Serum and intracellular magnesium deficiency in patients with metabolic syndrome—Evidences for its relation to insulin resistance

Detalhes bibliográficos
Autor(a) principal: Lima, Maria de Lourdes
Data de Publicação: 2009
Outros Autores: Cruz, Thomaz Rodrigues Porto da, Rodrigues, Luiz Erlon, Bomfim, Olívia, Melo, Juliana, Correia, Raquel, Porto, Mirna, Cedro, Alexandre, Vicente, Eliézer
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/5837
Resumo: Acesso restrito: Texto completo. p. 257-262
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spelling Lima, Maria de LourdesCruz, Thomaz Rodrigues Porto daRodrigues, Luiz ErlonBomfim, OlíviaMelo, JulianaCorreia, RaquelPorto, MirnaCedro, AlexandreVicente, EliézerLima, Maria de LourdesCruz, Thomaz Rodrigues Porto daRodrigues, Luiz ErlonBomfim, OlíviaMelo, JulianaCorreia, RaquelPorto, MirnaCedro, AlexandreVicente, Eliézer2012-05-11T13:37:05Z20090168-8227http://www.repositorio.ufba.br/ri/handle/ri/5837v. 83, n. 2Acesso restrito: Texto completo. p. 257-262This cross sectional study evaluated serum (SMg) and intramononuclear (MMg) magnesium in patients with metabolic syndrome without diabetes and correlated them with cardiovascular risk factors. 72 patients and 57 controls (blood donors) were studied. Hypomagnesemia (SMg < 1.7 mg/dL) was seen in 23.2% and intracellular depletion in 36.1% of the patients. SMg and MMg means were significantly lower in patients than in controls: 1.80 0.18 mg/dL vs. 2.43 0.43 mg/dL and 0.98 0.55 mg/mg vs. 1.67 0.64 mg/mg of protein (P < 0.001). Inverse correlation was observed between, SMg and MMg with BMI; SMg with systolic blood pressure and waist circumference in women. Patients with acanthosis nigricans had lower SMg (1.75 0.18 mg/dL vs. 1.85 0.18 mg/dL, P < 0.05). Non-white people had lower SMg (1.78 0.16 mg/dL vs. 1.92 0.24 mg/dL, P = 0.007) and MMg (0.95 0.59 mg/mg vs. 1.13 0.42 mg/mg, P = 0.03). Patients with IR showed lower MgM means (0.84 0.33 mg/mg vs. 1.14 0.69 mg/mg, P < 0.05). The same occurred in patients with low HDL-c levels (0.92 0.46 mg/mg vs. 1.20 0.70 mg/mg, P = 0.03), and those with moderate and severe hepatic steatosis (0.77 0.29 mg/mg vs. 1.21 0.80 mg/mg, P < 0.05). In conclusion, magnesium depletion in serum and mononuclear cells is common in obese people with metabolic syndrome, and it is more evident in non-white people with insulin resistance. This depletion may contribute to a post-receptor insulin resistanceSubmitted by JURANDI DE SOUZA SILVA (jssufba@hotmail.com) on 2012-05-11T13:37:05Z No. of bitstreams: 1 __ac.els-cdn.com_S016882...b740abb550b531830b4397496ef67.pdf: 214812 bytes, checksum: 22c975faf65f8acdd565963621a1e08d (MD5)Made available in DSpace on 2012-05-11T13:37:05Z (GMT). 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dc.title.pt_BR.fl_str_mv Serum and intracellular magnesium deficiency in patients with metabolic syndrome—Evidences for its relation to insulin resistance
dc.title.alternative.pt_BR.fl_str_mv Diabetes Research and Clinical Practice
title Serum and intracellular magnesium deficiency in patients with metabolic syndrome—Evidences for its relation to insulin resistance
spellingShingle Serum and intracellular magnesium deficiency in patients with metabolic syndrome—Evidences for its relation to insulin resistance
Lima, Maria de Lourdes
Metabolic Syndrome
Magnesium
Insulin Resistance
title_short Serum and intracellular magnesium deficiency in patients with metabolic syndrome—Evidences for its relation to insulin resistance
title_full Serum and intracellular magnesium deficiency in patients with metabolic syndrome—Evidences for its relation to insulin resistance
title_fullStr Serum and intracellular magnesium deficiency in patients with metabolic syndrome—Evidences for its relation to insulin resistance
title_full_unstemmed Serum and intracellular magnesium deficiency in patients with metabolic syndrome—Evidences for its relation to insulin resistance
title_sort Serum and intracellular magnesium deficiency in patients with metabolic syndrome—Evidences for its relation to insulin resistance
author Lima, Maria de Lourdes
author_facet Lima, Maria de Lourdes
Cruz, Thomaz Rodrigues Porto da
Rodrigues, Luiz Erlon
Bomfim, Olívia
Melo, Juliana
Correia, Raquel
Porto, Mirna
Cedro, Alexandre
Vicente, Eliézer
author_role author
author2 Cruz, Thomaz Rodrigues Porto da
Rodrigues, Luiz Erlon
Bomfim, Olívia
Melo, Juliana
Correia, Raquel
Porto, Mirna
Cedro, Alexandre
Vicente, Eliézer
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Lima, Maria de Lourdes
Cruz, Thomaz Rodrigues Porto da
Rodrigues, Luiz Erlon
Bomfim, Olívia
Melo, Juliana
Correia, Raquel
Porto, Mirna
Cedro, Alexandre
Vicente, Eliézer
Lima, Maria de Lourdes
Cruz, Thomaz Rodrigues Porto da
Rodrigues, Luiz Erlon
Bomfim, Olívia
Melo, Juliana
Correia, Raquel
Porto, Mirna
Cedro, Alexandre
Vicente, Eliézer
dc.subject.por.fl_str_mv Metabolic Syndrome
Magnesium
Insulin Resistance
topic Metabolic Syndrome
Magnesium
Insulin Resistance
description Acesso restrito: Texto completo. p. 257-262
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2012-05-11T13:37:05Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/5837
dc.identifier.issn.none.fl_str_mv 0168-8227
dc.identifier.number.pt_BR.fl_str_mv v. 83, n. 2
identifier_str_mv 0168-8227
v. 83, n. 2
url http://www.repositorio.ufba.br/ri/handle/ri/5837
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1016/j.diabres.2008.11.019
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
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