A new vaginal antimicrobial contraceptive formulation: phase I clinical pilot studies

Detalhes bibliográficos
Autor(a) principal: Ladipo, Oladapo A.
Data de Publicação: 2000
Outros Autores: Castro, Marcos P. de., T. Filho, Lois C. C., Coutinho, Elsimar Metzker, Waller, Donald P., Cone, Fred, Zaneveld, Lourens J. D.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/7811
Resumo: Texto completo: acesso restrito. p.91–97
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spelling Ladipo, Oladapo A.Castro, Marcos P. de.T. Filho, Lois C. C.Coutinho, Elsimar MetzkerWaller, Donald P.Cone, FredZaneveld, Lourens J. D.Ladipo, Oladapo A.Castro, Marcos P. de.T. Filho, Lois C. C.Coutinho, Elsimar MetzkerWaller, Donald P.Cone, FredZaneveld, Lourens J. D.2013-01-11T14:31:50Z20000010-7824http://www.repositorio.ufba.br/ri/handle/ri/7811v. 62, n. 2Texto completo: acesso restrito. p.91–97Pilot clinical trials were performed with a new vaginal suppository called “Long Acting, Sustained Release of Spermicide” (“LASRS”). No visual or colposcopic lesions or patient complaints occurred as a result of using LASRS with increasing doses of nonoxynol-9 (up to 20%) for 5 days or of applying the highest dose of nonoxynol-9 (20%; total 400 mg) for 8 h. Colposcopic or visual lesions were also not induced when LASRS with 20% nonoxynol-9 was used for 7 consecutive days by the study participants except for those who developed symptomatic monilia vaginitis. Symptoms were reported although these were mostly minor. A long-lasting, bioadhesive, translucent layer (film) of formulation formed over the vaginal and cervical surfaces. Postcoital spermicidal studies showed LASRS to be highly effective for prolonged periods of time. Although intercourse was delayed for 5 to 8.5 h after insertion of the formulation, an average of only 0.2 motile sperm/HPF could be found in cervical mucus. These studies suggest LASRS to possess advantages over presently marketed formulations by having long-term efficacy and by forming a bioadhesive, presumably protective layer over the genital tract epithelium. The results also suggest the formulation to decrease the vaginal irritation caused by nonoxynol-9 as noted by colposcopy. These pilot data support a more extensive study with the LASRS suppository.Submitted by Suelen Reis (suelen_suzane@hotmail.com) on 2013-01-11T14:31:50Z No. of bitstreams: 1 1-s2.0-S0010782400001384-main.pdf: 64429 bytes, checksum: f84c28cb13b9729ed09681934405bab8 (MD5)Made available in DSpace on 2013-01-11T14:31:50Z (GMT). No. of bitstreams: 1 1-s2.0-S0010782400001384-main.pdf: 64429 bytes, checksum: f84c28cb13b9729ed09681934405bab8 (MD5) Previous issue date: 2000http://dx.doi.org/10.1016/S0010-7824(00)00138-4reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBASuppositoryHumanVaginaIrritationPostcoital testA new vaginal antimicrobial contraceptive formulation: phase I clinical pilot studiesContraceptioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessLICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/7811/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52ORIGINAL1-s2.0-S0010782400001384-main.pdf1-s2.0-S0010782400001384-main.pdfapplication/pdf64429https://repositorio.ufba.br/bitstream/ri/7811/1/1-s2.0-S0010782400001384-main.pdff84c28cb13b9729ed09681934405bab8MD51TEXT1-s2.0-S0010782400001384-main.pdf.txt1-s2.0-S0010782400001384-main.pdf.txtExtracted texttext/plain38896https://repositorio.ufba.br/bitstream/ri/7811/3/1-s2.0-S0010782400001384-main.pdf.txtf5692c39ec8033c47eeea7d1e64a41d7MD53ri/78112022-07-05 14:03:03.856oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:03Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv A new vaginal antimicrobial contraceptive formulation: phase I clinical pilot studies
dc.title.alternative.pt_BR.fl_str_mv Contraception
title A new vaginal antimicrobial contraceptive formulation: phase I clinical pilot studies
spellingShingle A new vaginal antimicrobial contraceptive formulation: phase I clinical pilot studies
Ladipo, Oladapo A.
Suppository
Human
Vagina
Irritation
Postcoital test
title_short A new vaginal antimicrobial contraceptive formulation: phase I clinical pilot studies
title_full A new vaginal antimicrobial contraceptive formulation: phase I clinical pilot studies
title_fullStr A new vaginal antimicrobial contraceptive formulation: phase I clinical pilot studies
title_full_unstemmed A new vaginal antimicrobial contraceptive formulation: phase I clinical pilot studies
title_sort A new vaginal antimicrobial contraceptive formulation: phase I clinical pilot studies
author Ladipo, Oladapo A.
author_facet Ladipo, Oladapo A.
Castro, Marcos P. de.
T. Filho, Lois C. C.
Coutinho, Elsimar Metzker
Waller, Donald P.
Cone, Fred
Zaneveld, Lourens J. D.
author_role author
author2 Castro, Marcos P. de.
T. Filho, Lois C. C.
Coutinho, Elsimar Metzker
Waller, Donald P.
Cone, Fred
Zaneveld, Lourens J. D.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Ladipo, Oladapo A.
Castro, Marcos P. de.
T. Filho, Lois C. C.
Coutinho, Elsimar Metzker
Waller, Donald P.
Cone, Fred
Zaneveld, Lourens J. D.
Ladipo, Oladapo A.
Castro, Marcos P. de.
T. Filho, Lois C. C.
Coutinho, Elsimar Metzker
Waller, Donald P.
Cone, Fred
Zaneveld, Lourens J. D.
dc.subject.por.fl_str_mv Suppository
Human
Vagina
Irritation
Postcoital test
topic Suppository
Human
Vagina
Irritation
Postcoital test
description Texto completo: acesso restrito. p.91–97
publishDate 2000
dc.date.issued.fl_str_mv 2000
dc.date.accessioned.fl_str_mv 2013-01-11T14:31:50Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/7811
dc.identifier.issn.none.fl_str_mv 0010-7824
dc.identifier.number.pt_BR.fl_str_mv v. 62, n. 2
identifier_str_mv 0010-7824
v. 62, n. 2
url http://www.repositorio.ufba.br/ri/handle/ri/7811
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1016/S0010-7824(00)00138-4
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
instname_str Universidade Federal da Bahia (UFBA)
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