Lower prevalence of human immunodeficiency virus type 1 Brazilian subtype B found in Northeastern Brazil with slower progression to AIDS

Detalhes bibliográficos
Autor(a) principal: Araujo, Adriano Fernando
Data de Publicação: 2010
Outros Autores: Brites, Carlos, Cunha, Joana Monteiro, Santos, Luciane Amorim, Galvão, Bernardo Castro, Alcântara, Luiz Carlos Júnior
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/12349
Resumo: Texto completo: acesso restrito. p.1249-1254
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spelling Araujo, Adriano FernandoBrites, CarlosCunha, Joana MonteiroSantos, Luciane AmorimGalvão, Bernardo CastroAlcântara, Luiz Carlos JúniorAraujo, Adriano FernandoBrites, CarlosCunha, Joana MonteiroSantos, Luciane AmorimGalvão, Bernardo CastroAlcântara, Luiz Carlos Júnior2013-07-30T15:01:45Z20100889-2229http://www.repositorio.ufba.br/ri/handle/ri/12349v. 26, n. 11Texto completo: acesso restrito. p.1249-1254Besides being extremely useful in measuring the level of HIV-1 diversity and prevalence in populations, the molecular analysis of genomic sequences provides crucial surveillance support and aids in the development of new therapies and effective vaccines. The present study focused on gag and env DNA and amino acid sequences that were generated from samples taken from 61 infected patients in the City of Salvador, Bahia, located in northeastern Brazil. In order to determine selective pressure and predict coreceptor usage, Bioinformatics tools were employed in phylogeny reconstruction. Fifty-six (91.8%) viruses were classified as belonging to subtype B, three (4.9%) from F1, and two (3.3%) from BF1 recombinants. Based on the characterization of the V3 region, the subtype B strains were represented by eight (18.2%) Brazilian variants (B’-GWGR), 20 (46.5%) European/EUA B variants (GPGR), and 15 (34.9%) GXGX variants. The mean time elapsed since diagnosis was 13 years among subtype B’ and 9 years in subtype B. The mean dN/dS ratios from the GWGR, GPGR, and GXGX groups, when compared to an HXB2 reference, were 0.72, 0.77, and 0.67, respectively. Seventy-six percent of the viruses studied were predicted to use the CCR5 coreceptor for cell entry (R5 viruses), while 24% were predicted to use the CXCR4 or were classified as dual tropic viruses. The prevalence of subtypes B' and recombinant B/F1 was shown to be lower than findings from previous studies performed both in Brazil (B’) and in Bahia (B/F1). The association between subtype B’ and a lengthy period of time since diagnosis can be correlated with a slower disease progression in infected patients, when compared with those infected with subtype B.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2013-07-12T13:39:26Z No. of bitstreams: 1 aid%2E2010%2E0068.pdf: 1878328 bytes, checksum: c8905a23e5212aeaabc9ce9b8f103d4c (MD5)Approved for entry into archive by Flávia Ferreira(flaviaccf@yahoo.com.br) on 2013-07-30T15:01:45Z (GMT) No. of bitstreams: 1 aid%2E2010%2E0068.pdf: 1878328 bytes, checksum: c8905a23e5212aeaabc9ce9b8f103d4c (MD5)Made available in DSpace on 2013-07-30T15:01:45Z (GMT). No. of bitstreams: 1 aid%2E2010%2E0068.pdf: 1878328 bytes, checksum: c8905a23e5212aeaabc9ce9b8f103d4c (MD5) Previous issue date: 2010http://dx.doi.org/10.1089/aid.2010.0068reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBALower prevalence of human immunodeficiency virus type 1 Brazilian subtype B found in Northeastern Brazil with slower progression to AIDSAIDS Research and Human Retrovirusesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessORIGINALaid%2E2010%2E0068.pdfaid%2E2010%2E0068.pdfapplication/pdf1878328https://repositorio.ufba.br/bitstream/ri/12349/1/aid%252E2010%252E0068.pdfc8905a23e5212aeaabc9ce9b8f103d4cMD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/12349/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTaid%2E2010%2E0068.pdf.txtaid%2E2010%2E0068.pdf.txtExtracted texttext/plain19420https://repositorio.ufba.br/bitstream/ri/12349/3/aid%252E2010%252E0068.pdf.txt3596d8d1ff89e535c3547e38df22ccecMD53ri/123492022-08-08 13:17:31.518oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-08-08T16:17:31Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Lower prevalence of human immunodeficiency virus type 1 Brazilian subtype B found in Northeastern Brazil with slower progression to AIDS
dc.title.alternative.pt_BR.fl_str_mv AIDS Research and Human Retroviruses
title Lower prevalence of human immunodeficiency virus type 1 Brazilian subtype B found in Northeastern Brazil with slower progression to AIDS
spellingShingle Lower prevalence of human immunodeficiency virus type 1 Brazilian subtype B found in Northeastern Brazil with slower progression to AIDS
Araujo, Adriano Fernando
title_short Lower prevalence of human immunodeficiency virus type 1 Brazilian subtype B found in Northeastern Brazil with slower progression to AIDS
title_full Lower prevalence of human immunodeficiency virus type 1 Brazilian subtype B found in Northeastern Brazil with slower progression to AIDS
title_fullStr Lower prevalence of human immunodeficiency virus type 1 Brazilian subtype B found in Northeastern Brazil with slower progression to AIDS
title_full_unstemmed Lower prevalence of human immunodeficiency virus type 1 Brazilian subtype B found in Northeastern Brazil with slower progression to AIDS
title_sort Lower prevalence of human immunodeficiency virus type 1 Brazilian subtype B found in Northeastern Brazil with slower progression to AIDS
author Araujo, Adriano Fernando
author_facet Araujo, Adriano Fernando
Brites, Carlos
Cunha, Joana Monteiro
Santos, Luciane Amorim
Galvão, Bernardo Castro
Alcântara, Luiz Carlos Júnior
author_role author
author2 Brites, Carlos
Cunha, Joana Monteiro
Santos, Luciane Amorim
Galvão, Bernardo Castro
Alcântara, Luiz Carlos Júnior
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Araujo, Adriano Fernando
Brites, Carlos
Cunha, Joana Monteiro
Santos, Luciane Amorim
Galvão, Bernardo Castro
Alcântara, Luiz Carlos Júnior
Araujo, Adriano Fernando
Brites, Carlos
Cunha, Joana Monteiro
Santos, Luciane Amorim
Galvão, Bernardo Castro
Alcântara, Luiz Carlos Júnior
description Texto completo: acesso restrito. p.1249-1254
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2013-07-30T15:01:45Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/12349
dc.identifier.issn.none.fl_str_mv 0889-2229
dc.identifier.number.pt_BR.fl_str_mv v. 26, n. 11
identifier_str_mv 0889-2229
v. 26, n. 11
url http://www.repositorio.ufba.br/ri/handle/ri/12349
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1089/aid.2010.0068
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