Effects of acute cold stress on phagocytosis of apoptotic cells: the role of corticosterone

Detalhes bibliográficos
Autor(a) principal: Costa, Renata Sesti
Data de Publicação: 2010
Outros Autores: Baccan, Gyselle Chrystina, Silva, Silvana Chedraoui, Mantovani, Bernardo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/12897
Resumo: Texto completo: acesso restrito. p. 79-87
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spelling Costa, Renata SestiBaccan, Gyselle ChrystinaSilva, Silvana ChedraouiMantovani, BernardoCosta, Renata SestiBaccan, Gyselle ChrystinaSilva, Silvana ChedraouiMantovani, Bernardo2013-09-10T19:38:36Z20101021-7401http://www.repositorio.ufba.br/ri/handle/ri/12897v. 17, n. 2Texto completo: acesso restrito. p. 79-87Background and Aims: Stress can alter many aspects of the immune response, and many studies have been conducted on the effects of stress on inflammatory processes, but little is known about its influence on the resolution of inflammation in tissue homeostasis, which includes the clearance of apoptotic cells by macrophages in a non-phlogistic way. In the present study, we investigated the effect of acute cold stress on the phagocytosis of apoptotic cells by macrophages. Methods: Mice were submitted to acute cold stress (4°C for 4 h) and the capacity of peritoneal macrophages to phagocyte apoptotic thymocytes and to secrete anti-inflammatory cytokines was evaluated. Plasma corticosterone and catecholamine levels were investigated to assess their effect on the phagocytic capacity of macrophages in vitro. Results: We showed that acute cold stress decreases phagocytosis of apoptotic cells at the inflammatory site by lipopolysaccharide-activated macrophages but did not affect resting macrophages. The inhibitory effect on phagocytosis is accompanied by a reduced level of TGF-β and higher IL-10 secretion. After stress, plasma concentrations of corticosterone increased 6-fold, epinephrine 2-fold and norepinephrine 1.7-fold compared to control mice. In vitro experiments showed that the decrease in phagocytosis after stress could be attributed, at least in part, to the effects of corticosterone; epinephrine and norepinephrine had no effect. Conclusions: The current study shows that acute cold stress decreases phagocytosis of apoptotic cells from an inflammatory environment by macrophages, and this inhibition is mediated by the intracellular glucocorticoid receptor.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2013-09-10T16:40:52Z No. of bitstreams: 1 258690.pdf: 158054 bytes, checksum: 8afae736b0fc567cac496e4af42fd4cf (MD5)Approved for entry into archive by Patricia Barroso(pbarroso@ufba.br) on 2013-09-10T19:38:36Z (GMT) No. of bitstreams: 1 258690.pdf: 158054 bytes, checksum: 8afae736b0fc567cac496e4af42fd4cf (MD5)Made available in DSpace on 2013-09-10T19:38:36Z (GMT). No. of bitstreams: 1 258690.pdf: 158054 bytes, checksum: 8afae736b0fc567cac496e4af42fd4cf (MD5) Previous issue date: 2010http://dx.doi.org/10.1159/000258690reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAApoptotic cellsCatecholaminesGlucocorticoidsMacrophagesPhagocytosisEffects of acute cold stress on phagocytosis of apoptotic cells: the role of corticosteroneNeuroimmunomodulationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessORIGINAL258690.pdf258690.pdfapplication/pdf158054https://repositorio.ufba.br/bitstream/ri/12897/1/258690.pdf8afae736b0fc567cac496e4af42fd4cfMD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/12897/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXT258690.pdf.txt258690.pdf.txtExtracted texttext/plain37351https://repositorio.ufba.br/bitstream/ri/12897/3/258690.pdf.txtafec9058bdb3b565808633a60e56b0cbMD53ri/128972022-08-08 13:17:48.695oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-08-08T16:17:48Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Effects of acute cold stress on phagocytosis of apoptotic cells: the role of corticosterone
dc.title.alternative.pt_BR.fl_str_mv Neuroimmunomodulation
title Effects of acute cold stress on phagocytosis of apoptotic cells: the role of corticosterone
spellingShingle Effects of acute cold stress on phagocytosis of apoptotic cells: the role of corticosterone
Costa, Renata Sesti
Apoptotic cells
Catecholamines
Glucocorticoids
Macrophages
Phagocytosis
title_short Effects of acute cold stress on phagocytosis of apoptotic cells: the role of corticosterone
title_full Effects of acute cold stress on phagocytosis of apoptotic cells: the role of corticosterone
title_fullStr Effects of acute cold stress on phagocytosis of apoptotic cells: the role of corticosterone
title_full_unstemmed Effects of acute cold stress on phagocytosis of apoptotic cells: the role of corticosterone
title_sort Effects of acute cold stress on phagocytosis of apoptotic cells: the role of corticosterone
author Costa, Renata Sesti
author_facet Costa, Renata Sesti
Baccan, Gyselle Chrystina
Silva, Silvana Chedraoui
Mantovani, Bernardo
author_role author
author2 Baccan, Gyselle Chrystina
Silva, Silvana Chedraoui
Mantovani, Bernardo
author2_role author
author
author
dc.contributor.author.fl_str_mv Costa, Renata Sesti
Baccan, Gyselle Chrystina
Silva, Silvana Chedraoui
Mantovani, Bernardo
Costa, Renata Sesti
Baccan, Gyselle Chrystina
Silva, Silvana Chedraoui
Mantovani, Bernardo
dc.subject.por.fl_str_mv Apoptotic cells
Catecholamines
Glucocorticoids
Macrophages
Phagocytosis
topic Apoptotic cells
Catecholamines
Glucocorticoids
Macrophages
Phagocytosis
description Texto completo: acesso restrito. p. 79-87
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2013-09-10T19:38:36Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/12897
dc.identifier.issn.none.fl_str_mv 1021-7401
dc.identifier.number.pt_BR.fl_str_mv v. 17, n. 2
identifier_str_mv 1021-7401
v. 17, n. 2
url http://www.repositorio.ufba.br/ri/handle/ri/12897
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1159/000258690
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
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instname_str Universidade Federal da Bahia (UFBA)
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reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
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