Plasma lipoproteins in visceral leishmaniasis and their effect on Leishmania-infected macrophages
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFBA |
Texto Completo: | http://www.repositorio.ufba.br/ri/handle/ri/5846 |
Resumo: | Trabalho completo: acesso restrito, p. 259–266 |
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Soares, N. M.Leal, T. F.Fiúza, M. C.Reis, E. A. G.Souza, M. A. L.Santos, W. L. dosCarvalho, Lain Carlos Pontes deSoares, N. M.Leal, T. F.Fiúza, M. C.Reis, E. A. G.Souza, M. A. L.Santos, W. L. dosCarvalho, Lain Carlos Pontes de2012-05-11T20:12:55Z2010-040141-9838http://www.repositorio.ufba.br/ri/handle/ri/5846v. 32, n. 4Trabalho completo: acesso restrito, p. 259–266This work aimed at investigating the lipid profile of zoonotic visceral leishmaniasis (VL) patients’ sera and the effect of lipoproteins on the in vitro production of tumour necrosis factor-α (TNF-α), interleukin (IL)-6, IL-10 and IL-12 by Leishmania infantum-infected and uninfected macrophages. Lipids were quantified in 26 VL patients’ sera and 26 healthy controls from a VL endemic area. The patients’ sera had higher triglyceride and very low density lipoprotein (VLDL) levels, and much lower apolipoprotein A1, total cholesterol, low density lipoprotein (LDL) and high density lipoprotein (HDL) levels than the control sera. Lipoprotein fractions were obtained by ultracentrifugation of sera. The addition of LDL and HDL to Leishmania-infected and uninfected macrophages, in physiological concentrations, enhanced the production of IL-6 and IL-10, but not of IL-12. LDL stimulated the production of TNF-α only in infected macrophages, whereas HDL stimulated the production of lower amounts of TNF-α in both infected and uninfected macrophages. VLDL stimulated only the production of IL-10. It is proposed herein that LDL may influence the development of VL by promoting the production of TNF-α by infected macrophages. A decrease in plasma LDL in some VL patients (to 20 mg/mL or less); however, would tend to reduce the production of TNF-α and therefore to limit the development of immune-mediated pathology, not withstanding the fact that it would perhaps increase the permissiveness of macrophages to Leishmania growth.Submitted by Bruna Lessa (lessbruna@gmail.com) on 2012-05-11T20:12:55Z No. of bitstreams: 1 (14)j.1365-3024.2009.01187.x.pdf: 289581 bytes, checksum: 3e5ad12c855fc824f7d44ae0902a861d (MD5)Made available in DSpace on 2012-05-11T20:12:55Z (GMT). No. of bitstreams: 1 (14)j.1365-3024.2009.01187.x.pdf: 289581 bytes, checksum: 3e5ad12c855fc824f7d44ae0902a861d (MD5) Previous issue date: 2010-04John Wiley & Sons A/S10.1111/j.1365-3024.2009.01187.xreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAcytokinesLeishmanialipoproteinsPlasma lipoproteins in visceral leishmaniasis and their effect on Leishmania-infected macrophagesParasite Immunologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessORIGINAL(14)j.1365-3024.2009.01187.x.pdf(14)j.1365-3024.2009.01187.x.pdfapplication/pdf289581https://repositorio.ufba.br/bitstream/ri/5846/1/%2814%29j.1365-3024.2009.01187.x.pdf3e5ad12c855fc824f7d44ae0902a861dMD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/5846/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXT(14)j.1365-3024.2009.01187.x.pdf.txt(14)j.1365-3024.2009.01187.x.pdf.txtExtracted texttext/plain37838https://repositorio.ufba.br/bitstream/ri/5846/3/%2814%29j.1365-3024.2009.01187.x.pdf.txt67d6aaf004d02a6e884029ccdc307447MD53ri/58462022-07-05 14:03:21.921oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:21Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
dc.title.pt_BR.fl_str_mv |
Plasma lipoproteins in visceral leishmaniasis and their effect on Leishmania-infected macrophages |
dc.title.alternative.pt_BR.fl_str_mv |
Parasite Immunology |
title |
Plasma lipoproteins in visceral leishmaniasis and their effect on Leishmania-infected macrophages |
spellingShingle |
Plasma lipoproteins in visceral leishmaniasis and their effect on Leishmania-infected macrophages Soares, N. M. cytokines Leishmania lipoproteins |
title_short |
Plasma lipoproteins in visceral leishmaniasis and their effect on Leishmania-infected macrophages |
title_full |
Plasma lipoproteins in visceral leishmaniasis and their effect on Leishmania-infected macrophages |
title_fullStr |
Plasma lipoproteins in visceral leishmaniasis and their effect on Leishmania-infected macrophages |
title_full_unstemmed |
Plasma lipoproteins in visceral leishmaniasis and their effect on Leishmania-infected macrophages |
title_sort |
Plasma lipoproteins in visceral leishmaniasis and their effect on Leishmania-infected macrophages |
author |
Soares, N. M. |
author_facet |
Soares, N. M. Leal, T. F. Fiúza, M. C. Reis, E. A. G. Souza, M. A. L. Santos, W. L. dos Carvalho, Lain Carlos Pontes de |
author_role |
author |
author2 |
Leal, T. F. Fiúza, M. C. Reis, E. A. G. Souza, M. A. L. Santos, W. L. dos Carvalho, Lain Carlos Pontes de |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Soares, N. M. Leal, T. F. Fiúza, M. C. Reis, E. A. G. Souza, M. A. L. Santos, W. L. dos Carvalho, Lain Carlos Pontes de Soares, N. M. Leal, T. F. Fiúza, M. C. Reis, E. A. G. Souza, M. A. L. Santos, W. L. dos Carvalho, Lain Carlos Pontes de |
dc.subject.por.fl_str_mv |
cytokines Leishmania lipoproteins |
topic |
cytokines Leishmania lipoproteins |
description |
Trabalho completo: acesso restrito, p. 259–266 |
publishDate |
2010 |
dc.date.issued.fl_str_mv |
2010-04 |
dc.date.accessioned.fl_str_mv |
2012-05-11T20:12:55Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.repositorio.ufba.br/ri/handle/ri/5846 |
dc.identifier.issn.none.fl_str_mv |
0141-9838 |
dc.identifier.number.pt_BR.fl_str_mv |
v. 32, n. 4 |
identifier_str_mv |
0141-9838 v. 32, n. 4 |
url |
http://www.repositorio.ufba.br/ri/handle/ri/5846 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
John Wiley & Sons A/S |
publisher.none.fl_str_mv |
John Wiley & Sons A/S |
dc.source.pt_BR.fl_str_mv |
10.1111/j.1365-3024.2009.01187.x |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFBA instname:Universidade Federal da Bahia (UFBA) instacron:UFBA |
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Universidade Federal da Bahia (UFBA) |
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UFBA |
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UFBA |
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Repositório Institucional da UFBA |
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Repositório Institucional da UFBA |
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