barral-Netto, ManoelVon Sohsten, R. L.Barral-Netto, ManoelVon Sohsten, R. L.2012-12-13T19:03:26Z2012-12-13T19:03:26Z19910041-0101http://www.repositorio.ufba.br/ri/handle/ri/7515v, 29, n. 4–5Texto completo: acesso restrito. p. 527–531M. Barral-Netto and R. L. von Sohsten. Serum kinetics of crotoxin from Crotalus durissus terrificus venom in mice: evidence for a rapid clearance. Toxicon29, 527–531, 1991.—We report on an ELISA for the detection of crotoxin with a detection limit of 1–3 pg/ml of sample. Cross-reactivity with other animal venoms occurred only at concentrations above 1 μg/ml. Serum kinetics of crotoxin were investigated in BALB/c mice after a single 10 μg s.c. dose of venom obtained from Crotalus durissus terrificus. Crotoxin levels were 254±141 ng/ml serum (View the MathML source) 15 min after venom injection, 3.9±0.5 ng/ml serum at 30 min and undetectable thereafter. The rapid clearance of crotoxin from the serum suggests that the test may be unsuitable for the clinical management of envenomation victims.Submitted by Santiago Fabio (fabio.ssantiago@hotmail.com) on 2012-12-13T19:03:26Z No. of bitstreams: 1 5555555.pdf: 642042 bytes, checksum: 81e46c7e29a9a849b802fc4e489e4469 (MD5)Made available in DSpace on 2012-12-13T19:03:26Z (GMT). No. of bitstreams: 1 5555555.pdf: 642042 bytes, checksum: 81e46c7e29a9a849b802fc4e489e4469 (MD5) Previous issue date: 1991SalvadorToxiconhttp://dx.doi.org/10.1016/0041-0101(91)90028-Preponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBASerum kinetics of crotoxin from Crotalus durissus terrificus venom in mice: evidence for a rapid clearanceToxiconinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleenginfo:eu-repo/semantics/openAccessLICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/7515/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52ORIGINAL5555555.pdf5555555.pdfapplication/pdf642042https://repositorio.ufba.br/bitstream/ri/7515/1/5555555.pdf81e46c7e29a9a849b802fc4e489e4469MD51TEXT5555555.pdf.txt5555555.pdf.txtExtracted texttext/plain5https://repositorio.ufba.br/bitstream/ri/7515/3/5555555.pdf.txtcc9067c2ee470dc248b14b194209a34eMD53ri/75152022-07-05 14:03:19.402oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:19Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Serum kinetics of crotoxin from Crotalus durissus terrificus venom in mice: evidence for a rapid clearance
dc.title.alternative.pt_BR.fl_str_mv Toxicon
title Serum kinetics of crotoxin from Crotalus durissus terrificus venom in mice: evidence for a rapid clearance
spellingShingle Serum kinetics of crotoxin from Crotalus durissus terrificus venom in mice: evidence for a rapid clearance
Barral-Netto, Manoel
title_short Serum kinetics of crotoxin from Crotalus durissus terrificus venom in mice: evidence for a rapid clearance
title_full Serum kinetics of crotoxin from Crotalus durissus terrificus venom in mice: evidence for a rapid clearance
title_fullStr Serum kinetics of crotoxin from Crotalus durissus terrificus venom in mice: evidence for a rapid clearance
title_full_unstemmed Serum kinetics of crotoxin from Crotalus durissus terrificus venom in mice: evidence for a rapid clearance
title_sort Serum kinetics of crotoxin from Crotalus durissus terrificus venom in mice: evidence for a rapid clearance
author Barral-Netto, Manoel
author_facet Barral-Netto, Manoel
Von Sohsten, R. L.
author_role author
author2 Von Sohsten, R. L.
author2_role author
dc.contributor.author.fl_str_mv Barral-Netto, Manoel
Von Sohsten, R. L.
Barral-Netto, Manoel
Von Sohsten, R. L.
description Texto completo: acesso restrito. p. 527–531
publishDate 1991
dc.date.issued.fl_str_mv 1991
dc.date.accessioned.fl_str_mv 2012-12-13T19:03:26Z
dc.date.available.fl_str_mv 2012-12-13T19:03:26Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/7515
dc.identifier.issn.none.fl_str_mv 0041-0101
dc.identifier.number.pt_BR.fl_str_mv v, 29, n. 4–5
identifier_str_mv 0041-0101
v, 29, n. 4–5
url http://www.repositorio.ufba.br/ri/handle/ri/7515
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Toxicon
publisher.none.fl_str_mv Toxicon
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1016/0041-0101(91)90028-P
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
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