HLA-Bw4-B*57 and Cw*18 alleles are associated with plasma viral load modulation in HIV-1 infected individuals in Salvador, Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2010 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://www.repositorio.ufba.br/ri/handle/ri/5048 |
Resumo: | p.468-475 |
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Silva, Edinete Melo daAcosta, Angelina XavierSantos, Eduardo José MeloMartins Netto, EduardoLemaire, Denise CarneiroOliveira, Adriano SilvaBarbosa, Carolina MatosBendicho, Maria Teresita Del Niño Jesus FernandezCastro, Bernardo GalvãoBrites, CarlosSilva, Edinete Melo daAcosta, Angelina XavierSantos, Eduardo José MeloMartins Netto, EduardoLemaire, Denise CarneiroOliveira, Adriano SilvaBarbosa, Carolina MatosBendicho, Maria Teresita Del Niño Jesus FernandezCastro, Bernardo GalvãoBrites, Carlos2012-01-06T12:44:44Z2012-01-06T12:44:44Z20101678-4391http://www.repositorio.ufba.br/ri/handle/ri/504814(5)p.468-475Host genetic factors play an important role in mediating resistance to HIV-1 infection and may modify the course of infection. HLA-B alleles (Bw4 epitope; B*27 and B*57) as well as killer cell immunoglobulin-like receptors have been associated with slow progression of HIV-1 infection. Objective: To evaluate the association between serological epitopes HLA-Bw4 and HLA-Bw6 and prognostic markers in AIDS. Methods: 147 HIV-infected individuals in Bahia, Northeast Brazil, were genotyped for HLA class I locus. HLA class I genotyping was performed by hybridization with sequence-specifi c oligonucleotide probes following amplifi cation of the corresponding HLA-A, HLA-B and HLA-C genes. Statistical analysis was performed using Fisher´s exact and ANOVA tests for categorical and continuous variables, respectively. Results: We detected a signifi cant association (χ2 = 4.856; p = 0.018) between the presence of HLA-Bw4 and low levels of viremia. Eighteen out of the 147 HIV-infected individuals presented viremia 1,800 copies/mL and 129 presented viremia > 2,000 copies/mL. Ninety and four percent (17/18) of all individuals with viremia 1,800 copies/mL carried HLA-Bw4, compared to 67.4% (87/129) of individuals with viremia > 2,000 copies/mL. Additionally, we found a signifi cantly higher frequency of B*57 (OR = 13.94; 95% CI = 4.19-46.38; p < 0.0001) and Cw*18 (OR = 16.15; 95% CI = 3.46-75.43; p ≤ 0.0001) alleles, favoring the group with lower viremia levels, in comparison with those with higher viral load. Conclusion: HLA-Bw4-B*57 and Cw*18 alleles are associated with lower level of viral load in HIV-infected Brazilian patients. These fi ndings may help us in understanding the determinants of HIV evolution in Brazilian patients, as well as in providing important information on immune response correlates of protection for such population.Submitted by Ana Valéria de Jesus Moura (anavaleria_131@hotmail.com) on 2012-01-06T12:44:44Z No. of bitstreams: 1 v14n5a08.pdf: 1127408 bytes, checksum: c1dcc191f66c4fc3f41da516e7194f25 (MD5)Made available in DSpace on 2012-01-06T12:44:44Z (GMT). No. of bitstreams: 1 v14n5a08.pdf: 1127408 bytes, checksum: c1dcc191f66c4fc3f41da516e7194f25 (MD5) Previous issue date: 2010HIVAIDSMHCHLApolymorphismHLA-Bw4-B*57 and Cw*18 alleles are associated with plasma viral load modulation in HIV-1 infected individuals in Salvador, BrazilThe Brazilian Journal of Infectiousinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAinfo:eu-repo/semantics/openAccessORIGINALv14n5a08.pdfv14n5a08.pdfapplication/pdf1127408https://repositorio.ufba.br/bitstream/ri/5048/1/v14n5a08.pdfc1dcc191f66c4fc3f41da516e7194f25MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/5048/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTv14n5a08.pdf.txtv14n5a08.pdf.txtExtracted texttext/plain34844https://repositorio.ufba.br/bitstream/ri/5048/3/v14n5a08.pdf.txt4d4d46b603f3cc05e85a35cca136540eMD53ri/50482022-07-05 14:03:20.46oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:20Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
