Spontaneous Neutrophil Activation in HTLV-1 Infected Patients

Detalhes bibliográficos
Autor(a) principal: Guerreiro, Jaqueline B.
Data de Publicação: 2005
Outros Autores: Porto, Maria Aurélia da Fonseca, Santos, Silvane Maria Braga, Lacerda, Lino, Ho, John L., Carvalho Filho, Edgar Marcelino de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/6927
Resumo: p. 510-514
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spelling Guerreiro, Jaqueline B.Porto, Maria Aurélia da FonsecaSantos, Silvane Maria BragaLacerda, LinoHo, John L.Carvalho Filho, Edgar Marcelino deGuerreiro, Jaqueline B.Porto, Maria Aurélia da FonsecaSantos, Silvane Maria BragaLacerda, LinoHo, John L.Carvalho Filho, Edgar Marcelino de2012-10-10T19:01:59Z2012-10-10T19:01:59Z2005http://www.repositorio.ufba.br/ri/handle/ri/6927p. 510-514Human T cell lymphotropic Virus type-1 (HTLV-1) induces lymphocyte activation and proliferation, but little is known about the innate immune response due to HTLV-1 infection. We evaluated the percentage of neutrophils that metabolize Nitroblue tetrazolium (NBT) to formazan in HTLV-1 infected subjects and the association between neutrophil activation and IFN-γ and TNF- α levels. Blood was collected from 35 HTLV-1 carriers, from 8 patients with HAM/TSP (HTLV-1- associated myelopathy); 22 healthy individuals were evaluated for spontaneous and lipopolysaccharide (LPS)-stimulated neutrophil activity (reduction of NBT to formazan). The production of IFN-γ and TNF-α by unstimulated mononuclear cells was determined by ELISA. Spontaneous NBT levels, as well as spontaneous IFN-γ and TNF-α production, were significantly higher (p<0.001) in HTLV-1 infected subjects than in healthy individuals. A trend towards a positive correlation was noted, with increasing percentage of NBT positive neutrophils and levels of IFN-γ. The high IFN-γ producing HTLV-1 patient group had significantly greater NBT than healthy controls, 43+24% and 17+4.8% respectively (p< 0.001), while no significant difference was observed between healthy controls and the low IFN-γ-producing HTLV-1 patient group (30+20%). Spontaneous neutrophil activation is another marker of immune perturbation resulting from HTLV-1 infection. In vivo activation of neutrophils observed in HTLV-1 infected subjects is likely to be the same process that causes spontaneous IFN-γ production, or it may partially result from direct IFN-γ stimulation.Submitted by Santiago Fabio (fabio.ssantiago@hotmail.com) on 2012-10-10T19:01:59Z No. of bitstreams: 1 Guerreiro, Jaqueline B..pdf: 46169 bytes, checksum: c97c65a83232a4ec2e1293a84ae84a84 (MD5)Made available in DSpace on 2012-10-10T19:01:59Z (GMT). No. of bitstreams: 1 Guerreiro, Jaqueline B..pdf: 46169 bytes, checksum: c97c65a83232a4ec2e1293a84ae84a84 (MD5) Previous issue date: 2005SalvadorThe Brazilian Journal of Infectious DiseasesHTLV-1IFN-γTNF-αLPSneutrophil activationSpontaneous Neutrophil Activation in HTLV-1 Infected PatientsThe Brazilian Journal of Infectious Diseasesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAinfo:eu-repo/semantics/openAccessORIGINALGuerreiro, Jaqueline B..pdfGuerreiro, Jaqueline B..pdfapplication/pdf46169https://repositorio.ufba.br/bitstream/ri/6927/1/Guerreiro%2c%20Jaqueline%20B..pdfc97c65a83232a4ec2e1293a84ae84a84MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/6927/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTGuerreiro, Jaqueline B..pdf.txtGuerreiro, Jaqueline B..pdf.txtExtracted texttext/plain19523https://repositorio.ufba.br/bitstream/ri/6927/3/Guerreiro%2c%20Jaqueline%20B..pdf.txte21f6855beeeaa9253b9adb85f7021acMD53ri/69272022-07-05 14:03:09.076oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:09Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Spontaneous Neutrophil Activation in HTLV-1 Infected Patients
dc.title.alternative.pt_BR.fl_str_mv The Brazilian Journal of Infectious Diseases
title Spontaneous Neutrophil Activation in HTLV-1 Infected Patients
spellingShingle Spontaneous Neutrophil Activation in HTLV-1 Infected Patients
Guerreiro, Jaqueline B.
HTLV-1
IFN-γ
TNF-α
LPS
neutrophil activation
title_short Spontaneous Neutrophil Activation in HTLV-1 Infected Patients
title_full Spontaneous Neutrophil Activation in HTLV-1 Infected Patients
title_fullStr Spontaneous Neutrophil Activation in HTLV-1 Infected Patients
title_full_unstemmed Spontaneous Neutrophil Activation in HTLV-1 Infected Patients
title_sort Spontaneous Neutrophil Activation in HTLV-1 Infected Patients
author Guerreiro, Jaqueline B.
author_facet Guerreiro, Jaqueline B.
Porto, Maria Aurélia da Fonseca
Santos, Silvane Maria Braga
Lacerda, Lino
Ho, John L.
Carvalho Filho, Edgar Marcelino de
author_role author
author2 Porto, Maria Aurélia da Fonseca
Santos, Silvane Maria Braga
Lacerda, Lino
Ho, John L.
Carvalho Filho, Edgar Marcelino de
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Guerreiro, Jaqueline B.
Porto, Maria Aurélia da Fonseca
Santos, Silvane Maria Braga
Lacerda, Lino
Ho, John L.
Carvalho Filho, Edgar Marcelino de
Guerreiro, Jaqueline B.
Porto, Maria Aurélia da Fonseca
Santos, Silvane Maria Braga
Lacerda, Lino
Ho, John L.
Carvalho Filho, Edgar Marcelino de
dc.subject.por.fl_str_mv HTLV-1
IFN-γ
TNF-α
LPS
neutrophil activation
topic HTLV-1
IFN-γ
TNF-α
LPS
neutrophil activation
description p. 510-514
publishDate 2005
dc.date.issued.fl_str_mv 2005
dc.date.accessioned.fl_str_mv 2012-10-10T19:01:59Z
dc.date.available.fl_str_mv 2012-10-10T19:01:59Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/6927
url http://www.repositorio.ufba.br/ri/handle/ri/6927
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv The Brazilian Journal of Infectious Diseases
publisher.none.fl_str_mv The Brazilian Journal of Infectious Diseases
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
instname_str Universidade Federal da Bahia (UFBA)
instacron_str UFBA
institution UFBA
reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
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