HLA-Bw4-B*57 and Cw*18 alleles are associated with plasma viral load modulation in HIV-1 infected individuals in Salvador, Brazil |
| dc.title.alternative.pt_BR.fl_str_mv |
The Brazilian Journal of Infectious |
| title |
HLA-Bw4-B*57 and Cw*18 alleles are associated with plasma viral load modulation in HIV-1 infected individuals in Salvador, Brazil |
| spellingShingle |
HLA-Bw4-B*57 and Cw*18 alleles are associated with plasma viral load modulation in HIV-1 infected individuals in Salvador, Brazil Silva, Edinete Melo da HIV AIDS MHC HLA polymorphism |
| title_short |
HLA-Bw4-B*57 and Cw*18 alleles are associated with plasma viral load modulation in HIV-1 infected individuals in Salvador, Brazil |
| title_full |
HLA-Bw4-B*57 and Cw*18 alleles are associated with plasma viral load modulation in HIV-1 infected individuals in Salvador, Brazil |
| title_fullStr |
HLA-Bw4-B*57 and Cw*18 alleles are associated with plasma viral load modulation in HIV-1 infected individuals in Salvador, Brazil |
| title_full_unstemmed |
HLA-Bw4-B*57 and Cw*18 alleles are associated with plasma viral load modulation in HIV-1 infected individuals in Salvador, Brazil |
| title_sort |
HLA-Bw4-B*57 and Cw*18 alleles are associated with plasma viral load modulation in HIV-1 infected individuals in Salvador, Brazil |
| author |
Silva, Edinete Melo da |
| author_facet |
Silva, Edinete Melo da Acosta, Angelina Xavier Santos, Eduardo José Melo Martins Netto, Eduardo Lemaire, Denise Carneiro Oliveira, Adriano Silva Barbosa, Carolina Matos Bendicho, Maria Teresita Del Niño Jesus Fernandez Castro, Bernardo Galvão Brites, Carlos |
| author_role |
author |
| author2 |
Acosta, Angelina Xavier Santos, Eduardo José Melo Martins Netto, Eduardo Lemaire, Denise Carneiro Oliveira, Adriano Silva Barbosa, Carolina Matos Bendicho, Maria Teresita Del Niño Jesus Fernandez Castro, Bernardo Galvão Brites, Carlos |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Silva, Edinete Melo da Acosta, Angelina Xavier Santos, Eduardo José Melo Martins Netto, Eduardo Lemaire, Denise Carneiro Oliveira, Adriano Silva Barbosa, Carolina Matos Bendicho, Maria Teresita Del Niño Jesus Fernandez Castro, Bernardo Galvão Brites, Carlos Silva, Edinete Melo da Acosta, Angelina Xavier Santos, Eduardo José Melo Martins Netto, Eduardo Lemaire, Denise Carneiro Oliveira, Adriano Silva Barbosa, Carolina Matos Bendicho, Maria Teresita Del Niño Jesus Fernandez Castro, Bernardo Galvão Brites, Carlos |
| dc.subject.por.fl_str_mv |
HIV AIDS MHC HLA polymorphism |
| topic |
HIV AIDS MHC HLA polymorphism |
| description |
p.468-475 |
| publishDate |
2010 |
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2010 |
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2012-01-06T12:44:44Z |
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2012-01-06T12:44:44Z |
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1678-4391 |
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14(5) |
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1678-4391 14(5) |
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